| Entry |
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| Name |
demethylsterigmatocystin 6-O-methyltransferase;
demethylsterigmatocystin methyltransferase;
O-methyltransferase I
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 6-demethylsterigmatocystin = S-adenosyl-L-homocysteine + sterigmatocystin [RN: R03112]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
6-demethylsterigmatocystin [CPD: C03683]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
sterigmatocystin [CPD: C00961]
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| Comment |
Dihydrodemethylsterigmatocystin can also act as acceptor. Involved in the biosynthesis of aflatoxins in fungi.
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| History |
EC 2.1.1.109 created 1992
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K17649 | demethylsterigmatocystin 6-O-methyltransferase |
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| Genes |
| MBRN: | 26243136(aflO_1) 26247609(lepI) |
| ALUC: | AKAW2_20291A AKAW2_60089S |
| APUU: | APUU_20054A APUU_50253S APUU_50657S |
| PPSF: | 300794102(PFLUO_LOCUS7886) |
| ADAC: | 96080480(ACET3X_000158) 96080555(ACET3X_000233) 96089010(ACET3X_008688) 96089949(ACET3X_009627) |
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| Reference |
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| Authors |
Yabe K, Ando Y, Hashimoto J, Hamasaki T. |
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| Title |
Two distinct O-methyltransferases in aflatoxin biosynthesis. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.109 |
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| LinkDB |
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