KEGG   ENZYME: 1.2.1.4
Entry
EC 1.2.1.4                  Enzyme                                 
Name
aldehyde dehydrogenase (NADP+);
NADP-acetaldehyde dehydrogenase;
NADP-dependent aldehyde dehydrogenase;
aldehyde dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
aldehyde:NADP+ oxidoreductase
Reaction(IUBMB)
an aldehyde + NADP+ + H2O = a carboxylate + NADPH + H+ [RN:R00634]
Reaction(KEGG)
R00634 > R00711 R05099
Substrate
aldehyde [CPD:C00071];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
carboxylate [CPD:C00060];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.2.1.4 created 1961
Pathway
ec00930  Caprolactam degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14519  NADP-dependent aldehyde dehydrogenase
Genes
POLBpro_2298
AAVAave_0115
HBAHbal_2501
MDXBTO20_21660
MMAGMMAD_17910
MTYMTOK_16350
MMATMMAGJ_18140
MBRML2Z93_003446
MGOAFA91_18385
CSURN24_0341(aldH)
CCYCSCMU_32610
CFGCFREI_06645(aldH)
NBRO3I_014410
NOZDMB37_12025
NAHF5544_03970 F5544_18980
NIEKV110_32105
RHARHA1_ro02898 RHA1_ro08151
REBXU06_29340
ROPROP_04960 ROP_33690
ROAPd630_LPD01864 Pd630_LPD07647
RPYY013_12795
RKOJWS14_15360 JWS14_29370
RPSKJWS13_19910
GPOGPOL_c08310
GAMGII34_11230
SCOSCO1871(SCI39.18c)
SALBXNR_4954
SMASAVERM_6389
SGRSGR_5625
SGBWQO_07195
SFISFUL_1445
SANLKZO11_06900
SGRFSGFS_088010
SCYER2B67_29140
SCBSCAB_70651
SSXSACTE_1304
SVLStrvi_6068 Strvi_6961
SHYSHJG_3333
SHOSHJGH_3098
SRCM271_36920 M271_42100
SMALSMALA_1828
SSOII1A49_12290
SFASfla_4940
SBHSBI_08125
SVESVEN_1516
SDVBN159_6637
SALSSLNWT_3889 SLNWT_5169
STRPF750_1741
SCIB446_09735
SLVSLIV_28360
SGUSGLAU_08360
SVTSVTN_09040
STREGZL_06632
SCWTU94_07955
SXISXIM_08460
STRMM444_09735
STRCAA958_05410
SAMBSAM23877_1946(aldH)
SPRISPRI_5639 SPRI_6598
SCZABE83_05080 ABE83_28580
SCXAS200_33840
SRWTUE45_02355(aldH)
STRFASR50_09120
SLEsle_52630(sle_52630)
SRNA4G23_01098(aldH)
SPAVSpa2297_07475
STRTA8713_06920
SGSAVL59_36200
STSIA4E84_09445
SKYD0C37_26780
SALWCP975_07930
SGMGCM10017557_63870
SCADDN051_29150
SPHWNFX46_30000
SLSSLINC_2143
SNRSNOUR_30860
SALUDC74_2375
SALLSAZ_13230
SPLULK06_006345
STRDNI25_29855
SNWBBN63_27130
SAUOBV401_12610
SSIAA7J05_27570
SPUNBFF78_31920
SGVB1H19_11460
SALFSMD44_02024(aldH)
SLXSLAV_28055(aldH)
SFKKY5_1790c
SNZDC008_07595
SGEDWG14_06529(aldH)
SLKSLUN_09055
SDXC4B68_30950
SGDELQ87_30185
SCYAEJ357_10760
SASTCD934_26295
SNQCP978_09035
SKACP970_33710
SGZC0216_22605
SVNCP980_25430
SNKCP967_26925
SHAWCEB94_09900
SFICEIZ62_25730
SGALCP966_08010
SPADDVK44_05385
SFYGFH48_30745
SAQUEJC51_12510
SGFHEP81_07415
SCAVCVT27_06070
SSEOD0Z67_06320
SBYH7H31_27955
SRIMCP984_31595
SSUBCP968_25250
SPHVF9278_09390 F9278_41905
SCINCP977_08425
SFUGCNQ36_08105
SPACB1H29_28125
SCHACP983_33330
SGXH4W23_09490
SCOECP976_10630
SBATG4Z16_27200 G4Z16_31395
SSPBCP982_11050
SNFJYK04_02543(aldH)
SPLACP981_09390
SBROGQF42_12225
STUIGCM10017668_14690
SATAC5746_10310
SCHFIPT68_08685
SHUNDWB77_05847(aldH)
SHARHUT13_04790
SCYGS1361_10270(aldH)
SFEUIM697_12885
SLIAHA039_26585
SDWK7C20_08905
SVDCP969_10400 CP969_21185
SAUHSU9_007405
SFBCP974_05695
SPRACP972_08485
SROIIAG44_31050
SXNIAG42_27470
SGJIAG43_06880
SHKJ2N69_07750
SANUK7396_27430
SDDD9753_27385
SACTDMT42_08595
SMAOCAG99_10430 CAG99_23505
SINEKI385_12000
SLFJEQ17_35575
SDECL3078_10880
SAOVG3H79_29000
SDURM4V62_32055
SYANNRK68_08440
SRUGF0345_05355
SAKBK1J60_34670
STAALDH80_29925
SNIGHEK616_16040
SVIOHWN34_25015
SCAEIHE65_34760
STUBMMF93_07335
SSPNLXH13_09680
SCIRSTRCI_002007
SXTKPP03845_102113(aldH)
SLONLGI35_13000
SDRZNEH16_24745
STUDSTRTU_005512
STEEF3L20_08415
SENGOJ254_18620
SGKPET44_08340
SANTQR300_32505
SYUNMOV08_30870
SARGHKX69_26700
SJNRI060_32955
SCYNN8I84_10410
SFIYF0344_29005
SHAUK9S39_33570
SKGKJK29_29860
SCOAQU709_33825
SLAIP8A22_30020
SFPQUY26_30985
SCHGNRO40_06140
STTNBSL84_08165
SINNABB07_29130
STRZOYE22_27225
SCTSCAT_1069(aldH)
SCYSCATT_10640
KABB7C62_06205
STRIC7M71_026240
YIALO772_29230
STRHGXP74_30895
ABRYNYE86_10160
AGLAOIE69_29940
LEIFHF024_03025 HF024_15475 HF024_15560
LSEF1C12_02900
CMICMM_0812
CMHVO01_12315
CMSCMS0069
CMCCMN_00768
CCAPAES38_03600
CZHH9X71_03675
CPHAFGI33_09290
CCAFFGD68_06105
MCWA8L33_01720
MPALBO218_08130 BO218_12285
MPRTET475_03200
MCHNHCR76_14865
MICSC1N74_02830 C1N74_14770
MTECOAU46_03975
MSUWGCM10025863_16690
MARKQUC20_02590 QUC20_14930
MRGSM116_00515 SM116_06865 SM116_15340 SM116_16410 SM116_17005
MINVT9R20_01615
MESTPTQ19_13205
MOJD7D94_11425
FSBGCM10025867_00480 GCM10025867_45210
AGYATC03_04975 ATC03_15645
AARCG127AT_04820
AMAUDSM26151_06040 DSM26151_17850(aldH)
ASOIMTP13_01615
AMAVGCM10025877_10010 GCM10025877_25320
ALAVMTO99_18995
AILFLP10_04420 FLP10_15845
MDBOVN18_05585
LEULeucomu_04515
LTREVS81_03560
LEBG7066_05385
LDNH9L06_03900
LVIG7068_14510 G7068_14680
LLUTK1X41_04820
LARIKI794_05430
LALLMUN78_04065
LRPMUN76_04920 MUN76_10700
LTNKVY00_04460
HEAHL652_16540 HL652_20135
GLNF1C58_00235
GSDM3M28_01495
ARTArth_3335
ARRARUE_c34530(aldH)
ARMART_2596
AREAL755_00525
AAQAOC05_16125
ARWMB46_17645
ARZAUT26_15885
AWWG8758_14840
AODQ8Z05_03630
ARIUM93_13775
AAUAAur_3317(aldH)
PUEFV140_17450
PNVJMY29_15825
ACHAchl_3135
APNAsphe3_32640
PSULAU252_14625
PDELJCQ34_15810
POKSMD14_16620
GMYXH9_10795
RSARSal33209_1814
CMUAP8192_03680
BCVBcav_0786
DAYFV141_11200
DERMH7F30_06010
