Entry
Name
precorrin-3B C17-methyltransferase;
precorrin-3 methyltransferase;
CobJ
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin-4 [RN:
R05180 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
precorrin 3B [CPD:
C06406 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
precorrin 4 [CPD:
C06407 ]
Comment
The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses a crucial reaction where the tetrapyrrole ring contracts as a result of methylation of C-17. See EC
2.1.1.272 , cobalt-factor III methyltransferase, for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway.
History
EC 2.1.1.131 created 1999
Pathway
Orthology
K05934 precorrin-3B C17-methyltransferase / cobalt-factor III methyltransferase
K13540 precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase
K13541 cobalt-precorrin 5A hydrolase / cobalt-factor III methyltransferase / precorrin-3B C17-methyltransferase
Genes
SETC : CFSAN001921_06650(cbiH)
SEEN : SE451236_16345(cbiH)
SENH : CFSAN002069_21685(cbiH)
SEEH : SEEH1578_19415(cbiH)
SENJ : CFSAN001992_01300(cbiH)
SEEC : CFSAN002050_17095(cbiH)
SEEB : SEEB0189_009330(cbiH)
SENC : SEET0819_17280(cbiH)
KIE : NCTC12125_04868(cbiH)
BUF : D8682_20860 D8682_24240
BFT : MNO13_05080 MNO13_08220
METY : MRY16398_18710(cbiH)
PAEB : NCGM1900_3408(cobJ)
PAEU : BN889_03244(cobJ_2)
PPRC : PFLCHA0_c06670(cobJ)
PMUD : NCTC8068_00609(cobJ)
PFW : PF1751_v1c05690(cobJ)
PPUU : PputUW4_00541(cobJ)
PTRT : HU722_0003940(cobJ)
PTW : TUM18999_08410(cobJ)
PTAE : NCTC10697_03992(cobJ)
PKK : QQ992_01925(cobJ) QQ992_25095(cobJ)
TFRI : Thiofri_03990(cobJ)
GAI : IMCC3135_08945(cobJ)
HAAH : HALA3H3_800141(cobJ)
BMV : BMASAVP1_A1605(cbiG_cobJ)
BML : BMA10229_A0267(cbiG_cobJ)
BMN : BMA10247_0893(cbiG_cobJ)
BPM : BURPS1710b_2110(cobJ)
BPL : BURPS1106A_1964(cbiG_cobJ)
PLG : NCTC10937_00833(cobJ)
LMIR : NCTC12852_01764(cbiH)
MPT : Mpe_B0447(cobJ) Mpe_B0482(cobJ)
AZA : AZKH_4165(cbiH_cobJ)
PHYL : HB779_02255(cobJ) HB779_17730
SMEL : SM2011_c03190(cobJ)
SFD : USDA257_c53940(cobJ)
SAME : SAMCFNEI73_Ch3350(cobJ)
AGR : AGROH133_09252(cobJ)
AVF : RvVAR031_22330(cobJ)
REC : RHECIAT_PA0000375(cobJ)
REL : REMIM1_PD00475(cobJ)
REP : IE4803_PA00411(cobJ)
REI : IE4771_PC00424(cobJ)
RTR : RTCIAT899_PC07005(cobJ)
RHL : LPU83_pLPU83d0184(cobJ)
RGA : RGR602_PC01213(cobJ)
RPHA : AMC79_PB00384(cobJ)
RRHO : PR018_08405 PR018_17450
RTU : PR017_08575 PR017_17340
NEN : NCHU2750_36480(cobJ)
BMEL : DK63_715(cobJ) DK63_728
