KEGG ENZYME: 1.8.5.10

ENZYME: 1.8.5.10

Entry

EC 1.8.5.10                 Enzyme

Name

[DsrC]-trisulfide reductase;
DsrMKJOP complex

Class

Oxidoreductases;
Acting on a sulfur group of donors;
With a quinone or similar compound as acceptor

Sysname

hydrogen sulfide:[DsrC protein]-dithiol oxidoreductase (trisulfide-forming)

Reaction(IUBMB)

hydrogen sulfide + a [DsrC protein]-dithiol + 2 quinone = a [DsrC protein]-trisulfide + 2 quinol [RN:R13227]

Reaction(KEGG)

R13227

Substrate

hydrogen sulfide [CPD:C00283];
[DsrC protein]-dithiol;
quinone [CPD:C00472]

Product

[DsrC protein]-trisulfide;
quinol [CPD:C00530]

Comment

This enzyme complex is present in both sulfate-reducing bacteria and sulfur-oxidizing bacteria, and acts in opposite directions during the reductive and oxidative pathways, respectively. DsrM and DsrP contain b-type hemes, DsrJ contains c-type hemes, DsrO is a ferredoxin-like protein, and DsrK is the catalytic subunit that acts as a disulfide reductase on DsrC proteins that contain a trisulfide bridge [1,3,4]. The complex receives the electrons from the membrane quinone pool [2,3].

History

EC 1.8.5.10 created 2023

Pathway

ec00920

Sulfur metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K27187

[DsrC]-trisulfide reductase subunit M

K27188

[DsrC]-trisulfide reductase subunit K

Genes

TIG:	THII_0617 THII_0618

BLEP:

AL038_07455 AL038_07460

THIS:

HZT40_16470 HZT40_16475

TUN:	J9260_02830 J9260_02835

TLO:	J9253_11285 J9253_11290

TSB:	HMY34_03675 HMY34_03680

TANI:

J8380_00580 J8380_00585

TWN:	L2Y54_11520 L2Y54_11525

TLC:	RCF98_13425 RCF98_13430

TSJ:	L3K52_08885 L3K52_08890

TPUT:

QJT81_16870 QJT81_16875

TDU:	QJT80_01920 QJT80_01925

ALV:	Alvin_1257(dsrM) Alvin_1258(dsrK)

ATEP:

Atep_14760 Atep_14770

TVI:	Thivi_0550 Thivi_0551

TMB:	Thimo_0149 Thimo_0150

MPUR:

MARPU_10880 MARPU_10885

TSY:	THSYN_22510 THSYN_22515

TTP:	E6P07_09355 E6P07_09360

THIP:

N838_27005 N838_27010

CJAP:

GWK36_02320 GWK36_02325

THIM:

KFB96_10645 KFB96_10650

TBOG:

LT988_06630 LT988_06635

TLR:	Thiosp_04051(dsrM) Thiosp_04052(narI)

TFRI:

Thiofri_03972(dsrM) Thiofri_03973(narI)

TWG:	Thiowin_00384(narI) Thiowin_00385(dsrM)

AEH:	Mlg_1659 Mlg_1660

HHA:	Hhal_1957 Hhal_1958

HHK:	HH1059_16600 HH1059_16610

TGR:	Tgr7_2191 Tgr7_2192

TNI:	TVNIR_0853(hmeD_[H]) TVNIR_0854(hmeC_[H])

TTI:	THITH_12010 THITH_12015

GAI:	IMCC3135_06980 IMCC3135_06985

TBN:	TBH_C2455 TBH_C2456

EPS:	L0Y14_12150 L0Y14_12155

SEDS:

AAY24_17330 AAY24_17335

TTC:	FOKN1_1951 FOKN1_1952

THIC:

TspCOW1_07030 TspCOW1_07040

SLIM:

SCL_1267 SCL_1268

SVA:	SVA_1960 SVA_1961

ACII:

C4901_06795 C4901_06800

ATY:	A9R16_006385 A9R16_006390

TSN:	W908_06815 W908_06820

THO:	SP60_01835 SP60_01840

REV:	HUE57_11030 HUE57_11035

RMA:	Rmag_0863 Rmag_0864

REO:	HUE58_04335 HUE58_04340

VOK:	COSY_0788(dsrK) COSY_0789(dsrM)

EBH:	BSEPE_1254(dsrL) BSEPE_1255(dsrM)

BTHG:

MS2017_1742 MS2017_1743

ENM:	EBS_1777(dsrK) EBS_1778(dsrM)

IFO:	CVFO_0518(dsrM) CVFO_0519(dsrK)

APHF:

CVPH_1064(dsrK) CVPH_1065(dsrM)

RHOB:

HTY51_04585 HTY51_04590

RLH:	MIZ03_2113 MIZ03_2114

HTN:	KI616_02600 KI616_02605

SMIO:

CATMQ487_48960 CATMQ487_48970

BBAG:

E1O_03080 E1O_03090

SHD:	SUTH_01437(dsrK) SUTH_01438(dsrM)

