KEGG   ENZYME: 1.14.14.79
Entry
EC 1.14.14.79               Enzyme                                 
Name
docosahexaenoic acid omega-hydroxylase;
CYP4F3B;
CYP4V2;
docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
docosahexaenoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (22-hydroxydocosahexaenoate-forming)
Reaction(IUBMB)
docosahexaenoate + [reduced NADPH---hemoprotein reductase] + O2 = 22-hydroxydocosahexaenoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R10795]
Reaction(KEGG)
R10795
Substrate
docosahexaenoate [CPD:C06429];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
22-hydroxydocosahexaenoate [CPD:C20855];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid.
History
EC 1.14.14.79 created 2014 as EC 1.14.13.199, transferred 2018 to EC 1.14.14.79
Orthology
K07427  docosahexaenoic acid omega-hydroxylase
K17726  phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
Genes
HSA285440(CYP4V2) 4051(CYP4F3) 8529(CYP4F2)
PTR100609185 744981(CYP4V2) 748117(CYP4F3) 748531(CYP4F2)
PPS100967411(CYP4F2) 100969141(CYP4F3) 100985937(CYP4V2)
GGO101125692 101135418 101142243 101152881
PON100172140(CYP4V2) 100434096 100437847 100453229
NLE100579320 100588006 100602871 115836096 115836968
MCC696520(CYP4V2) 718349 719317
MCF102130440(CYP4F3) 102134301(CYP4F2) 102141321(CYP4V2)
MTHB126942252 126942253 126955236
CSAB103234079 103234089 103236636
CATY105594263 105601614 105601627
PANU101003969 101005940 101010705
TGE112612404 112613097 112625202
RRO104661012 104661014 104673816
RBB108522429 108543262 108543288 108543294
TFN117076174 117086225
PTEH111548494 111554233 111554287
CJC100408123(CYP4V2) 100411160 100412575(CYP4F2)
SBQ101049306 101050944 101051361
CSYR103250633 103271968
MMUR105867925 105867928 105867931 105882473
LCAT123634142 123636967 123638621 123639775
OGA100942215 100943471 100950748 100952962 100956186
MMU102294(Cyp4v3)
MCAL110300005
MPAH110337006
RNO266761(Cyp4v3)
MCOC116069215
MUN110558009
CGE100750743
MAUA101842758
PLEU114701165
MORG121433839
MFOT126504756
AAMP119811191
NGI103750492
HGL101716986
CPOC100716074 100733735
CCAN109684291
DORD105991323
DSP122127372
NCAR124982271
OCU100348038 100350957 100356012
OPI101524068
TUP102483333 102485250
GVR103606854
CFA102152484(CYP4V2)
CLUD112675196
VVP112934751
VLG121489190 121495723
AML100468607
UMR103681006
UAH113262286
UAR123779961 123780007 123784493
ELK111144567
LLV125083145 125091643
MPUF101684052
ORO101378686
EJU114206180
ZCA113917975 113924431
MLX118005050 118010048
NSU110584266
LWW102726129
FCA101097556
PYU121039710
PBG122471005
LRUF124520538
PTG102960154
PPAD109250992
AJU106982209
HHV120237797
BTA510156(CYP4V2)
BOM102268997
BIU109553482
BBUB102394892
BBIS104985559
CHX102188826
OAS101116121
ODA120865741
CCAD122432373
SSC100113469(CYP4V2)
CFR102512100
CBAI105067667
CDK105102385
VPC102525832
BACU102999883
LVE103081363
OOR101278344
DLE111173427
PCAD102990897
PSIU116746666
ECB100056687
EPZ103543058
EAI106840365
MYB102240114 102240725 102242692 102247921 102260288
MYD102754363 102756718 102762764 102763048 102765134 102765327
MMYO118650029 118650794
MLF102425173 102427238 102427536 102427859 102428489 102428801 102429106 102429710 102436085
MNA107534032
PKL118706555 118730056 118730057 118730058 118730060
HAI109395858
DRO112305042 112306751
SHON118993095
AJM119036852
PDIC114503445 114508725
PHAS123807470
MMF118623007
RFQ117021398 117038128
PALE102883230
PGIG120606485 120618464
PVP105294689 105311420
RAY107510438 107517263
MJV108396407
TOD119240020 119257928 119257929 119257930
SARA101551663 101556979 101557255
LAV100657832 100661067
TMU101342431
ETF101648603
