KEGG ENZYME: 1.2.1.81

ENZYME: 1.2.1.81

Entry

EC 1.2.1.81                 Enzyme

Name

sulfoacetaldehyde dehydrogenase (acylating);
SauS

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

2-sulfoacetaldehyde:NADP+ oxidoreductase (CoA-acetylating)

Reaction(IUBMB)

2-sulfoacetaldehyde + CoA + NADP+ = sulfoacetyl-CoA + NADPH + H+ [RN:R09557]

Reaction(KEGG)

R09557

Substrate

2-sulfoacetaldehyde [CPD:C00593];
CoA [CPD:C00010];
NADP+ [CPD:C00006]

Product

sulfoacetyl-CoA [CPD:C19685];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme is involved in degradation of sulfoacetate. In this pathway the reaction is catalysed in the reverse direction. The enzyme is specific for sulfoacetaldehyde and NADP+.

History

EC 1.2.1.81 created 2011

Pathway

ec00430

Taurine and hypotaurine metabolism

Orthology

K15515

sulfoacetaldehyde dehydrogenase

Genes

BGJ:	AWC36_05910

BNG:	EH206_07455

BIZ:	HC231_15885

SLIG:

GTU79_10145

SHAI:

LMH63_05605

GAI:	IMCC3135_23095(sauS)

HPIS:

P1P91_06520

PAUR:

FGL86_09035

MRZ:	KDW95_20215

NJP:	NEJAP_1576(sauS)

SVA:

SVA_0813

TSN:	W908_04745

RPJ:	N234_15545

REH:	H16_A2747(h16_A2747)

CNC:	CNE_1c26440(sucD2)

CUH:	BJN34_14795

REU:	Reut_A0867

COX:	E0W60_22990

CUK:	KB879_25670

BYI:	BYI23_C010330

BUE:	BRPE67_CCDS00590

BXE:

Bxe_B0701

BXB:

DR64_6032

BPH:

Bphy_6218

BPY:	Bphyt_4382

BFN:

OI25_4376

PARA:

BTO02_11375

PARB:

CJU94_25795

PEW:	KZJ38_11905

PBRY:

NDK50_10310

PPAI:

E1956_27740

PANI:

DCO16_07820

PYT:	PKF023_05270

PPK:	U875_18455

PPNO:

DA70_10965

PPNM:

LV28_20085

PRB:	X636_15655

PSPU:

NA29_22760

PTX:	ABW99_12080

PFG:	AB870_16590

PCOM:

NTU39_06470

PANN:

PanNE5_01020

PANX:

OYT13_06425

CABA:

SBC2_17240(sauS)

BUO:	BRPE64_CCDS00820

CABK:

NK8_76920

TVL:	FAZ95_11780

BOH:	AKI39_13675

AKA:	TKWG_02680

RHF:	EUB48_15050

VEI:

Veis_4280

VAP:	Vapar_3831

VPE:	Varpa_4409

VPD:	VAPA_1c39430(sucD1)

VAZ:	H7F35_02270

DIH:	G7047_16580

DRG:	H9K76_05380

GLC:	JQN73_01135

AZA:	AZKH_2613(gabD)

RPE:

RPE_3204

OCA:

OCAR_6738

OCG:	OCA5_c13340(sucD1)

OCO:	OCA4_c13340(sucD1)

PCAX:

AFIC_002211

MDI:

METDI0777

MCH:

Mchl_4208

META:

Y590_17370

METD:

C0214_07130

METS:

DK389_25455 DK389_30405

RVA:

Rvan_3429

RLAC:

QMO75_16340

FIL:	BN1229_v1_2532(sauS)

FIY:	BN1229_v1_3384(sauS)

PSIN:

CAK95_09385

RUA:	D1823_07690

RUT:	FIU92_17625(sauS)

RCON:

K3740_08305

RUY:	NOR97_00110

JAN:

Jann_1566

RDE:	RD1_2918(adhE)

RLI:	RLO149_c015190

RPON:

G3256_00045

RFU:	ROLI_009600(sauS)

LMD:	METH_04545

LEJ:	ETW24_05665

LEV:	ETW23_14030

SUAM:

BOO69_18705

SULZ:

C1J03_10940

TOM:	BWR18_19590

RMM:	ROSMUCSMR3_02418(sauS)

ROK:	RAK1035_0765

ROH:	FIU89_14815(sauS)

PDE:

Pden_1013

PYE:	A6J80_14110

PAMN:

pAMV3p0587(sauS)

PSEW:

JHW44_08720

PVER:

E3U25_15825

PFEO:

E3U26_04465

PTP:	RCA23_c28350(sucD2)

AMYL:

QBD29_03035

BOSG:

GKR98_14020

ABS:	AZOBR_p480045

ABQ:	ABAZ39_30000

ABF:	AMK58_25725

AZT:	TSH58p_19695

AARE:

D3093_29155

BACA:

FAY30_11795

NMK:	CHR53_14040

DSY:

DSY0244

DHD:

Dhaf_0190

DRU:	Desru_3835

MSIM:

MSIM_08960

CCAW:

CCANI_02880(sauS)

CFEU:

CFELI_05790(sauS)

SVIO:

HWN34_17615

KBU:	Q4V64_44220

SGRG:

L0C25_12205

PHH:	AFB00_27935

HALJ:

G9465_20580

HLA:

Hlac_0665

HEZZ:

EO776_04580

HALQ:

Hrr1229_003530

HSS:	J7656_12245

HSAI:

HPS36_02610

HAZZ:

KI388_02185

HXA:	Halxa_2456

NARA:

QQ977_05455 QQ977_09450

» show all

Reference

1 [PMID:20693281]

Authors

Weinitschke S, Hollemeyer K, Kusian B, Bowien B, Smits TH, Cook AM

Title

Sulfoacetate is degraded via a novel pathway involving sulfoacetyl-CoA and sulfoacetaldehyde in Cupriavidus necator H16.

Journal

J Biol Chem 285:35249-54 (2010)
DOI:10.1074/jbc.M110.127043

Sequence

[reh:H16_A2747]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.81

IUBMB Enzyme Nomenclature:

1.2.1.81

ExPASy - ENZYME nomenclature database:

1.2.1.81

BRENDA, the Enzyme Database:

1.2.1.81

LinkDB

DBGET integrated database retrieval system