KEGG   ENZYME: 1.8.99.2
Entry
EC 1.8.99.2                 Enzyme                                 
Name
adenylyl-sulfate reductase;
adenosine phosphosulfate reductase;
adenosine 5'-phosphosulfate reductase;
APS-reductase;
APS reductase;
AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With unknown physiological acceptors
Sysname
AMP,sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)
Reaction(IUBMB)
AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor [RN:R00860]
Reaction(KEGG)
R00860 > R08553;
(other) R04927
Substrate
AMP [CPD:C00020];
sulfite [CPD:C00094];
acceptor [CPD:C00028]
Product
adenylyl sulfate [CPD:C00224];
reduced acceptor [CPD:C00030]
Comment
An iron flavoprotein (FAD). Methyl viologen can act as acceptor.
History
EC 1.8.99.2 created 1972
Pathway
ec00920  Sulfur metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
ec01320  Sulfur cycle
Orthology
K00394  adenylylsulfate reductase, subunit A
K00395  adenylylsulfate reductase, subunit B
Genes
TIG: THII_3105 THII_3106
THIS: HZT40_21240(aprB) HZT40_21245
TUN: J9260_16720(aprB) J9260_16725
TLO: J9253_18120(aprB) J9253_18125
TSB: HMY34_11175(aprB) HMY34_11180
TANI: J8380_05600 J8380_12965(aprB) J8380_12970
TWN: L2Y54_05785(aprB) L2Y54_05790(aprA)
TLC: RCF98_10685(aprB) RCF98_10690(aprA)
TSJ: L3K52_04575(aprB) L3K52_04580(aprA)
TPUT: QJT81_03285(aprB) QJT81_03290(aprA)
ALV: Alvin_1120 Alvin_1121
ATEP: Atep_15380 Atep_15390
TVI: Thivi_3299 Thivi_3300
TMB: Thimo_1219 Thimo_1220
TSY: THSYN_16395 THSYN_16400
TTP: E6P07_06890 E6P07_06895(aprB)
THIP: N838_08140 N838_08145(aprB) N838_10735(aprB) N838_10740
CJAP: GWK36_04765(aprB) GWK36_04770
THIM: KFB96_04245(aprB) KFB96_04250
TBOG: LT988_00210(aprA) LT988_00215(aprB)
TLR: Thiosp_01613(aprB) Thiosp_01614(aprA)
TFRI: Thiofri_03807(aprA) Thiofri_03808(aprB)
TWG: Thiowin_00433(aprB) Thiowin_00434(aprA)
TGR: Tgr7_0350 Tgr7_0351
TKM: TK90_0064 TK90_0065
TNI: TVNIR_3611 TVNIR_3612
TTI: THITH_01410 THITH_01415
EBX: D5085_13870(aprB) D5085_13875
TBN: TBH_C0421 TBH_C0422
EPS: L0Y14_00895(aprB) L0Y14_00900(aprA)
SEDS: AAY24_12255 AAY24_12260
MFRA: D5125_08060 D5125_08065(aprB)
TTC: FOKN1_1662 FOKN1_1663
THIC: TspCOW1_09810 TspCOW1_09820
SLIM: SCL_0600 SCL_0601 SCL_2473 SCL_2474
SVA: SVA_2607 SVA_2608 SVA_3564 SVA_3565
ACII: C4901_07620(aprA) C4901_07625(aprB) C4901_14675(aprB) C4901_14680(aprA)
ATY: A9R16_009310(aprA) A9R16_009315(aprB) A9R16_013560(aprB) A9R16_013565(aprA)
TSN: W908_01270 W908_01275
THIN: CRN91_00270(aprB) CRN91_00275(aprA)
THO: SP60_04585 SP60_04590
RMA: Rmag_0087 Rmag_0088
REO: HUE58_06190(aprB) HUE58_06195
VOK: COSY_0091(aprB) COSY_0092(aprA)
REV: HUE57_00495 HUE57_00500(aprB)
EBH: BSEPE_0126(aprB) BSEPE_0127(aprA)
BTHG: MS2017_2046 MS2017_2047
ENM: EBS_2148(aprA) EBS_2149(aprB)
IFO: CVFO_0391(aprB) CVFO_0392(aprA)
APHF: CVPH_1379(aprA) CVPH_1380(aprB)
SHD: SUTH_02771(aprA) SUTH_02772(aprB)
NPV: OHM77_12500(aprB) OHM77_12505(aprA)
TBD: Tbd_0872 Tbd_0873 Tbd_2282 Tbd_2283
TSW: VA613_04525(aprA) VA613_04530(aprB)
SLT: Slit_1714 Slit_1715
SEME: MIZ01_1494 MIZ01_1495
SDR: SCD_n01726(aprB) SCD_n01727(aprA)
SPLB: SFPGR_21700 SFPGR_21710(aprB) SFPGR_28000(aspB) SFPGR_28010(apsA)
SLAC: SKTS_25230(aspB) SKTS_25240(apsA) SKTS_27380 SKTS_27390
DDZ: DSYM_23230 DSYM_23240
FIL: BN1229_v1_3249 BN1229_v1_3251
FIY: BN1229_v1_2672 BN1229_v1_2673
MAGQ: MGMAQ_3494 MGMAQ_3495
VSU: P3M64_01125(aprB) P3M64_01130(aprA)
PUB: SAR11_0836(aprB) SAR11_0837(aprA)
PEG: E5R92_01800 E5R92_01805(aprB)
PELA: B5L73_02725 B5L73_02730
APM: HIMB5_00004970 HIMB5_00004980
DDS: Ddes_2129 Ddes_2130
DFI: AXF13_12610 AXF13_12615
DPG: DESPIGER_1662 DESPIGER_1663 DESPIGER_2209 DESPIGER_2210
DEF: CNY67_01435(aprB) CNY67_01440(aprA)
DTR: RSDT_0365(aprA) RSDT_0366(aprB)
DFL: DFE_2055 DFE_2056
PSYF: N1030_16805(aprB) N1030_16810(aprA)
DSB: LN040_15555(aprB) LN040_15560(aprA)
DELF: DESU86_0423 DESU86_0424 DESU86_1235(aprA) DESU86_1236(aprB)
DMA: DMR_05390(aprB) DMR_05400(aprA) DMR_29670 DMR_29680
DCB: C3Y92_17705(aprA) C3Y92_17710(aprB)
SOLI: ACP59X_03240(aprB) ACP59X_03245(aprA)
DGG: DGI_0457(aprA) DGI_0458(aprB)
DDE: Dde_1109 Dde_1110
DMS: E8L03_09650 E8L03_09655(aprB)
DSA: Desal_0229 Desal_0230
DHY: DESAM_20543(aprA) DESAM_20544
DAF: Desaf_0100 Desaf_0101 Desaf_0338 Desaf_0339
DAS: Daes_3033 Daes_3034
DPI: BN4_11809(aprA) BN4_11810(aprB)
DEJ: AWY79_04195 AWY79_04200
PPRF: DPRO_2420(aprB) DPRO_2421(aprA)
PSEL: GM415_07085(aprB) GM415_07090
DDN: DND132_2643 DND132_2644
PSEF: PSDVSF_18940(aprA) PSDVSF_18950(aprB)
PPOR: JCM14722_15710(aprA) JCM14722_15720(aprB)
PNW: SYK_21010(aprA) SYK_21020(aprB)
PTHE: LF599_17890(aprB) LF599_17895(aprA)
PMEN: V8V93_01105(aprA) V8V93_01110(aprB)
DSX: GD604_03185(aprB) GD604_03190
DSD: GD606_15920(aprB) GD606_15925
PBIZ: LWC08_14795(aprA) LWC08_14800(aprB)
DVU: DVU_0846(aprB) DVU_0847(aprA)
DVL: Dvul_2136 Dvul_2137
DVM: DvMF_1710 DvMF_2892 DvMF_2893
DVG: Deval_0776 Deval_0777
