Entry
Name
precorrin-2 C20-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:precorrin-2 C20-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A [RN:
R03948 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
precorrin 2 [CPD:
C02463 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
precorrin 3A [CPD:
C05772 ]
Comment
This enzyme participates in the aerobic (late cobalt insertion) cobalamin biosynthesis pathway. See EC
2.1.1.151 , cobalt-factor II C20-methyltransferase, for the equivalent enzyme that participates in the anaerobic cobalamin biosynthesis pathway.
History
EC 2.1.1.130 created 1999
Pathway
Orthology
K03394 precorrin-2/cobalt-factor-2 C20-methyltransferase
K13540 precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase
Genes
KIE : NCTC12125_04871(cbiL_1) NCTC12125_04872(cbiL_2)
BUF : D8682_20870 D8682_24255
BFT : MNO13_05090 MNO13_08235
BSEL : RHD99_04900 RHD99_08270
METY : MRY16398_18740(cbiL)
OPO : DSM2777_13910 DSM2777_20770
PAEB : NCGM1900_3407(cobI)
PPRC : PFLCHA0_c06660(cobI)
PMUD : NCTC8068_00608(cobI)
PFW : PF1751_v1c05680(cobI)
PPUU : PputUW4_00540(cobI)
PTW : TUM18999_08420(cobI)
PTAE : NCTC10697_03993(cobI)
PKK : QQ992_01930 QQ992_25100
TFRI : Thiofri_03990(cobJ)
HHK : HH1059_08950 HH1059_09320(cbiL)
GAI : IMCC3135_08940(cobI)
HAAH : HALA3H3_800140(cobI)
BMV : BMASAVP1_A1604(cobI)
BML : BMA10229_A0266(cobI)
BPM : BURPS1710b_2111(cobI)
BPL : BURPS1106A_1965(cobI)
PDIO : PDMSB3_1863.1(cobI)
PLG : NCTC10937_00832(cobI)
ASAH : AVXHC19_00860(cobI)
MPT : Mpe_B0443(cobF) Mpe_B0478(cobF)
AZA : AZKH_4160(cbiL_vobI)
THAG : CKCBHOJB_02803(cbiL)
SMEL : SM2011_c03191(cobI)
SFD : USDA257_c53950(cobI)
SAME : SAMCFNEI73_Ch3351(cobI)
AGR : AGROH133_09254(cobI)
AVV : RvVAT039_01160(cobI)
AVF : RvVAR031_22340(cobI)
REC : RHECIAT_PA0000376(cobI)
REL : REMIM1_PD00476(cobI)
REP : IE4803_PA00412(cobI)
REI : IE4771_PC00425(cobI)
RTR : RTCIAT899_PC07000(cobI)
RHL : LPU83_pLPU83d0185(cobI)
RGA : RGR602_PC01214(cobI)
RPHA : AMC79_PB00385(cobI)
NGL : RG1141_CH39020(cobI)
NEN : NCHU2750_36470(cobI)
BVL : BF3285c1_2098(cobI1)
BIO : BR141012304_11409(cobI)
MAQU : Maq22A_c09440(cobF)
MTUN : MTUNDRAET4_2076(cobI)
FIL : BN1229_v1_3173(cobI)
FIY : BN1229_v1_2749(cobI)
RLI : RLO149_c006200(cobI)
PHP : PhaeoP97_00781(cobI)
PPIC : PhaeoP14_00736(cobI)
SINL : DSM14862_03170(cobI_2)
SPSE : SULPSESMR1_02791(cobI)
RMM : ROSMUCSMR3_03054(cobI)
AHT : ANTHELSMS3_02548(cobI)
PMAU : CP157_03005(cobI_1)
LVS : LOKVESSMR4R_00336(cobI)
GEH : HYN69_05160 HYN69_19260 HYN69_20070
AALK : LGT41_0000215(cobI)
AALU : ABWI00_02920 ABWI00_13410
GEC : GEO60473_24180(cobI)
GBN : GEOBRER4_34620(cbiL)
DEJ : AWY79_07780 AWY79_14915
PPOR : JCM14722_27970(cobI)
DMM : dnm_050780(cbiL) dnm_086630
LMAY : DPV73_18180(cobI) DPV73_19670(cobI)
BCEL : BcellWH2_00375(cobI)
PCRE : NCTC12858_01244(cobI)
PCAG : NCTC12856_00423(cbiL)
PROC : Ptc2401_01276(cbiL)
MSCH : N508_000946 N508_001118(cobI)
PASA : BAOM_4952(cobI-cbiL)
PARG : PspKH34_20120(cbiL)
LMOC : LMOSLCC5850_1192(cbiL)
LMW : LMOSLCC2755_1195(cbiL)
LMX : LMOSLCC2372_1199(cbiL)
LMZ : LMOSLCC2482_1243(cbiL)
LMON : LMOSLCC2376_1154(cbiL)
LMOS : LMOSLCC7179_1170(cbiL)
LMOO : LMOSLCC2378_1208(cbiL)
LMOY : LMOSLCC2479_1200(cbiL)
LMOT : LMOSLCC2540_1182(cbiL)
LMOA : LMOATCC19117_1202(cbiL)
BAYD : BSPP4475_15690(cobI)
PPQ : PPSQR21_047900(cobF)
PCHI : PC41400_25705(cobI)
SMEN : SAMEA4412692_0365(cbiL)
LRU : HMPREF0538_20897(cobI)
AUR : HMPREF9243_1730(cobI)
AMIT : DBT49_0001575(cobI)
CTYK : CTK_C09470(cobI_cbiL)
CCOH : SAMEA4530647_0619(cbiL)
CGEL : psyc5s11_38520(cobI_cbiL)
BIE : RFF05_03120(cobI) RFF05_08665(cobI)
HCV : FTV88_0725 FTV88_2834
BPRO : PMF13cell1_04267(cbiL)
CSCI : HDCHBGLK_00123(cbiL)
ACEL : acsn021_39710(cobI_cbiL)
ACHT : bsdcttw_22400(cbiL)
CBIL : EUBC25_20830(cobI_cbiL)
CBAR : PATL70BA_0227(cobI)
AMIC : Ami3637_03215(cobI)
ABUT : Ami103574_05910(cobI)
PHX : KGNDJEFE_00489(cbiL)
EAC : EAL2_808p01030(cbiL)
PIV : NCTC13079_00685(cbiL)
VRM : 44547418_01199(cbiL)
VDN : NCTC11831_00761(cbiL)
MANA : MAMMFC1_01673(cbiL)
PFAC : PFJ30894_01760(cbiL)
CALK : HUE98_09270 HUE98_10550(cobI)
MAVM : MAA44156_01801(cobI)
MMAE : MMARE11_29690(cobI)
MBAI : MB901379_02825(cobI)
MHEK : JMUB5695_02275(cobIJ)
MKY : IWGMT90018_27300(cobIJ)
MPHL : MPHLCCUG_02699(cobI)
MTHN : 4412656_01957(cobI_1)
MAUU : NCTC10437_03306(cobI)
MFLV : NCTC10271_02122(cobI)
MGO : AFA91_20120 AFA91_20695
MSAL : DSM43276_01911(cobI)
MTER : 4434518_03150(cobI)
CDD : CDCE8392_1134(cobIJ)
CDIP : ERS451417_01233(cobIJ)
COI : CPCIP5297_05330(cobJ)
CUN : Cul210932_1135(cobJ)
CUQ : Cul210931_1087(cobJ)
CUJ : CUL131002_1119(cobJ)
NFR : ERS450000_00921(cobI)
NAD : NCTC11293_04432(cobI)
RPY : Y013_10505 Y013_14625
RCR : NCTC10994_03357(cobI)
RANT : RHODO2019_04720(cobI)
REQ : REQ_23560(cobI_cobJ)
SGRF : SGFS_088300 SGFS_096410
SLE : sle_52800(sle_52800)
SALF : SMD44_02001(cobI-cbiL)
SCOE : CP976_10535(cobI) CP976_34775
SGOB : test1122_02365(cobI)
SXT : KPP03845_105799(cobIJ)
SCT : SCAT_1052 SCAT_p1405(cobIJ)
SCY : SCATT_10460 SCATT_p03210
DCO : SAMEA4475696_1935(cobI)
PAK : HMPREF0675_3453(cobI)
CGRN : 4412665_00754(cobI)
PAUS : NCTC13651_00948(cobI)
PPC : HMPREF9154_0398(cobI)
TEZ : BKM78_01675 BKM78_05775
TLA : TLA_TLA_00341(cobIJ) TLA_TLA_01168(cobI)
RAIN : Rai3103_03650(cobI) Rai3103_07660(cobJ)
BROO : brsh051_09620(cobI)
NAQU : ENKNEFLB_00279(cobIJ_1) ENKNEFLB_01626(cobIJ_2)
MSAG : GCM10017556_51990(cobI)
ACTR : Asp14428_65770(cobI)
BALA : DSM104299_01716(cobI)
PARQ : DSM112329_00641(cobIJ)
SYR : SynRCC307_0460(cobI)
SYX : SynWH7803_0561(cobI)
SYH : Syncc8109_2114(cobI_cbiL)
SYNW : SynWH8103_00752(cobI)
PMG : P9301_04091(cobI_cbiL)
PMH : P9215_04661(cobI_cbiL)
PMJ : P9211_03851(cobI_cbiL)
TVN : NIES2134_102080(cobI)
LET : O77CONTIG1_00720(cbiL)
MVZ : myaer102_37810(cobI)
PAGH : NIES204_04460(cobI)
PRUN : PCC7821_03839(cobI)
NSPH : BDGGKGIB_01189(cobIJ)
CALS : NIES3974_22080(cobI)
DOU : BMF77_04144(cobIJ_2)
GLT : GlitD10_2259(cobI-cbiL)
DFO : Dform_01780(cobI-cbiL)
FPOL : ERS445057_01270(cbiL)
HAAD : MW046_12720 MW046_16925
TVO : TVG0971375(TVG0971375)
SJV : SJAV_02260 SJAV_25610
AMAN : B6F84_01395 B6F84_04175
ABRI : DFR85_01635 DFR85_03435
ACIH : HS5_08220 HS5_16350
» show all
Taxonomy
Reference
Authors
Roessner CA, Warren MJ, Santander PJ, Atshaves BP, Ozaki S, Stolowich NJ, Iida K, Scott AI.
Title
Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis.
Journal
Reference
Authors
Roessner CA, Spencer JB, Ozaki S, Min C, Atshaves BP, Nayar P, Anousis N, Stolowich NJ, Holderman MT, Scott AI.
Title
Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes.
Journal
Reference
Authors
Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F
Title
Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.130
LinkDB
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