KEGG   ENZYME: 1.3.8.13
Entry
EC 1.3.8.13                 Enzyme                                 
Name
crotonobetainyl-CoA reductase;
caiA (gene name)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
gamma-butyrobetainyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
gamma-butyrobetainyl-CoA + electron-transfer flavoprotein = crotonobetainyl-CoA + reduced electron-transfer flavoprotein [RN:R11600]
Reaction(KEGG)
R11600
Substrate
gamma-butyrobetainyl-CoA [CPD:C20749];
electron-transfer flavoprotein [CPD:C04253]
Product
crotonobetainyl-CoA [CPD:C20748];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
The enzyme has been purified from the bacterium Escherichia coli O44 K74, in which it forms a complex with EC 2.8.3.21, L-carnitine CoA-transferase. The electron donor is believed to be an electron-transfer flavoprotein (ETF) encoded by the fixA and fixB genes.
History
EC 1.3.8.13 created 2017
Orthology
K08297  crotonobetainyl-CoA dehydrogenase
Genes
ECO: b0039(caiA)
ECJ: JW0038(caiA)
ECD: ECDH10B_0040(caiA)
EBW: BWG_0037(caiA)
ECOK: ECMDS42_0032(caiA)
ECOC: C3026_00205
ECE: Z0045(caiA)
ECS: ECs_0042(caiA)
ECF: ECH74115_0043(caiA)
ETW: ECSP_0042(caiA)
ELX: CDCO157_0041
EOI: ECO111_0040(caiA)
EOJ: ECO26_0040(caiA)
EOH: ECO103_0041(caiA)
ECOO: ECRM13514_0040(caiA)
ECOH: ECRM13516_0042(caiA)
ESL: O3K_21350
ESO: O3O_04035
ESM: O3M_21250
ECK: EC55989_0039(caiA)
ECG: E2348C_0040(caiA)
EOK: G2583_0041(caiA)
ELR: ECO55CA74_00195
ELH: ETEC_0039
ECW: EcE24377A_0041(caiA)
EUN: UMNK88_39
ECP: ECP_0039
ENA: ECNA114_0026(caiA)
ECOS: EC958_0173(caiA)
ECV: APECO1_1942(caiA)
ECOA: APECO78_03655
ECX: EcHS_A0043(caiA)
ECM: EcSMS35_0040(caiA)
ECY: ECSE_0040
ECR: ECIAI1_0041(caiA)
ECQ: ECED1_0038(caiA)
EUM: ECUMN_0041(caiA)
ECT: ECIAI39_0040(caiA)
EOC: CE10_0040(caiA)
EBR: ECB_00043(caiA)
ECOB: C3029_03950
EBL: ECD_00043(caiA)
EBE: B21_00042(caiA)
EBD: ECBD_3576
ECI: UTI89_C0045(caiA)
EIH: ECOK1_0038(caiA)
ECZ: ECS88_0042(caiA)
ECC: c0048(caiA)
ELO: EC042_0041(caiA)
ELN: NRG857_00205
ESE: ECSF_0044
ECL: EcolC_3616
EKO: EKO11_3873
EKF: KO11_00195(caiA)
EAB: ECABU_c00440(caiA)
EDH: EcDH1_3560
EDJ: ECDH1ME8569_0038(caiA)
ELU: UM146_22975
ELW: ECW_m0039(caiA)
ELL: WFL_00195(caiA)
ELC: i14_0041(caiA)
ELD: i02_0041(caiA)
ELP: P12B_c0034(caiA)
ELF: LF82_0257(caiA)
ECOL: LY180_00200
ECOI: ECOPMV1_00040(caiA_1)
ECOJ: P423_00195
EFE: EFER_0047(caiA)
EAL: EAKF1_ch1383(caiA)
EMA: C1192_12775
ESZ: FEM44_14690(caiA)
ERUY: OSH18_09410(caiA)
