| Entry |
|
| Name |
7-dehydrocholesterol reductase;
DHCR7 (gene name);
7-DHC reductase;
7-dehydrocholesterol dehydrogenase/cholesterol oxidase;
Delta7-sterol reductase
|
| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
|
| Sysname |
cholesterol:NADP+ Delta7-oxidoreductase
|
| Reaction(IUBMB) |
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ [RN: R01456]
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
|
| Comment |
The enzyme is part of the cholesterol biosynthesis pathway.
|
| History |
EC 1.3.1.21 created 1972, modified 2013
|
| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
|
| Orthology |
| K00213 | 7-dehydrocholesterol reductase |
|
| Genes |
| PMUR: | 107294554 107294556 107294557 |
| CTIG: | 120316163 120316165 |
| PMUA: | 114596913 114596955 |
| XLA: | 379273(dhcr7.S) 380248(dhcr7.L) |
| SRX: | 107727115(dhcr7) 107730061 |
| SANH: | 107679738 107686818 |
| CCAR: | 109103437 122145687 |
| CAUA: | 113052398 113106502(dhcr7) |
| MASI: | 127414967 127440584 |
| TNG: | GSTEN00019198G001 GSTEN00019199G001 |
| SASA: | 106562054(dhcr7) 106587139 |
| STRU: | 115167486 115202959 |
| ONE: | 115112100 115113560(dhcr7) |
| OCLA: | 139385094 139411339 |
| SALP: | 111969284 111974247 |
| CCLU: | 121573333 121582316 |
| PSPA: | 121294271 121330286 |
| ARUT: | 117432415 117435021 |
| AFIL: | 140146488 140157287 140168680 |
| PFLL: | 139151070 139151071 |
| BTAB: | 109033727 109040108 |
| PPOI: | 119093227 119093228 119093748 |
| DSV: | 119461006 119461010 119462124 119462125 119465009 119465134 |
| DALB: | 135906185 135906438 135906441 135916110 |
| RSAN: | 119378567 119396498 119396499 119397514 |
| RMP: | 119174557 119174682 119174683 |
| CSCU: | 111636841 111636843 |
| PCAN: | 112574082 112574092 |
| LSAX: | 138966598 138966601 |
| BARL: | 143280082 143280084 |
| BGT: | 106053689 106067257 106067259 106068985 106071865 |
| PMAX: | 117326295 117328004 |
| MMER: | 123525122 123533770 |
| RPHI: | 132725325 132737374 132737377 132752645 |
| DPOL: | 127853110 127861466 127862103 127862104 127862105 127862107 |
| MAEA: | 128213071 128215561 128230743 |
| CCLM: | 134181493 134195596 134195659 |
| CSAT: | 104742576 104758352 104777974 |
| RSZ: | 108848514 108848528 108859250 |
| MSYL: | 126612363 126634227 |
| PCOX: | 137708042 137739096 |
| HLP: | 133783020 133785583 133791871 133796118 133799908 133804288 133812875 133812926 133814376 133815241 133817974 133821783 133823753 133830809 133830903 133832562 |
| PALZ: | 118045106 118060206 |
| SLY: | 101248602 101256596(DWF5-2) |
| SPEN: | 107008408 107023649 |
| SOT: | 102589505 102604909(StDWF5) |
| SSTN: | 125872987 125873602 |
| SDUL: | 129887626 129898764 |
| SVER: | 125807437 125817530 |
| CANN: | 107845860 107875679 |
| SSPL: | 121797430 121801269 |
| CARB: | 113739580 113742633 |
| BHW: | 143532913 143537134 143580335 143582006 143613574 |
| SLAF: | 141622611 141626248 |
| PSOM: | 113298913 113298926 113358687 |
| TAES: | 123063456 123072467 123080701 |
| MFLO: | 136463303 136473573 136473592 |
| PVIR: | 120655686 120700873 |
| PAUA: | 133918910 133922165 |
| ZOF: | 122027064 122029360 122031900 122034394 |
| SMO: | SELMODRAFT_135440(DWF5-2) SELMODRAFT_185064(DWF5-1) |
| FOX: | FOXG_12967 FOXG_16578 |
| CDET: | 87949448(CDEST_12948) |
| PSCO: | LY89DRAFT_698617 LY89DRAFT_746866 |
| AOR: | AO090001000167 AO090003000792 AO090010000319 AO090010000690 |
| AFV: | AFLA_000891 AFLA_008510 AFLA_013802 AFLA_014184 |
| APUU: | APUU_22197A APUU_40100A |
| FFU: | CLAFUR5_03217 CLAFUR5_09494 |
| LJR: | NCTC11533_02823(DWF) |
| LCJ: | NCTC11976_02540(DWF) |
» show all
|
| Reference |
|
| Authors |
DEMPSEY ME, SEATON JD, SCHROEPFER GJ Jr, TROCKMAN RW. |
| Title |
THE INTERMEDIARY ROLE OF DELTA-5,7-CHOLESTADIEN-3-BETA-OL IN CHOLESTEROL BIOSYNTHESIS. |
| Journal |
J Biol Chem 239:1381-7 (1964) |
| Reference |
|
| Authors |
Moebius FF, Fitzky BU, Lee JN, Paik YK, Glossmann H |
| Title |
Molecular cloning and expression of the human delta7-sterol reductase. |
| Journal |
|
| Sequence |
|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.3.1.21 |
| ExPASy - ENZYME nomenclature database: | 1.3.1.21 |
|
| LinkDB |
|