KEGG   ENZYME: 1.2.99.7
Entry
EC 1.2.99.7                 Enzyme                                 
Name
aldehyde dehydrogenase (FAD-independent);
aldehyde oxidase;
aldehyde oxidoreductase;
Mop;
AORDd
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With unknown physiological acceptors
Sysname
aldehyde:acceptor oxidoreductase (FAD-independent)
Reaction(IUBMB)
an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor [RN:R00544]
Reaction(KEGG)
R00544 > R00638
Substrate
aldehyde [CPD:C00071];
H2O [CPD:C00001];
acceptor [CPD:C00028]
Product
carboxylate [CPD:C00060];
reduced acceptor [CPD:C00030]
Comment
Belongs to the xanthine oxidase family of enzymes. The enzyme from Desulfovibrio sp. contains a molybdenum-molybdopterin-cytosine dinucleotide (MCD) complex and two types of [2Fe-2S] cluster per monomer, but does not contain FAD.
History
EC 1.2.99.7 created 2004
Orthology
K07469  aldehyde oxidoreductase
Genes
BCEWDM40_5295
BAMBamb_5751
BACBamMC406_5518
BDLAK34_5296
BPYRABD05_31095
BLATWK25_17150
BTEIWS51_26525
RGUA4W93_01525
SDLSdel_1475
SMULSMUL_2101
SHALSHALO_1855
SULSSdiek1_1939
SULJSJPD1_1855
SULTFA592_01805
GURGura_0998
PCAPcar_0220
PACEA6070_10775 A6070_14425
PEFA7E78_09400
PPDPpro_1551
DVUDVU_1559(mop)
DVLDvul_1574
DVMDvMF_0641
DVGDeval_1735
DDSDdes_1823
DFIAXF13_03440
DPGDESPIGER_0125
DEFCNY67_03300
DSDGD606_04460
DMADMR_05980
DCBC3Y92_17455
DGGDGI_0902(mop)
DDEDde_3539
DMSE8L03_03670 E8L03_11880
DSADesal_0299
DHYDESAM_20433(mop)
DAFDesaf_0413
DPIBN4_11183 BN4_11879(mop)
DEJAWY79_13680
PPRFDPRO_1126(mop)
PSELGM415_09125 GM415_15685
DDNDND132_0141
DSXGD604_04725
PBIZLWC08_01190
DBADbac_1562
DOAAXF15_08755
DRTDret_1808
DPSDP0270
DSFUWK_01309
DPRDespr_1636
DEOCAY53_03230 CAY53_03300
DOGHP555_04800
DATHRM2_07080(mop1) HRM2_38770(mop2)
DTOTOL2_C39330(mop)
DOVDSCO28_12970(mop_1) DSCO28_16460(mop_2) DSCO28_22590 DSCO28_54420(mop_3)
DWDDSCW_31270(mop) DSCW_61540
DALKDSCA_49590(mop)
DLIdnl_22250
HOHHoch_4147
DTIDesti_0720 Desti_1799
SFUSfum_1310
MLNA9174_02930
MCIMesci_0582
MOPMesop_0592
MAMMesau_00496
MAMOA6B35_05605
MESWA9K65_002925
MESMEJ066_08410
MESPC1M53_10270
MHUAMCHK_5950
MJREB229_02985
MERDEB233_03085
MESRFGU64_20365
MESOBSQ44_15110
AAKAA2016_0465
AMIHCO731_00453(mop)
NIYFQ775_19710
BOSBSY19_2962
BVVBHK69_21675
LNEFZC33_27030
METM446_1983
MNOMnod_1247
MICOGDR74_16685
CHELAL346_07265
CDQBOQ54_00405
RBMTEF_05295
PHRC6569_02190
PSTGE8M01_20805
SUAMBOO69_08870
RIDRIdsm_05003(mop)
ROHFIU89_19770(mop)
THAACFI11_12465
RBLB6K69_01545
TAWEI545_19705
SALOEF888_04490
PAEDG5B38_12200
THASC6Y53_07615
RAPRHOA_5093(mop)
FERFNB15_14110
HTQFRZ44_34540
HADHFRZ61_33730
LCYLC20004_04335
EFLEF62_2740
EFIOG1RF_11951
EFDEFD32_2139
EFSEFS1_2048
EFNDENG_02507
EFQDR75_1278
ENEENT_17490
ESSATZ33_06975
CLJCLJU_c24050 CLJU_c24130
CLSCXIVA_04850(CoxL)
CSRCspa_c06890(mop1)
CAHCAETHG_0471
CSQCSCA_3243
CCKCcar_24780
CTYKCTK_C17200
CEUA7L45_05835
CFMBJL90_11360
CDRKB9W14_03710
CDYF3K33_02770(xdh)
CGASJ1C67_15775(xdh)
CLOSDMR38_12345 DMR38_12385
