Entry
Name
carboxyaminopropylagmatine dehydrogenase;
slr0049 (locus name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N1-[(S)-2-aminobutanoate]agmatine:NADP+ oxidoreductase (agmatine-forming)
Reaction(IUBMB)
N1-[(S)-3-amino-3-carboxypropyl]agamatine + NADP+ + H2O = agmatine + L-aspartate 4-semialdehyde + NADPH + H+ [RN:
R13291 ]
Reaction(KEGG)
Substrate
N1-[(S)-3-amino-3-carboxypropyl]agamatine;
NADP+ [CPD:
C00006 ];
H2O [CPD:
C00001 ]
Product
Comment
The enzyme, characterized from the cyanobacterium Synechocystis sp. PCC 6803, catalyses the reductive condensation of agmatine and L-aspartate 4-semialdehyde. It participates in a biosynthetic pathway for spermidine.
History
EC 1.5.1.55 created 2024
Pathway
ec00330 Arginine and proline metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K27502 carboxyaminopropylagmatine dehydrogenase
Genes
CATE : C2869_06635 C2869_13100
SALH : HMF8227_02643(lys1)
OAI : OLEAN_C07010 OLEAN_C24260
SBIN : SBA_ch1_25000(lys1)
HPO : HMPREF4655_20104(LYS1)
HPX : HMPREF0462_1493(LYS1)
NAM : NAMH_0224(lys) NAMH_0225(lys)
NAP : C3L23_01130 C3L23_01135
CMED : FE773_03055 FE773_03065
CPAF : C6V80_01380 C6V80_01400
PPOR : JCM14722_30440(lys1)
SNC : HMPREF0837_11566(LYS1)
CLO : HMPREF0868_0009(LYS1)
SYY : SYNGTS_2301(slr0049)
SYT : SYNGTI_2300(slr0049)
SYS : SYNPCCN_2299(slr0049)
SYQ : SYNPCCP_2299(slr0049)
PMZ : HMPREF0659_A5557(LYS1)
PDN : HMPREF9137_1758(LYS1)
PSEZ : HME7025_01355(lys1)
» show all
Taxonomy
Reference
Authors
Xi H, Nie X, Gao F, Liang X, Li H, Zhou H, Cai Y, Yang C.
Title
A bacterial spermidine biosynthetic pathway via carboxyaminopropylagmatine.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.55
ExPASy - ENZYME nomenclature database: 1.5.1.55
LinkDB
All DBs