Entry Name N-acyl-aromatic-amino-acid desaturase;
Class Oxidoreductases;BRITE hierarchy
Sysname N-acyl-aromatic amino acid:oxygen 2-oxidoreductase
Reaction(IUBMB) (1) an N-acyl-L-tryptophan + O2 = a (2E)-N-acyl-2-dehydrotryptophan + H2O2 [RN:
R13709 ];
(2) an N-acyl-L-tyrosine + O2 = a (2E)-N-acyl-2-dehydrotyrosine + H2O2 [RN:
R13708 ];
(3) an N-acyl-L-phenylalanine + O2 = a (2E)-N-acyl-2-dehydrophenylalanine + H2O2 [RN:
R13710 ]
Reaction(KEGG) Substrate Product (2E)-N-acyl-2-dehydrotryptophan [CPD:
C23178 ];
H2O2 [CPD:
C00027 ];
(2E)-N-acyl-2-dehydrotyrosine [CPD:
C23177 ];
(2E)-N-acyl-2-dehydrophenylalanine [CPD:
C23179 ]
Comment Contains FMN. The enzyme catalyses a step in the biosynthesis of oxazolone compounds (phenazolones, tyrazolones, and tryptazolones), which have been reported from Gram-negative as well as Gram-positive bacteria. The enzyme acts along EC
6.1.3.2 , N-acyl-2-dehydroaromatic-amino-acid cyclase, and the order in which the two enzymes act has not been determined conclusively. In some organisms the two enzymes form a fusion protein.
History EC 1.3.3.19 created 2026
Reference Authors de Rond T, Asay JE, Moore BS.
Title Co-occurrence of enzyme domains guides the discovery of an oxazolone synthetase.
Journal Reference Authors Grigg JC, Copp JN, Krekhno JMC, Liu J, Ibrahimova A, Eltis LD.
Title Deciphering the biosynthesis of a novel lipid in Mycobacterium tuberculosis expands the known roles of the nitroreductase superfamily.
Journal Sequence Reference Authors Kleetz J, Grigg JC, Hassan AA, Ibtisam A, Copp JN, Lian J, Liu J, Eltis LD.
Title The biosynthesis of N-acylated tryptazolone in Mycobacterium tuberculosis and related bacteria.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 1.3.3.19
ExPASy - ENZYME nomenclature database: 1.3.3.19
LinkDB All DBs