STY: STY0083(caiA)
STT: t0074(caiA)
SEX: STBHUCCB_840
SENT: TY21A_00380
STM: STM0073(caiA)
SEO: STM14_0087(caiA)
SEV: STMMW_00751
SEY: SL1344_0074(caiA)
SEM: STMDT12_C00740
SEJ: STMUK_0074(caiA)
SEB: STM474_0076(caiA)
SEF: UMN798_0081(caiA)
SETU: STU288_00365
SETC: CFSAN001921_17055
SENR: STMDT2_00741(caiA)
SEND: DT104_00741(caiA)
SENI: CY43_00360
SEEN: SE451236_06375
SPT: SPA0074(caiA)
SEK: SSPA0070
SPQ: SPAB_00090
SEI: SPC_0078(caiA)
SEC: SCH_0067(caiA)
SEH: SeHA_C0077(caiA)
SHB: SU5_0708
SENH: CFSAN002069_08865
SEEH: SEEH1578_09395
SEE: SNSL254_A0077(caiA)
SENN: SN31241_10520
SEW: SeSA_A0081(caiA)
SEA: SeAg_B0080(caiA)
SENS: Q786_00360
SED: SeD_A0079(caiA)
SEG: SG0076(caiA)
SEL: SPUL_0078(caiA)
SEGA: SPUCDC_0078(caiA)
SET: SEN0074(caiA)
SENA: AU38_00360
SENO: AU37_00360
SENV: AU39_00360
SENQ: AU40_00395
SENL: IY59_00375
SENJ: CFSAN001992_10660
SEEC: CFSAN002050_06815
SEEB: SEEB0189_019020
SEEP: I137_00340
SENB: BN855_760(caiA)
SENE: IA1_00370
SENC: SEET0819_07255
SES: SARI_02927
SBG: SBG_0058(caiA)
SBZ: A464_61
SBV: N643_00280
SALZ: EOS98_18875
SFL: SF0036(caiA)
SFX: S0038(caiA)
SFV: SFV_0033(caiA)
SFE: SFxv_0037(caiA)
SFN: SFy_0045
SFS: SFyv_0049
SFT: NCTC1_00036(caiA)
SSN: SSON_0047(caiA)
SDY: SDY_0061(caiA)
SDZ: Asd1617_00066
SHQ: A0259_04035
CRO: ROD_00411(caiA)
CKO: CKO_03344
CFD: CFNIH1_09905
CBRA: A6J81_13205
CWE: CO701_18215
CYO: CD187_20355
CPOT: FOB25_07450(caiA)
CFQ: C2U38_03525
CSED: JY391_18140(caiA)
CAMA: F384_00210
CAF: AL524_22255
CIF: AL515_05000
CFAR: CI104_04650
CIR: C2U53_04680
CIE: AN232_26285
CPAR: CUC49_00190
CTEL: GBC03_25645(caiA)
CITZ: E4Z61_13390(caiA)
CARS: E1B03_04740(caiA)
CIX: M4I31_19965(caiA)
CIB: HF677_019720(caiA)
CENS: P2W74_19330(caiA)
EBT: EBL_c33140(caiA)
ESC: Entcl_2475
KLE: AO703_09860
ASUB: NLZ15_03200(caiA)
YRE: HEC60_04865(caiA)
KIN: AB182_21535
PDZ: HHA33_24100(caiA)
METY: MRY16398_47840(caiA)
PSGC: G163CM_28640(caiA)
TOE: QMG90_18000(caiA)
EBF: D782_3830
EBC: C2U52_03230
EBB: F652_2816
PMR: PMI2655(caiA)
PMIB: BB2000_2646(caiA)
PVL: AOB99_14510
PVG: CRN77_06415
PHAU: PH4a_04750
PROT: BTA34_14490
PCOL: F1325_16705(caiA)
PCIB: F9282_17050(caiA)
PPEE: I6G31_11900(caiA)
PAPP: QQS39_16350(caiA)
PRG: RB151_007300(caiA_2)
PHEI: NCTC12003_00738(caiA)
PRQ: CYG50_11995(caiA)
PHAG: PZ638_03510(caiA)
PZJ: QS795_003840(caiA)
EIC: NT01EI_2959
ETD: ETAF_2401
ETE: ETEE_0764
ETR: ETAE_2663(caiA)
ETC: ETAC_12795
EDW: QY76_07180
EDL: AAZ33_14085(caiA)
EHO: A9798_03955
HAV: AT03_19300
