Entry
Name
docosahexaenoic acid omega-hydroxylase;
CYP4F3B;
CYP4V2;
docosahexaenoate,NADPH:O2 oxidoreductase (22-hydroxydocosahexaenoate forming)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
docosahexaenoate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (22-hydroxydocosahexaenoate-forming)
Reaction(IUBMB)
docosahexaenoate + [reduced NADPH---hemoprotein reductase] + O2 = 22-hydroxydocosahexaenoate + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
R10795 ]
Reaction(KEGG)
Substrate
docosahexaenoate [CPD:
C06429 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product
22-hydroxydocosahexaenoate [CPD:
C20855 ];
[oxidized NADPH---hemoprotein reductase] [CPD:
C03161 ];
H2O [CPD:
C00001 ]
Comment
A cytochrome P-450 (heme-thiolate) protein isolated from human eye tissue. Defects in the enzyme are associated with Bietti crystalline corneoretinal dystrophy. The enzyme also produces some 21-hydroxydocosahexaenoate. Acts in a similar way on icosapentaenoic acid.
History
EC 1.14.14.79 created 2014 as EC 1.14.13.199, transferred 2018 to EC 1.14.14.79
Orthology
K07427 docosahexaenoic acid omega-hydroxylase
K17726 phylloquinone omega-hydroxylase / docosahexaenoic acid omega-hydroxylase / leukotriene-B4 20-monooxygenase
Genes
HSA : 285440(CYP4V2) 4051(CYP4F3) 8529(CYP4F2)
PTR : 100609185 744981(CYP4V2) 748117(CYP4F3) 748531(CYP4F2)
PPS : 100967411(CYP4F2) 100969141(CYP4F3) 100985937(CYP4V2)
GGO : 101125692 101135418 101142243 101152881
PON : 100172140(CYP4V2) 100434096 100437847 100453229
NLE : 100579320 100588006 100602871 115836096 115836968
MCC : 696520(CYP4V2) 718349 719317
MCF : 102130440(CYP4F3) 102134301(CYP4F2) 102141321(CYP4V2)
MTHB : 126942252 126942253 126955236
CSAB : 103234079 103234089 103236636
CATY : 105594263 105601614 105601627
PANU : 101003969 101005940 101010705
TGE : 112612404 112613097 112625202
RRO : 104661012 104661014 104673816
RBB : 108522429 108543262 108543288 108543294
PTEH : 111548494 111554233 111554287
CJC : 100408123(CYP4V2) 100411160 100412575(CYP4F2)
SBQ : 101049306 101050944 101051361
CSYR : 103250633 103271968
MMUR : 105867925 105867928 105867931 105882473
LCAT : 123634142 123636967 123638621 123639775
OGA : 100942215 100943471 100950748 100952962 100956186
CPOC : 100716074 100733735
OCU : 100348038 100350957 100356012
UAR : 123779961 123780007 123784493
MYB : 102240114 102240725 102242692 102247921 102260288
MYD : 102754363 102756718 102762764 102763048 102765134 102765327
MMYO : 118650029 118650794
MLF : 102425173 102427238 102427536 102427859 102428489 102428801 102429106 102429710 102436085
PKL : 118706555 118730056 118730057 118730058 118730060
PDIC : 114503445 114508725
PGIG : 120606485 120618464
TOD : 119240020 119257928 119257929 119257930
SARA : 101551663 101556979 101557255
HALD : 104315325 104322980
ASN : 102369346 102369869 112550784
AMJ : 102563402(CYP4V2) 102563645(CYP4V2) 102570586
CPOO : 109321858 109322022 109322023
GGN : 109303665 109303762 109303763 109303764
CPIC : 101941514 101941793 101952270
CABI : 116835909 116835915
MRV : 120405535 120405610 120406861
PMUA : 114604215 114604282 114604283 114604284
ZVI : 118083468 118083469 118083470
XLA : 100337567(cyp4v4) 444482(cyp4v2.1.L)
XTR : 100485929(cyp4v2.1) 780124(cyp4v2.2)
RTEM : 120921880 120921889
DRE : 558851(cyp4v2a) 562008(cyp4v2b)
SRX : 107707218 107736720 107752071 107754133
SANH : 107656409 107658042 107670167
SGH : 107558204 107561656 107562739 107600159
CAUA : 113044178 113057798 113057916 113107224
PPRM : 120461003 120493055 120493130
MAMB : 125259134 125272564
PHYP : 113528690 113547369
SMEO : 124381082 124385624
AMEX : 103031293 111195187
CTUL : 119797184 119797185
ALIM : 106519688 106519689
BPEC : 110166101 110166102
SASA : 106602559 106612026
STRU : 115191902 115201982 115205526
SALP : 111971620 112074167
CCLU : 121561203 121563044 121586966
AANG : 118227724 118231082
SCLV : 120342785 120342788 120344346 120344612
SPU : 100893947 115918097 115918464 577955 579739 581875 594737 762892
AJC : 117117008 117117030 117121847
RZE : 108368329 108377766 108378434 108378788 108381916
AARA : 120895624 120896510 120896512 120896513 120897018 120897050 120897515 120901996
ASTE : 118502450 118504587 118504593 118508259 118515262
CQU : CpipJ_CPIJ005683 CpipJ_CPIJ005684 CpipJ_CPIJ007085 CpipJ_CPIJ007089 CpipJ_CPIJ007090 CpipJ_CPIJ007092 CpipJ_CPIJ007093 CpipJ_CPIJ007095
CPII : 120417522 120417528 120421611 120421612 120421615 120424836 120424837 120424866 120431553 120431555 120431725
CNS : 116344591 116345516 116347675 116347967 116348422 116350509 116351388 116351389 116351390 116351391 116351392
BCOO : 119069540 119071872 119073031 119078024 119078035 119078036 119078519 119083265
ACER : 107997710 107997912
PFUC : 122513580 122514292 122514925 122515566 122515567 122515568 122515587 122517710 122517774 122517839 122518856 122518857 122518922 122518941 122520409 122520498 122521032 122521752 122522732 122522733 122523798 122523799 122524229 122524230 122524526 122524527 122524532 122525657 122525658 122525686 122525688 122525689 122525691 122525693 122526167
VPS : 122635813 122635814 122635815 122637187
TPRE : 106648534 106649101 106649102 106649184 106649330 106650915 106651281 106651572 106653058 106654078
CGLO : 123259233 123259234 123259602 123264579 123267240 123273420 123274240
FAS : 105263310 105263312 105266799 105270877 105270987
DAM : 107039824 107039826 107039828 107039829 107043310 107043861 107047963 107048684 107048697
AGIF : 122853693 122853949 122853950 122855220 122855221 122860411
CCIN : 107272935 107274457 107274924
SOY : 115874320 115874482 115877484 115880077 115880922 115880923 115881582 115881583 115881664 115881704 115881719 115881735 115888687
AGB : 108904168 108905403 108906962 108911484 111691345 111693089
APLN : 108736863 112904022
PPYR : 116159257 116165076 116167564 116170339 116172291 116172361 116177880 116177881 116177882 116177885 116177886 116177887 116177888
OTU : 111413314 111416483 111418207 111418402 111419493 111421753 111421875 111421945 111422059 111422074 111422210 111422421 111422514 111423053 111424102 111424154 111425838 111427012 111427333 111427382 111427936 111428978 111428979 111428982 111428983 111429322 111429505
MSEX : 115443293 115444780 115444887 115449016 115449044 115451411 115454101 115455802 119188928
BANY : 112046024 112049165 112051069 112051293 112051904 112055100 112055634 112055643 112055677 112055688 112055700
PPOT : 106100072 106105327 106105328 106105618
PXU : 106124585 106125043 106125217 106125231 106125542 106125543
PRAP : 110993186 110994344 110994420 110995875 110995886 111000470 123689605
PNAP : 125050232 125050233
SLIU : 111349291 111349292 111349331 111349484 111349528 111356994 111360017 111360018 111360019 111360469
OFU : 114353129 114355081 114356078 114362233 114365283
CFEL : 113363865 113377060 113385375
DNX : 107163873 107163874 107163881
AGS : 114121961 114121962 114121977
BTAB : 109030014 109030151 109031969 109036074 109036972 109036973 109037834 109038941 109040639 109040640 109043040 109043831 109044441
DCI : 103506319 103507738 103510882 103511778 103515115 103515942 103516706 103516895 113469017
HHAL : 106677250 106678066 106678472 106678588 106679066 106679197 106679207 106680051 106680054 106682501 106683607 106683620 106683621 106683623 106686317
FOC : 113202370 113202374 113203168 113203280 113203758 113205100 113206492 113206720 113208681 113209238 113209334 113209335 113209348 113210186 113210762 113210802 113212592 113212737 113213039 113213146 113214245 113215782 113215794
TPAL : 117641045 117641094 117641118 117641244 117641416 117641570 117642561 117643291 117643540 117644026 117644036 117644669 117645135 117645526 117645727 117647338 117647438 117647805 117647806 117649385 117649485 117649707 117650517 117650556 117650605 117651230 117653089 117653090 117653828
CSEC : 111862487 111863323 111863395 111864296 111864297 111864307
SGRE : 126281314 126298354
DMK : 116927068 116934248 116934506 123475997
DPZ : 124315080 124327130 124348966
PPOI : 119098772 119101356 119101456 119101563 119101701
ISC : IscW_ISCW005544 IscW_ISCW005615 IscW_ISCW007225 IscW_ISCW010786 IscW_ISCW010787 IscW_ISCW010788 IscW_ISCW019906 IscW_ISCW022693 IscW_ISCW022699 IscW_ISCW022701 IscW_ISCW022703 IscW_ISCW022705
DSV : 119436562 119436669 119436670 119436672 119436678 119436679 119436878 119437020 119437021 119437022 119438566 119439862 119441446 119447252 119456484 119458628 119464912
RSAN : 119378826 119386632 119389477 119393194 119393687 119393693 119394404 119394422 119394432 119394445 119394458 119395113 119395138 119395151 119395164 119397961 119402449
RMP : 119161155 119161157 119161233 119161234 119161235 119161237 119161238 119161239 119161241 119161314 119161448 119162010 119162051 119171835 119177153 119177950 119181658
VDE : 111243321 111244152 111246554 111248731 111249946 111252654 111252664 111253965
VJA : 111259234 111259235 111260960 111261338 111261710 111268873 111273090 111273739
TUT : 107360193 107361555 107361951 107362192 107362448 107363943 107366931 107368146 107368147 107369794 107369959 107371897 107372191
DFR : 124492534 124492679 124495885 124496436 124496437 124496438 124496439 124496868 124496869 124497018 124499987
CSCU : 111612503 111613750 111613800 111614327 111614707 111614911 111614915 111615085 111616480 111616481 111617004 111617105 111617625 111621817 111622186 111623434 111624260 111625199 111625200 111625806 111625807 111626390 111627630 111627631 111627633 111631621 111632089 111633067 111634551 111634987 111634990 111635853 111639943
PTEP : 107436838 107441954 107443360 107443468 107443469 107443641 107443713 107443864 107446851 107447204 107447784 107450173 107450174 107456117
SDM : 118181948 118185968 118188928 118189905 118191056 118191192 118192212 118192753 118192978 118194678 118194680 118197240 118200418 118204276 118204389 118205520
CEL : CELE_Y80D3A.5(cyp-42A1)
CBR : CBG_20323(Cbr-cyp-42A1)
BMY : BM_BM7159(Bma-cyp-42A1.1) BM_BM8635(Bma-cyp-42A1.2)
NAI : NECAME_03284 NECAME_06856 NECAME_15256
MMER : 123527893 123563759
OBI : 106876141 106876144 106878048
OSN : 115211833 115212028 115212039 115212041 115212257 115212422
ATEN : 116295183 116295184
ADF : 107329895 107329913 107330438 107330484 107335891
AMIL : 114965427 114965429 114965430 114965431
PDAM : 113664116 113664119
SPIS : 111325112 111341124 111347199 111347203
DGT : 114524910 114537125 114539322 114539407 114539409 114540646 114541977
» show all
Taxonomy
Reference
Authors
Nakano M, Kelly EJ, Wiek C, Hanenberg H, Rettie AE
Title
CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of omega-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant.
Journal
Sequence
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