KEGG ENZYME: 1.14.99.34

ENZYME: 1.14.99.34

Entry

EC 1.14.99.34               Enzyme

Name

monoprenyl isoflavone epoxidase;
monoprenyl isoflavone monooxygenase;
7-O-methylluteone:O2 oxidoreductase;
7-O-methylluteone,NADPH:O2 oxidoreductase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous

Sysname

7-O-methylluteone,NADPH:oxygen oxidoreductase

Reaction(IUBMB)

7-O-methylluteone + NADPH + H+ + O2 = dihydrofurano derivatives + NADP+ + H2O [RN:R05741]

Reaction(KEGG)

R05741

Substrate

7-O-methylluteone [CPD:C07290];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]

Product

dihydrofurano derivative [CPD:C07291];
NADP+ [CPD:C00006];
H2O [CPD:C00001]

Comment

A flavoprotein (FAD) with high specificity for monoprenyl isoflavone. The product of the prenyl epoxidation reaction contains an oxygen atom derived from O2, but not from H2O. It is slowly and non-enzymically converted into the corresponding dihydrofurano derivative. The enzyme in the fungus Botrytis cinerea is induced by the substrate analogue, 6-prenylnaringenin.

History

EC 1.14.99.34 created 2000

Reference

Authors

Tanaka M, Tahara S.

Title

FAD-dependent epoxidase as a key enzyme in fungal metabolism of prenylated flavonoids.

Journal

Phytochemistry 46:433-439 (1997)

Other DBs

ExplorEnz - The Enzyme Database:

1.14.99.34