GFEGferi_19165
RUMCK1_27440
OVAOBV_43650(mop)
CCTCC1_17680
ROBCK5_22910
BYLA4V09_21845
BPROPMF13cell1_01056(mop_1)
BLABEYS05_07740
LACYA4V08_07960
CSCIHDCHBGLK_02491(pucD)
CSHClosa_0937
ACACEYQ97_05565(xdh)
LUAD4A81_03745(xdh)
ACELacsn021_14170
RTORTO_09230
RGNRGna_16200(xdh)
CBOLCGC65_06510
PDCCDIF630_03469(xdhA5)
CDCCD196_2987(xdhA3)
CDLCDR20291_3033(xdhA3)
PDFCD630DERM_31770
ROCHF520_00005(xdh)
TEMJW646_03490
TGCL0P85_04810
TEBT8CH_1499(mop)
DSYDSY0872 DSY1987
DHDDhaf_3146
DDHDesde_2603
DORDesor_1273 Desor_3016
DAIDesaci_2677 Desaci_2707
DMIDesmer_1171 Desmer_1863
DCADesca_1570
PTHPTH_0679
DRUDesru_0522
DFGB0537_02740
DAEDtox_3440
FWADCMF_02040 DCMF_08470 DCMF_14090 DCMF_14115 DCMF_21835 DCMF_26870
DGIDesgi_0268 Desgi_0270 Desgi_2922 Desgi_3899
ELMELI_2450
EMTCPZ25_004590(xdh)
ELIMB2M23_18880
AWOAwo_c03890(mop1) Awo_c14980(mop3) Awo_c27190
AWICHL1_002337
VGUHYG85_23235(xdh)
VPYHZI73_14850(xdh)
IBUIB211_02864c
AVGI6H45_07650(xdh)
AOBI6H46_01605(xdh)
MEDMELS_0607
MHWACT01_13630
MMAXLCQ47_07125(xdh)
PFTJBW_01067
STEDSPTER_09650(mop)
PBFCFX0092_B0235
BHYBHWA1_00070(coxL)
BHDBHYOB78_02635
BRMBmur_2657
BPOBP951000_0728
BPJB2904_orf2108(coxL)
BPIPBPP43_11515
BPWWESB_2048(coxL)
BIPBint_1931
BHPBHAMNSH16_01320
FVAFV113G1_27980
FULC4N20_09745(xdh)
FMOC4N19_00290(xdh)
LEOAMK43_04750
STRSterm_3270
AMOAnamo_0983 Anamo_1057
CPORBED41_02500 BED41_02975 BED41_11740
TTZFHG85_06335(xdh)
BLQL21SP5_02720(mop)
 » show all
Reference
1  [PMID:14659539]
  Authors
Uchida H, Kondo D, Yamashita A, Nagaosa Y, Sakurai T, Fujii Y, Fujishiro K, Aisaka K, Uwajima T.
  Title
Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690.
  Journal
FEMS Microbiol Lett 229:31-6 (2003)
DOI:10.1016/S0378-1097(03)00781-X
Reference
2  [PMID:10679276]
  Authors
Duarte RO, Archer M, Dias JM, Bursakov S, Huber R, Moura I, Romao MJ, Moura JJ
  Title
Biochemical/spectroscopic characterization and preliminary X-ray analysis of a new aldehyde oxidoreductase isolated from Desulfovibrio desulfuricans ATCC 27774.
  Journal
Biochem Biophys Res Commun 268:745-9 (2000)
DOI:10.1006/bbrc.2000.2135
Reference
3  [PMID:10727945]
  Authors
Andrade SL, Brondino CD, Feio MJ, Moura I, Moura JJ
  Title
Aldehyde oxidoreductase activity in Desulfovibrio alaskensis NCIMB 13491 EPR assignment of the proximal [2Fe-2S] cluster to the Mo site.
  Journal
Eur J Biochem 267:2054-61 (2000)
DOI:10.1046/j.1432-1327.2000.01209.x
Reference
4  [PMID:7502041]
  Authors
Romao MJ, Archer M, Moura I, Moura JJ, LeGall J, Engh R, Schneider M, Hof P, Huber R
  Title
Crystal structure of the xanthine oxidase-related aldehyde oxido-reductase from D. gigas.
  Journal
Science 270:1170-6 (1995)
DOI:10.1126/science.270.5239.1170
  Sequence
[dgg:DGI_0902]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.99.7
IUBMB Enzyme Nomenclature: 1.2.99.7
ExPASy - ENZYME nomenclature database: 1.2.99.7
BRENDA, the Enzyme Database: 1.2.99.7
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