DNM101424148 101441145
MDO100014017
GAS123251454
SHR100917708
PCW110222598
OAA100090407
GGA415121(CYP4V2)
PCOC116238901
MGP100549160
CJO107313678
APLA101790057
ACYG106035235
AFUL116488669
TGU100230859
LSR110484918
SCAN103825461
PMOA120497991
OTC121331412
PRUF121360302
GFR102033190
FAB101813952
PHI102107875
PMAJ107203122
CCAE111927975
CCW104690591
CBRC103622483
ETL114067779
ZAB102064910
ACHL103810795
FPG101918235
FCH102054486
CLV102094289
EGZ104129484
NNI104021298
PLET104624448
PCRI104029040
PCAO104047317
ACUN113479206
TALA104358687
PADL103922516
AFOR103897378
ACHC115341167
HALD104315325 104322980
HLE104833395
AGEN126037341
GCL127016010
CCRI104158115
CSTI104564114
EHS104508114
CMAC104483329
MUI104546959
FGA104080000
GSTE104262044
LDI104354849
MNB103780297
OHA104334544
NNT104401741
DPUB104301789
PGUU104462378
ACAR104518228
CPEA104393017
CVF104285445
CUCA104063478
TEO104376290
BRHI104500235
AAM106484032
AROW112964066
NPD112949823
TGT104575333
DNE112986138
SCAM104145247
ASN102369346 102369869 112550784
AMJ102563402(CYP4V2) 102563645(CYP4V2) 102570586
CPOO109321858 109322022 109322023
GGN109303665 109303762 109303763 109303764
PSS102455571 102455815
CMY102938005 102943258
CPIC101941514 101941793 101952270
TST117878349
CABI116835909 116835915
MRV120405535 120405610 120406861
ACS100557625
PVT110077895
SUND121931691
PBI103052236
PMUR107302659
CTIG120316638
TSR106542020
PGUT117680125
VKO123036294
PMUA114604215 114604282 114604283 114604284
ZVI118083468 118083469 118083470
GJA107121984
STOW125440340
XLA100337567(cyp4v4) 444482(cyp4v2.1.L)
XTR100485929(cyp4v2.1) 780124(cyp4v2.2)
NPR108784939 108794276
RTEM120921880 120921889
BBUF120990164
BGAR122940960
DRE558851(cyp4v2a) 562008(cyp4v2b)
SRX107707218 107736720 107752071 107754133
SANH107656409 107658042 107670167
SGH107558204 107561656 107562739 107600159
CCAR109073701
CAUA113044178 113057798 113057916 113107224
PPRM120461003 120493055 120493130
MAMB125259134 125272564
IPU108260937 108269274
PHYP113528690 113547369
SMEO124381082 124385624
TFD113635486 113635594
AMEX103031293 111195187
EEE113579251
TRU101061436
TNGGSTEN00013691G001
LCO104917763
NCC104952998
CGOB115011785
ELY117254651
EFO125886063
PLEP121942358
SLUC116051748
ECRA117954687
ESP116701830
PFLV114569292
GAT120824559
PPUG119218150
MSAM119898795
CUD121508566
ALAT119027599
MZE101485601
ONL100703355
OAU116312391
OLA101162575
OML112137079
XMA102237202
XCO114145628
XHE116720394
PRET103461721
PFOR103136377
PLAI106953322
PMEI106931969
GAF122829941
CVG107094912 107094916
CTUL119797184 119797185
GMU124868668
NFU107374000
KMR108231369
ALIM106519688 106519689
NWH119423011
AOCE111582916
MCEP125004692
CSEM103384330
POV109641907
SSEN122771630
HHIP117767577
HSP118122569
LCF108901662
SDU111216661
SLAL111663247
XGL120800930
HCQ109510969
BPEC110166101 110166102
MALB109968238
BSPL114862008
SASA106602559 106612026
STRU115191902 115201982 115205526
OTW112231806 112255983
OMY110504717 110534411
OGO124011109 124012828
ONE115129253 115137326
SALP111971620 112074167
SNH120052871 120062472
CCLU121561203 121563044 121586966
ELS105022860 105026638
SFM108924579 108931099
PKI111853609 111859276
AANG118227724 118231082
LOC102683375
PSPA121297888
ARUT117409049
PSEX120527497
LCM102361464
CMK103178199
RTP109916600
BFO118407885
BBEL109477858
CIN100180750 100183395
SCLV120342785 120342788 120344346 120344612
SPU100893947 115918097 115918464 577955 579739 581875 594737 762892
APLC110987520
AJC117117008 117117030 117121847
SKO100375440
RZE108368329 108377766 108378434 108378788 108381916
ACOZ120951683
AARA120895624 120896510 120896512 120896513 120897018 120897050 120897515 120901996
