| Entry |
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| Name |
(S)-scoulerine 9-O-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine [RN: R03835]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
(S)-scoulerine [CPD: C02106]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
(S)-tetrahydrocolumbamine [CPD: C04118]
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| Comment |
The product of this reaction is a precursor for protoberberine alkaloids in plants
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| History |
EC 2.1.1.117 created 1999
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| Pathway |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K13397 | (S)-scoulerine 9-O-methyltransferase |
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| Genes |
| AANS: | 126785966 126786871 126787924 126788651 |
| RCN: | 112164599 112175727 112178128 |
| PXB: | 103951323 103951351 103951352 103966079 103966114 |
| PCOX: | 137728497 137728498 |
| JRE: | 108979314 108981078 108981935 108986025 109004694 109018241 109018878 118348298 |
| CILL: | 122278514 122278733 122278857 122278863 |
| PSOM: | 113293137 113322507 113362144 |
| MSIN: | 131239482 131242245 131242246 131242247 131242248 131252155 131252157 |
| ACAK: | 137937030 137937183 137937184 137937185 137937413 137937414 137937415 137937416 137937417 137937821 |
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| Reference |
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| Authors |
Muemmler S, Rueffer M, Nagakura N, Zenk MH |
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| Title |
S-adenosyl-L-methionine: (S)-scoulerine 9-O-methyltransferase, a highly stereo- and regio-specific enzyme in tetrahydroprotoberberine biosynthesis. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.117 |
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| LinkDB |
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