KEGG   ENZYME: 1.5.1.30
Entry
EC 1.5.1.30                 Enzyme                                 
Name
flavin reductase (NADPH);
NADPH:flavin oxidoreductase;
riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase;
flavin mononucleotide reductase;
flavine mononucleotide reductase;
FMN reductase (NADPH);
NADPH-dependent FMN reductase;
NADPH-flavin reductase;
NADPH-FMN reductase;
NADPH-specific FMN reductase;
riboflavin mononucleotide reductase;
riboflavine mononucleotide reductase;
NADPH2 dehydrogenase (flavin);
NADPH2:riboflavin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
reduced-riboflavin:NADP+ oxidoreductase
Reaction(IUBMB)
reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]
Reaction(KEGG)
R05707;
(other) R09520
Substrate
reduced riboflavin [CPD:C01007];
NADP+ [CPD:C00006]
Product
riboflavin [CPD:C00255];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme reduces riboflavin, and, less efficiently, FMN and FAD. NADH is oxidized less efficiently than NADPH.
History
EC 1.5.1.30 created 1982 as EC 1.6.8.2, transferred 2002 to EC 1.5.1.30, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K05901  biliverdin reductase / flavin reductase
Genes
HSA645(BLVRB)
PTR456039(BLVRB)
PPS100989093(BLVRB)
GGO101142015(BLVRB)
PON100446184(BLVRB)
NLE100587172(BLVRB)
MCC703020(BLVRB)
MCF102142962(BLVRB)
CSAB103234707(BLVRB)
CATY105597983(BLVRB)
PANU101021963(BLVRB)
TGE112613110(BLVRB)
RRO104676113(BLVRB)
RBB108539085(BLVRB)
TFN117091948(BLVRB) 117092438
PTEH111553962(BLVRB)
CJC100391206(BLVRB)
SBQ101043206(BLVRB)
CSYR103272286(BLVRB)
MMUR105876763(BLVRB)
OGA100956880(BLVRB)
MMU233016(Blvrb)
MCAL110297893(Blvrb)
MPAH110331802(Blvrb)
RNO292737(Blvrb)
MCOC116101881(Blvrb)
MUN110556744(Blvrb)
CGE100768929(Blvrb)
PLEU114681553(Blvrb)
NGI103750766(Blvrb)
HGL101697384(Blvrb)
CPOC100723970(Blvrb)
CCAN109688540(Blvrb)
DORD105998024(Blvrb)
DSP122097439(Blvrb)
OCU100340115(BLVRB)
OPI101535891(BLVRB)
TUP102490802(BLVRB)
CFA476456(BLVRB)
VVP112928368(BLVRB)
VLG121485710(BLVRB)
AML100467254(BLVRB)
UMR103661047(BLVRB)
UAH113243564(BLVRB)
UAR123784022(BLVRB)
ELK111161593
MPUF101682683(BLVRB)
ORO101371765(BLVRB)
EJU114202467(BLVRB)
ZCA113936395(BLVRB)
MLX118022653(BLVRB)
FCA101092315(BLVRB)
PYU121011436(BLVRB)
PBG122494035(BLVRB)
PTG102957700(BLVRB)
PPAD109256587(BLVRB)
AJU106979604(BLVRB)
HHV120240932(BLVRB)
BTA281650(BLVRB)
BOM102277747(BLVRB)
BIU109572681(BLVRB)
BBUB102402107(BLVRB)
CHX102187796(BLVRB)
OAS101119750(BLVRB)
ODA120872449(BLVRB)
CCAD122420884(BLVRB) 122443458
SSC100625219(BLVRB)
CFR102522968(BLVRB)
CBAI105062862(BLVRB)
CDK105093394(BLVRB)
BACU103014515(BLVRB)
LVE103082225(BLVRB)
OOR101269881(BLVRB)
DLE111180848(BLVRB)
PCAD102992855(BLVRB)
PSIU116743687(BLVRB)
ECB100068145(BLVRB)