HPAR: AL518_07295
OPO: DSM2777_06085
LPV: HYN51_05075
PRAG: EKN56_12490(caiA)
LRI: NCTC12151_02504(caiA)
LGB: V8L73_13315(caiA)
SLO: Shew_2675
SSE: Ssed_3228
SPL: Spea_4037
SHL: Shal_0221
SWP: swp_4937
SALG: BS332_05315 BS332_05360
SLJ: EGC82_18075
SCAA: TUM17387_35670(caiA_1) TUM17387_35760(caiA_2)
SCHK: GII14_20175(caiA) GII14_20235(caiA)
SAEG: K0H80_13660(caiA)
SSPA: K0I31_13905(caiA)
SHNS: K0J45_13750(caiA)
SRHS: K0I63_13835(caiA)
CPIN: CPIN18020_0491(caiA)
CRX: CRECT_1851(caiA)
AHS: AHALO_2624(caiA)
AMAR: AMRN_2723(caiA)
PBIZ: LWC08_01450(caiA)
BACI: B1NLA3E_21285
CAPR: EQM14_13825
DRM: Dred_0570
RHO: RHOM_09505
CSH: Closa_3931
CALK: HUE98_15945
ELE: Elen_1834
EYY: EGYY_17990(CaiA)
EGD: GS424_010370(caiA)
CBAC: JI75_07140
BWA: HLV38_02055(caiA)
XYL: ET495_16520(caiA)
CELC: K5O09_10670(caiA)
OEK: FFI11_010750(caiA)
GYU: FE374_07885(caiA)
PFR: PFREUD_02420(caiA)
PFRE: RM25_0219
AHE: Arch_1363
ARCA: HC352_07040(caiA)
TPY: CQ11_04205
TPYO: X956_03580
TPEC: HLG82_02695(caiA)
TBER: QPC17_02455(caiA)
AMY: ADJ76_00875
FSL: EJO69_02440
WNE: PIG85_00160(caiA)
VCB: CYK25_001665(caiA)
PHON: BH719_04000
 » show all
Reference
1  [PMID:8060125]
  Authors
Roth S, Jung K, Jung H, Hommel RK, Kleber HP
  Title
Crotonobetaine reductase from Escherichia coli--a new inducible enzyme of anaerobic metabolization of L(-)-carnitine.
  Journal
Antonie Van Leeuwenhoek 65:63-9 (1994)
DOI:10.1007/BF00878280
Reference
2  [PMID:10209289]
  Authors
Preusser A, Wagner U, Elssner T, Kleber HP
  Title
Crotonobetaine reductase from Escherichia coli consists of two proteins.
  Journal
Biochim Biophys Acta 1431:166-78 (1999)
DOI:10.1016/S0167-4838(99)00032-1
  Sequence
[eco:b0039]
Reference
3  [PMID:10978161]
  Authors
Elssner T, Hennig L, Frauendorf H, Haferburg D, Kleber HP
  Title
Isolation, identification, and synthesis of gamma-butyrobetainyl-CoA and crotonobetainyl-CoA, compounds involved in carnitine metabolism of E. coli.
  Journal
Biochemistry 39:10761-9 (2000)
DOI:10.1021/bi000776c
Reference
4  [PMID:12081978]
  Authors
Walt A, Kahn ML
  Title
The fixA and fixB genes are necessary for anaerobic carnitine reduction in Escherichia coli.
  Journal
J Bacteriol 184:4044-7 (2002)
DOI:10.1128/JB.184.14.4044-4047.2002
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.13
IUBMB Enzyme Nomenclature: 1.3.8.13
ExPASy - ENZYME nomenclature database: 1.3.8.13
BRENDA, the Enzyme Database: 1.3.8.13
LinkDB

DBGET integrated database retrieval system