KEGG ENZYME: 1.14.19.20

ENZYME: 1.14.19.20

Entry

EC 1.14.19.20               Enzyme

Name

Delta7-sterol 5(6)-desaturase;
lathosterol oxidase;
Delta7-sterol Delta5-dehydrogenase;
Delta7-sterol 5-desaturase;
Delta7-sterol-C5(6)-desaturase;
5-DES;
SC5DL (gene name);
ERG3 (gene name)

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water

Sysname

Delta7-sterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating

Reaction(IUBMB)

a Delta7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ = a Delta5,7-sterol + 2 ferricytochrome b5 + 2 H2O

Reaction(KEGG)

(other) R07215 R07486 R07491

Substrate

Delta7-sterol;
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080]

Product

Delta5,7-sterol;
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001]

Comment

This enzyme, found in eukaryotic organisms, catalyses the introduction of a double bond between the C5 and C6 carbons of the B ring of Delta7-sterols, to yield the corresponding Delta5,7-sterols. The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively. The enzyme is located at the endoplasmic reticulum and is membrane bound.

History

EC 1.14.19.20 created 1972 as EC 1.3.3.2, transferred 2005 to EC 1.14.21.6, transferred 2015 to EC 1.14.19.20

Pathway

ec00100

Steroid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K00227

Delta7-sterol 5-desaturase

Genes

HSA:	6309(SC5D)

PTR:	451624(SC5D)

PPS:	100979606(SC5D)

GGO:	101151866(SC5D)

PON:	100459805(SC5D)

PPYG:

129007958(SC5D)

NLE:	100604476(SC5D)

HMH:	116477081(SC5D)

SSYN:

129479788(SC5D)

MCC:	706827(SC5D)

MCF:	101867112(SC5D)

MTHB:

126934768

MNI:	105476342(SC5D)

CSAB:

103248668(SC5D)

CATY:

105582529(SC5D)

PANU:

101015312(SC5D)

TGE:	112606122(SC5D)

MLEU:

105528269(SC5D)

RRO:	104657234(SC5D)

RBB:	108523218(SC5D)

TFN:	117079880(SC5D)

PTEH:

111540259(SC5D)

CANG:

105501143(SC5D)

CJC:	100387284(SC5D) 100392016

SBQ:	101038292(SC5D)

CIMI:

108300668(SC5D)

ANAN:

105729493(SC5D)

CSYR:

103258745 103274563(SC5D)

MMUR:

105885179(SC5D)

LCAT:

123641240(SC5D)

PCOQ:

105810866(SC5D)

OGA:	100950231(TECTA)

MMU:	235293(Sc5d)

MCAL:

110301807(Sc5d)

MPAH:

110327921(Sc5d) 110334695

RNO:	114100(Sc5d)

MCOC:

116072823(Sc5d)

ANU:	117699139(Sc5d)

MUN:	110540918(Sc5d)

CGE:	100752960(Sc5d)

MAUA:

101823983(Sc5d)

PROB:

127231575(Sc5d)

PLEU:

114691145(Sc5d)

MORG:

121451721(Sc5d)

MFOT:

126487358

AAMP:

119809515(Sc5d)

NGI:	103727913(Sc5d)

HGL:	101713479(Sc5d)

CPOC:

100723104(Sc5d)

CCAN:

109698547(Sc5d)

DORD:

105980854(Sc5d)

DSP:	122110385(Sc5d)

PLOP:

125349668(Sc5d)

NCAR:

124958738

MMMA:

107145756(Sc5d)

OCU:

100358493

OPI:	101524086(SC5D)

TUP:	102481940(SC5D)

GVR:	103607838(SC5D)

CFA:	610411(SC5D)

CLUD:

112671173(SC5D)

VVP:	112920309(SC5D)

VLG:	121500224(SC5D)

NPO:	129497504(SC5D)

AML:	100467645(SC5D)

UMR:	103662293(SC5D)

UAH:	113259940(SC5D)

UAR:	123792673(SC5D)

ELK:

111153897

LLV:

125078720

MPUF:

101683752(SC5D)

MNP:	132026825(SC5D)

MLK:	131837453(SC5D)

NVS:	122912379(SC5D)

ORO:	101367504(SC5D)

EJU:	114226005(SC5D)

ZCA:	113914200(SC5D)

MLX:	118013329(SC5D)

NSU:	110586241(SC5D)

LWW:	102731354(SC5D)

FCA:	101099997(SC5D)

PYU:	121035539(SC5D)

PCOO:

112865015(SC5D)

PBG:	122483081(SC5D)

PVIV:

125146744(SC5D)

LRUF:

124504850

PTG:	102956406(SC5D)

PPAD:

109278494(SC5D)

PUC:

125915225

AJU:

106976671

HHV:	120229652(SC5D)

BTA:	525154(SC5D)

BOM:	102283021(SC5D)

BIU:	109569702(SC5D)

BBUB:

102394495(SC5D) 102410497

BBIS:

104981410(SC5D)

CHX:	102180515(SC5D)

OAS:	101109313 101117697(SC5D)

BTAX:

128045497 128060473(SC5D)

ODA:	120876379(SC5D)

CCAD:

122449770(SC5D)

MBEZ:

129554448(SC5D)

SSC:	100520925(SC5D)

CFR:	102520592(SC5D)

CBAI:

105078647(SC5D)

CDK:	105097554(SC5D)

VPC:	102530730(SC5D)

BACU:

103004682(SC5D)

BMUS:

118899956(SC5D)

LVE:	103083016(SC5D)

OOR:	101282178(SC5D)

DLE:	111167467(SC5D)

PCAD:

102980120 102994174(SC5D)

PSIU:

116758028(SC5D)

NASI:

112404144(SC5D)

ECB:	100063543(SC5D)

EPZ:	103543812(SC5D)

EAI:	106842373(SC5D)

MYB:	102246367(SC5D)

MYD:	102754805(SC5D)

MMYO:

118678221(SC5D)

MLF:	102440339(SC5D)

MDT:	132221953(SC5D)