NPV:	OHM77_04485 OHM77_04490

TBD:	Tbd_2478 Tbd_2479

SLT:	Slit_1679 Slit_1680

FAM:	OYT1_ch1909 OYT1_ch1910

SEME:

MIZ01_1469 MIZ01_1470

SDR:	SCD_n02711(dsrK) SCD_n02712(dsrM)

SLAC:

SKTS_33600 SKTS_33610

DDZ:	DSYM_11170 DSYM_11180

RVA:	Rvan_0593 Rvan_0594

BLAG:

BLTE_30770 BLTE_30780

PAMO:

BAR1_04785 BAR1_04790

MGY:	MGMSRv2__3905(hmeD) MGMSRv2__3906

MGRY:

MSR1_25080 MSR1_25090

MAGX:

XM1_4250 XM1_4251(hmeD)

MAGN:

WV31_00325 WV31_00330

MAG:	amb3373 amb3374

MAGQ:

MGMAQ_2116(dsrM) MGMAQ_2117(dsrK)

VSU:	P3M64_01020 P3M64_01025

MGM:	Mmc1_0049 Mmc1_0050

DAV:	DESACE_07185

PPD:	Ppro_1534 Ppro_1535

DDS:	Ddes_0450 Ddes_0451

DFI:	AXF13_00280 AXF13_00285

DPG:	DESPIGER_2166 DESPIGER_2167

DEF:	CNY67_12175 CNY67_12180

DTR:	RSDT_0779(dsrM) RSDT_0780(dsrK)

DFL:	DFE_2310 DFE_2311

PSYF:

N1030_06530(dsrM) N1030_06535(dsrK)

DSB:	LN040_04655(dsrM) LN040_04660(dsrK)

DMA:	DMR_03710(hmeD) DMR_03720(hmeC)

DCB:	C3Y92_18535 C3Y92_18540

DGG:	DGI_2334(dsrM) DGI_2335(dsrK)

DDE:	Dde_2271 Dde_2272

DMS:	E8L03_20405 E8L03_20410

DSA:	Desal_0185 Desal_0186

DHY:	DESAM_20517(hmeC) DESAM_20518(hmeD)

DAF:	Desaf_1465 Desaf_1466

DAS:	Daes_0370 Daes_0371

DPI:	BN4_12502(dsrK) BN4_12503(dsrM)

DEJ:	AWY79_04535 AWY79_04540

PPRF:

DPRO_2315(hmeD) DPRO_2316(hmeC)

PSEL:

GM415_06575 GM415_06580

DDN:	DND132_1831 DND132_1832

PSEF:

PSDVSF_26780 PSDVSF_26790

PPOR:

JCM14722_14960 JCM14722_14970

PNW:	SYK_20530 SYK_20540

PTHE:

LF599_02115(dsrM) LF599_02120

DSX:	GD604_17150 GD604_17155

DSD:	GD606_12785 GD606_12790

PBIZ:

LWC08_13060 LWC08_13065(dsrM)

DVU:	DVU_1289 DVU_1290

DVL:	Dvul_1775 Dvul_1776

DVM:	DvMF_0069 DvMF_0070

DVG:	Deval_1188 Deval_1189

CLIH:

KPS_000087(dsrK) KPS_000088(dsrM)

TMUR:

JBF11_08160(dsrM) JBF11_08165

DBA:	Dbac_0270 Dbac_0271

DOA:	AXF15_07335 AXF15_07340

DESU:

NLA06_11505 NLA06_11510(dsrM)

THEW:

TDMWS_09150 TDMWS_09160

DRT:	Dret_0235(dsrM) Dret_0236(dsrK)

DPS:	DP3074 DP3075

DSF:	UWK_00241 UWK_00242

DLM:	DPPLL_23970 DPPLL_23980

DAK:	DaAHT2_2298 DaAHT2_2299

DPR:	Despr_0298 Despr_0299

DEO:	CAY53_01280 CAY53_01285

DOG:	HP555_05125(dsrM) HP555_05130

DBK:	DGMP_25060 DGMP_25070

DDU:	GF1_26970 GF1_26980

ECOM:

QTN59_13205 QTN59_13210(dsrM)

EAJ:	Q3M24_03485(dsrK) Q3M24_03490(dsrM)

DOL:	Dole_0450 Dole_0451

DAL:	Dalk_0605 Dalk_0606

DAT:	HRM2_31640(hmeC) HRM2_31650(hmeD)

DTO:	TOL2_C34120(dsrM) TOL2_C34130(dsrK)

DOV:	DSCO28_25660 DSCO28_25670

DWD:	DSCW_62090 DSCW_62100

DALK:

DSCA_21900 DSCA_21910

DESB:

BuS5_01862

DML:	Dmul_35710(dsrK) Dmul_35720(dsrM)

DLI:	dnl_60810(dsrM) dnl_60820(dsrK)

DMM:	dnm_008670(dsrM) dnm_008680(dsrK)

DEK:	DSLASN_39780 DSLASN_39790

DAO:	Desac_2729 Desac_2730

DTI:	Desti_2672 Desti_2673

SFU:	Sfum_1146 Sfum_1147

DAX:	FDQ92_08540 FDQ92_08545

DBR:	Deba_0564 Deba_0565

DMP:	FAK_09000 FAK_09010 FAK_29780

TID:	Thein_1549 Thein_1550

TOP:	TOPB45_1200 TOPB45_1201

TCM:	HL41_01625 HL41_01630

THET:

F1847_05815 F1847_05820

CTHI:

THC_0590 THC_0591

TAV:	G4V39_00010 G4V39_00015

TMAI:

FVE67_01445 FVE67_01450

DAW:	HS1_002294(hmeD) HS1_002295(hmeC)

DHR:	LGS26_01030 LGS26_01035(dsrM)

DSY:	DSY0312(hmeC) DSY0313(hmeD) DSY4517 DSY4518

DHD:	Dhaf_0256 Dhaf_0257

DDH:	Desde_0270 Desde_0271

DDL:	Desdi_0246 Desdi_0247

DOR:	Desor_1698 Desor_1699

DAI:	Desaci_2281 Desaci_2282

DMI:	Desmer_1641 Desmer_1642

DCA:	Desca_2678 Desca_2679

PTH:	PTH_0690 PTH_0691

DRM:	Dred_3198 Dred_3199

DRU:	Desru_3514 Desru_3735 Desru_3736

DFG:	B0537_15900 B0537_15905

DAE:	Dtox_0075 Dtox_0076

DKU:	Desku_3486 Desku_3487

DAU:	Daud_2191 Daud_2192

TFR:	BR63_06725 BR63_06730

FWA:	DCMF_23795 DCMF_23815

AACX:

DEACI_0672 DEACI_0673

DGI:	Desgi_3064 Desgi_4649 Desgi_4650

CHY:	CHY_2403 CHY_2404

ADG:	Adeg_0033 Adeg_0034

MTA:	Moth_1602 Moth_1606

MTHO:

MOTHE_c16010 MOTHE_c16050

MTHZ:

MOTHA_c16840 MOTHA_c16880

EGD:	GS424_009545 GS424_009550(dsrM)

GPA:	GPA_16760 GPA_16770

CBAC:

JI75_04625

TNR:	Thena_1369 Thena_1370

TACI:

TDSAC_1345 TDSAC_1346

CTE:	CT2243(dsrK) CT2244(dsrM)

CPC:	Cpar_0033 Cpar_0034

CLZ:	BIU88_11255 BIU88_11260

CCH:	Cag_1947 Cag_1948

CPH:	Cpha266_0136 Cpha266_0137

CPB:	Cphamn1_1848 Cphamn1_1849

CLI:	Clim_0703 Clim_0704

PVI:	Cvib_0047 Cvib_0048

PLT:	Plut_0044 Plut_0045

PPH:	Ppha_2312 Ppha_2313

PAA:	Paes_0037 Paes_0038

PROC:

Ptc2401_00036 Ptc2401_00037

PRS:	B9H02_00180 B9H02_00185

PROS:

CHL67_00195 CHL67_00200

PROW:

OO006_03255(dsrM) OO006_03260

PROI:

OO005_03155(dsrM) OO005_03160

TYE:	THEYE_A0005 THEYE_A0006

DTP:	JZK55_23400 JZK55_23410

AFU:	AF_0501 AF_0502

AFG:	AFULGI_00005110 AFULGI_00005120

APO:	Arcpr_1729 Arcpr_1730

AVE:	Arcve_1688 Arcve_1689

AST:	Asulf_02288 Asulf_02289

» show all

Reference

1 [PMID:9695921]

Authors

Pott AS, Dahl C

Title

Sirohaem sulfite reductase and other proteins encoded by genes at the dsr locus of Chromatium vinosum are involved in the oxidation of intracellular sulfur.

Journal

Microbiology 144 ( Pt 7):1881-94 (1998)
DOI:10.1099/00221287-144-7-1881

Sequence

[alv:Alvin_1257 Alvin_1258]

Reference

2 [PMID:16388601]

Authors

Pires RH, Venceslau SS, Morais F, Teixeira M, Xavier AV, Pereira IA.

Title

Characterization of the Desulfovibrio desulfuricans ATCC 27774 DsrMKJOP complex--a membrane-bound redox complex involved in the sulfate respiratory pathway.

Journal

Biochemistry 45:249-62 (2006)
DOI:10.1021/bi0515265

Sequence

[dds:Ddes_0447 Ddes_0448 Ddes_0449 Ddes_0450 Ddes_0451]

Reference

3 [PMID:20952577]

Authors

Grein F, Pereira IA, Dahl C.

Title

Biochemical characterization of individual components of the Allochromatium vinosum DsrMKJOP transmembrane complex aids understanding of complex function in vivo.

Journal

J Bacteriol 192:6369-77 (2010)
DOI:10.1128/JB.00849-10

Reference

4 [PMID:26680199]

Authors

Santos AA, Venceslau SS, Grein F, Leavitt WD, Dahl C, Johnston DT, Pereira IA.

Title

A protein trisulfide couples dissimilatory sulfate reduction to energy conservation.

Journal

Science 350:1541-5 (2015)
DOI:10.1126/science.aad3558

Other DBs

ExplorEnz - The Enzyme Database: