KEGG   ENZYME: 1.14.99.44
Entry
EC 1.14.99.44               Enzyme                                 
Name
diapolycopene oxygenase;
crtP (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
4,4'-diapolycopene,AH2:oxygen oxidoreductase (4,4'-hydroxylating)
Reaction(IUBMB)
4,4'-diapolycopene + 4 reduced acceptor + 4 O2 = 4,4'-diapolycopenedial + 4 acceptor + 6 H2O [RN:R09671]
Reaction(KEGG)
R09671;
(other) R07654 R09727 R09728
Substrate
4,4'-diapolycopene [CPD:C19797];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
4,4'-diapolycopenedial [CPD:C19798];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
Little activity with neurosporene or lycopene. Involved in the biosynthesis of C30 carotenoids such as staphyloxanthin. The enzyme oxidizes each methyl group to the hydroxymethyl and then a dihydroxymethyl group, followed by the spontaneous loss of water to give an aldehyde group.
History
EC 1.14.99.44 created 2011
Pathway
ec00906  Carotenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K10210  diapolycopene oxygenase
Genes
MMTMetme_3774
MDNJT25_002365
MDHAYM39_15930
MKOMKLM6_3290
METLU737_16970(crtI)
MPADKEF85_14155(crtI)
MELLIVG45_20685(crtI)
MPSYCEK71_14805
KUSB9G99_06335
KMAB9H00_08720
MEAMex_1p3665(ctrI)
MDIMETDI4240(ctrI)
MEXMext_3436
MCHMchl_3745
MPOMpop_3632
MZAB2G69_24740
MRDMrad2831_5031
METM446_3156
MORMOC_5734
METAY590_16875
MAQUMaq22A_c06955
MPHYMCBMB27_04475
MEEDA075_07760
METDC0214_18825
METXA3862_05965
METIDK427_17340
MMESMMSR116_03635(crtI)
MTEADK419_25140
MINDmvi_47440
MOGMMB17_18215(crtI)
MOCBB934_38295
BBARRHAL1_01931
LIZLGH83_14110(crtI)
GOHB932_2266
GALA0U94_05050
GTIFXF46_11910(crtI) FXF46_15790(crtI)
ABGAsbog_01465(crtI)
KBAA0U89_05405
RGIRGI145_04005
ROSCTJ15_13405
RMUCFOB66_05790(crtI)
NCHA0U93_12590
NTND5366_08600(crtI)
LCKHN018_16745(crtI)
ALIAZOLI_p10672
ABSAZOBR_150005
ABQABAZ39_01055
ABFAMK58_25210
AZTTSH58p_12600
AZMDM194_17000
AOZHUE56_02795(crtI)
SKTIGS68_00375(crtI)
SMUCJL100_001155(crtI)
SROEJL101_000380(crtI)
BPUBPUM_2690
BPUMBW16_14510
BPUSUP12_13760
BIFN288_02870
BACWQR42_13585
BWHA9C19_15125 A9C19_17020
BXIBK049_13585
BALTCFN77_14445(crtI)
BSAFBSL056_15160
BCOBcell_3994
BHKB4U37_06820 B4U37_10405
BMQBMQ_2021(crtI) BMQ_2949
BMDBMD_1977(crtI) BMD_2978
BMHBMWSH_2233 BMWSH_3258(crtI)
BMEGBG04_4322(crtP) BG04_5481(crtI)
PKSIE339_15755(crtI)
BLEBleG1_3942
BPFBpOF4_14565(crtP)
BKOCKF48_16145
CGOTJ1899_01870(crtI)
OIHOB2459
AFLAflv_2195
AGNAFK25_03165
LGYT479_06405
HHDHBHAL_1313 HBHAL_2763(crtNb)
HMNHM131_12850 HM131_19705
HLIHLI_02855 HLI_09930
TAPGZ22_08185
TAIDKS242_09280(crtI)
VHLBME96_14530
FPNABE65_002095 ABE65_002110
SJEAAV35_007820 AAV35_012005
BMURABE28_002620 ABE28_013810
PPSRI6J18_04190(crtI)
PSYHD0S48_20355(crtI)
POFGS400_07995(crtI)
MEKUHUW50_18265(crtI)
RMFD5E69_12340(crtI)
BBEVBBEV_0577(crtP-1) BBEV_1363(crtP-2)
BSEBsel_1103 Bsel_2212
MCUIG8O30_05935(crtI)
SAUSA2351
SAVSAV2564
SAWSAHV_2548
SAHSaurJH1_2640
SAJSaurJH9_2586
SAMMW2485
