KEGG   ENZYME: 1.8.4.17
Entry
EC 1.8.4.17                 Enzyme                                 
Name
sulfur-oxidizing heterodisulfide reductase-like enzyme system (type I);
sHdr system (type I)
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor
Sysname
[TusA sulfur-carrier protein]-S-sulfanyl-L-cysteine:[LbpA protein]-N6-lipoyl-L-lysine oxidoreductase
Reaction(IUBMB)
[TusA sulfur-carrier protein]-S-sulfanyl-L-cysteine + 2 [LbpA protein]-N6-lipoyl-L-lysine + 3 H2O = [TusA sulfur-carrier protein]-L-cysteine + 2 [LbpA protein]-N6-dihydrolipoyl-L-lysine + sulfite [RN:R13542]
Reaction(KEGG)
R13542
Substrate
[TusA sulfur-carrier protein]-S-sulfanyl-L-cysteine;
[LbpA protein]-N6-lipoyl-L-lysine;
H2O [CPD:C00001]
Product
[TusA sulfur-carrier protein]-L-cysteine;
[LbpA protein]-N6-dihydrolipoyl-L-lysine;
sulfite [CPD:C00094]
Comment
This enzyme complex, usually referred to as the sHdr system (type I), is a cytoplasmic sulfur oxidation system found in many bacterial and archaeal sulfur oxidizers. The system consists of a dimer of the iron-sulfur flavoprotein sHdrA and one subunit each of the proposed catalytic subunit sHdrB1, the disulfide reductase sHdrB2, and the ferredoxin-like electron carrier proteins sHdrC1 and sHdrC2. The system oxidizes a sulfane sulfur, provided by the TusA sulfur-carrier protein, to sulfite, using a dedicated lipoylated protein (LbpA) as the electron acceptor.
History
EC 1.8.4.17 created 2025
Orthology
K28385  sulfur-oxidizing heterodisulfide reductase-like enzyme system (type I) subunit A
K28386  sulfur-oxidizing heterodisulfide reductase-like enzyme system (type I) subunit B
K28387  sulfur-oxidizing heterodisulfide reductase-like enzyme system (type I) subunit C
Genes
HHCM911_11215 M911_11220 M911_11230 M911_11235 M911_11240
EBSECTOBSL9_0282 ECTOBSL9_0283 ECTOBSL9_0285 ECTOBSL9_0286 ECTOBSL9_0287
TGRTgr7_2211 Tgr7_2212 Tgr7_2214 Tgr7_2215 Tgr7_2216
TKMTK90_0632 TK90_0633 TK90_0634 TK90_0636 TK90_0637
TNITVNIR_3244(hdrB_[H]) TVNIR_3245(hdlC_[H]) TVNIR_3247(hdrA_[H]) TVNIR_3248(hdlB_[H]) TVNIR_3249
TVRTVD_10625 TVD_10630 TVD_10640 TVD_10645 TVD_10650
APRSBI364_13790 BI364_13795 BI364_13805 BI364_13810 BI364_13815
AAEOBJI67_04060 BJI67_04065 BJI67_04070 BJI67_04080 BJI67_04085
AFYBW247_09910 BW247_09915 BW247_09925 BW247_09930 BW247_09935
ACIIC4901_12955 C4901_12960 C4901_12970 C4901_12975 C4901_12980
ATYA9R16_003990 A9R16_003995 A9R16_004000 A9R16_004010 A9R16_004015
SULFCAP31_01840 CAP31_01845 CAP31_01850 CAP31_01860 CAP31_01865
SPLBSFPGR_29420(hdrB) SFPGR_29430(hdrC) SFPGR_29450(hdrA) SFPGR_29460 SFPGR_29470
SNIVSFSGTM_27260(hdrB) SFSGTM_27270(hdrC) SFSGTM_27290(hdrA) SFSGTM_27300 SFSGTM_27310
HDNHden_0689 Hden_0690 Hden_0691 Hden_0693 Hden_0694
RHCRGUI_1278 RGUI_1279 RGUI_1281 RGUI_1282 RGUI_1283
AEPAMC99_00775 AMC99_00776 AMC99_00778 AMC99_00779 AMC99_00780
QSOIRL76_11075 IRL76_11080 IRL76_11085 IRL76_11095 IRL76_11100
AFRAFE_2550(sdhC) AFE_2551 AFE_2553 AFE_2554 AFE_2555 AFE_2586
AFELferr_2178 Lferr_2183 Lferr_2184 Lferr_2185 Lferr_2215
ACUAtc_2347 Atc_2348 Atc_2350 Atc_2351 Atc_2352 Atc_2393 Atc_2523
ACZAcaty_c2190 Acaty_c2191 Acaty_c2193 Acaty_c2194 Acaty_c2195 Acaty_c2236 Acaty_c2366
AFIAcife_2471 Acife_2472 Acife_2474 Acife_2475 Acife_2476 Acife_2519
AFJAFERRID_05100 AFERRID_05110 AFERRID_05130 AFERRID_05140 AFERRID_05150 AFERRID_05460
ATXGCD22_01577(hdrB1) GCD22_02661(hdrB1) GCD22_03145(hdrB) GCD22_03146(hdlC) GCD22_03148(hdrA) GCD22_03149(hdrB1) GCD22_03150 GCD22_03192(hdrB1) GCD22_03279(hdrA)
AFPK1Y48_08825 K1Y48_09025 K1Y48_09030 K1Y48_09035 K1Y48_09045 K1Y48_09050
ACIYMQE22_02535 MQE22_02740 MQE22_02745 MQE22_02750 MQE22_02760 MQE22_02765 MQE22_10710
AFHGL267_002305 GL267_002480 GL267_002485 GL267_002490 GL267_002500 GL267_002505
TROtrd_0153 trd_0154 trd_0155
OSPOdosp_0421 Odosp_0422 Odosp_0423
BUYD8S85_20540 D8S85_20545 D8S85_20550
BVIRI6J59_08945 I6J59_08950 I6J59_08955
BFHF1611_02855 F1611_02860 F1611_02865
AFDAlfi_2099 Alfi_2100 Alfi_2101
ASHAL1_26630 AL1_26650
ALDGFH31_08495 GFH31_08500 GFH31_08505
AOKA3BBH6_05090 A3BBH6_05100 A3BBH6_05110
ACOUA5CBH24_14810 A5CBH24_14820 A5CBH24_14830
ADAA5CPEGH6_16740 A5CPEGH6_16750 A5CPEGH6_16760
AITAI2BBH_11650 AI2BBH_11660 AI2BBH_11670
APUTL6V35_06375
ASENNQ519_03355 NQ519_03360 NQ519_03365
AIUNQ491_07875 NQ491_07880 NQ491_07885
BACCBRDCF_p1058 BRDCF_p1059(hdrB) BRDCF_p1060 BRDCF_p1818 BRDCF_p1819(hdrC)
ANFAQPE_4789 AQPE_4790 AQPE_4791
ALKQM9189_04050 M9189_04055 M9189_04060
CTSCtha_0136 Ctha_0137 Ctha_0138
AAEaq_391 aq_392 aq_394 aq_395(hdrA) aq_398(hdrC) aq_400(hdrB)
HYAHY04AAS1_1077 HY04AAS1_1078 HY04AAS1_1080 HY04AAS1_1081 HY04AAS1_1082
HHOHydHO_1072 HydHO_1073 HydHO_1075 HydHO_1076 HydHO_1077
HYSHydSN_1099 HydSN_1100 HydSN_1102 HydSN_1103 HydSN_1104
HTHHTH_1878(hdrB1) HTH_1879(hdrC1) HTH_1881(hdrA) HTH_1882(hdrB2) HTH_1883(hdrC2)
HTEHydth_1860 Hydth_1861 Hydth_1863 Hydth_1864 Hydth_1865
TALThal_1343 Thal_1344 Thal_1346 Thal_1347 Thal_1348
TRDTHERU_00165 THERU_00170 THERU_00175 THERU_00185 THERU_00190
BTSBtus_2496 Btus_2497 Btus_2498
KYRCVV65_12490 CVV65_12495 CVV65_12500
SAYTPY_3529(hdrA) TPY_3530 TPY_3531
SAPSulac_1384 Sulac_1385 Sulac_1386
STHRBXT84_01295 BXT84_01300 BXT84_01310 BXT84_01315 BXT84_01320 BXT84_06250 BXT84_06255
HFVR50_0688 R50_0689 R50_0690 R50_0692 R50_0693 R50_1169 R50_1170 R50_1171
PARNNBH00_11855 NBH00_11860
AFOAfer_0964 Afer_0965 Afer_0966
CANCyan10605_2790 Cyan10605_2791 Cyan10605_2792
CYDDongsha4_08955 Dongsha4_08960 Dongsha4_08965
SYLAWQ21_15425 AWQ21_15430 AWQ21_15435
CYCPCC7424_1697 PCC7424_1698 PCC7424_1699
PPSUNO713_02684(hdrA) NO713_02685(hdrB1) NO713_02687(hdrC1)
OACOscil6304_5894 Oscil6304_5896 Oscil6304_5898
NOPNos7524_5055 Nos7524_5056 Nos7524_5057
RSINB6N60_02610 B6N60_02611 B6N60_02612
DTBBH720_005360 BH720_005365 BH720_005370
STOSTK_18700 STK_18710 STK_18730 STK_18740 STK_18750
SOHD1869_10540 D1869_10545 D1869_10555 D1869_10560 D1869_10565
SJVSJAV_03190 SJAV_03200 SJAV_03220 SJAV_03230 SJAV_03240
SSOSSO1127(hdrC-1) SSO1129(hdrB-1) SSO1131(hdrA) SSO1134(hdrC-2) SSO1135(hdrB-2)
SOLSsol_2099 Ssol_2100 Ssol_2101 Ssol_2103 Ssol_2104
SSOASULA_2130 SULA_2131 SULA_2132 SULA_2134 SULA_2135
SSOLSULB_2131 SULB_2132 SULB_2133 SULB_2135 SULB_2136
SSOFSULC_2129 SULC_2130 SULC_2131 SULC_2133 SULC_2134
SSHIJ5U23_02350 J5U23_02351 J5U23_02353 J5U23_02354 J5U23_02355
SCASSACC_10170 SACC_10180 SACC_10190 SACC_10210 SACC_10220
SISLS215_1193 LS215_1194 LS215_1196 LS215_1197 LS215_1198
SIAM1425_1096 M1425_1097 M1425_1099 M1425_1100 M1425_1101
SIMM1627_1160 M1627_1161 M1627_1163 M1627_1164 M1627_1165
SIDM164_1086 M164_1087 M164_1089 M164_1090 M164_1091
SIYYG5714_1092 YG5714_1093 YG5714_1095 YG5714_1096 YG5714_1097
SINYN1551_1761 YN1551_1762 YN1551_1763 YN1551_1765 YN1551_1766
SIILD85_1214 LD85_1215 LD85_1217 LD85_1218 LD85_1219
SIHSiH_1057 SiH_1058 SiH_1060 SiH_1061 SiH_1062
SIRSiRe_0970 SiRe_0971 SiRe_0973 SiRe_0974 SiRe_0975
SICSiL_0976 SiL_0977 SiL_0979 SiL_0980 SiL_0981
SULABFU36_00895 BFU36_00900 BFU36_00910 BFU36_00915 BFU36_00920
SULEGFS03_06300 GFS03_06305 GFS03_06315 GFS03_06320 GFS03_06325
SAISaci_0325(hdrB) Saci_0326 Saci_0328(hdrA) Saci_0329 Saci_0334(hdrC)
SACNSacN8_01595 SacN8_01600 SacN8_01610 SacN8_01615 SacN8_01640
SACRSacRon12I_01595 SacRon12I_01600 SacRon12I_01610 SacRon12I_01615 SacRon12I_01640
SACSSUSAZ_01655 SUSAZ_01660 SUSAZ_01670 SUSAZ_01675 SUSAZ_01700
SULOGFS33_11680 GFS33_11685 GFS33_11695 GFS33_11700 GFS33_11705
SULLEWF20_12020 EWF20_12025 EWF20_12035 EWF20_12040 EWF20_12045
MSEMsed_1542 Msed_1543 Msed_1545 Msed_1546 Msed_1547
MEMJMJ1HA_1759 MJ1HA_1760 MJ1HA_1762 MJ1HA_1763 MJ1HA_1764
MCNMcup_0684 Mcup_0685 Mcup_0686 Mcup_0688 Mcup_0689
MHKDFR87_11005 DFR87_11010 DFR87_11015 DFR87_11025 DFR87_11030
MPRUDFR88_10565 DFR88_10570 DFR88_10575 DFR88_10585 DFR88_10590
MTENGWK48_01305 GWK48_01310 GWK48_01320 GWK48_01325 GWK48_01330
MJNMjAS7_2640 MjAS7_2641 MjAS7_2643 MjAS7_2644 MjAS7_2645
AHOAhos_1691 Ahos_1692 Ahos_1694 Ahos_1695 Ahos_1696
AMANB6F84_12580 B6F84_12585 B6F84_12590 B6F84_12600 B6F84_12605
ABRIDFR85_11425 DFR85_11430 DFR85_11435 DFR85_11445 DFR85_11450
