Entry
Name
NADPH dehydrogenase (quinone);
reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase;
NADPH oxidase;
NADPH2 dehydrogenase (quinone)
Class
Oxidoreductases;
Acting on NADH or NADPH;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
NADPH:(quinone-acceptor) oxidoreductase
Reaction(IUBMB)
NADPH + H+ + a quinone = NADP+ + a quinol [RN:
R07359 ]
Reaction(KEGG)
Substrate
Product
Comment
A flavoprotein [1, 2]. The enzyme from Escherichia coli is specific for NADPH and is most active with quinone derivatives and ferricyanide as electron acceptors [3].
Menaquinone can act as acceptor. The enzyme from hog liver is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol [1].
History
EC 1.6.5.10 created 1972 as EC 1.6.99.6, transferred 2011 to EC 1.6.5.10
Orthology
K03923 NADPH dehydrogenase (quinone)
Genes
ECOO : ECRM13514_3929(mdaB)
ECOH : ECRM13516_3797(mdaB)
ECW : EcE24377A_3492(mdaB)
EDJ : ECDH1ME8569_2924(mdaB)
ECOI : ECOPMV1_03336(mdaB)
CMW : AFK63_02095 AFK63_07050
KLC : K7H21_03615 K7H21_06695
REE : electrica_00645(mdaB)
RTG : NCTC13098_00906(mdaB)
CLAP : NCTC11466_00526(mdaB)
KIE : NCTC12125_04586(mdaB)
LEA : GNG26_04205 GNG26_18780
SYM : K6K13_01535 K6K13_13550
AHN : NCTC12129_00833(mdaB)
SMW : SMWW4_v1c41930(mdaB)
SRR : SerAS9_3311 SerAS9_4375
SRL : SOD_c30860(mdaB1) SOD_c40740(mdaB)
SRY : M621_16835 M621_22225
SPLY : Q5A_016740(mdaB_1) Q5A_022240(mdaB_2)
SRS : SerAS12_3312 SerAS12_4376
SRA : SerAS13_3314 SerAS13_4376
SFJ : SAMEA4384070_4230(mdaB)
SOF : NCTC11214_02418(mdaB)
RBAD : H2866_05235 H2866_21680
PPOA : BJK05_10600 BJK05_18405
PVZ : OA04_03800(mdaB_1) OA04_27990(mdaB_2)
DDC : Dd586_0330 Dd586_2654
ETO : RIN69_08715 RIN69_18965
TPTY : NCTC11468_00622(mdaB)
PHAU : PH4a_00115 PH4a_18100
PCOL : F1325_11915 F1325_13250
PPEE : I6G31_14845 I6G31_16410
LRI : NCTC12151_03256(mdaB)
HIC : NTHIC486_00349(mdaB)
HPIT : NCTC13334_00121(mdaB_1) NCTC13334_00127(mdaB_2)
HHZ : NCTC10839_00559(mdaB)
HAEG : NCTC8502_00452(mdaB)
HSEM : L3077_01600 L3077_01625
ASEG : NCTC10977_00706(mdaB)
AVT : NCTC3438_02056(mdaB)
RPNE : NCTC8284_01584(mdaB)
PAET : NCTC13378_00672(mdaB)
VAU : VANGNB10_cII0245c(mdaB)
VPG : LZI70_19695 LZI70_19760
VIH : AB0763_15715 AB0763_16515
PAEB : NCGM1900_3938(mdaB)
PPRC : PFLCHA0_c07800(mdaB)
PMUD : NCTC8068_00697(mdaB)
PFW : PF1751_v1c46340(mdaB)
PTAE : NCTC10697_03907(mdaB)
EAZ : JHT90_05520 JHT90_05525
ENTO : MTZ49_14115 MTZ49_14120
PRR : AT705_00050 AT705_19285
PSPO : PSPO_b0117(mdaB) PSPO_b0869(mdaB)
MNY : R50073_09610 R50073_32750
HAAH : HALA3H3_100018(mdaB)
HAXI : HAALTHF_51770n(mdaB)
AEL : NCTC12917_01942(mdaB)
CHJ : NCTC10426_01330(mdaB)
NME : NMB0977 NMB1857(mdaB)
NMP : NMBB_1648 NMBB_2119(mdaB)
NMH : NMBH4476_1198 NMBH4476_1801
NMD : NMBG2136_0361 NMBG2136_0948
NMM : NMBM01240149_0330 NMBM01240149_1112
NMS : NMBM01240355_0972 NMBM01240355_1789
NMQ : NMBM04240196_1187 NMBM04240196_1797
NMZ : NMBNZ0533_0468 NMBNZ0533_1025
NMX : NMA510612_0663(mdaB) NMA510612_1309
NMN : NMCC_0365(mdaB) NMCC_0920
NMI : NMO_0309(mdaB) NMO_0877
NCZ : NCTC10294_00413(mdaB)
PLG : NCTC10937_04608(mdaB)
LMIR : NCTC12852_00474(mdaB)
SUTK : FG381_00515 FG381_06125
BBAY : A4V04_02505 A4V04_09630
KNA : B0W47_01015 B0W47_05810
HCL : NCTC13205_01053(mdaB)
HPUL : NCTC13154_00085(mdaB)
HFI : NHP21005_00870(mda66)
HGA : NHP190012_04250(mda66)
HGS : NHP190003_01250(mda66)
ANT : Arnit_1164 Arnit_1585
AANA : AANAER_1334 AANAER_2195
PCM : AY601_0179 AY601_4148
SPDR : G6053_06655 G6053_18385
SDJ : NCTC13534_01878(mdaB)
STHA : NCTC11429_00301(mdaB)
SSIY : JVX97_08930 JVX97_17770
FLM : MY04_0290 MY04_3828 MY04_4527
FLL : EI427_11580 EI427_16105
FYA : KMW28_14845 KMW28_17405 KMW28_24880
FKA : KM029_13250 KM029_17905
FKI : FK004_02420 FK004_17895
FPEC : Q1W71_04945 Q1W71_09190
FAG : K5I29_03075 K5I29_03330
NSD : BST91_05580 BST91_05695
MOA : I6I89_08310 I6I89_08530
AALG : AREALGSMS7_03513(mdaB)
MARX : INR76_12575 INR76_12615
LPAL : LDL79_13145 LDL79_13495
ELB : VO54_01448(mdaB_1) VO54_01449(mdaB_2) VO54_03247(mdaB_3)
CJT : EG359_06520 EG359_19750
CGLE : NCTC11432_04467(mdaB)
CHRJ : CHRYMOREF3P_3890(mdaB)
CORA : N0B40_09170 N0B40_09845 N0B40_10890
PCHU : QNI29_05740 QNI29_07065
SMIE : NCTC11169_01884(mdaB_1)
PUE : FV140_17895 FV140_17905
» show all
Taxonomy
Reference
Authors
Koli AK, Yearby C, Scott W, Donaldson KO.
Title
Purification and properties of three separate menadione reductases from hog liver.
Journal
J Biol Chem 244:621-9 (1969)
Reference
Authors
Hayashi M, Hasegawa K, Oguni Y, Unemoto T
Title
Characterization of FMN-dependent NADH-quinone reductase induced by menadione in Escherichia coli.
Journal
Reference
Authors
Hayashi M, Ohzeki H, Shimada H, Unemoto T
Title
NADPH-specific quinone reductase is induced by 2-methylene-4-butyrolactone in Escherichia coli.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.6.5.10
ExPASy - ENZYME nomenclature database: 1.6.5.10
LinkDB
All DBs