PKL:	118704704(SC5D)

EFUS:

103304079(SC5D)

MNA:	107534112(SC5D)

DRO:	112301615 112301887(SC5D)

SHON:

118975222(SC5D)

AJM:	119039314(SC5D)

PDIC:

114509676(SC5D)

PHAS:

123832502(SC5D)

MMF:	118640120(SC5D)

PPAM:

129081955(SC5D)

HAI:	109395291(SC5D)

RFQ:	117017665(SC5D)

PALE:

102891666(SC5D)

PGIG:

120612225(SC5D)

PVP:	105307909(SC5D)

RAY:	107519049(SC5D)

MJV:	108389489(SC5D)

TOD:	119240773(SC5D)

SARA:

101551203(SC5D)

SETR:

126015444(SC5D)

LAV:	100661853(SC5D)

TMU:

101351645

ETF:	101663789(SC5D)

DNM:	101444253(SC5D)

MDO:	100030841(SC5D)

GAS:	123239133(SC5D)

SHR:	100932949(SC5D) 116419258

PCW:	110207244(SC5D)

TVP:	118836129(SC5D)

OAA:	100073392(SC5D)

GGA:	100857756(SC5D)

PCOC:

116233108(SC5D)

MGP:	100538497(SC5D)

CJO:	107324219(SC5D)

TPAI:

128087551(SC5D)

LMUT:

125703673(SC5D)

NMEL:

110387590(SC5D)

APLA:

101803446(SC5D)

ACYG:

106039809(SC5D)

CATA:

118252513(SC5D)

AFUL:

116497927(SC5D)

TGU:	100226384(SC5D)

LSR:	110477544(SC5D)

SCAN:

103823051(SC5D)

OTC:	121340913(SC5D)

PRUF:

121360638(SC5D)

GFR:	102043549(SC5D)

FAB:	101811093(SC5D)

OMA:	130262428(SC5D)

PHI:	102109366(SC5D)

PMAJ:

107214298(SC5D)

CCAE:

111939317(SC5D)

CCW:	104692196(SC5D)

CBRC:

103618491(SC5D)

ETL:	114066789(SC5D) 114072326

ZAB:	102075381(SC5D)

ZLE:	135457520(SC5D)

ACHL:

103803450(SC5D)

SVG:	106861823(SC5D)

MMEA:

130585698(SC5D)

HRT:	120762670(SC5D)

SATI:

136370916(SC5D)

FPG:	101920444(SC5D)

FCH:	102057522(SC5D)

CCRI:

104159146(SC5D)

NNT:	104412076(SC5D)

SHAB:

115616257(SC5D)

ACUN:

113488442(SC5D)

TALA:

116962956(SC5D)

ACHC:

115344990(SC5D)

HLE:	104840474(SC5D)

AGEN:

126038282

GCL:

127025871

CSTI:

104555237(SC5D)

MNB:	103773236(SC5D)

DPUB:

104301068(SC5D)

AVIT:

104275998(SC5D)

BRHI:

104500149(SC5D)

EGZ:	104125957(SC5D)

NNI:	104016662(SC5D)

PADL:

103916253(SC5D)

AFOR:

103905157(SC5D)

FGA:	104080189(SC5D)

GSTE:

104254208(SC5D)

CLV:	102095349(SC5D)

MUI:	104533967(SC5D)

PGUU:

104460152(SC5D)

EHS:	104507720(SC5D)

CMAC:

104473515(SC5D)

CUCA:

104056288(SC5D)

CPEA:

104386088(SC5D)

RTD:	128918629(SC5D)

AAM:	106490218(SC5D) 106491711

AROW:

112968933(SC5D)

NPD:	112946332(SC5D)

TGT:	104568315(SC5D)

DNE:	112982681(SC5D)

SCAM:

104143508(SC5D)

ASN:	102385911(SC5D)

AMJ:	102571716(SC5D)

CPOO:

109318043(SC5D)

GGN:	109292520(SC5D)

PSS:	102463426(SC5D)

CMY:	102931181(SC5D)

CCAY:

125625513(SC5D)

DCC:	119846596(SC5D)

CPIC:

101952975(SC5D)

TST:	117868480(SC5D)

CABI:

116837729(SC5D)

MRV:	120375850(SC5D)

ACS:	100566753(sc5d)

ASAO:

132782378(SC5D)

PVT:	110078414(SC5D)

SUND:

121934927(SC5D)

PBI:	103051481(SC5D)

PMUR:

107285543(SC5D)

CTIG:

120319543(SC5D)

TSR:	106551450(SC5D)

PGUT:

117673231(SC5D)

APRI:

131203777(SC5D)

PTEX:

113441958(SC5D)

NSS:	113421504(SC5D)

VKO:	123028099(SC5D)

PMUA:

114585161(SC5D)

PRAF:

128403123(SC5D)

ZVI:	118097123(SC5D)

HCG:	128333573(SC5D)

GJA:	107125348(SC5D)

STOW:

125442139(SC5D)

EMC:	129342448(SC5D)

XLA:	108697607(sc5d.S) 447026(sc5d.L)

XTR:	100490845(sc5d)

NPR:	108797036(SC5D)

RTEM:

120915548(SC5D)

BBUF:

121000786(SC5D)

BGAR:

122926803(SC5D)

MUO:	115481565(SC5D)

GSH:	117347713(SC5D)

DRE:	447891(sc5d)

SRX:	107715322 107756074

SANH:

107703513

SGH:	107548136 107561054

CCAR:

109105967 109111460

CAUA:

113038585 113078828 113092286

CGIB:

127942367 127985742

PTET:

122326817(sc5d)

LROH:

127152976(sc5d)

OMC:	131528423(sc5d)

PPRM:

120490106(sc5d)

RKG:	130096528(sc5d)

MAMB:

125252773(sc5d)

CIDE:

127504377

CERY:

137012921(sc5d)

MASI:

127429392 127430624

TROS:

130570210(sc5d)

TDW:	130407999(sc5d)

MANU:

129424160(sc5d)

