KEGG   ENZYME: 1.3.1.8
Entry
EC 1.3.1.8                  Enzyme                                 
Name
acyl-CoA dehydrogenase (NADP+);
2-enoyl-CoA reductase;
dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate);
enoyl coenzyme A reductase;
crotonyl coenzyme A reductase;
crotonyl-CoA reductase;
acyl-CoA dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
acyl-CoA:NADP+ 2-oxidoreductase
Reaction(IUBMB)
acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+ [RN:R00385]
Reaction(KEGG)
R00385 > R01278 R03776 R03856 R03989 R04753 R06985
Substrate
acyl-CoA [CPD:C00040];
NADP+ [CPD:C00006]
Product
2,3-dehydroacyl-CoA [CPD:C00605];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The liver enzyme acts on enoyl-CoA derivatives of carbon chain length 4 to 16, with optimum activity on 2-hexenoyl-CoA. In Escherichia coli, cis-specific and trans-specific enzymes exist [EC 1.3.1.37 cis-2-enoyl-CoA reductase (NADPH) and EC 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)].
History
EC 1.3.1.8 created 1972, modified 1986
Pathway
ec00062  Fatty acid elongation
ec01100  Metabolic pathways
Reference
1  [PMID:6749495]
  Authors
Dommes V, Luster W, Cvetanovic M, Kunau WH.
  Title
Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli.
  Journal
Eur J Biochem 125:335-41 (1982)
DOI:10.1111/j.1432-1033.1982.tb06688.x
Reference
2  [PMID:4387390]
  Authors
Seubert W, Lamberts I, Kramer R, Ohly B
  Title
On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA.
  Journal
Biochim Biophys Acta 164:498-517 (1968)
DOI:10.1016/0005-2760(68)90180-X
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.8
IUBMB Enzyme Nomenclature: 1.3.1.8
ExPASy - ENZYME nomenclature database: 1.3.1.8
BRENDA, the Enzyme Database: 1.3.1.8
CAS: 37251-07-3
LinkDB

KEGG   REACTION: R00385
Entry
R00385                      Reaction                               
Name
acyl-CoA:NADP+ 2-oxidoreductase
Definition
Acyl-CoA + NADP+ <=> 2,3-Dehydroacyl-CoA + NADPH + H+
Equation
C00040 + C00006 <=> C00605 + C00005 + C00080
Comment
general reaction
Reaction class
RC00001  C00005_C00006
Enzyme
1.3.1.8
Pathway
rn00062  Fatty acid elongation
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.8
     R00385  Acyl-CoA + NADP+ <=> 2,3-Dehydroacyl-CoA + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.3.1.8
   R00385  Acyl-CoA <=> 2,3-Dehydroacyl-CoA
Other DBs
RHEA: 22463
LinkDB

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