Entry
Name
5,10-methylenetetrahydromethanopterin reductase;
5,10-methylenetetrahydromethanopterin cyclohydrolase;
N5,N10-methylenetetrahydromethanopterin reductase;
methylene-H4MPT reductase;
coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase;
N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
5-methyltetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420 [RN:
R04464 ]
Reaction(KEGG)
Substrate
5-methyltetrahydromethanopterin [CPD:
C04488 ];
oxidized coenzyme F420 [CPD:
C00876 ]
Product
5,10-methylenetetrahydromethanopterin [CPD:
C04377 ];
reduced coenzyme F420 [CPD:
C01080 ]
Comment
Catalyses an intermediate step in methanogenesis from CO2 and H2 in methanogenic archaea.
History
EC 1.5.98.2 created 2000 as EC 1.5.99.11, modified 2004, transferred to EC 1.5.98.2 2014
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K00320 5,10-methylenetetrahydromethanopterin reductase
Genes
BIC : LMTR13_24555 LMTR13_24680
BRAZ : LRP30_33355 LRP30_33475
SPHD : HY78_07885 HY78_23075
SBD : ATN00_17390 ATN00_17485
SPMI : K663_17326 K663_17801
SPHT : K426_23754 K426_23849
SHYD : CJD35_15390 CJD35_15495
SUFL : FIL70_06830 FIL70_06930 FIL70_11560
ERZ : ER308_02385 ER308_09985 ER308_12970 ER308_13090
MIT : OCO_13230 OCO_25030 OCO_39800
MIA : OCU_13700 OCU_24900 OCU_39700
MID : MIP_00259 MIP_03465 MIP_05993
MCHI : AN480_12585 AN480_20895
MIR : OCQ_23580 OCQ_28210 OCQ_29400 OCQ_40880
MSA : Mycsm_03546 Mycsm_04592 Mycsm_06787 Mycsm_06803
MMM : W7S_08445 W7S_12080 W7S_19830
MYV : G155_01495 G155_03345 G155_28015
MDX : BTO20_10285 BTO20_23080 BTO20_34590
MFJ : MFLOJ_08070 MFLOJ_18720 MFLOJ_23560 MFLOJ_42820 MFLOJ_56420
MSTO : MSTO_09290 MSTO_20260 MSTO_27520 MSTO_46930
MHEK : JMUB5695_00830(fgd)
MYW : BVC93_04905 BVC93_07250
MSM : MSMEG_2103 MSMEG_2456 MSMEG_3445
MSG : MSMEI_2056 MSMEI_2395 MSMEI_3365
MSB : LJ00_10475 LJ00_12225 LJ00_17140
MSN : LI99_10475 LI99_12225 LI99_17145
MSH : LI98_10475 LI98_12230 LI98_17150
MFT : XA26_03220 XA26_06010 XA26_56620
MVQ : MYVA_0266 MYVA_2357 MYVA_4061
MLL : B1R94_12750 B1R94_16695
MTHN : 4412656_00262 4412656_03260(fgd1_4)
MDU : MDUV_19340 MDUV_30540 MDUV_40590
MAUU : NCTC10437_00266 NCTC10437_02307(fgd1_5) NCTC10437_04003 NCTC10437_05699
MMAG : MMAD_05430 MMAD_39820
MMOR : MMOR_05480 MMOR_22830 MMOR_28450(hmd) MMOR_42210
MALV : MALV_21310 MALV_28120 MALV_30900 MALV_32630
MTY : MTOK_12730 MTOK_26490 MTOK_30960
MARZ : MARA_16780 MARA_35350 MARA_40190
MGAD : MGAD_45740 MGAD_56050
MHEV : MHEL_32200 MHEL_51230
MANY : MANY_24330(hmd) MANY_41960
MAUB : MAUB_13640 MAUB_36340 MAUB_37910
MPOF : MPOR_08040 MPOR_27800
MPHU : MPHO_32370 MPHO_33950
MMUC : C1S78_001170 C1S78_001810 C1S78_018685
MBOK : MBOE_17960 MBOE_50810
MGO : AFA91_08815 AFA91_27215 AFA91_32745
MGRO : FZ046_08030 FZ046_16835
MTER : 4434518_02913 4434518_02982
NNO : NONO_c47850 NONO_c58860
NWL : NWFMUON74_53980 NWFMUON74_57790
RKO : JWS14_25785 JWS14_43070 JWS14_45920
GRU : GCWB2_11310(fgd4) GCWB2_12090(ssuD) GCWB2_19375
GOM : D7316_01986 D7316_02156(fgd2_4)
