KEGG   ENZYME: 1.5.1.30
Entry
EC 1.5.1.30                 Enzyme                                 
Name
flavin reductase (NADPH);
NADPH:flavin oxidoreductase;
riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase;
flavin mononucleotide reductase;
flavine mononucleotide reductase;
FMN reductase (NADPH);
NADPH-dependent FMN reductase;
NADPH-flavin reductase;
NADPH-FMN reductase;
NADPH-specific FMN reductase;
riboflavin mononucleotide reductase;
riboflavine mononucleotide reductase;
NADPH2 dehydrogenase (flavin);
NADPH2:riboflavin oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
reduced-riboflavin:NADP+ oxidoreductase
Reaction(IUBMB)
reduced riboflavin + NADP+ = riboflavin + NADPH + H+ [RN:R05707]
Reaction(KEGG)
R05707;
(other) R09520
Substrate
reduced riboflavin [CPD:C01007];
NADP+ [CPD:C00006]
Product
riboflavin [CPD:C00255];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme reduces riboflavin, and, less efficiently, FMN and FAD. NADH is oxidized less efficiently than NADPH.
History
EC 1.5.1.30 created 1982 as EC 1.6.8.2, transferred 2002 to EC 1.5.1.30, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K05901  biliverdin reductase / flavin reductase
Genes
HSA: 645(BLVRB)
PTR: 456039(BLVRB)
PPS: 100989093(BLVRB)
GGO: 101142015(BLVRB)
PON: 100446184(BLVRB)
PPYG: 129020793(BLVRB)
NLE: 100587172(BLVRB)
HMH: 116480674(BLVRB)
SSYN: 129467021(BLVRB)
MCC: 703020(BLVRB)
MCF: 102142962(BLVRB)
MTHB: 126942092
MNI: 105495336(BLVRB)
CSAB: 103234707(BLVRB)
CATY: 105597983(BLVRB)
PANU: 101021963(BLVRB)
TGE: 112613110(BLVRB)
MLEU: 105542622(BLVRB)
RRO: 104676113(BLVRB)
RBB: 108539085(BLVRB)
TFN: 117091948(BLVRB) 117092438
PTEH: 111553962(BLVRB)
CANG: 105519183(BLVRB)
CJC: 100391206(BLVRB)
SBQ: 101043206(BLVRB)
CIMI: 108285782(BLVRB)
ANAN: 105723427(BLVRB)
CSYR: 103272286(BLVRB)
MMUR: 105876763(BLVRB)
LCAT: 123624314(BLVRB)
PCOQ: 105820481(BLVRB)
OGA: 100956880(BLVRB)
MMU: 233016(Blvrb)
MCAL: 110297893(Blvrb)
MPAH: 110331802(Blvrb)
RNO: 292737(Blvrb)
MCOC: 116101881(Blvrb)
ANU: 117698969(Blvrb)
ASYL: 127672855(Blvrb)
MUN: 110556744(Blvrb)
CGE: 100768929(Blvrb)
MAUA: 101844617(Blvrb)
PROB: 127238361(Blvrb)
PLEU: 114681553(Blvrb)
MORG: 121449703(Blvrb) 121453592
MFOT: 126492547
AAMP: 119821315 119821342(Blvrb)
NGI: 103750766(Blvrb)
HGL: 101697384(Blvrb)
CPOC: 100723970(Blvrb)
CCAN: 109688540(Blvrb)
DORD: 105998024(Blvrb)
DSP: 122097439(Blvrb)
PLOP: 125368345(Blvrb)
NCAR: 124966872
MMMA: 107151453(Blvrb)
ITI: 101955814(Blvrb)
OCU: 100340115
OPI: 101535891(BLVRB)
TUP: 102490802(BLVRB)
GVR: 103598605(BLVRB)
CFA: 476456(BLVRB)
CLUD: 112645456(BLVRB)
VVP: 112928368(BLVRB)
VLG: 121485710(BLVRB)
NPO: 129500870(BLVRB)
AML: 100467254(BLVRB)
UMR: 103661047(BLVRB)
UAH: 113243564(BLVRB)
UAR: 123784022(BLVRB)
ELK: 111161593
LLV: 125088933 125098045
MPUF: 101682683(BLVRB)
MNP: 132005993(BLVRB)
MLK: 131818594(BLVRB)
NVS: 122912043(BLVRB)
ORO: 101371765(BLVRB)
EJU: 114202467(BLVRB)
ZCA: 113936395(BLVRB)
MLX: 118022653(BLVRB)
NSU: 110590243(BLVRB)
LWW: 102749984(BLVRB)
FCA: 101092315(BLVRB)
PYU: 121011436(BLVRB)
PBG: 122494035(BLVRB)
PVIV: 125152916(BLVRB)
LRUF: 124511113
LGF: 123578935(BLVRB)
AJU: 106979604
PTG: 102957700(BLVRB)
PPAD: 109256587(BLVRB)
PUC: 125915658
PLEZ: 122208317(BLVRB)
HHV: 120240932(BLVRB)
BTA: 281650(BLVRB)
BOM: 102277747(BLVRB)
BIU: 109572681(BLVRB)
BBUB: 102402107(BLVRB)
BBIS: 104995362(BLVRB)
CHX: 102187796(BLVRB)
OAS: 101119750(BLVRB)
BTAX: 128063605(BLVRB)
CSUM: 138096686(BLVRB)
ODA: 120872449(BLVRB)
CCAD: 122420884(BLVRB) 122443458
MREE: 136158780(BLVRB)
OVR: 110122434(BLVRB)
MBEZ: 129546807(BLVRB)
SSC: 100625219(BLVRB)
CFR: 102522968(BLVRB)
CBAI: 105062862(BLVRB)
CDK: 105093394(BLVRB)
VPC: 102543677(BLVRB)
BACU: 103014515(BLVRB)
BMUS: 118885044(BLVRB)
LVE: 103082225(BLVRB)
OOR: 101269881(BLVRB)
LALB: 132510176(BLVRB)
DLE: 111180848(BLVRB)
PCAD: 102992855(BLVRB)
PSIU: 116743687(BLVRB)
NASI: 112415632(BLVRB)
ECB: 100068145(BLVRB)
EPZ: 103560493(BLVRB)
EAI: 106843297(BLVRB)
MYB: 102251416(BLVRB)
MYD: 102759928(BLVRB)
MMYO: 118674559(BLVRB)
MLF: 102432652(BLVRB)
MDT: 132216881(BLVRB)
MYUM: 138997034(BLVRB)
PKL: 118702235(BLVRB)
EFUS: 103284696(BLVRB) 103290292
MNA: 107534172(BLVRB)
DRO: 112320111(BLVRB)
SHON: 118988083(BLVRB)
AJM: 119040590(BLVRB)
PDIC: 114511105(BLVRB)
PHAS: 123823786(BLVRB)
MMF: 118639318(BLVRB)
PPAM: 129076686(BLVRB)
HAI: 109374869(BLVRB)
RFQ: 117035103(BLVRB)
PALE: 102879551(BLVRB)
PGIG: 120595620(BLVRB)
PVP: 105300209(BLVRB)
RAY: 107521823(BLVRB)
MJV: 108404844(BLVRB)
TOD: 119249327(BLVRB)
SARA: 101557111(BLVRB)
SFUM: 130044131(BLVRB)
SETR: 126028163(BLVRB)
LAV: 100665167(BLVRB)
TMU: 101354315
ETF: 101645971(BLVRB)
DNM: 101437673(BLVRB)
MDO: 100017892(BLVRB)
GAS: 123255652(BLVRB)
SHR: 100930351(BLVRB)
AFZ: 127556203
PCW: 110202810(BLVRB)
TVP: 118836107 118840391(BLVRB)
PBRV: 138154389(BLVRB)
OAA: 100073853(BLVRB)
TACU: 119946004(BLVRB)
MGP: 100303679(BLVRB)
APLA: 113841036(BLVRB)
ACYG: 136787513(BLVRB)
CATA: 118261579(BLVRB)
ATRC: 139586799(BLVRB)
PHI: 102113532(BLVRB)
CCAE: 111943368(BLVRB)
ZLE: 135441467(BLVRB)
SHAB: 115603330(BLVRB)
ACHC: 115337712
HALD: 104321959(BLVRB)
AGEN: 126036625 126037224
HHAR: 128138135(BLVRB)
BREG: 104641217(BLVRB)
RTD: 128903851(BLVRB)
CRID: 134507696(BLVRB)
AAM: 106493723(BLVRB)
AROW: 112960997(BLVRB)
NPD: 112955489(BLVRB)
TGT: 104572768(BLVRB)
DNE: 112996331(BLVRB)
ASN: 102387963(BLVRB)
AMJ: 102574563(BLVRB)
CMY: 114022374(BLVRB)
CCAY: 125628119(BLVRB)
DCC: 119847368(BLVRB)