BMI : BMEA_A1336(cobJ) BMEA_A1348
BMZ : BM28_A1300(cbiG) BM28_A1314
BMG : BM590_A1291 BM590_A1305
BMW : BMNI_I1250 BMNI_I1264
BMEE : DK62_126 DK62_139(cobJ)
BMB : BruAb1_1290 BruAb1_1302
BMC : BAbS19_I12200 BAbS19_I12340
BAA : BAA13334_I01900 BAA13334_I01925
BABO : DK55_1284(cobJ) DK55_1297
BABR : DO74_594 DO74_606(cobJ)
BABT : DK49_1041(cobJ) DK49_1053
BABB : DK48_823 DK48_836(cobJ)
BABU : DK53_1268(cobJ) DK53_1280
BABS : DK51_180 DK51_192(cobJ)
BABC : DO78_1189(cobJ) DO78_1201
BSI : BS1330_I1285 BS1330_I1297
BSF : BSS2_I1256 BSS2_I1268
BSUI : BSSP1_I0392(cobE) BSSP1_I0404(cobJ)
BSUP : BSPT1_I0399(cobE) BSPT1_I0411(cobJ)
BSUV : BSPT2_I0394(cobE) BSPT2_I0406(cobJ)
BSUC : BSSP2_I1315(cobJ) BSSP2_I1327(cobE)
BMT : BSUIS_A1339(cobJ) BSUIS_A1351(cobE)
BSZ : DK67_1009(cobJ) DK67_997
BSV : BSVBI22_A1285 BSVBI22_A1297
BSW : IY71_06380 IY71_06440
BSG : IY72_06120 IY72_06180
BCS : BCAN_A1312(cobJ) BCAN_A1324(cobE)
BSK : BCA52141_I3106 BCA52141_I3126
BOL : BCOUA_I1289 BCOUA_I1301
BCAR : DK60_1328(cobJ) DK60_1340
BCAS : DA85_06185 DA85_06245
BMR : BMI_I1302(cobJ) BMI_I1314
BPP : BPI_I1341(cobJ) BPI_I1353
BPV : DK65_79 DK65_91(cobJ)
BVL : BF3285c1_2100(cobJ) BF3285c1_2114
BRU : BFS01_06230 BFS01_06300
BRJ : BKD03_15630 BKD03_15690
BIO : BR141012304_11396 BR141012304_11408(cobJ)
BPSN : NIK97_04230(cobJ) NIK97_04290
BRUC : LJ361_16930(cobJ) LJ361_17000
BRUB : GRI33_05910(cobJ) GRI33_05970
BSEP : HAP48_0032375(cobJ)
BCAN : BcanWSM471_15560(cobJ)
MAQU : Maq22A_c09445(cobJ)
MMES : MMSR116_15290(cobJ)
MTUN : MTUNDRAET4_2077(cobJ)
FIL : BN1229_v1_3172(cobJ)
FIY : BN1229_v1_2750(cobJ)
DEA : FPZ08_00575 FPZ08_01585
DNP : N8A98_03005 N8A98_04715
DEVD : GHV40_21235(cobJ) GHV40_21340
DRI : QOV41_15675 QOV41_16690
RLI : RLO149_c006210(cobJ)
PHP : PhaeoP97_00780(cobJ)
PPIC : PhaeoP14_00735(cobJ)
SINL : DSM14862_03169(cobJ)
SPSE : SULPSESMR1_02792(cobJ)
RMM : ROSMUCSMR3_03055(cobJ)
AHT : ANTHELSMS3_02549(cobJ)
LVS : LOKVESSMR4R_00337(cobJ)
GEH : HYN69_05165(cobJ) HYN69_19255(cobJ) HYN69_20065(cobJ)
AALK : LGT41_0000210(cobJ)
PPOR : JCM14722_14140(cobJ)
DMM : dnm_047320(cobJ) dnm_086630
BON : A361_03605 A361_27950
LFU : HR49_01340 HR49_12990
LMOC : LMOSLCC5850_1188(cbiH)
LMW : LMOSLCC2755_1191(cbiH)
LMX : LMOSLCC2372_1195(cbiH)
LMZ : LMOSLCC2482_1239(cbiH)
LMON : LMOSLCC2376_1150(cbiH)
LMOS : LMOSLCC7179_1166(cbiH)
LMOO : LMOSLCC2378_1204(cbiH)
LMOY : LMOSLCC2479_1196(cbiH)
LMOT : LMOSLCC2540_1178(cbiH)
