KEGG   ENZYME: 1.14.18.3
Entry
EC 1.14.18.3                Enzyme                                 
Name
methane monooxygenase (particulate)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With another compound as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
methane,quinol:oxygen oxidoreductase
Reaction(IUBMB)
methane + quinol + O2 = methanol + quinone + H2O [RN:R09518]
Reaction(KEGG)
R09518
Substrate
methane [CPD:C01438];
quinol [CPD:C15603];
O2 [CPD:C00007]
Product
methanol [CPD:C00132];
quinone [CPD:C15602];
H2O [CPD:C00001]
Comment
Contains copper. It is membrane-bound, in contrast to the soluble methane monooxygenase (EC 1.14.13.25).
History
EC 1.14.18.3 created 2011
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
Orthology
K10944  methane/ammonia monooxygenase subunit A
Genes
MCAMCA1797(pmoA) MCA2854(pmoA2)
METUGNH96_03570 GNH96_09690
MMTMetme_0304
MDNJT25_004545 JT25_012445
MDHAYM39_18580 AYM39_19770
MKOMKLM6_3758 MKLM6_3997
METLU737_00525 U737_22530
MPADKEF85_05595 KEF85_15100
MELLIVG45_01190 IVG45_17415
MAHMEALZ_0515(pmoA)
MBUREQU24_19305
MPSYCEK71_17435
MMAIsS8_1788 sS8_3977
MMOBF6R98_01475 F6R98_16060
MEINmethR_P0112
MOZMoryE10_29180 MoryE10_29210
MISZMishRS11D_20920 MishRS11D_40480 MishRS11D_42080
MESLKKZ03_06640
NOCNoc_2502
NHLNhal_0676
NWANwat_0632
NWRE3U44_00915
NTTTAO_1521(amoA)
NTGNSCAC_1278(amoA)
HPSEHPF_13160(pmoA1)
NEUNE0944(amoA1) NE2063(amoA2)
NETNeut_2077 Neut_2318
NITNAL212_0798 NAL212_1387 NAL212_2605
NIINit79A3_0472 Nit79A3_1080 Nit79A3_2885
NCOAAW31_01085 AAW31_05380
NURATY38_01310 ATY38_07255 ATY38_13755
NSTNstercoris_00328 Nstercoris_01426
NMUNmul_A0799 Nmul_A2325 Nmul_A2765
NLCEBAPG3_006230 EBAPG3_014830 EBAPG3_15005
NIZNNRS527_00820 NNRS527_02502 NNRS527_03102
AZRCJ010_10955
MSCBN69_0203(pmoA2) BN69_2827(pmoA) BN69_3534(pmoA)
MBRYB1812_00565 B1812_13465 B1812_14775 B1812_18680
MROSEHO51_01980 EHO51_08605
MHEYH2LOC_006300 H2LOC_011625 H2LOC_017530
MPARF7D14_03105 F7D14_11665 F7D14_16695
MTWCQW49_01220 CQW49_10255
MDXBTO20_38255
MCBMycch_5910
MRHMycrhN_3041
MINMinf_1507(pmoA) Minf_1510(pmoA) Minf_1590(pmoA)
MKCkam1_1359(pmoA3) kam1_1509(pmoA2) kam1_1512(pmoA1) kam1_1972(pmoA4)
MEAPMTHMO_0894(pmoA1) MTHMO_0897(pmoA2)
NIONITINOP_1853(amoA)
NKFNkreftii_003170
MOXDAMO_2450(pmoA)
NMRNmar_1500
NIRNSED_08255
NKRNKOR_08170
NIDNPIRD3C_2147(amoA)
NINNADRNF5_0394(amoA)
NIWNisw_06415
NCLC5F47_07870
NOXC5F49_07755
NUEC5F50_11085
NIPNsoK4_00795
NCTNMSP_0259
NICDSQ20_08765
CSYCENSYa_0402
NGANgar_c25350(amoA)
NVNNVIE_027270(amoA)
NEVNTE_00961
TAANMY3_03280
NFNNFRAN_0675(amoA)
NCVNCAV_0492(amoA)
NBVT478_0302
TAHSU86_008325
NIUDSQ19_08460
NDVNDEV_1777(amoA)
 » show all
Reference
1  [PMID:7646068]
  Authors
Shiemke AK, Cook SA, Miley T, Singleton P
  Title
Detergent solubilization of membrane-bound methane monooxygenase requires plastoquinol analogs as electron donors.
  Journal
Arch Biochem Biophys 321:421-8 (1995)
DOI:10.1006/abbi.1995.1413
  Sequence
Reference
2  [PMID:12379148]
  Authors
Basu P, Katterle B, Andersson KK, Dalton H
  Title
The membrane-associated form of methane mono-oxygenase from Methylococcus capsulatus (Bath) is a copper/iron protein.
  Journal
Biochem J 369:417-27 (2003)
DOI:10.1042/BJ20020823
  Sequence
Reference
3  [PMID:16101279]
  Authors
Kitmitto A, Myronova N, Basu P, Dalton H
  Title
Characterization and structural analysis of an active particulate methane monooxygenase trimer from Methylococcus capsulatus (Bath).
  Journal
Biochemistry 44:10954-65 (2005)
DOI:10.1021/bi050820u
  Sequence
Reference
4  [PMID:17444606]
  Authors
Balasubramanian R, Rosenzweig AC
  Title
Structural and mechanistic insights into methane oxidation by particulate methane monooxygenase.
  Journal
Acc Chem Res 40:573-80 (2007)
DOI:10.1021/ar700004s
Other DBs
ExplorEnz - The Enzyme Database: 1.14.18.3
IUBMB Enzyme Nomenclature: 1.14.18.3
ExPASy - ENZYME nomenclature database: 1.14.18.3
BRENDA, the Enzyme Database: 1.14.18.3
LinkDB

DBGET integrated database retrieval system