CPIC: 101948417(BLVRB)
TST: 117888630(BLVRB)
CABI: 116833857(BLVRB)
MRV: 120388171(BLVRB)
ACS: 100564796(blvrb)
ASAO: 132780135(BLVRB)
PVT: 110075662(BLVRB)
SUND: 121916153(BLVRB)
PBI: 103053858(BLVRB)
PMUR: 107285666(BLVRB)
CTIG: 120316372(BLVRB)
TSR: 106541075(BLVRB)
PGUT: 117677851(BLVRB)
APRI: 131204274(BLVRB)
PTEX: 113450296(BLVRB)
NSS: 113425551(BLVRB)
VKO: 123021032(BLVRB)
PMUA: 114603071(BLVRB)
PRAF: 128418178(BLVRB)
ZVI: 118078075 118086651(BLVRB)
HCG: 128332650(BLVRB)
GJA: 107107369(BLVRB)
STOW: 125430722(BLVRB)
EMC: 129343090(BLVRB)
XLA: 443881(blvrb.L)
XTR: 100124834(blvrb) 116406791
NPR: 108791950(BLVRB)
RTEM: 120913299(BLVRB)
BBUF: 120977966(BLVRB)
BGAR: 122923946(BLVRB)
PWL: 138259461(BLVRB)
MUO: 115480591(BLVRB)
GSH: 117364657(BLVRB)
DRE: 436959(blvrb)
SRX: 107717620(blvrb)
SANH: 107670601 107692505
SGH: 107602119(blvrb)
CCAR: 109109302 109109306(blvrb)
CAUA: 113061728 113082608 113118645
CGIB: 127934336 127977858
PTET: 122323140(blvrb)
LROH: 127180549(blvrb)
OMC: 131523974(blvrb)
PPRM: 120460021 120460038
RKG: 130069968(blvrb)
MAMB: 125254500(blvrb)
CIDE: 127499299
CERY: 137022554(blvrb)
MASI: 127455779
TROS: 130562861(blvrb)
TDW: 130435551(blvrb)
MANU: 129419592(blvrb)
PDAB: 135741678 135773344
IPU: 124626957
IFU: 128606874(blvrb)
PHYP: 113526426(blvrb)
SMEO: 124396010(blvrb)
TFD: 113638812(blvrb)
TVC: 132851041(blvrb)
CGAR: 128528350(blvrb)
NGRA: 132887848(blvrb)
TRN: 134322999(blvrb)
AMEX: 103040962(blvrb)
CMAO: 118818247(blvrb)
EEE: 113580124(blvrb)
CHAR: 105909718(blvrb)
SPIL: 134099319(blvrb)
TRU: 101061122(blvrb)
TFS: 130534656(blvrb)
TNG: GSTEN00035152G001
LCO: 104927805(blvrb)
NCC: 104965039(blvrb)
TBEN: 117471124(blvrb)
CGOB: 115018241(blvrb)
PGEO: 117457425(blvrb)
GACU: 117555581(blvrb)
EMAC: 134880858(blvrb)
ELY: 117259444(blvrb)
EFO: 125888677(blvrb)
PLEP: 121943190(blvrb)
SLUC: 116053283(blvrb)
ECRA: 117942519(blvrb)
ESP: 116687001(blvrb)
PFLV: 114552606(blvrb)
GAT: 120829425(blvrb)
PPUG: 119222042(blvrb)
AFB: 129090654(blvrb)
CLUM: 117741131(blvrb)
PSWI: 130210565(blvrb)
CANA: 137790521(blvrb) 137799596
CVE: 137882065(blvrb)
MSAM: 119882831(blvrb)
SCHU: 122879513(blvrb)
CUD: 121526977(blvrb)
SPUL: 138597214(blvrb)
LMIX: 132980822(blvrb)
ALAT: 119033096(blvrb)
ASTR: 137596573(blvrb)
MZE: 101484658(blvrb)
ONL: 100702669(blvrb)
OAU: 116320348(blvrb)
OLA: 101163919(blvrb)
OML: 112149783(blvrb)
CSAI: 133442247(blvrb)
XMA: 102228591(blvrb)
XCO: 114133538(blvrb)
XHE: 116707592 116707593
PRET: 103475161(blvrb)
PFOR: 103138303(blvrb)
PLAI: 106947919(blvrb)
PMEI: 106921476(blvrb)
GAF: 122832913(blvrb)
PPRL: 129358719(blvrb)
CVG: 107094869(blvrb)
CTUL: 119796633(blvrb)
GMU: 124883659(blvrb)
NFU: 107379787(blvrb)
KMR: 108247879(blvrb)
ALIM: 106522783(blvrb)