LMOA : LMOATCC19117_1198(cbiH)
SOB : CSE16_00840 CSE16_07470
SMEN : SAMEA4412692_0361(cbiH)
LRU : HMPREF0538_20901(cobJ)
AUR : HMPREF9243_1734(cobJ)
AMIT : DBT49_0001555(cobJ)
CTYK : CTK_C09500(cbiH_cobJ)
CCOH : SAMEA4530647_0622(cbiH)
CGEL : psyc5s11_37870(cbiH)
BIE : RFF05_08605(cobJ) RFF05_11325(cobJ)
BPRO : PMF13cell1_04264(cbiH)
BLUI : Blut17040_11500(cobJ)
CSCI : HDCHBGLK_00120(cbiH)
ACEL : acsn021_39670(cbiH)
ACHT : bsdcttw_22320(cbiH)
CBAR : PATL70BA_0224(cbiH)
AMIC : Ami3637_15820(cobJ)
ABUT : Ami103574_09195(cobJ)
ETM : CE91St48_21110(cbiH)
PDF : CD630DERM_34240(cbiH)
PHX : KGNDJEFE_00486(cbiH)
EAC : EAL2_808p01060(cbiH)
PIV : NCTC13079_00693(cbiH)
SPOA : EQM13_01820(cobJ) EQM13_15080
VRM : 44547418_01211(cbiH)
VDN : NCTC11831_00752(cbiH)
SELM : TAMA11512_14900(cobJ)
MANA : MAMMFC1_04002(cbiH)
PFAC : PFJ30894_01757(cbiH)
MAVM : MAA44156_01801(cobI)
MMAE : MMARE11_29690(cobI)
MBAI : MB901379_02825(cobI)
MHEK : JMUB5695_02275(cobIJ)
MKY : IWGMT90018_27300(cobIJ)
MPHL : MPHLCCUG_02699(cobI)
MTHN : 4412656_01957(cobI_1)
MAUU : NCTC10437_03306(cobI)
MFLV : NCTC10271_02122(cobI)
MGO : AFA91_20120 AFA91_20695
MSAL : DSM43276_01911(cobI)
MTER : 4434518_03150(cobI)
CDD : CDCE8392_1134(cobIJ)
CDIP : ERS451417_01233(cobIJ)
COI : CPCIP5297_05330(cobJ)
CUN : Cul210932_1135(cobJ)
CUQ : Cul210931_1087(cobJ)
CUJ : CUL131002_1119(cobJ)
NFR : ERS450000_00921(cobI)
NAD : NCTC11293_04432(cobI)
RPY : Y013_10505 Y013_14625
RCR : NCTC10994_03357(cobI)
RANT : RHODO2019_04740(cobJ)
REQ : REQ_23560(cobI_cobJ)
SGRF : SGFS_088270 SGFS_096410
STRF : ASR50_09010 ASR50_31635
SLE : sle_52760(sle_52760)
SALF : SMD44_02005(cbiGH-cobJ)
SVR : CP971_05295 CP971_09060
SCOE : CP976_10545(cobJ) CP976_34775
SGOB : test1122_02380(cobJ)
SXT : KPP03845_105799(cobIJ)
SJN : RI060_01525 RI060_33030
SARM : DVA86_30360 DVA86_34575
SCT : SCAT_1054 SCAT_p1405(cobIJ)
SCY : SCATT_10480 SCATT_p03210
KAU : B6264_00700 B6264_04120
KIT : CFP65_4032 CFP65_6482
KCH : O1G21_08120 O1G21_11955
DCO : SAMEA4475696_1935(cobI)
PAK : HMPREF0675_3455(cobJ)
CGRN : 4412665_00756(cbiH)
PAUS : NCTC13651_00950(cbiH)
PPC : HMPREF9154_0396(cobJ)
TEZ : BKM78_01675 BKM78_05765
TLA : TLA_TLA_00341(cobIJ) TLA_TLA_01166(cbiH)
RAIN : Rai3103_03660(cobJ) Rai3103_07660(cobJ)
BROO : brsh051_09590(cobJ)
NAQU : ENKNEFLB_00279(cobIJ_1) ENKNEFLB_01626(cobIJ_2)
APRE : CNX65_08880 CNX65_28735
SESP : BN6_25810(cobIJ) BN6_70160(cbiG)
SSYI : EKG83_11645 EKG83_39325
