Entry Name Class Oxidoreductases;BRITE hierarchy
Sysname loganin,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (ring-cleaving)
Reaction(IUBMB) loganin + [reduced NADPH---hemoprotein reductase] + O2 = secologanin + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:
R03555 ]
Reaction(KEGG) Substrate loganin [CPD:
C01433 ];
[reduced NADPH---hemoprotein reductase] [CPD:
C03024 ];
O2 [CPD:
C00007 ]
Product secologanin [CPD:
C01852 ];
[oxidized NADPH---hemoprotein reductase] [CPD:
C03161 ];
H2O [CPD:
C00001 ]
Comment A cytochrome P-450 (heme-thiolate) protein. Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids.
History EC 1.14.19.62 created 2002 as EC 1.3.3.9, transferred 2018 to EC 1.14.19.62
Pathway ec01110 Biosynthesis of secondary metabolites
Orthology Reference 1
Authors Yamamoto H, Katano N, Ooi Y, Inoue K.
Title Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures.
Journal Phytochemistry 50:417-422 (1999)
Reference Authors Yamamoto H, Katano N, Ooi A, Inoue K.
Title Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450.
Journal Reference Authors Irmler S, Schroder G, St-Pierre B, Crouch NP, Hotze M, Schmidt J, Strack D, Matern U, Schroder J
Title Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase.
Journal Sequence Other DBs LinkDB All DBs