NWH: 119411413(blvrb)
AOCE: 111586211(blvrb)
EJA: 138205433(blvrb)
BFRE: 138632581(blvrb)
MCEP: 125012958(blvrb)
CSEM: 103377891(blvrb)
POV: 109630121(blvrb)
SSEN: 122773296(blvrb)
SSOE: 131462914(blvrb)
HHIP: 117773323(blvrb)
HSP: 118105862(blvrb)
PPLT: 128439617(blvrb)
SMAU: 118294571(blvrb)
LCF: 108876241
SDU: 111216890(blvrb)
SLAL: 111662215(blvrb)
XGL: 120792571(blvrb)
HCQ: 109529422(blvrb)
SSCV: 125972512(blvrb)
SBIA: 133504585(blvrb)
PEE: 133405512(blvrb)
PTAO: 133482614(blvrb)
BPEC: 110172712(blvrb)
ENY: 140373236(blvrb)
MALB: 109963258(blvrb)
BSPL: 114867627(blvrb)
SJO: 128360742(blvrb)
SSCO: 133980389(blvrb)
GMH: 115560834(blvrb)
SASA: 106580739(blvrb) 106612705(BLVRB)
STRU: 115163034(blvrb) 115205994
OTW: 112265119 112266772
OMY: 110503591 110507468
OGO: 123993025 124005618
ONE: 115137042 115141548
OKI: 109905459 109908908
OKE: 118385438 118397176
OMM: 135546137 135552619
OCLA: 139382399 139385633
SALP: 111982788 111982809
SNH: 120018812 120028367
CCLU: 121562566 121568255
ELS: 105023068(blvrb)
OEP: 134028704(blvrb)
SFM: 108928749(blvrb)
PKI: 111844029(blvrb)
AANG: 118209415(blvrb)
AROT: 135236095(blvrb)
CCOG: 133108634(blvrb)
LOC: 102698532(blvrb)
PSPA: 121303818 121304996(blvrb)
ARUT: 117397815 117415212
PSEX: 120538736(blvrb)
LCM: 102358034(BLVRB)
CMK: 103173572(blvrb)
RTP: 109926910(blvrb)
CPLA: 122542852(blvrb)
HOC: 132836604(blvrb)
LERI: 129714249(blvrb)
PMRN: 116953899(BLVRB)
LRJ: 133356338
CIN: 100185152
SCLV: 120347803 120347819 120347831 120347846 120347854 120347866
DME: Dmel_CG9471(CG9471)
DER: 6552273
DSE: 6607040
DSI: Dsimw501_GD20759(Dsim_GD20759)
DYA: Dyak_GE24730
DAN: 6505836
DSR: 110188190
DPO: 4801507
DPE: 6588134
DMN: 108156553
DWI: 6647397
DMO: Dmoj_GI24882
DAZ: 108618551
DNV: 108659243
DHE: 111602756
DVI: 6630042
CCAT: 101455152
BOD: 106623986
BDR: 105231095
RZE: 108368232
AOQ: 129235377
ALUD: 128854877
TDA: 119683508
MDE: 101892800
SCAC: 106088079
LCQ: 111676095
LSQ: 119604323
CVJ: 135964047
GFS: 119634816
ECOE: 129938982
CLON: 129611628
HIS: 119652638
AGA: 1281857
ACOZ: 120949584
AMER: 121588441
ASTE: 118507626
AMAP: 126559099
AFUN: 125760443
AMOU: 128297711
AMRS: 128707374
AALI: 118461718
ACOS: 131260598
AAG: 5565330
AALB: 109405306 109406365 115258289
ASUA: 134205303
CQU: CpipJ_CPIJ011826
CPII: 120431012
CNS: 116352016
BCOO: 119067850
LLL: 129787276
PPAP: 129799734 129809276
AME: 412445
ACER: 107994237
ALAB: 122714807
ADR: 102680187
AFLR: 105736343
BIM: 100749252
BBIF: 117205099
BVK: 117231092
BVAN: 117157637
BHUN: 126871633
BTER: 100646178
BAFF: 126921994
BPYO: 122567783
BPAS: 132912730
FVI: 122538628
CCAL: 108630984
OBB: 114877540
OLG: 117603050
MGEN: 117219339
NMEA: 116423944
CGIG: 122399091
SOC: 105203443 105203453 105204185