LMOIVV02_11040
HALTIM660_17765
RHALLQF10_17490
RSUALQF12_15025
NCANoca_0086
MUZH4N58_00735
SGRGL0C25_11030
KFLKfla_6632
KQIF1D05_17890
KSLOG809_08885
TFUTfu_1706
THAONI17_003845
TALXFOF52_07935
NDANdas_5346
NALB005_1809
NFEHUT17_01055
NEXNE857_16965 NE857_33615
NECKGD82_00515
NAKEKGD83_28310
NCGKGD84_00590
SNAHOUQ99_00850
SAIUJ4H86_15000
AMAZLUW76_33655
ACIROG979_39880
SPIQOHA34_05085 OHA34_26290
ACTQOG417_24665 OG417_28700
SROSros_1486
NCXNocox_10180(aldH)
NGNLCN96_11480
NFSOIE67_35545
TBITbis_1086 Tbis_1743
MHAIOHB01_21520
FREFranean1_4676
NAKAH7F38_03500
GOBGobs_2395
BSDBLASA_1682(aldH)
SENSACE_1997 SACE_2783
SACGFDZ84_03090
AMDAMED_5971
AMNRAM_30625
AMMAMES_5887
AMZB737_5887
AOIAORI_3623(aldH) AORI_4998(aldH)
AJAAJAP_14530 AJAP_21020
AMQAMETH_6878
AMYCCU254_22190
AMYBBKN51_17445
AORISD37_24610
AACDLWP59_12210 LWP59_13140 LWP59_13260
APRTMUY14_06015
AROONQK81_04430 NQK81_41980
ATHML1857_01275 L1857_22100
ARHDVSH64_17280
PHHAFB00_20980
AMIAmir_1484 Amir_4721
KALKALB_6874
KUTJJ691_102100 JJ691_97310
KBUQ4V64_11665
KPHYAOZ06_14455
LEDBBK82_01545 BBK82_46985
AHMTL08_12515
ACTIUA75_13535
ACADUA74_13450
ACTUActkin_02660(aldH)
CROSN8J89_10455
UMERM788_36595
MPRNQ3V37_25000
AMSAMIS_59920
AIHAiant_90370
ACTLL3i22_052280
ASICQ0Z83_067080
ATLAthai_51790
ASERAsera_23020
PRYPrubr_70620
DFUDfulv_14200
DROSDrose_16805 Drose_25845
DAURDaura_21340
NHYJQS43_03115 JQS43_13575
CAICaci_7805
SNASnas_4113
NAVJQS30_15595
JTLM6D93_07025
JCYM6B22_09570
BALADSM104299_01704(aldH)
CWOCwoe_3952
RBARB1887
MICAP0L94_11315
 » show all
Reference
1
  Authors
Adachi, O., Matsushita, K., Shinagawa, E. and Ameyama, M.
  Title
Crystallization and properties of NADP-dependent aldehyde dehydrogenase from Gluconobacter melanogenus.
  Journal
Agric Biol Chem 44:155-164 (1980)
Reference
2
  Authors
Jakoby, W.B.
  Title
Aldehyde dehydrogenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
Reference
3
  Authors
Nakayama, T.
  Title
Acetic acid bacteria. II. Intracellular distribution of enzymes related to acetic acid fermentation, and some properties of a highly purified triphosphopyridine nucleotide (TPN)-dependent aldehyde dehydrogenase.
  Journal
J Biochem (Tokyo) 48:812-830 (1960)
Reference
4  [PMID:13061400]
  Authors
SEEGMILLER JE.
  Title
Triphosphopyridine nucleotide-linked aldehyde dehydrogenase from yeast.
  Journal
J Biol Chem 201:629-37 (1953)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.4
IUBMB Enzyme Nomenclature: 1.2.1.4
ExPASy - ENZYME nomenclature database: 1.2.1.4
BRENDA, the Enzyme Database: 1.2.1.4
CAS: 9028-87-9
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