CLIH: KPS_001953 KPS_003337(aprB) KPS_003338(aprA)
TMUR: JBF11_01690 JBF11_01695
BWS: WCP94_000741 WCP94_000742
DBA: Dbac_3197 Dbac_3198
DOA: AXF15_05945 AXF15_05950
DESU: NLA06_15975(aprB) NLA06_15980(aprA)
THEW: TDMWS_04730(aprB) TDMWS_04740(aprA)
DRT: Dret_1966(aprA) Dret_1967(aprB)
DPS: DP1104 DP1105
DSF: UWK_02023 UWK_02024
DLM: DPPLL_04770(aprB) DPPLL_04780(aprA)
DAK: DaAHT2_1471 DaAHT2_1472
DPR: Despr_0771 Despr_0772
DEO: CAY53_05535 CAY53_05540 CAY53_10880 CAY53_10885
DOG: HP555_07435(aprB) HP555_07440
DBK: DGMP_04490(aprB) DGMP_04500(aprA)
DDU: GF1_23660(aprA) GF1_23670(aprB)
ECOM: QTN59_11325(aprA) QTN59_11330(aprB)
EAJ: Q3M24_01205(aprA) Q3M24_01210(aprB)
ELAX: KKHLCK_17275(aprB) KKHLCK_17280(aprA)
ESD: SD837_19565(aprA) SD837_19570(aprB)
ELGW: WGN25_02255(aprB) WGN25_02260(aprA)
EAQ: LDFHOB_02325(aprB) LDFHOB_02330(aprA)
DOL: Dole_0997 Dole_0998
DAL: Dalk_1569 Dalk_1570
DAT: HRM2_04510(aprA) HRM2_04520(aprB)
DTO: TOL2_C04460(aprA) TOL2_C04470(aprB)
DHG: EYB58_05120(aprB) EYB58_05125
DOV: DSCO28_47930(aprA) DSCO28_47940(aprB)
DWD: DSCW_40190(aprB) DSCW_40200(aprA) DSCW_42360 DSCW_42370(aspB)
DALK: DSCA_38700(aprA) DSCA_38710(aprB_1) DSCA_40820 DSCA_40830 DSCA_58900(aprB_2)
DESB: BuS5_02433 BuS5_02434
DVR: Dvar_70620 Dvar_83840 Dvar_83850
DML: Dmul_31450(aprA) Dmul_31460(aprB)
DLI: dnl_16910(aprB) dnl_16920(aprA)
DMM: dnm_076460(aprB) dnm_076470(aprA)
DEK: DSLASN_36220(aspB_2) DSLASN_36230(aprA)
DAO: Desac_0736 Desac_0737
DTI: Desti_1442 Desti_1443
SFU: Sfum_1047 Sfum_1048
DAX: FDQ92_09410(aprB) FDQ92_09415(aprA)
DBR: Deba_0981 Deba_0982
DMP: FAK_04710(aspB) FAK_04720
TID: Thein_0285 Thein_0286
TOP: TOPB45_0176 TOPB45_0177
TCM: HL41_08915 HL41_08920
THET: F1847_07175 F1847_07180(aprB)
CTHI: THC_1311 THC_1312
TAV: G4V39_03260 G4V39_03265(aprB)
TMAI: FVE67_03060 FVE67_03065(aprB)
DAW: HS1_000253(aprA) HS1_000254(aprB)
TNR: Thena_1598 Thena_1599
TACI: TDSAC_1570 TDSAC_1571
KST: KSMBR1_3875(aprB) KSMBR1_3876(apsA)
BROC: IPI25_12130 IPI25_12135
BPIT: BPIT_06990 BPIT_07000
JET: L3J17_12740 L3J17_12745
FSU: Fisuc_0144 Fisuc_0145
FSC: FSU_0547 FSU_0548
CTE: CT0864(aspB) CT0865(apsA)
CLZ: BIU88_06785 BIU88_06790
CCH: Cag_1585 Cag_1586
CPB: Cphamn1_1837 Cphamn1_1838
PPH: Ppha_0039 Ppha_0040
PROW: OO006_03305(aprB) OO006_03310(aprA)
PROI: OO005_03210(aprB) OO005_03215(aprA)
TYE: THEYE_A1832(aprA) THEYE_A1833(aprB)
TOB: V4D31_02155(aprB) V4D31_02160(aprA)
TAUT: V4D30_05895(aprA) V4D30_05900(aprB)