ASTE118502450 118504587 118504593 118508259 118515262
AAG5567661
AALB109411363
CQUCpipJ_CPIJ005683 CpipJ_CPIJ005684 CpipJ_CPIJ007085 CpipJ_CPIJ007089 CpipJ_CPIJ007090 CpipJ_CPIJ007092 CpipJ_CPIJ007093 CpipJ_CPIJ007095
CPII120417522 120417528 120421611 120421612 120421615 120424836 120424837 120424866 120431553 120431555 120431725
CNS116344591 116345516 116347675 116347967 116348422 116350509 116351388 116351389 116351390 116351391 116351392
BCOO119069540 119071872 119073031 119078024 119078035 119078036 119078519 119083265
ACER107997710 107997912
ALAB122715191
BBIF117211931
BVK117239101
BVAN117165994
BPYO122577027
MGEN117222071
NMEA116427591
PFUC122513580 122514292 122514925 122515566 122515567 122515568 122515587 122517710 122517774 122517839 122518856 122518857 122518922 122518941 122520409 122520498 122521032 122521752 122522732 122522733 122523798 122523799 122524229 122524230 122524526 122524527 122524532 122525657 122525658 122525686 122525688 122525689 122525691 122525693 122526167
VPS122635813 122635814 122635815 122637187
TPRE106648534 106649101 106649102 106649184 106649330 106650915 106651281 106651572 106653058 106654078
CGLO123259233 123259234 123259602 123264579 123267240 123273420 123274240
FAS105263310 105263312 105266799 105270877 105270987
DAM107039824 107039826 107039828 107039829 107043310 107043861 107047963 107048684 107048697
AGIF122853693 122853949 122853950 122855220 122855221 122860411
LHT122507966
CCIN107272935 107274457 107274924
SOY115874320 115874482 115877484 115880077 115880922 115880923 115881582 115881583 115881664 115881704 115881719 115881735 115888687
ATD109606373
CSET123321060
AGB108904168 108905403 108906962 108911484 111691345 111693089
LDC111504218 111510743
APLN108736863 112904022
PPYR116159257 116165076 116167564 116170339 116172291 116172361 116177880 116177881 116177882 116177885 116177886 116177887 116177888
OTU111413314 111416483 111418207 111418402 111419493 111421753 111421875 111421945 111422059 111422074 111422210 111422421 111422514 111423053 111424102 111424154 111425838 111427012 111427333 111427382 111427936 111428978 111428979 111428982 111428983 111429322 111429505
MSEX115443293 115444780 115444887 115449016 115449044 115451411 115454101 115455802 119188928
BANY112046024 112049165 112051069 112051293 112051904 112055100 112055634 112055643 112055677 112055688 112055700
PPOT106100072 106105327 106105328 106105618
PXU106124585 106125043 106125217 106125231 106125542 106125543
PRAP110993186 110994344 110994420 110995875 110995886 111000470 123689605
PNAP125050232 125050233
ZCE119831326
SLIU111349291 111349292 111349331 111349484 111349528 111356994 111360017 111360018 111360019 111360469
OFU114353129 114355081 114356078 114362233 114365283
CFEL113363865 113377060 113385375
API100160629 100166760
DNX107163873 107163874 107163881
AGS114121961 114121962 114121977
RMD113554854 113554855
BTAB109030014 109030151 109031969 109036074 109036972 109036973 109037834 109038941 109040639 109040640 109043040 109043831 109044441
DCI103506319 103507738 103510882 103511778 103515115 103515942 103516706 103516895 113469017
CLEC106672025
HHAL106677250 106678066 106678472 106678588 106679066 106679197 106679207 106680051 106680054 106682501 106683607 106683620 106683621 106683623 106686317
FOC113202370 113202374 113203168 113203280 113203758 113205100 113206492 113206720 113208681 113209238 113209334 113209335 113209348 113210186 113210762 113210802 113212592 113212737 113213039 113213146 113214245 113215782 113215794