EPZ103560493(BLVRB)
EAI106843297(BLVRB)
MYB102251416(BLVRB)
MYD102759928(BLVRB)
MMYO118674559(BLVRB)
MLF102432652(BLVRB)
MNA107534172(BLVRB)
PKL118702235(BLVRB)
HAI109374869(BLVRB)
DRO112320111(BLVRB)
SHON118988083(BLVRB)
AJM119040590(BLVRB)
PDIC114511105(BLVRB)
PHAS123823786(BLVRB)
MMF118639318(BLVRB)
RFQ117035103(BLVRB)
PALE102879551(BLVRB)
PGIG120595620(BLVRB)
PVP105300209(BLVRB)
RAY107521823(BLVRB)
MJV108404844(BLVRB)
TOD119249327(BLVRB)
SARA101557111(BLVRB)
LAV100665167(BLVRB)
TMU101354315
DNM101437673(BLVRB)
MDO100017892(BLVRB)
GAS123255652(BLVRB)
SHR100930351(BLVRB)
PCW110202810(BLVRB)
OAA100073853(BLVRB)
MGP100303679(BLVRB)
APLA113841036(BLVRB)
PHI102113532(BLVRB)
CCAE111943368(BLVRB)
ACHC115337712
AAM106493723(BLVRB)
AROW112960997(BLVRB)
NPD112955489(BLVRB)
DNE112996331(BLVRB)
ASN102387963(BLVRB)
AMJ102574563(BLVRB)
CMY114022374(BLVRB)
CPIC101948417(BLVRB)
TST117888630(BLVRB)
CABI116833857(BLVRB)
MRV120388171(BLVRB)
ACS100564796(blvrb)
PVT110075662(BLVRB)
SUND121916153(BLVRB)
PBI103053858(BLVRB)
PMUR107285666(BLVRB)
TSR106541075(BLVRB)
PGUT117677851(BLVRB)
VKO123021032(BLVRB)
PMUA114603071(BLVRB)
ZVI118078075 118086651(BLVRB)
GJA107107369(BLVRB)
XLA443881(blvrb.L)
XTR100124834(blvrb) 116406791
NPR108791950(BLVRB)
RTEM120913299(BLVRB)
BBUF120977966(BLVRB)
BGAR122923946(BLVRB)
DRE436959(blvrb)
SRX107717620(blvrb)
SANH107670601 107692505
SGH107602119(blvrb)
CCAR109109302 109109306
CAUA113061728 113082608 113118645
IPU108264654 124626957
PHYP113526426(blvrb)
SMEO124396010(blvrb)
AMEX103040962(blvrb)
EEE113580124(blvrb)
TRU101061122(blvrb)
TNGGSTEN00035152G001
LCO104927805(blvrb)
NCC104965039(blvrb)
CGOB115018241(blvrb)
ELY117259444(blvrb)
PLEP121943190(blvrb)
SLUC116053283(blvrb)
ECRA117942519(blvrb)
PFLV114552606(blvrb)
GAT120829425(blvrb)
PPUG119222042(blvrb)
MSAM119882831(blvrb)
CUD121526977(blvrb)
MZE101484658(blvrb)
ONL100702669(blvrb)
OAU116320348(blvrb)
OLA101163919(blvrb)
OML112149783(blvrb)
XMA102228591(blvrb)
XCO114133538(blvrb)
XHE116707592 116707593
PRET103475161(blvrb)
PFOR103138303(blvrb)
PLAI106947919(blvrb)
PMEI106921476(blvrb)
GAF122832913(blvrb)
CVG107094869(blvrb)
CTUL119796633(blvrb)
NFU107379787(blvrb)
KMR108247879(blvrb)
ALIM106522783(blvrb)
NWH119411413(blvrb)
AOCE111586211(blvrb)
CSEM103377891(blvrb)
POV109630121(blvrb)
SSEN122773296(blvrb)
HHIP117773323(blvrb)
LCF108876241(blvrb)
SDU111216890(blvrb)
SLAL111662215(blvrb)
XGL120792571(blvrb)
HCQ109529422(blvrb)
BPEC110172712(blvrb)
MALB109963258(blvrb)
SASA106580739(blvrb) 106612705(BLVRB)
OTW112265119 112266772
OMY110503591 110507468
OGO123993025 124005618
ONE115137042 115141548
SALP111982788 111982809
SNH120018812 120028367
ELS105023068(blvrb)
SFM108928749(blvrb)
PKI111844029(blvrb)
AANG118209415(blvrb)