DTP: JZK55_21800(aprA) JZK55_21810(aprB)
LFC: LFE_1826 LFE_1827
LFI: LFML04_0489 LFML04_0490
LFP: Y981_02510 Y981_02515
LEG: ABH19_02945 ABH19_02950
DHR: LGS26_04230(aprB) LGS26_04235(aprA)
CAC: CA_C0104 CA_C0105
CAE: SMB_G0105(frdA) SMB_G0106
CAY: CEA_G0105 CEA_G0106
CBE: Cbei_4188 Cbei_4189
CBZ: Cbs_4188 Cbs_4189
CBEI: LF65_04697 LF65_04698
CKL: CKL_1797 CKL_1798(aprA)
CKR: CKR_1669 CKR_1670
CCB: Clocel_0525 Clocel_0526
CLS: CXIVA_15130 CXIVA_15140
CSR: Cspa_c29740 Cspa_c29750
CPAS: Clopa_4346 Clopa_4347
CPAT: CLPA_c35250 CLPA_c35260
CPAE: CPAST_c35250 CPAST_c35260
CSB: CLSA_c38940 CLSA_c38950
CLT: CM240_2791 CM240_2792
CACE: CACET_c13370 CACET_c13380
CCK: Ccar_10430 Ccar_10435
CBUT: ATN24_08820 ATN24_08825
CTYK: CTK_C12860 CTK_C12870
CEU: A7L45_10245 A7L45_10250
CFM: BJL90_12010 BJL90_12015
CDY: F3K33_21430 F3K33_21435
CMAH: C1I91_02180 C1I91_02185
CRW: CROST_003020(aprA) CROST_003030
CFB: CLFE_000110(cutD) CLFE_000120(aprA)
CAUN: CLAUR_027070(cutD) CLAUR_027080(aprA)
CNN: CNEO_3245 CNEO_3246
CGEL: psyc5s11_27950 psyc5s11_27960
CINT: HZF06_00540 HZF06_00545
CLOL: ONV75_07610 ONV75_07615
CLOM: AXY43_09100 AXY43_09105
CLOO: RCG18_20875 RCG18_20880
HSC: HVS_02765(nadB1) HVS_02770
RUM: CK1_29010 CK1_29020
RUJ: E5Z56_09520 E5Z56_09525
RUC: LCN94_02905 LCN94_02910
CARL: PXC00_10960 PXC00_10965
DOR: Desor_1735 Desor_1736
DAI: Desaci_2312 Desaci_2319 Desaci_2320
DMI: Desmer_0631 Desmer_0632 Desmer_1686 Desmer_1687
DCA: Desca_2377 Desca_2378
PTH: PTH_0239(SdhA) PTH_0240
DRM: Dred_0636 Dred_0637
DRU: Desru_0816 Desru_0817 Desru_3376 Desru_3377
DFG: B0537_03650 B0537_03655
DAE: Dtox_3577 Dtox_3578
DKU: Desku_1073 Desku_1074 Desku_1950 Desku_1951
AACX: DEACI_0464 DEACI_0465 DEACI_4177 DEACI_4178
TJR: TherJR_2248 TherJR_2249
DGI: Desgi_1510 Desgi_1511 Desgi_3701 Desgi_3702
CTHM: CFE_1042 CFE_1043
RRK: H8S51_003600 H8S51_003605
RFC: ACIRUI_08475 ACIRUI_08480
COO: CCU_23240 CCU_23250
CEV: LK421_04960 LK421_04965
ROB: CK5_24520
BLAB: EYS05_06475 EYS05_06480
BLIQ: INP51_13750 INP51_13755
BWX: NQ550_19060 NQ550_19065
BMAS: LK422_16945 LK422_16950
BLUI: Blut17040_30580 Blut17040_30590
CPY: Cphy_1830 Cphy_1831
LXA: OW255_14580 OW255_14585
LSIA: VIG27_05035 VIG27_05040
BPRL: CL2_12010 CL2_12020
EHL: EHLA_0507 EHLA_0508
ANR: Ana3638_18045
ACEL: acsn021_29500 acsn021_29510
EEL: EUBELI_01895 EUBELI_01896
WCP: H9Q76_03810 H9Q76_03815
ERE: EUBREC_2471 EUBREC_2472
ERT: EUR_26600 EUR_26610
ERA: ERE_07490 ERE_07500