SASSAS2450
SARSAR2646
SACSACOL2579
SAXUSA300HOU_2559
SAASAUSA300_2501
SAOSAOUHSC_02881
SAENWMN_2464(crtI)
SADSAAV_2630
SUUM013TW_2538
SUVSAVC_11700
SUESAOV_2609c
SUJSAA6159_02460(crtI)
SUKSAA6008_02603(crtI)
SUCECTR2_2417(crtI)
SUTSAT0131_02775
SUQHMPREF0772_10625(crtI)
SUZMS7_2571(crtP)
SUDST398NM01_2615
SUXSAEMRSA15_24670
SUWSATW20_26860
SUGSAPIG2615
SUFSARLGA251_23390
SAUASAAG_00385
SAUERSAU_002405
SAUNSAKOR_02556
SAUSSA40_2318
SAUUSA957_2402
SAUGSA268_2480
SAUZSAZ172_2664
SAUTSAI1T1_2019090
SAUJSAI2T2_1019100
SAUKSAI3T3_1019090
SAUQSAI4T8_1019100
SAUVSAI7S6_1019090(crtP)
SAUWSAI5S5_1019030(crtP)
SAUXSAI6T6_1019040(crtP)
SAUYSAI8T7_1019070(crtP)
SAUFX998_2547
SABSAB2437c
SUYSA2981_2501
SAUBC248_2622
SAUMBN843_26010
SAUCCA347_2640(crtP)
SAURSABB_01120(crtP)
SAUIAZ30_13435
SAUDCH52_06180
SAMSNI36_12830
SHASH0488
SHHShL2_00389(crtI)
SLGSLGD_00185
SLNSLUG_01830
SXYBE24_11840 BE24_13830
SXLSXYLSMQ121_0051
SXOSXYL_00051(crtP)
SCAPAYP1020_1735(crtP)
SEQOSE1039_25810
SPETCEP67_08105
SNLBJD96_00585
SKLC7J89_02350
SHOMEGX58_06050
SCARDWB96_01935
SARLSAP2_00910(crtP)
SPICSAMEA4384060_0087(crtP)
SSHNCTC13712_02520(crtP)
SSIMSAMEA4384339_2370(crtP)
SDBCNQ82_01430
SLLOISP08_00310
SSCUCEP64_13160
MLENH3V22_08605(crtI)
MACRBHM04_10275
LGZNCTC10812_02741(crtP)
ESIExig_0517 Exig_0738
EATEAT1b_2163 EAT1b_2493
EANEab7_0711
EXMU719_02710 U719_03910
EXUESP131_05155 ESP131_06330
EAPKB235_12905(crtI) KB235_14645(crtI)
EACEKKI46_02915(crtI) KKI46_04105(crtI)
PMSKNP414_02931
PMQPM3016_3171
PMWB2K_16040
PBDPBOR_33875
PAENP40081_35205
PAEQR50912_31835
PAEAR70723_30700
PAEER70331_29455
PBVAR543_14100
PXLBS614_00330
PSWUSY83_14360 SY83_16585
PLUTEI981_26715(crtI)
PBKBack11_13210(crtP)
PBACHUB98_14510(crtI)
PTRIKDC22_30830(crtI)
PALOE6C60_1954
PALRHGI30_11850(crtI) HGI30_22120(crtI)
COHNKCTCHS21_30250(crtP_1) KCTCHS21_30350(crtP_2)
SACAFFV09_16680(crtI)
SIVSSIL_3759
SSILSOLI23_19230
PLNPlano_0604 Plano_2714
PKUAUO94_02190 AUO94_13335
PRTAUC31_06455 AUC31_12730
PLLI858_004200 I858_009375
PANABBH88_05400 BBH88_17560
PDGBCM40_01765 BCM40_12610
PHCBBI08_10745 BBI08_16110
PMARB0X71_03860
PPLABBI15_09585 BBI15_15430
PFAEAJGP001_03885 AJGP001_15430
PLXCW734_04965 CW734_15685
PMATBBI11_04595 BBI11_15115
PDECH1Q58_03735(crtI) H1Q58_14400(crtI)
JEOJMA_07510 JMA_18970
SURESporoP32a_09250
SPOSDV702_13350(crtI)
PANCE2636_00235(crtI)
PLAYDNR44_006400(crtI) DNR44_016995(crtI)
LFBC1X05_05355
TVUAB849_000755
KPULGXN76_05120(crtI)
ECASECBG_01335
EMUEMQU_0489
EGAAL523_06010
EIEENLAB_20230
CRNCAR_c19220(crtP)
CAWQ783_08810
MARRBKP56_12405
JEPBW721_07800
JDABW727_102018(crtP)
RRSRoseRS_1811
RCARcas_2535
CAUCaur_2410
CHLChy400_2597
CAGCagg_2983
HAUHaur_0609
CAPCLDAP_20440
PMETG4Y79_17140(crtI)
CCZCCALI_00231
ROOG5S37_15655(crtI)
SOAG3M56_005565(crtI)
RBARB11943
PIRVN12_20065(crtP)
RULUC8_21150(crtP)
RMLFF011L_10680(crtP)
ROLCA51_34620(crtP)
AHELQ31a_22280(crtP)
RLCK227x_30590(crtP)
PNDPla175_40250(crtP)
PLMPlim_2740
PEHSpb1_35070(crtP)