TPAL117641045 117641094 117641118 117641244 117641416 117641570 117642561 117643291 117643540 117644026 117644036 117644669 117645135 117645526 117645727 117647338 117647438 117647805 117647806 117649385 117649485 117649707 117650517 117650556 117650605 117651230 117653089 117653090 117653828
CSEC111862487 111863323 111863395 111864296 111864297 111864307
SGRE126281314 126298354
FCD110862369
DMK116927068 116934248 116934506 123475997
DPZ124315080 124327130 124348966
PJA122245276 122261367
PCHN125029046
HAZT108679188
PPOI119098772 119101356 119101456 119101563 119101701
ISCIscW_ISCW005544 IscW_ISCW005615 IscW_ISCW007225 IscW_ISCW010786 IscW_ISCW010787 IscW_ISCW010788 IscW_ISCW019906 IscW_ISCW022693 IscW_ISCW022699 IscW_ISCW022701 IscW_ISCW022703 IscW_ISCW022705
DSV119436562 119436669 119436670 119436672 119436678 119436679 119436878 119437020 119437021 119437022 119438566 119439862 119441446 119447252 119456484 119458628 119464912
RSAN119378826 119386632 119389477 119393194 119393687 119393693 119394404 119394422 119394432 119394445 119394458 119395113 119395138 119395151 119395164 119397961 119402449
RMP119161155 119161157 119161233 119161234 119161235 119161237 119161238 119161239 119161241 119161314 119161448 119162010 119162051 119171835 119177153 119177950 119181658
VDE111243321 111244152 111246554 111248731 111249946 111252654 111252664 111253965
VJA111259234 111259235 111260960 111261338 111261710 111268873 111273090 111273739
TUT107360193 107361555 107361951 107362192 107362448 107363943 107366931 107368146 107368147 107369794 107369959 107371897 107372191
DPTE113793077
DFR124492534 124492679 124495885 124496436 124496437 124496438 124496439 124496868 124496869 124497018 124499987
CSCU111612503 111613750 111613800 111614327 111614707 111614911 111614915 111615085 111616480 111616481 111617004 111617105 111617625 111621817 111622186 111623434 111624260 111625199 111625200 111625806 111625807 111626390 111627630 111627631 111627633 111631621 111632089 111633067 111634551 111634987 111634990 111635853 111639943
PTEP107436838 107441954 107443360 107443468 107443469 107443641 107443713 107443864 107446851 107447204 107447784 107450173 107450174 107456117
SDM118181948 118185968 118188928 118189905 118191056 118191192 118192212 118192753 118192978 118194678 118194680 118197240 118200418 118204276 118204389 118205520
CELCELE_Y80D3A.5(cyp-42A1)
CBRCBG_20323(Cbr-cyp-42A1)
BMYBM_BM7159(Bma-cyp-42A1.1) BM_BM8635(Bma-cyp-42A1.2)
LOALOAG_16760
NAINECAME_03284 NECAME_06856 NECAME_15256
TSPTsp_10837
LGILOTGIDRAFT_206515
PCAN112556660
BGT106065596
GAE121378638
HRF124113704
HRJ124277695
CRG105323364
MYI110451224
PMAX117331221
MMER123527893 123563759
OBI106876141 106876144 106878048
OSN115211833 115212028 115212039 115212041 115212257 115212422
LAK106156039
NVE5502706 5502709
EPA110235098
ATEN116295183 116295184
ADF107329895 107329913 107330438 107330484 107335891
AMIL114965427 114965429 114965430 114965431
PDAM113664116 113664119
SPIS111325112 111341124 111347199 111347203
DGT114524910 114537125 114539322 114539407 114539409 114540646 114541977
XEN124454973
HMG100198963 105845269
 » show all
Reference
1  [PMID:22772592]
  Authors
Nakano M, Kelly EJ, Wiek C, Hanenberg H, Rettie AE
  Title
CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of omega-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant.
  Journal
Mol Pharmacol 82:679-86 (2012)
DOI:10.1124/mol.112.080085
  Sequence
[hsa:285440]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.79
IUBMB Enzyme Nomenclature: 1.14.14.79
ExPASy - ENZYME nomenclature database: 1.14.14.79
BRENDA, the Enzyme Database: 1.14.14.79
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