Contains bis(tungstenpterin) cofactor, FAD, and iron-sulfur clusters. While the physiological electron acceptor is thought to be ferredoxin, the enzyme from Aromatoleum aromaticum can use benzyl viologen, NAD+, and molecular hydrogen. Unlike some other aldehyde oxidorductases, in the presence of strong reductants this enzyme is able to catalyse the reverse reaction, reducing non-activated acids to aldehydes. cf. EC 1.2.7.5, aldehyde ferredoxin oxidoreductase.
Simultaneous involvement of a tungsten-containing aldehyde:ferredoxin oxidoreductase and a phenylacetaldehyde dehydrogenase in anaerobic phenylalanine metabolism.
Adaptations to a Loss-of-Function Mutation in the Betaproteobacterium Aromatoleum aromaticum: Recruitment of Alternative Enzymes for Anaerobic Phenylalanine Degradation.
Arndt F, Schmitt G, Winiarska A, Saft M, Seubert A, Kahnt J, Heider J.
Title
Characterization of an Aldehyde Oxidoreductase From the Mesophilic Bacterium Aromatoleum aromaticum EbN1, a Member of a New Subfamily of Tungsten-Containing Enzymes.