MPHA: 105830426
AEC: 105144797
ACEP: 105624072
PBAR: 105426660
VEM: 105557622
COBS: 139105001
TLN: 139821568
HST: 105187135
DQU: 106744067
CFO: 105252649
FEX: 115234327
PMEC: 138941039
LHU: 105674651
PGC: 109861802
OBO: 105281931
PCF: 106793889
PFUC: 122526549
VPS: 122634421
VVE: 124947535
NVI: 100113525
CSOL: 105360908
TPRE: 106653900
LHT: 122498967
LBD: 127280477
MDL: 103574018 103575546
CGLO: 123265630 123268538
FAS: 105271813
DAM: 107036908
AGIF: 122854794
CINS: 118064459
VCAN: 122408838 122408839
CCIN: 107270862
DSM: 124411805
NPT: 124220145
NFB: 124183337
NLO: 107221269
NVG: 124305854
AROA: 105686570
TCA: 664311
TMOL: 138123682
DPA: 109534878
ESIM: 136416975
EFOR: 136342253
SOY: 115876520
AGRG: 126736645
ATD: 109595167
CSET: 123308381
HAXR: 123670834
AGB: 108917320
LDC: 111511470
DVV: 114325400
NVL: 108556546
DCOR: 135798964
APLN: 108739508
PPYR: 116167174
OTU: 111422790
BMOR: 101736226
BMAN: 114248437
MSEX: 115449431
DPL: KGM_212873
BANY: 112054677
MJU: 123874749
NIQ: 126775902
VCD: 124538436
MCIX: 123662021
PMAC: 106708927
PPOT: 106101151
PXU: 106120319
BPHI: 137919782
PRAP: 111001233
PBX: 123718550
PNAP: 125054450
ZCE: 119828598
CCRC: 123699980
LSIN: 126964809
AAGE: 121726639
HAW: 110382146
HZE: 124640134
TNL: 113504959
SLIU: 111350206
OFU: 114353154
ONU: 135080487
ATRA: 106137869
GMW: 113512708
PXY: 105393340
PGW: 126375316
LGLY: 125232571
CSTB: 134748197
CFEL: 113387723
CCRN: 123292441
API: 100168586(Blvrb) 100574136
DNX: 107162985
AGS: 114130365
RMD: 113557849
ACOO: 126833512
DVT: 126906640
BTAB: 109043576
NLU: 111052374
HVI: 124353097 124353098 124353110 124373554
MQU: 129006004
PHU: Phum_PHUM514080
FOC: 113215946
TPAL: 117644131
ZNE: 110828593
CSEC: 111868350
SGRE: 126359882
BROR: 134535992
IEL: 124168153
HAMR: 139698719
DPX: DAPPUDRAFT_230602
DMK: 116929398
DPZ: 124311410
PMOO: 119585705
MNZ: 135210720
HAZT: 108664641
ISC: 8030073
DSV: 119458384
RSAN: 119373566
RMP: 119167602
TUT: 107359695 107367634
CSCU: 111640897
CVS: 136978293
PTEP: 107444427
ABRU: 129957424
UDV: 129229318
SDM: 118193070
LPOL: 106471531
LJP: 135466868
 » show all
Reference
1  [PMID:3453680]
  Authors
Yubisui T, Tamura M, Takeshita M.
  Title
Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes.
  Journal
Biochem Int 15:1-8 (1987)
Reference
2  [PMID:10620517]
  Authors
Cunningham O, Gore MG, Mantle TJ
  Title
Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).
  Journal
Biochem J 345 Pt 2:393-9 (2000)
DOI:10.1042/bj3450393
  Sequence
[hsa:645]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.30
IUBMB Enzyme Nomenclature: 1.5.1.30
ExPASy - ENZYME nomenclature database: 1.5.1.30
BRENDA, the Enzyme Database: 1.5.1.30
CAS: 56626-29-0
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