KEGG   ENZYME: 1.14.14.187
Entry
EC 1.14.14.187              Enzyme                                 
Name
rhazimal synthase;
RHS (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
geissoschizine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (rhazimal forming)
Reaction(IUBMB)
geissoschizine + [reduced NADPH---hemoprotein reductase] + O2 = rhazimal + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R13378]
Reaction(KEGG)
R13378
Substrate
geissoschizine;
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
rhazimal [CPD:C22893];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450) isolated from the plant Alstonia scholaris (blackboard tree).
History
EC 1.14.14.187 created 2024
Pathway
ec00901  Indole alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K27859  rhazimal synthase
Reference
1  [PMID:36349266]
  Authors
Wang Z, Xiao Y, Wu S, Chen J, Li A, Tatsis EC.
  Title
Deciphering and reprogramming the cyclization regioselectivity in bifurcation of indole alkaloid biosynthesis.
  Journal
Chem Sci 13:12389-12395 (2022)
DOI:10.1039/d2sc03612f
  Sequence
[ag:URS65384]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.187
IUBMB Enzyme Nomenclature: 1.14.14.187
ExPASy - ENZYME nomenclature database: 1.14.14.187
BRENDA, the Enzyme Database: 1.14.14.187
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