CLE: Clole_0049 Clole_0050
CEW: EKH84_03165 EKH84_03170
ABUT: Ami103574_14725 Ami103574_14730
AMT: Amet_3494 Amet_3495
GFE: Gferi_06095 Gferi_06100
TEB: T8CH_2747 T8CH_2748(aprA)
DAU: Daud_0788 Daud_0789 Daud_1885 Daud_1886 Daud_1889
ADG: Adeg_0924 Adeg_0925 Adeg_1080 Adeg_1081
DBC: MFMK1_002773 MFMK1_002774
HOR: Hore_02120 Hore_02130
HALS: D7D81_17745 D7D81_17750
IFN: GM661_14395 GM661_14400
AAR: Acear_1952 Acear_1970 Acear_1971
HHL: Halha_2337 Halha_2338
CAD: Curi_c25240 Curi_c25250(aprA)
VRM: 44547418_00331(frdA) 44547418_00332
MED: MELS_1712 MELS_1713
MMAX: LCQ47_01130 LCQ47_01135
SRI: SELR_27430(fdx) SELR_27440
PUF: UFO1_1134 UFO1_1135
PFT: JBW_03276 JBW_03277
MANA: MAMMFC1_02591(nadB_1) MAMMFC1_02592
SSPH: SPSPH_008440(aprA) SPSPH_008450
SSID: SPSIL_035690(aprB) SPSIL_035700(aprA)
SCAO: SCACP_28460 SCACP_28470(aprA)
EBM: SG0102_26840 SG0102_26850
CSC: Csac_1640 Csac_1641
ATE: Athe_1191 Athe_1192
CHD: Calhy_1541 Calhy_1542
CKI: Calkr_1174 Calkr_1175
CKN: Calkro_1506 Calkro_1507
CCHA: ELD05_08150 ELD05_08155
CDIA: CaldiYA01_13150 CaldiYA01_13160
CDAN: SOJ16_001141 SOJ16_001142
ATB: J4859_12670 J4859_12675
IPO: Ilyop_2845 Ilyop_2846
LBA: Lebu_0374 Lebu_0375
LOT: AXF11_03240 AXF11_03245
LEQ: BCB68_05990 BCB68_05995
LHF: JCM16775_2043 JCM16775_2044
LSZ: JCM16776_1593 JCM16776_1594
LWD: JCM16777_1749 JCM16777_1750
LRUG: AB8B22_07795 AB8B22_07800
LMES: AB8B23_02150 AB8B23_02155
AFU: AF_1669 AF_1670
AFG: AFULGI_00019180 AFULGI_00019190
APO: Arcpr_1261 Arcpr_1262
AVE: Arcve_0422 Arcve_0423
AST: Asulf_02111 Asulf_02112
FPL: Ferp_2217 Ferp_2218
GAC: GACE_1095 GACE_1096
GAH: GAH_02065
PAI: PAE2561 PAE2562 PAE2563 PAE2564
PCL: Pcal_1428 Pcal_1429
PAS: Pars_1234 Pars_1235
PYR: P186_1798 P186_1799
POG: Pogu_1003 Pogu_1004
CMA: Cmaq_0272 Cmaq_0273
TTN: TTX_0438(apsA) TTX_0439
TUZ: TUZN_0714 TUZN_0715
VDI: Vdis_2089 Vdis_2090
VMO: VMUT_0493 VMUT_0494
VSO: Vsou_25680 Vsou_25690
 » show all
Reference
1  [PMID:5421934]
  Authors
Michaels GB, Davidson JT, Peck HD Jr.
  Title
A flavin-sulfite adduct as an intermediate in the reaction catalyzed by adenylyl sulfate reductase from Desulfovibrio vulgaris.
  Journal
Biochem Biophys Res Commun 39:321-8 (1970)
DOI:10.1016/0006-291X(70)90579-6
Other DBs
ExplorEnz - The Enzyme Database: 1.8.99.2
IUBMB Enzyme Nomenclature: 1.8.99.2
ExPASy - ENZYME nomenclature database: 1.8.99.2
BRENDA, the Enzyme Database: 1.8.99.2
CAS: 9027-75-2
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