KEGG   ENZYME: 1.2.3.1
Entry
EC 1.2.3.1                  Enzyme                                 
Name
aldehyde oxidase;
quinoline oxidase;
retinal oxidase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With oxygen as acceptor
Sysname
aldehyde:oxygen oxidoreductase
Reaction(IUBMB)
an aldehyde + H2O + O2 = a carboxylate + H2O2 [RN:R00635]
Reaction(KEGG)
Substrate
aldehyde [CPD:C00071];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
carboxylate [CPD:C00060];
H2O2 [CPD:C00027]
Comment
Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides [4,6].
The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11, retinal oxidase) [5,7].
History
EC 1.2.3.1 created 1961, modified 2002, modified 2004, modified 2012
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec00350  Tyrosine metabolism
ec00380  Tryptophan metabolism
ec00750  Vitamin B6 metabolism
ec00760  Nicotinate and nicotinamide metabolism
ec00830  Retinol metabolism
ec00982  Drug metabolism - cytochrome P450
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00157  aldehyde oxidase
Genes
HSA316(AOX1)
PTR459863(AOX1) 747025
PPS100968717(AOX1) 117979316
GGO101125522(AOX1) 115933782
PON100451794(AOX4) 100939468(AOX1)
NLE100583419 100583754(AOX1)
MCC701024(AOX1) 701502(AOX4) 701613(AOX2)
MCF102131116(AOX1) 102134468(AOX2) 102134825(AOX4)
CSAB103217611 103217617 103217619
CATY105580017 105580021 105580200
PANU101001006(AOX1) 101002286(AOX4) 101002632(AOX2)
TGE112635867 112636354(AOX1) 112636356
RRO104670351 104670357 104670457
RBB108531964 108532268 108532294
TFN117095234 117095238 117095242
PTEH111546911 111546926
CJC100393665(AOX1) 100394388(AOX2)
SBQ101032494 101033246 101042764
CSYR103271035 103271036 103272311(AOX1)
MMUR105856978 105856979 105856981
LCAT123643320 123643621 123643919
OGA100941419(AOX2) 100951638(AOX4) 100952155(AOX1)
MMU11761(Aox1) 213043(Aox2) 71724(Aox3) 71872(Aox4)
MCAL110290283 110290296(Aox1) 110291452 110301976
MPAH110321275 110321290(Aox1) 110321921
RNO316421(Aox2) 316424(Aox4) 493909(Aox3) 54349(Aox1)
MCOC116088453 116088454 116088456 116089178
MUN110559600(Aox1) 110559602 110559604 110559605
CGE100759157 100760212 100760504 100765484 113830655
MAUA101823275 101823544 101823809 101842897
PLEU114704265 114704588 114704606 114704613
MORG121444847 121444853 121444857 121458912 121458936 121458975
AAMP119803860 119803866 119803907 119803936
NGI103734373 103734384 103734392(Aox1) 103734495
HGL101710340 101722324(Aox4) 101722898(Aox1)
CPOC100714172(Aox4) 100719938(Aox2) 100720210(Aox1)
CCAN109680764 109688486 109692416(Aox1)
DORD105981417(Aox1) 105983958 105984047 105997286
DSP122096444 122096445(Aox1) 122096446 122096447
NCAR124979845 124980255 124980836
OCU100008601(AOX1) 100345417(AOX2) 100345675(AOX3) 100354428(AOX4)
OPI101522091 101522599 101522842 101522997(AOX1)
TUP102482260 102484619(AOX1) 102490052
CFA488467(AOX4) 608849(AOX2)
VVP112922800 112922804 112922830
VLG121480502 121480828
AML100470835(AOX4) 100471086(AOX2) 100474367(AOX1)
UMR103659730 103659731 103659946
UAH113250605 113250606 113250607
UAR123798185(AOX1) 123798186 123798188
ELK111141059 111142784 111153602
LLV125094988 125095839 125095960
MPUF101693479 101694323
ORO101369776 101370075 101382582
EJU114222997 114225005 114225222
ZCA113919830(AOX1) 113919964 113920864
MLX118012164 118012656 118012657
FCA101085487(AOX1)
PYU121030893
PBG122481631
PTG102949513(AOX1) 102967431
PPAD109254456
AJU106979979(AOX1)
HHV120220681(AOX1)
BTA338074(AOX1) 518393(AOX4) 531699(AOX2)
BOM102272565(AOX1) 102281032 102283927