ASULDFR86_10760 DFR86_10765 DFR86_10770 DFR86_10780 DFR86_10785
AAMBD1866_03535 D1866_03540 D1866_03550 D1866_03555 D1866_03560
ACIHHS5_01350 HS5_01360 HS5_01370 HS5_01390 HS5_01400
SACDHS1genome_0376 HS1genome_0377 HS1genome_0378 HS1genome_0380 HS1genome_0381
SAZOD1868_10010 D1868_10015 D1868_10020 D1868_10030 D1868_10035
CSTYKN1_04050 KN1_04060 KN1_04080 KN1_04090 KN1_04100
STEPIC006_0774 IC006_0775 IC006_0777 IC006_0778 IC006_0779
SMETRQ359_001049 RQ359_001050 RQ359_001051 RQ359_001053 RQ359_001054
SAHSHS7_01150 HS7_01160 HS7_01170 HS7_01190 HS7_01200
 ยป show all
Reference
1  [PMID:27284018]
  Authors
Boughanemi S, Lyonnet J, Infossi P, Bauzan M, Kosta A, Lignon S, Giudici-Orticoni MT, Guiral M.
  Title
Microbial oxidative sulfur metabolism: biochemical evidence of the membrane-bound heterodisulfide reductase-like complex of the bacterium Aquifex aeolicus.
  Journal
FEMS Microbiol Lett 363:fnw156 (2016)
DOI:10.1093/femsle/fnw156
  Sequence
Reference
2  [PMID:29930335]
  Authors
Koch T, Dahl C.
  Title
A novel bacterial sulfur oxidation pathway provides a new link between the cycles of organic and inorganic sulfur compounds.
  Journal
ISME J 12:2479-2491 (2018)
DOI:10.1038/s41396-018-0209-7
  Sequence
Reference
3  [PMID:30004385]
  Authors
Cao X, Koch T, Steffens L, Finkensieper J, Zigann R, Cronan JE, Dahl C.
  Title
Lipoate-binding proteins and specific lipoate-protein ligases in microbial sulfur oxidation reveal an atpyical role for an old cofactor.
  Journal
Elife 7:37439 (2018)
DOI:10.7554/eLife.37439
Reference
4  [PMID:32750208]
  Authors
Ernst C, Kayastha K, Koch T, Venceslau SS, Pereira IAC, Demmer U, Ermler U, Dahl C.
  Title
Structural and spectroscopic characterization of a HdrA-like subunit from Hyphomicrobium denitrificans.
  Journal
FEBS J 288:1664-1678 (2021)
DOI:10.1111/febs.15505
  Sequence
[hdn:Hden_0691]
Reference
5  [PMID:33460586]
  Authors
Appel L, Willistein M, Dahl C, Ermler U, Boll M.
  Title
Functional diversity of prokaryotic HdrA(BC) modules: Role in flavin-based electron bifurcation processes and beyond.
  Journal
Biochim Biophys Acta Bioenerg 1862:148379 (2021)
DOI:10.1016/j.bbabio.2021.148379
Reference
6  [PMID:38747384]
  Authors
Tanabe TS, Bach E, D'Ermo G, Mohr MG, Hager N, Pfeiffer N, Guiral M, Dahl C.
  Title
A cascade of sulfur transferases delivers sulfur to the sulfur-oxidizing heterodisulfide reductase-like complex.
  Journal
Protein Sci 33:e5014 (2024)
DOI:10.1002/pro.5014
Other DBs
ExplorEnz - The Enzyme Database: 1.8.4.17
IUBMB Enzyme Nomenclature: 1.8.4.17
ExPASy - ENZYME nomenclature database: 1.8.4.17
BRENDA, the Enzyme Database: 1.8.4.17
LinkDB

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