LOC102698532(blvrb)
PSPA121303818 121304996(blvrb)
ARUT117397815 117415212
LCM102358034(BLVRB)
CMK103173572(blvrb)
RTP109926910(blvrb)
BFO118410084 118414353 118424422
CIN100185152
SCLV120347803 120347819 120347831 120347846 120347854 120347866
SPU100889296 576533 578603
APLC110978883 110978939
SKO100374763
DER6552273
DSIDsimw501_GD20759(Dsim_GD20759)
DYADyak_GE24730
DSR110188190
DPODpse_GA21813
DPE6588134
DMN108156553
DWI6647397
DMODmoj_GI24882
DAZ108618551
DNV108659243
DHE111602756
DVI6630042
MDE101892800
LCQ111676095
AGAAgaP_AGAP001321
ACOZ120949584
AAG5565330
AALB109405306 109406365 115258289
CQUCpipJ_CPIJ011826
CPII120431012
AME412445
ACER107994237
ALAB122714807
BIM100749252
BBIF117205099
BVK117231092
BVAN117157637
BTER100646178
BPYO122567783
CCAL108630984
OBB114877540
MGEN117219339
NMEA116423944
SOC105203387 105203429 105203443 105203453 105204185 113003480
MPHA105830426
AEC105144797
ACEP105624072
PBAR105426660
VEM105557622
HST105187135
DQU106744067
CFO105252649
FEX115234327
LHU105674651
PGC109861802
OBO105281931
PCF106793889
PFUC122526549
VPS122634421
NVI100113525
CSOL105360908
MDL103574018 103575546
TCA664311
DPA109534878
ATD109595167
NVL108556546
BMOR101736226
BMAN114248437
DPLKGM_212873
BANY112054677
PMAC106708927
PPOT106101151
PXU106120319
PRAP111001233
ZCE119828598
HAW110382146
TNL113504959
OFU114353154
PXY105393340
API100168586(Blvrb) 100574136
DNX107162985
AGS114130365
RMD113557849
BTAB109043576
NLU111052374
PHUPhum_PHUM514080
ZNE110828593
CSEC111868350
DPXDAPPUDRAFT_230602
DMK116929398
PVM113830326
HAZT108664641
ISCIscW_ISCW003581
DSV119458384
RSAN119373566
RMP119167602
TUT107359695 107367634
CSCU111640897
PTEP107444427
SDM118193070
LGILOTGIDRAFT_113739 LOTGIDRAFT_145414
PCAN112555334 112555727
HRJ124291888
MYI110441547 110448057 110462494
LAK106151286 106161246 106163455 106163456 106163458
NVE5503663
EPA110232712 110232713
ADF107351009
AMIL114961956
PDAM113669019 113669042 113678890 113678891
SPIS111322492 111322494 111325275 111325299
BCOMBAUCODRAFT_75006
GTTGUITHDRAFT_77488
NGRNAEGRDRAFT_69441 NAEGRDRAFT_71868(FM182)
 » show all
Reference
1  [PMID:3453680]
  Authors
Yubisui T, Tamura M, Takeshita M.
  Title
Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes.
  Journal
Biochem Int 15:1-8 (1987)
Reference
2  [PMID:10620517]
  Authors
Cunningham O, Gore MG, Mantle TJ
  Title
Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).
  Journal
Biochem J 345 Pt 2:393-9 (2000)
DOI:10.1042/bj3450393
  Sequence
[hsa:645]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.30
IUBMB Enzyme Nomenclature: 1.5.1.30
ExPASy - ENZYME nomenclature database: 1.5.1.30
BRENDA, the Enzyme Database: 1.5.1.30
CAS: 56626-29-0
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