| Entry |
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| Name |
tetrahydroberberine oxidase;
(S)-THB oxidase
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
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| Sysname |
(S)-tetrahydroberberine:oxygen oxidoreductase
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| Reaction(IUBMB) |
(S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2 [RN: R02880]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme from Berberis sp. is a flavoprotein; that from Coptis japonica is not. (R)-Tetrahydroberberines are not oxidized.
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| History |
EC 1.3.3.8 created 1990 (EC 1.5.3.8 created 1989, incorporated 1992)
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| Pathway |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K22089 | tetrahydroprotoberberine oxidase |
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| Genes |
| PSOM: | 113274966 113303200 |
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| Reference |
1 |
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| Authors |
Amann M, Nagakura N, Zenk MH. |
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| Title |
(S)-Tetrahydroprotoberberine oxidase the final enzyme in protoberberine biosynthesis. |
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| Journal |
Tetrahedron Lett 25:953-954 (1984) |
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| Reference |
2 |
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| Authors |
Okada N, Shinmyo A, Okada H, Yamada Y. |
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| Title |
Purification and characterization of (S)-tetrahydroberberine oxidase from cultured Coptis japonica cells. |
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| Journal |
Phytochemistry 27:979-982 (1988) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.3.3.8 |
| ExPASy - ENZYME nomenclature database: | 1.3.3.8 |
| BRENDA, the Enzyme Database: | 1.3.3.8 |
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| LinkDB |
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