BIU109569300(AOX1) 109569310 109569328
BBUB102390255(AOX1) 102391150 102391488
CHX102171556 102187632 102188176
OAS101102548 101104557(AOX1) 101104808
ODA120854638 120854640(AOX1) 120854641
CCAD122426455 122426514 122426516
SSC100523701(AOX1) 100525616(AOX2) 100623394(AOX4)
CFR102510869 102511253 102511500
CBAI105082310 105082311 105082336
CDK105099168 105099169 105099170
VPC102539001 102539248 102539743(AOX1)
BACU102998479 103003536
LVE103073473 103073747
OOR101285123(AOX1)
DLE111171714
PCAD102987494 102992680(AOX1)
PSIU116757111
ECB100067782(AOX4) 100070976(AOX1) 100146423 100146833 111767394
EPZ103541147(AOX1) 103543311
EAI106823492 106823501 106825581 106829471 123285083
MYB102249846 102257951(AOX1)
MYD102755298(AOX1) 102771691
MMYO118661030(AOX1) 118661465
MLF102432042 102432361 102434556(AOX1)
MNA107524097 107524106 107544193(AOX1)
PKL118709128 118709266
HAI109379197 109379198 109379243(AOX1)
DRO112307752
SHON118985255 118985256(AOX1)
AJM119065501 119065518
PDIC114494690 114495389
PHAS123824455(AOX1) 123824456
MMF118624997 118624998 118625352
RFQ117025797(AOX1) 117025942 117026362
PALE102879869 102895358
PGIG120587516 120587727(AOX1) 120587729
PVP105298171 105298172
RAY107503175 107503179
MJV108391579(AOX1) 108391580 108391581
TOD119254820 119254822 119256085(AOX1)
SARA101540525(AOX1) 101540787 101541048
LAV100662726 100665003 100665288 100665571(AOX1)
TMU101340907 101341581
DNM101442318 101443649 101444097
MDO100016433(AOX2) 100029977(AOX1) 100030014(AOX4) 107648868
GAS123241402 123241403 123241891 123242136
SHR100921509 100923855(AOX1) 100924119 100929481
PCW110197327 110207269 110207271(AOX1)
OAA100092481(AOX1)
GGA424071(AOX1) 424072(AOX2)
PCOC116233962 116233971
MGP100548803(AOX1) 100549268
CJO107316537(AOX1)
NMEL110400687(AOX1)
APLA101795737(AOX1)
ACYG106039970(AOX1)
AFUL116490590(AOX1)
TGU100217503(AOX1)
LSR110484579(AOX1)
SCAN103814515(AOX1)
PMOA120496991(AOX1)
OTC121335283(AOX1)
PRUF121356479(AOX1)
GFR102031924(AOX1)
FAB101818190(AOX1)
PHI102105114(AOX1)
PMAJ107207425
CCAE111931979(AOX1)
CCW104693769(AOX1)
ETL114055687 114055700(AOX1)
ZAB102060431(AOX1)
FPG101915658(AOX1)
FCH102057814(AOX1)
CLV102097486(AOX1)
EGZ104130522
NNI104010254(AOX1)
PLET104617618(AOX1)
ACUN113480959
TALA104368060
PADL103923316(AOX1)
ACHC115342961(AOX1)
AAM106492369 106492373
AROW112969295 112969296
NPD112955066 112955438
DNE112985928(AOX1) 112986459
ASN102376558 102377274 102377506 102383614
AMJ102557817 102558050 102558282 102558513(AOX1)
CPOO109322697 109322746 109322941
GGN109301888 109301889 109301892
PSS102452808(AOX1) 102453236
CMY102932261 102932848
CPIC101949109 101949373(AOX1)
TST117885114
CABI116836083 116836084
MRV120374990 120375097
ACS100565091 100565481 100565681 100565879
PVT110089018 110089019(AOX1)
SUND121919022(AOX1)
PBI103048615(AOX1)
PMUR107291766(AOX1)
PGUT117673209(AOX1)
VKO123024314(AOX1) 123024423
PMUA114607773 114607791(AOX1)
ZVI118095602 118095633
GJA107108261(AOX1) 107113599 107113600 107117016
STOW125426207 125427118 125427247
XLA108701447 108701448 108701449(aox1.L) 444490(aox1.S)
XTR100379890(aox1) 100493336 100495429(aox1)
NPR108797592 108799582 108799583 108799585
RTEM120943718 120943719 120943720 120943721
BBUF121007369 121007452 121008091 121008794
BGAR122944374 122945394 122945807 122945874
DRE570457(aox6) 64265(aox5)
SRX107739315 107739343
SANH107653532 107687882
SGH107600982 107600984
CCAR109060027
CAUA113040179 113064802(aox1)
PPRM120486809(aox6) 120486811(aox5)
MAMB125254213(aox5) 125254220(aox6)
IPU108259545(aox6)