IPU:	100528129(sc5d)

IFU:	128622490(sc5d)

PHYP:

113541626(sc5d)

SMEO:

124397552(sc5d)

TFD:	113634971(sc5d)

TVC:	132859589(sc5d)

TRN:	134330758(sc5d)

AMEX:

103032395(sc5d)

CMAO:

118820083(sc5d)

EEE:	113574240(sc5d)

CHAR:

105911049(sc5d)

TRU:	101067117(sc5d)

TFS:	130537061(sc5d)

TNG:	GSTEN00004803G001

LCO:	104921101(sc5d) 104938430

NCC:	104945906 104953696

TBEN:

117479898 117491402

CGOB:

115009867 115019205

PGEO:

117458494

GACU:

117542814(sc5d)

EMAC:

134872734(sc5d) 134880240

ELY:	117261604 117271255(sc5d)

EFO:	125888051 125898976(sc5d)

PLEP:

121950308 121952596

SLUC:

116052992 116056026(sc5d)

ECRA:

117948451 117955360

ESP:	116693665 116700205(sc5d)

PFLV:

114559649 114560831 114567023(sc5d)

GAT:	120809680 120822803

PPUG:

119196021 119215758

AFB:	129108713 129113783(sc5d)

CLUM:

117732261 117743241(sc5d)

PSWI:

130191837(sc5d) 130195369

MSAM:

119893521 119893522 119895819(sc5d)

SCHU:

122874337 122888691(sc5d)

CUD:	121514677 121518327

ALAT:

119023839 119031780

MZE:	101470905(sc5d) 101479398 112429932

ONL:	100695064(sc5d) 100696185

OAU:	116326335 116326371

OLA:	101173647(sc5d)

OML:	112141555(sc5d)

CSAI:

133459939(sc5d)

XMA:	102219081(sc5d)

XCO:	114153517(sc5d)

XHE:	116728775(sc5d)

PRET:

103476328(sc5d)

PFOR:

103145520(sc5d)

PLAI:

106961497(sc5d)

PMEI:

106929089(sc5d)

GAF:	122845403(sc5d)

PPRL:

129370496(sc5d)

CVG:	107081853(sc5d)

CTUL:

119795555(sc5d)

GMU:	124876922(sc5d)

NFU:	107387205(sc5d)

KMR:	108238026(sc5d)

ALIM:

106514612 106514613

NWH:	119419898(sc5d)

AOCE:

111575129 111576308

MCEP:

125014312 125021234

CSEM:

103395378(sc5d)

POV:	109624686 109635651(sc5d)

SSEN:

122761001 122775748 122780108(sc5d)

HHIP:

117763772 117774596(sc5d)

HSP:	118110061 118121664(sc5d)

PPLT:

128445055 128457009

SMAU:

118301271(sc5d) 118315731

LCF:	108891924 108901922

SDU:	111225164 111233090(sc5d)

SLAL:

111656091(sc5d) 111666108

XGL:	120803169(sc5d)

HCQ:	109515690(sc5d) 109526775

SSCV:

125970171 125982243

SBIA:

133492000(sc5d) 133502532

PEE:	133402484 133416198

PTAO:

133466928 133478651

BPEC:

110168196 110169547

MALB:

109959324(sc5d)

BSPL:

114857847 114869253 114869254 114869255

SJO:	128359104 128371521

SASA:

100195087(sc5d) 106576971

STRU:

115148693(sc5d) 115193389

OTW:	112253002 112257983(sc5d)

OMY:	110521978 110537613(sc5d)

OGO:	124000357(sc5d) 124040778

ONE:	115105426(sc5d) 115136340

OKI:	109888785 109892857(sc5d)

OKE:	118369688 118391046(sc5d)

SALP:

111952019 111980773(sc5d)

SNH:	120017780 120031213(sc5d)

CCLU:

121553736 121573933(sc5d)

ELS:	105023255 105024195(sc5d)

SFM:	108936096(sc5d)

PKI:	111844810(sc5d)

AANG:

118235410(sc5d)

LOC:	102684690(sc5d)

PSPA:

121303985(sc5d)

ARUT:

117397270 117966540

PSEX:

120535887(sc5d)

LCM:	102365779(SC5D)

CMK:	103190397 121850762

RTP:	109938738(sc5d)

CPLA:

122540600(sc5d)

HOC:	132829572(sc5d)

LERI:

129712241(sc5d)

PMRN:

116948188(SC5D)

LRJ:	133342101(SC5D)

BFO:	118404758 118419020

BBEL:

109470054 109476404

CIN:

100175543

SCLV:

120329567

SPU:	100890969 105439193 115921850 588561

LPIC:

129254162 129281357

APLC:

110980086 110980107 110983476 110983540

ARUN:

117288942 117289499 117301859 117305722

AJC:	117121637 117123455 117123521

SKO:

100375039

AAG:	110676479 110676480 110681460

AALB:

109427836 109427959 109428277 109428319 115266341

ASUA:

134209623 134216016

CQU:	CpipJ_CPIJ009044

CPII:

120422188 120422197

CNS:

116348616

BCOO:

119070895

CSOL:

105363535

AROA:

105684949

TCA:

103315179

DPA:

109535430

SOY:

115875973

ATD:

109596276

AGB:	108916275 111692538

LDC:

111503546

DVV:

126885299

APLN:

108734726

BMOR:

101741096

BMAN:

114240844

MSEX:

115450644

BANY:

112050995

NIQ:

126769239

PMAC:

106720255

PPOT:

106106039

PXU:

106121346

ZCE:

119838302

AAGE:

121727158

TNL:

113500445

SLIU:

111355760

ATRA:

106130278 106130279

GMW:

113514180

PGW:

126369673

LGLY:

125242725

API:

100163267

DNX:

107172322

ACOO:

126842352 126842354 126845556

DVT:

126910496

BTAB:

109030394 109032888

NLU:

111047819

MQU:	128990785 128990795

FOC:

113215353

TPAL:

117647647

ZNE:

110831824

CSEC:

111865150

BROR:

134533688

FCD:	110843818 110862568

DPX:	DAPPUDRAFT_300451 DAPPUDRAFT_309043

DMK:	116920244 116931897

DPZ:	124313282 124350672

PVM:

113810916

PJA:

122247694

PCHN:

125025776

PMOO:

119578856

HAME:

121876801

PCLA:

123767940

CQD:

128686256

PTRU:

123512390

ESN:

127008729

MNZ:	135223618 135223619

HAZT:

108666790

EAF:	111697529 111699796 111707825

TCF:

131889752

PPOI:

119094858

CSCU:

111625209

CVS:

136970289

SDM:	118187251 118188707

LPOL:

106473316

PMEO:

129588625

HRO:	HELRODRAFT_92484

LGI:	LOTGIDRAFT_206094

PVUL:

126830672

PCAN:

112567998

GAE:

121386508

HRJ:

124258227

CRG:	105323181 105323182 105348227

CANU:

128156348 128184008

CVN:	111127563 111129259

OED:	125646238 125646239 125682600

MYI:	110459659 110461770

PMAX:

117322145

MCAF:

127700852

MMER:

123559739 123561403

DPOL:

127855094

MAEA:

128234191 128234904 128235664

LJP:	135461953 135482046

LAK:	106161627 106164082 106173279

LLON:

135502292 135502293 135502380

NVE:	116617875 5495700 5511639 5515899

EPA:	110236617 110236759 110237983

ATEN:

116297165 116308311

PDAM:

113668803

SPIS:

111331638

DGT:

114523409

HSY:

130641803

TAD:	TRIADDRAFT_18639

AQU:

100635449

ATH:	AT3G02580(STE1) AT3G02590

ALY:	9306601 9306619 9318308 9320397

CRB:	111831373 17892493

CSAT:

104744338 104744339 104744340 104763875 104763876 104763877 104776707

EUS:	EUTSA_v10011706mg EUTSA_v10021274mg EUTSA_v10021293mg

BRP:	103843392 103843402 103858971 103858974 103870908

BNA:	106362772 106366810 106366813 106382858 106385223 106387284 106438943 106438944 106443864 125583341 125583342 125583343 125609181

BOE:	106295553 106299027 106329479 106329480 106329481 106342761

RSZ:	108859899 108859903 108862851 130495140

THJ:	104820939 104822096 104827161 104827162

CPAP:

110807494

CIT:

102630557

CIC:	CICLE_v10012450mg

PVY:

116132598

MINC:

123197378 123226134

TCC:

18602021

GRA:

105788590

GHI:	107934227 107953438

GAB:

108489860

HSYR:

120139199 120153920 120196776 120206895

DZI:	111305756 111305757

EGR:

104422113

GMX:	100782638 100790906

GSJ:	114382413 114400601

PVU:	PHAVU_004G067300g

VRA:

106765343

VAR:

108345518

VUN:

114181961

VUM:

124827098

CCAJ:

109791074

APRC:

113867234

MTR:

25495643

TPRA:

123910904

CAM:

101511716

PSAT:

127123440

VVO:	131624348 131647428

LJA:

130737743

ADU:	107471510 107486912

AIP:	107623531 107637475

AHF:	112716721 112740726 112782995 112794515

LANG:

109347424 109347425

PCIN:

129290136 129293829

QSA:	O6P43_005628

FVE:

101292472

RCN:

112174786

PPER:

18783760

PMUM:

103342673

PAVI:

110763174

PDUL:

117620560

MDM:	103401753 103444140

MSYL:

126582199 126612619

PXB:	103936617 103937470 103948488

ZJU:

125421776

MNT:

21409683

CSAV:

115721732

CSV:

101204738

CMO:

103487532

BHJ:

120082841

MCHA:

111016898

CMAX:

111479986 111492934

CMOS:

111452401 111457984

CPEP:

111788924 111790370

RCU:

8261209

MEAN:

126678884

JCU:

105638767

HBR:	110637842 110662172

MESC:

110604160 110613475

POP:	18099473 7456835

PEU:	105123394 105133013

PALZ:

118029721 118056023

PNZ:

133699283

JRE:	108988023 109016764 109021451

CILL:

122302834 122308219

CAVE:

132180416

QSU:

112006614

QLO:	115972095 115975774

TWL:	119986440 119998274

VVI:	100257622 100262743 100265283

VRI:	117912663 117917505 117917539 117930782

SLY:	101256156 101264777

SPEN:

107008645 107010781 107011506

SOT:	102587419 102594482 102602151

SSTN:

125846856 125846865 125848547

SDUL:

129873167 129875131

CANN:

107860069

LBB:	132622887 132623652

NTA:	107762070 107763191 107788284 107795770

NSY:	104230596 104235251

NTO:	104094653 104097923

NAU:	109239954 109244993

INI:	109168439 109174285

ITR:	116013608 116023506

SIND:

105177929

OEU:	111401052 111407991

EGT:	105974146 105976020

SSPL:

121773640 121775759

SMIL:

131001653

SHIS:

125201494

APAN:

127248380

HAN:	110868266 110908772

ECAD:

122579677 122580417 122585197 122610167

LSV:	111880301 111909847

CCAV:

112502094 112512711 112520405

DCR:	108193711 108220687

CSIN:

114261391 114319972

RVL:	131297984 131303636 131303637

AEW:	130768661 130773952 130778324

BVG:	104888098 104888101 104906256

SOE:	110785578 110796799 110801644

CQI:	110692968 110725245 110725405 110728228

ATRI:

130802273 130825795 130825948

MOF:

131144954

NNU:	104602594 104602901

MING:

122078514 122082807

TSS:	122645385 122649487

PSOM:

113275393 113282225

OSA:

4325687

OBR:

102707173

OGL:

127760280

BDI:

100823877

ATS:

109738537

TDC:	119266756 119274521

TAES:

123059923 123068378 123076056

TUA:

125542410

LPER:

127338124 127341072

LRD:	124659313 124661437 124664312 124665517 124680419 124705908

SBI:

8061354

ZMA:	100282407 100282855

SITA:

101780951

SVS:

117857749

PVIR:

120672692 120706090

PHAI:

112893472

PDA:	103718827 103723275

EGU:	105041251 105048406

MUS:	103968710 103977203 103987407 103987803

ZOF:	121992968 121992971 121996964 121996967

DCT:

110108874

PEQ:	110026203 110026229

AOF:	109833196 109844862

MSIN:

131237618

NCOL:

116257087 116257915 116263586 116263587 116263901 116263999 116264814

ATR:

18432187

SMO:	SELMODRAFT_146325 SELMODRAFT_182646

PPP:

112288804

CRE:	CHLRE_16g663950v5

VCN:	VOLCADRAFT_81225

MNG:	MNEG_2125 MNEG_3915

CSL:	COCSUDRAFT_15746

CVR:	CHLNCDRAFT_37407 CHLNCDRAFT_57760

APRO:

F751_3695 F751_6009

OLU:	OSTLU_6297

OTA:	OT_ostta05g00930 OT_ostta20g00840

BPG:	Bathy03g00990

MIS:	MICPUN_112695

MPP:	MICPUCDRAFT_55427

CME:	CYME_CMC055C

GSL:	Gasu_09900

CCP:	CHC_T00006481001

SCE:	YLR056W(ERG3)

SEUB:

DI49_3584

SPAO:

SPAR_L01120

AGO:	AGOS_AFR151C

ERC:

Ecym_1501

KLA:	KLLA0_F08855g

KMX:	KLMA_20308(ERG3)

LTH:	KLTH0G18304g

VPO:	Kpol_1035p33

ZRO:	ZYRO0F03212g

CGR:	2887958(ERG3)

NDI:	NDAI_0C06430(NDAI0C06430)

TPF:	TPHA_0D00440(TPHA0D00440) TPHA_0P00250(TPHA0P00250)

TBL:	TBLA_0D02520(TBLA0D02520)

TGB:	HG536_0B06600

TDL:	TDEL_0C00670(TDEL0C00670)

KAF:	KAFR_0D01010(KAFR0D01010)

KNG:	KNAG_0L00320(KNAG0L00320)

ZMK:	HG535_0D05760

SLUD:

SCDLUD_000666

DHA:	DEHA2F08866g

PIC:	PICST_28450(ERG3)

SPAA:

SPAPADRAFT_48108(ERG3)

LEL:	PVL30_001771(ERG3)

LBG:	92207818(LODBEIA_P26220)

CAL:	CAALFM_C104770CA(ERG3)

CTP:	CTRG_04480

COT:	CORT_0B06770

CDU:	CD36_04520(ERG3)

CTEN:

18250848(ERG3)

CLU:	CLUG_05120

CLUS:

A9F13_03g01188

CAUR:

CJI96_0002270

PPA:	PAS_chr1-4_0367

PKZ:	C5L36_0D00430

BNN:	FOA43_000494

BBRX:

BRETT_003090

OPA:	HPODL_03635

YLI:	2910270(YALI2_D00440g)

SLB:	AWJ20_2868(ERG3)

NCR:	NCU04983 NCU06207

NTE:	NEUTE1DRAFT116882(NEUTE1DRAFT_116882) NEUTE1DRAFT78153(NEUTE1DRAFT_78153)

SMP:	10803193(SMAC4_07109) 10807264(SMAC4_08592)

PAN:	PODANSg5469

PBEL:

QC761_710650(ERG3)

PPSD:

QC762_710650(ERG3)

PPSP:

QC763_710650(ERG3)

PPSA:

QC764_710650(ERG3)

TTT:	THITE_64954

MTM:	MYCTH_112329

CTHR:

CTHT_0019590

MGR:

MGG_08832

PPEI:

PpBr36_00503

PGRI:

PgNI_04576

TMN:	UCRPA7_1625 UCRPA7_347

SSCK:

SPSK_02588

FGR:	FGSG_02502 FGSG_04994

FPU:	FPSE_08622 FPSE_12291

FPOA:

FPOAC1_002624 FPOAC1_007889

FVN:	FVRRES_02920 FVRRES_08425

FVR:	FVEG_06768 FVEG_09178

FOX:	FOXG_09168 FOXG_10530

NHE:	NECHADRAFT_43685 NECHADRAFT_45966

FFC:	NCS54_00846400 NCS54_01011800

FKR:	NCS57_00889300 NCS57_01005700

FMU:	J7337_005220 J7337_009428

TRE:	TRIREDRAFT_78130

TRR:	M419DRAFT_104664

TATV:

25785193(TrAtP1_009717)

TASP:

36609111(TrAFT101_011449)

MAW:	19244664(ERG3_1) 19247970(ERG3_2)

MAJ:	MAA_00604 MAA_02529

MBRN:

26241976(G6M90_00g071150) 26242798(G6M90_00g058090)

PCHM:

VFPPC_07065 VFPPC_18773

CMT:	CCM_01839 CCM_08632

AMUS:

LMH87_003602

PLJ:	28886976(PLICBS_002287)

PTKZ:

JDV02_002728(ERG3_1) JDV02_009539(ERG3_2)

VAL:	VDBG_00635 VDBG_08651

VDA:	VDAG_00248 VDAG_06314

CFJ:	CFIO01_04916 CFIO01_13103

CLUP:

CLUP02_03571

CHIG:

CH63R_00352 CH63R_02632

CDET:

87937375(CDEST_00872) 87939051(CDEST_02548)

SAPO:

SAPIO_CDS2999 SAPIO_CDS7892

ELA:	UCREL1_10295

PFY:	PFICI_03760 PFICI_10769

SSL:	SS1G_08964

BFU:	BCIN_16g04720(Bcerg3)

MBE:

MBM_05730

PSCO:

LY89DRAFT_470878

GLZ:	GLAREA_10324

ANI:	ANIA_03638 ANIA_06506

AFM:	AFUA_6G05140 AFUA_8G01070

ACT:	ACLA_020750 ACLA_095400

NFI:	NFIA_051710 NFIA_094510

AOR:	AO090010000692 AO090103000138 AO090701000022

ANG:	An15g00150 An16g02930

AFV:	AFLA_004510 AFLA_013380 AFLA_014186

ALUC:

AKAW2_60670A(ERG3) AKAW2_70254A

ACHE:

ACHE_20394S ACHE_50257A(ERG3_1)

APUU:

APUU_10781A(ERG3_1) APUU_60236S

PCS:	N7525_002055 N7525_004854

PDP:	PDIP_18830 PDIP_52770

POU:	POX_c04465

TMF:	EYB26_007177 EYB26_009632

TRG:	TRUGW13939_07266 TRUGW13939_09806

CIM:	CIMG_02610 CIMG_10100

CPW:	CPC735_012260 CPC735_037410

URE:	UREG_03145

ABE:	ARB_04289 ARB_05812

TVE:	TRV_05362 TRV_06270

PBL:	PAAG_03651

PBN:	PADG_06181

AJE:	HCAG_06888

BGH:	BDBG_09413

PNO:	SNOG_09349

PTE:

PTT_15444

PTRR:

6339351(PtrM4_015160)

BZE:	COCCADRAFT_23737 COCCADRAFT_8476

BSC:	COCSADRAFT_111459 COCSADRAFT_182796

BOR:	COCMIDRAFT_2100 COCMIDRAFT_93800

AALT:

CC77DRAFT_934207 CC77DRAFT_990455

ARAB:

EKO05_0003036 EKO05_0003671

ZTR:	MYCGRDRAFT_74506(ERG3)

PFJ:	MYCFIDRAFT_32401

FFU:	CLAFUR5_07160

CBET:

CB0940_09933

BCOM:

BAUCODRAFT_68200

NPA:	UCRNP2_7814 UCRNP2_8453

TML:	GSTUM_00007875001

SPO:	2542109(erg31) 3361266(erg32)

SOM:	SOMG_01276(erg32) SOMG_01733(erg31)

CNE:

CNA05010

CNB:

CNBA4830

CNG:	CNAG_00519

CGI:	CGB_A5290W

CDEU:

CNBG_1396

CDEP:

91087960(L203_103750)

KMG:	30161126(I203_105503)

KNE:	92183885(IAR55_006627)

TMS:	TREMEDRAFT_45020

TASA:

A1Q1_03320

CCAC:

CcaHIS019_0301770(ERG3)

TVS:	TRAVEDRAFT_149751

DSQ:	DICSQDRAFT_166781

PCO:	PHACADRAFT_252075

SHS:	STEHIDRAFT_90966

HIR:	HETIRDRAFT_314892

PSQ:	PUNSTDRAFT_125877

ADL:	AURDEDRAFT_112131

FME:	FOMMEDRAFT_103044

GTR:	GLOTRDRAFT_101052

RSX:	RhiXN_02799

LBC:	LACBIDRAFT_190564(ERG3)

CCI:	CC1G_12572

ABP:	AGABI1DRAFT59529(AGABI1DRAFT_59529)

ABV:	AGABI2DRAFT218236(AGABI2DRAFT_218236)

PCUB:

JR316_0005992

MRR:	Moror_3018 Moror_3020

E1B28_005920

SCM:	SCHCO_02543117(SCHCODRAFT_02543117) SCHCO_02632253(SCHCODRAFT_02632253)

CPUT:

CONPUDRAFT_135618 CONPUDRAFT_159631 CONPUDRAFT_84469

SLA:	SERLADRAFT_348962

WSE:	WALSEDRAFT_61115

WIC:	J056_003563

UMA:	UMAG_03593

PFP:	PFL1_02493

SGRA:

EX895_006565

MGL:

MGL_0204

MRT:

MRET_1111

PTRC:

PtA15_16A275

PSTR:

Pst134EA_029220

MLR:	MELLADRAFT_50057

MBR:	MONBRDRAFT_24115 MONBRDRAFT_32318 MONBRDRAFT_39006

SRE:	PTSG_01052 PTSG_08398 PTSG_11590

DFA:

DFA_02096

ACAN:

ACA1_035520

TET:	TTHERM_00446080 TTHERM_00758950 TTHERM_01194720

PTM:	GSPATT00009441001 GSPATT00010502001 GSPATT00010676001 GSPATT00017257001 GSPATT00019457001 GSPATT00019548001 GSPATT00024717001 GSPATT00029323001

PTI:	PHATRDRAFT_14208

FCY:	FRACYDRAFT_141664

PIF:	PITG_21426

PSOJ:

PHYSODRAFT_474456

SPAR:

SPRG_11773 SPRG_18544

EHX:	EMIHUDRAFT_220113 EMIHUDRAFT_435021 EMIHUDRAFT_441353

GTT:	GUITHDRAFT_65403

TBR:	Tb927.8.3240

TBG:	TbgDal_VIII2980

TCR:	473111.10 507853.10

LMA:	LMJF_23_1300

LIF:	LINJ_23_1560

LDO:	LDBPK_231560

LMI:	LMXM_23_1300

LMAT:

92516091(LSCM1_06147) 92516130(LSCM1_06186)

LBZ:	LBRM_23_1420

LPAN:

LPMP_231460

LOI:	92360696(LSCM4_04781)

LEIS:

94180845(GH5_05474)

LENR:

94172746(CUR178_05547)

LEIN:

94189930(JIQ42_06314)

PHET:

94290959(JKF63_04911)

NGR:	NAEGRDRAFT_77816

LAB:	LA76x_0977

LAQ:	GLA29479_2179

LMB:	C9I47_1006

LYJ:	FKV23_04565

CEB:	B0D95_17770

SDE:

Sde_2984

SAGA:

M5M_05095 M5M_16375

ZAL:	AZF00_16120

MTHD:

A3224_03325

MICC:

AUP74_01594

MICT:

FIU95_03565

TUN:	J9260_16825

GAI:	IMCC3135_19420

IFL:	C1H71_17510

HYF:	DTO96_101664

BPAR:

BN117_0103

BPA:

BPP0105

BBH:	BN112_3308

BBX:	BBS798_0104

BPT:

Bpet4857

BHZ:	ACR54_02498

BTRM:

SAMEA390648703326

AXY:	AXYL_06328

AXO:	NH44784_023541

AXN:	AX27061_5940

AXX:	ERS451415_06070

ADT:	APT56_27470

AIS:	BUW96_24905

ACHR:

C2U31_04045

AFA:	UZ73_09045

AFQ:

AFA_01575

AAQU:

D3M96_01435

ODI:

ODI_R0206

PIG:	EGT29_14640

PACR:

FXN63_20635

DAC:

Daci_1692

DEL:	DelCs14_4887

DLA:	I6G47_15825

VAP:	Vapar_2347

VPE:	Varpa_2527

VPD:	VAPA_1c24860

VAA:	AX767_20775

VBO:	CKY39_19240

VAM:	C4F17_03620

VAV:	IG196_16400

JAB:	VN23_05000

CFU:

CFU_1702

DUG:	HH213_24600

FKU:	FGKAn22_02440

RVA:

Rvan_0861

BRN:	D1F64_14590

LAP:	ACP90_12815 ACP90_12820

LABR:

CHH27_07740 CHH27_07745 CHH27_17525

LABT:

FIU93_18605 FIU93_18610

LAGG:

B0E33_24755 B0E33_24760

BSB:	Bresu_2481

BRD:	JL11_05930

BRG:	A4249_04415

BRL:	BZG35_11195

BVC:	CEP68_00715

BRF:	E4M01_08515

BREV:

E7T10_10660

SIL:	SPO0619 SPO3848

RUA:	D1823_21290

RUT:	FIU92_18035 FIU92_20650

RUY:	NOR97_19370

JAN:

Jann_3403

RDE:

RD1_0610

RLI:	RLO149_c000730

RPON:

G3256_03375

PGA:	PGA1_c26100

PGL:	PGA2_c24130

PGD:

Gal_00823

PPIC:

PhaeoP14_02531

PHQ:	D1820_07710

OAT:	OAN307_c01260

OAR:	OA238_c47600

LEJ:	ETW24_11920

LEV:	ETW23_11925

LCAE:

K3721_06425

SULZ:

C1J03_20010

SULI:

C1J05_07035

TOM:	BWR18_18785

ROM:	EI983_00520

THAA:

CFI11_22800

CACT:

HZ995_01330 HZ995_12175

GCE:	KYE46_09415

NAR:

Saro_0236

NPP:	PP1Y_AT36759

NPN:	JI59_11990

NRE:	BES08_14035

NOV:	TQ38_000265

NOT:	C7W88_04915

NOR:	FA702_10655

NGF:	FRF71_05745

NOG:	GKE62_11730

SAL:

Sala_3136

SPHK:

SKP52_02245

SPHP:

LH20_01360

STER:

AOA14_09195

SPHQ:

BWQ93_18325

SPHX:

E5675_18390

SPHU:

SPPYR_3141

STAX:

MC45_14775

SSAN:

NX02_00960

SNJ:	A7E77_06785

SMY:	BJP26_02355

SPAN:

AWL63_06440

SKR:	BRX40_04555

SPLM:

BXU08_15545

SPLK:

AV944_01265

SPKC:

KC8_11295

SPHC:

CVN68_16225

SPHF:

DM480_06120

SPHA:

D3Y57_11060

SPAU:

DRN02_014660

SLUT:

H9L13_06650

SRHI:

H9L12_01855

SLAN:

GV829_07785

SDH:	H9L15_14570

SPAP:

H3Z74_21155

SXA:	FMM02_01290

SPAI:

FPZ24_16825

SSUA:

FPZ54_16445

SBIN:

SBA_ch1_00490

SAER:

NEF64_03365

SRAD:

LLW23_07525

SHAN:

PPZ50_03080

SNAP:

PQ455_16865

SNOS:

K8P63_17465

SSAG:

KV697_10520

SJP:	SJA_C1-28960

SINB:

SIDU_00390

SCH:	Sphch_2837

SSY:

SLG_31700

SYB:	TZ53_01450

SPMI:

K663_13655

SPHB:

EP837_01002(erg3)

SPHR:

BSY17_1944

SPHT:

K426_17475

SHYD:

CJD35_07600

SYA:	A6768_02315

SPYG:

YGS_C1P1994

SUFL:

FIL70_12970

SBAR:

H5V43_10575

SAMI:

SAMIE_1021640

SPPH:

KFK14_00390

SPAG:

sphantq_01321

CIJ:	WG74_03350

SPHL:

LPB140_00885

BLAS:

BSY18_2315

BFW:	B5J99_03140

SPZR:

G5C33_02000

PALG:

HFP57_12470

PARJ:

J4G78_04005 J4G78_15730

SMIC:

SmB9_24670

SPHS:

ETR14_09435

SAND:

H3309_11775

ALB:

AEB_P0654

ALH:	G6N82_08295 G6N82_13905

AAY:

WYH_02232

ADO:	A6F68_00557

CNA:	AB433_15915

CMAN:

A9D14_13165

ERY:	CP97_01785

EFV:	CHH26_00720

ERK:	CD351_07400

ERR:	DVR09_02185

EMV:	HQR01_05330

LCK:	HN018_22190

SUR:	STAUR_2074 STAUR_2747

AGE:	AA314_00282 AA314_07594

CFUS:

CYFUS_007448

MRM:	A7982_05543 A7982_06694 A7982_06884 A7982_09250

SAMY:

DB32_000704 DB32_004537

BBAC:

EP01_04755

BDQ:	CIK05_03560

BCO:	Bcell_3869

SYNE:

Syn6312_1119

HHG:	XM38_023260

MAR:

MAE_29450

ANB:	ANA_C13627

AWA:	AA650_13830

DFS:	HGD76_15975

CCUR:

IAR63_00190

CRK:	L3I90_11930

AFLO:

HEQ12_10125

ROO:	G5S37_14740

LUO:	HHL09_02055 HHL09_24385

RUL:

UC8_35600

AAGG:

ETAA8_15100 ETAA8_64410

PLS:	VT03_00340

GOG:	C1280_08430

LRS:	PX52LOC_07779

FTJ:

FTUN_4866

ULI:	ETAA1_36740

SACI:

Sinac_3507

HBS:	IPV69_17435

LBJ:

LBJ_0847

LBL:

LBL_2235

LST:

LSS_15791

LAJ:	A0128_16330

LMAY:

DPV73_10370

LKM:	EFP84_05150

TPX:	Turpa_3776

GMA:	AciX8_2716

CBAE:

COR50_14320

CHIT:

FW415_01355

FLA:	SY85_15460 SY85_21715

FGG:	FSB75_15470 FSB75_20815

PSEG:

D3H65_06845

PGIN:

FRZ67_18685

PGO:	FSB84_04535

LACS:

H4075_00440

HHY:	Halhy_4865

PEP:	AQ505_09680 AQ505_15745

PSTY:

BFS30_25505

PEK:	FFJ24_000400

MUP:	A0256_15850

MUC:

MuYL_4794

MGOT:

MgSA37_00138 MgSA37_02250

MUH:	HYN43_020620

MGIN:

FRZ54_16950

MGK:	FSB76_10775

MRUB:

DEO27_020705

MGOS:

DIU38_021715

CMR:	Cycma_3873

CAMU:

CA2015_3822

SLI:

Slin_3005

SRD:	SD10_16950

SPIR:

CWM47_18135

SPIK:

EXU85_09615

SPIB:

G8759_31065

STAE:

HNV11_06130 HNV11_17455

SOQ:	LQ777_19370

SFOL:

H3H32_19645

SENF:

GJR95_20500

RHOZ:

GXP67_29280

PSEZ:

HME7025_00151(erg3)

RSI:	Runsl_3742

RUN:	DR864_07130

RUP:	DTQ70_00965

FAE:

FAES_3530

FIB:	A6C57_19620

HYJ:	FHG12_18885

PACT:

CA264_15625

RUF:	TH63_00395

NIB:	GU926_14685

MTT:	Ftrac_0950

CHK:	D4L85_28820

FPSZ:

AMR72_17395

POA:	CW731_11350

PHAL:

H9I45_11280

PPEC:

H9W90_11450

PBAT:

JL193_10305

PCEA:

J3359_12245

MOD:	AS202_13795

MYZ:	BK054_13345

SALT:

AO058_01200

SMIS:

LDL76_08025

AQA:	D1815_20900

MUR:	EQY75_06655

AFLA:

FHG64_08410

ANP:	FK178_13300

EMN:	M876_02940

EEN:	BBD30_02595

EMG:	BBD33_16610

CIO:	CEQ15_04315

CHRY:

CEY12_01120

CPIP:

CJF12_06270

CHRS:

EAG08_09795

CCAU:

EG346_09670

CBEN:

EG339_15705

CGLE:

NCTC11432_00219

CLAC:

EG342_15705

CJG:	NCTC13459_01254

CCAS:

EIB73_06205

CANT:

NCTC13489_01265

KDA:	EIB71_07695

FTE:	Fluta_0640

» show all

Reference

1 [PMID:14189869]

Authors

DEMPSEY ME, SEATON JD, SCHROEPFER GJ Jr, TROCKMAN RW.

Title

THE INTERMEDIARY ROLE OF DELTA-5,7-CHOLESTADIEN-3-BETA-OL IN CHOLESTEROL BIOSYNTHESIS.

Journal

J Biol Chem 239:1381-7 (1964)

Reference

2 [PMID:4019441]

Authors

Honjo K, Ishibashi T, Imai Y

Title

Partial purification and characterization of lathosterol 5-desaturase from rat liver microsomes.

Journal

J Biochem 97:955-9 (1985)
DOI:10.1093/oxfordjournals.jbchem.a135137

Reference

3 [PMID:1864507]

Authors

Arthington BA, Bennett LG, Skatrud PL, Guynn CJ, Barbuch RJ, Ulbright CE, Bard M

Title

Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase.

Journal

Gene 102:39-44 (1991)
DOI:10.1016/0378-1119(91)90535-J

Sequence

[sce:YLR056W]

Reference

4 [PMID:8561508]

Authors

Taton M, Rahier A.

Title

Plant sterol biosynthesis: identification and characterization of higher plant delta 7-sterol C5(6)-desaturase.

Journal

Arch Biochem Biophys 325:279-88 (1996)
DOI:10.1006/abbi.1996.0035

Reference

5 [PMID:9056262]

Authors

Nishino H, Nakaya J, Nishi S, Kurosawa T, Ishibashi T.

Title

Temperature-induced differential kinetic properties between an initial burst and the following steady state in membrane-bound enzymes: studies on lathosterol 5-desaturase.

Journal

Arch Biochem Biophys 339:298-304 (1997)
DOI:10.1006/abbi.1996.9871

Reference

6 [PMID:10651635]

Authors

Taton M, Husselstein T, Benveniste P, Rahier A.

Title

Role of highly conserved residues in the reaction catalyzed by recombinant Delta7-sterol-C5(6)-desaturase studied by site-directed mutagenesis.

Journal

Biochemistry 39:701-11 (2000)
DOI:10.1021/bi991467t

Sequence

[ath:AT3G02580]

Reference

7 [PMID:22982564]

Authors

Poklepovich TJ, Rinaldi MA, Tomazic ML, Favale NO, Turkewitz AP, Nudel CB, Nusblat AD

Title

The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae.

Journal

Steroids 77:1313-20 (2012)
DOI:10.1016/j.steroids.2012.08.015

Other DBs

ExplorEnz - The Enzyme Database:

1.14.19.20

IUBMB Enzyme Nomenclature:

1.14.19.20

ExPASy - ENZYME nomenclature database:

1.14.19.20

BRENDA, the Enzyme Database:

1.14.19.20

CAS:	37255-37-1

LinkDB

DBGET integrated database retrieval system