PLSVT03_32435(crtP)
PLHVT85_17065(crtP)
GESVT84_20055(carA2)
GOGC1280_20095
GMSSOIL9_30650
TIMGMBLW1_01360
LRSPX52LOC_03471
FTJFTUN_7583
ULIETAA1_31530(crtP)
TSPHKIH39_01650(crtI)
PBORBSF38_05169(crtP)
AGVOJF2_67080(crtP)
PHMPSMK_03760(crtI)
MCADPan265_06390(crtP)
HBSIPV69_01380(crtI)
SFCSpiaf_2800
SLRL21SP2_2163
ACAACP_2301
ACMAciX9_0858
TSAAciPR4_3647
TRSTerro_0346
ABASACPOL_3674
CTMCabther_A1900
CVLJ8C06_02330(crtI)
CHLOJ8C02_09335(crtI)
DYSG7050_08290(crtI)
BLQL21SP5_01096(crtP)
ASXCDL62_12200
PGINFRZ67_12085(crtI)
FLSGLV81_02010(crtI)
LACSH4075_02190(crtI)
FLPLK994_03540(crtI)
HHYHalhy_4788
SGNSGRA_1067
PEJFYC62_10480(crtI)
PEKFFJ24_025770(crtI)
PROEH9L23_26270(crtI)
PEXIZT61_17310(crtI)
MUPA0256_02300
MUHHYN43_029955(crtI)
MGKFSB76_11385(crtI)
MRUBDEO27_031165(crtI)
MGOSDIU38_019705(crtI)
MGIKGO620_013835(crtI)
MDJLLH06_01120(crtI)
SBXCA265_25315
CMRCycma_1319
CAMUCA2015_1241
BBDBelba_0942
ALMAO498_02085
MDAIPZ59_07745(crtI)
SMONAWR27_12515
SPIBG8759_08155(crtI)
STAEHNV11_05550(crtI)
PSEZHME7025_02380(crtI)
RHOZGXP67_14360(crtI)
DSNHWI92_11400(crtI)
RSIRunsl_1846
RUNDR864_18110
RUPDTQ70_22340(crtI)
EOLEmtol_2657
FAEFAES_0082(crtI)
FIBA6C57_24075
FLIFleli_1387
HSWHsw_4190
HYMN008_08365
HYDPK28_01500
HYEAM218_14535
HYGAUC43_05160
HYPA0257_15235
HYZAXW84_19935
HNVDDQ68_14485
HYHD3Y59_13295(crtI)
HYJFHG12_08555(crtI)
HRSHER32_10695(crtI)
HBNGUY19_13355(crtI)
HTSHMJ29_07230(crtI)
PKOPKOR_06065
PACTCA264_17000
RUFTH63_17895
RTIDC20_08645
RUDTH61_06260
NIBGU926_12040(crtI)
ADDHUW48_24355(crtI)
ASWUHUW51_08650(crtI)
MTTFtrac_1976
FPFDCC35_05045
FLMMY04_1513(crtI)
FLLEI427_04945(crtI)
FYAKMW28_08635(crtI)
FKAKM029_05570(crtI)
FBTD770_12865
FUVJR347_10465(crtI)
MAREEJ994_07520(crtI)
SPONHME9304_02555(crtI)
PTQP700755_000615
NDODDD_2394
NOMAAT17_12185
NOBCW736_08190
NOJEJ995_11890(crtI)
POMMED152_02575(crtI1)
SYISB49_01450
AQBD1818_13185(crtI)
AQAD1815_18000(crtI)
AQDD1816_14625(crtI)
OCIFEZ18_11935(crtI)
CAGGHYG79_01990(crtI)
ASAGFGM00_06240(crtI)
FLGLV716_01735(crtI)
FTEFluta_0097
FLUCHH17_11240
OHOOweho_0231
CHYDH4K34_00090(crtI)
BBAUAEM51_00705
CTSCtha_0974
IALIALB_0396(crtI)
CPRVCYPRO_2658
MEAMMU439_03715
 » show all
Reference
1  [PMID:15850982]
  Authors
Mijts BN, Lee PC, Schmidt-Dannert C
  Title
Identification of a carotenoid oxygenase synthesizing acyclic xanthophylls: combinatorial biosynthesis and directed evolution.
  Journal
Chem Biol 12:453-60 (2005)
DOI:10.1016/j.chembiol.2005.02.010
  Sequence
[sav:SAV2564]
Reference
2  [PMID:15933032]
  Authors
Tao L, Schenzle A, Odom JM, Cheng Q
  Title
Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde.
  Journal
Appl Environ Microbiol 71:3294-301 (2005)
DOI:10.1128/AEM.71.6.3294-3301.2005
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.44
IUBMB Enzyme Nomenclature: 1.14.99.44
ExPASy - ENZYME nomenclature database: 1.14.99.44
BRENDA, the Enzyme Database: 1.14.99.44
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