PHYP113524277
SMEO124379761(aox6)
TFD113649223(aox6)
AMEX103034951 103035279
EEE113585478
TRU101069055(aox1)
TNGGSTEN00031889G001
LCO104937222(aox1)
CGOB115018359 115021409
ELY117249798(aox6)
SLUC116048613(aox6)
ECRA117939455(aox6)
PFLV114550961
GAT120825730(aox6)
PPUG119219585(aox6)
MSAM119905158(aox6)
CUD121506461(aox6)
ALAT119015200(aox6)
MZE101479847(aox1)
ONL100708434(aox1)
OAU116317008(aox6)
OLA101168436(aox1)
OML112156643(aox6)
XMA102223145(aox1)
XCO114140277(aox1)
XHE116716236(aox1)
PRET103457351(aox1)
PFOR103149483(aox1)
PLAI106951183(aox1)
PMEI106906675(aox1)
GAF122827269(aox6)
CVG107082806(aox1)
CTUL119791441(aox6)
GMU124861890(aox6)
NFU107384677(aox1)
NWH119428820 119428855
AOCE111570749(aox1)
POV109639006 109639051(aox1)
SSEN122758201 122758208
HHIP117778377(aox6) 117778544(aox5)
HSP118103339(aox6) 118103344(aox5)
LCF108873170(aox1)
SDU111232312 111232447
SLAL111670357(aox1)
XGL120798313(aox6)
HCQ109520227(aox1)
BPEC110175588(aox1) 110175628
MALB109955752(aox1)
BSPL114845600(aox6)
SASA106574294 106575224
OTW112253972(aox6) 112266560(aox5)
OMY110495922(aox5) 110527537(aox6)
OGO124008373 124010596(aox5)
ONE115129646 115129647
SALP111953152 111970984
SNH120033102(aox6) 120050454(aox5)
ELS105022540(aox1)
SFM108930665 108930901
PKI111856671(aox1)
AANG118223618(aox6) 118223619(aox5)
LOC102691296 102691496
PSPA121322943(aox5)
ARUT117402944(aox5)
LCM102354789(AOX1) 102358967
RTP109935677(aox1)
BBEL109484006
CELCELE_B0222.9(gad-3)
CBRCBG_19218 CBG_19219
 » show all
Reference
1  [PMID:16747217]
  Authors
Gordon AH, Green DE, Subrahmanyan V
  Title
Liver aldehyde oxidase.
  Journal
Biochem J 34:764-74 (1940)
DOI:10.1042/bj0340764
Reference
2  [PMID:20985642]
  Authors
KNOX WE
  Title
The quinine-oxidizing enzyme and liver aldehyde oxidase.
  Journal
J Biol Chem 163:699-711 (1946)
Reference
3  [PMID:13201608]
  Authors
MAHLER HR, MACKLER B, GREEN DE.
  Title
Studies on metalloflavoproteins. III. Aldehyde oxidase: a molybdoflavoprotein.
  Journal
J Biol Chem 210:465-80 (1954)
Reference
4  [PMID:5044040]
  Authors
Krenitsky TA, Neil SM, Elion GB, Hitchings GH
  Title
A comparison of the specificities of xanthine oxidase and aldehyde oxidase.
  Journal
Arch Biochem Biophys 150:585-99 (1972)
DOI:10.1016/0003-9861(72)90078-1
Reference
5  [PMID:8262244]
  Authors
Tomita S, Tsujita M, Ichikawa Y
  Title
Retinal oxidase is identical to aldehyde oxidase.
  Journal
FEBS Lett 336:272-4 (1993)
DOI:10.1016/0014-5793(93)80818-F
Reference
6  [PMID:9015384]
  Authors
Yoshihara S, Tatsumi K
  Title
Purification and characterization of hepatic aldehyde oxidase in male and female  mice.
  Journal
Arch Biochem Biophys 338:29-34 (1997)
DOI:10.1006/abbi.1996.9774
Reference
7  [PMID:10190983]
  Authors
Huang DY, Furukawa A, Ichikawa Y
  Title
Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli.
  Journal
Arch Biochem Biophys 364:264-72 (1999)
DOI:10.1006/abbi.1999.1129
  Sequence
[mmu:11761] [ocu:100008601]
Reference
8  [PMID:14659539]
  Authors
Uchida H, Kondo D, Yamashita A, Nagaosa Y, Sakurai T, Fujii Y, Fujishiro K, Aisaka K, Uwajima T.
  Title
Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690.
  Journal
FEMS Microbiol Lett 229:31-6 (2003)
DOI:10.1016/S0378-1097(03)00781-X
Other DBs
ExplorEnz - The Enzyme Database: 1.2.3.1
IUBMB Enzyme Nomenclature: 1.2.3.1
ExPASy - ENZYME nomenclature database: 1.2.3.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.3.1
BRENDA, the Enzyme Database: 1.2.3.1
CAS: 9029-07-6
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