GOD : GKZ92_18305 GKZ92_19915
SPRI : SPRI_3761 SPRI_6783
SLE : sle_06190(sle_06190)
STSD : HEP87_54900 HEP87_55015 HEP87_62345
MLV : CVS47_00302 CVS47_02477 CVS47_02481
CET : B8281_01045 B8281_02715
CCEU : CBR64_09100 CBR64_10955
CELZ : E5225_00855 E5225_03090
NANO : G5V58_00785 G5V58_03785
PSIM : KR76_02295 KR76_07600
ACTW : F7P10_01995 F7P10_02275 F7P10_05375 F7P10_37955
AMAZ : LUW76_20480 LUW76_21410 LUW76_45520 LUW76_46175
ACTQ : OG417_09765 OG417_33540 OG417_52320
FRI : FraEuI1c_2529 FraEuI1c_3450 FraEuI1c_3839
NAKA : H7F38_07035 H7F38_07050
AMYC : CU254_15235 CU254_17055
AAB : A4R43_03750 A4R43_05955 A4R43_15265
AMYY : YIM_15240 YIM_19200(fgd7) YIM_38415
ARHD : VSH64_05340 VSH64_17390 VSH64_21535
PAUT : Pdca_12860 Pdca_25040 Pdca_29260 Pdca_36040
PBRO : HOP40_21815 HOP40_22515 HOP40_24350 HOP40_29430 HOP40_33255
PSDS : K1T35_36315 K1T35_44495
PMAD : BAY61_05085 BAY61_09825 BAY61_22070 BAY61_24880
MCRA : ID554_06825 ID554_07060 ID554_30065 ID554_30185
VER : HUT12_06135 HUT12_12195 HUT12_14575 HUT12_14800
PFLA : Pflav_022530 Pflav_030270 Pflav_045200
PSUU : Psuf_080170 Psuf_082450 Psuf_093780
PRY : Prubr_38560(hmd_1) Prubr_57330 Prubr_59130
DFU : Dfulv_27640 Dfulv_32255
DACT : KZZ52_26755 KZZ52_45065
ABAI : IMCC26256_111288 IMCC26256_111527
BSOL : FSW04_00070 FSW04_23130
PSUB : Pelsub_P1656 Pelsub_P1764
CAP : CLDAP_07980 CLDAP_15430
PMET : G4Y79_17220 G4Y79_17225
AVE : Arcve_0808 Arcve_1055
AST : Asulf_00466 Asulf_02156
MBAK : MSBR3_0245 MSBR3_2771
SALR : FQU85_03600 FQU85_08510
HJE : HacjB3_04915 HacjB3_13295
HAQ : DU484_03660 DU484_04770
HAJ : DU500_04145 DU500_05210
HRA : EI982_10810 EI982_11685
HAE : halTADL_0321 halTADL_1346
HALU : HUG12_00730 HUG12_05610
HAKZ : J0X25_05575 J0X25_19080 J0X25_19090
CSU : CSUB_C0377 CSUB_C0386 CSUB_C0571 CSUB_C0806 CSUB_C1220 CSUB_C1712
» show all
Taxonomy
Reference
Authors
Ma K, Thauer RK
Title
Purification and properties of N5, N10-methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum (strain Marburg).
Journal
Sequence
Reference
Authors
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD
Title
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
Journal
Reference
Authors
Ma K, Thauer RK.
Title
Single step purification of methylenetetrahydromethanopterin reductase from Methanobacterium thermoautotrophicum by specific binding to blue sepharose CL-6B.
Journal
Reference
Authors
te Brommelstroet BW, Hensgens CM, Keltjens JT, van der Drift C, Vogels GD
Title
Purification and properties of 5,10-methylenetetrahydromethanopterin reductase, a coenzyme F420-dependent enzyme, from Methanobacterium thermoautotrophicum strain delta H.
Journal
J Biol Chem 265:1852-7 (1990)
Sequence
Reference
Authors
te Brommelstroet BW, Hensgens CM, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD.
Title
Purification and properties of 5,10-methenyltetrahydromethanopterin cyclohydrolase from Methanosarcina barkeri.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.5.98.2
ExPASy - ENZYME nomenclature database: 1.5.98.2
LinkDB
All DBs