KBR : Q4V65_16865(cobJ) Q4V65_33745
KPHY : AOZ06_33205 AOZ06_33705
SACE : GIY23_16875 GIY23_16910
UME : RM788_12800(cobJ) RM788_16375
MSAG : GCM10017556_51990(cobI)
ACTR : Asp14428_65770(cobI)
BALA : DSM104299_01719(cbiH)
PARQ : DSM112329_00641(cobIJ)
SYG : sync_0391(cbiG_cobJ)
SYR : SynRCC307_2160(cbiG)
SYX : SynWH7803_0388(cbiG)
CYA : CYA_1591(cbiG_cobJ-1) CYA_1847(cbiG_cobJ-2)
SYH : Syncc8109_0335(cobJ)
SYNW : SynWH8103_02442(cobJ)
PMM : PMM1525(cbiG_cobJ_fusion)
TVN : NIES2134_112480(cobJ)
LET : O77CONTIG1_00345(cbiH)
MVZ : myaer102_16530(cobJ_2)
PAGH : NIES204_04470(cobJ)
PPSU : NO713_00083(cbiH60)
PRUN : PCC7821_03838(cobJ)
NSPH : BDGGKGIB_01190(cobJ)
DOU : BMF77_04143(cobIJ_1)
GLT : GlitD10_2988(cbiGH-cobJ)
DFO : Dform_01778(cbiGH-cobJ)
FPOL : ERS445057_01282(cbiH)
MRU : mru_0890(cbiH1) mru_2210(cbiH)
MFEG : GCM10025860_07040 GCM10025860_15590
MCHK : MchiMG62_06360(cobJ)
HAL : VNG_1555G(cobH) VNG_1557G(cbiH)
HSL : OE_3214F(cbiH1) OE_3216F(cbiH2)
HANR : LJ422_06325 LJ422_06330(cobJ)
HHB : Hhub_2896(cbiH1) Hhub_2897(cbiH2)
HAGS : JT689_07665 JT689_07670(cobJ)
HABO : JRZ79_06080 JRZ79_06085(cobJ)
HNO : LT974_11260 LT974_11265(cobJ)
HANX : ABSL23_14340 ABSL23_14345(cobJ)
HALH : HTSR_1844(cbiH) HTSR_1845(cbiH2)
HHSR : HSR6_1913(cbiH) HSR6_1914(cbiH2)
HDO : MUK72_18260(cobJ) MUK72_18265
HALX : M0R89_15160(cobJ) M0R89_15165
SAIM : K0C01_09810 K0C01_09815(cobJ)
HARA : AArcS_1191(cobJ) AArcS_1192(cobJ2)
HMA : rrnAC3005(cobH) rrnAC3008(cbiH)
HHI : HAH_0263(cobJ1) HAH_0264(cobJ2)
HHN : HISP_01400 HISP_01405
HTA : BVU17_01300 BVU17_01305
HALJ : G9465_01500(cobJ) G9465_01505
HSIN : KDQ40_12330(cobJ) KDQ40_12335
NPH : NP_1114A(cbiH2) NP_1116A(cbiH1)
NMO : Nmlp_3782(cbiH2) Nmlp_3783(cbiH1)
NHO : HWV23_09005(cobJ) HWV23_09010
NSAL : HWV07_12725(cobJ) HWV07_12730
HALZ : E5139_12465(cobJ) E5139_12470
HALL : LC1Hm_1194(cobJ) LC1Hm_1195(cobJ2)
HAZP : GBQ70_12475(cobJ) GBQ70_12480
HALI : BV210_15265 BV210_15270
HAAD : MW046_12735 MW046_12740(cobJ)
HWA : HQ_3033A(cbiH2) HQ_3034A(cbiH1)
HWC : Hqrw_3551(cbiH2) Hqrw_3552(cbiH1)
HVO : HVO_B0057(cbiH2) HVO_B0058(cbiH1)
HALE : G3A49_06895 G3A49_06900(cobJ)
HLN : SVXHx_3414(cbih) SVXHx_3415(cbih2)
HME : HFX_5061(cobJ) HFX_5062(cobJ)
HGI : ABY42_15745 ABY42_15750
HLS : KU306_03925 KU306_03930(cobJ)
HBO : Hbor_03460 Hbor_03470
HRA : EI982_05810(cobJ) EI982_05815
HLM : DV707_02900(cobJ) DV707_02905
HAE : halTADL_3155 halTADL_3156
HMP : K6T50_18745 K6T50_18750(cobJ)
HRE : K6T36_17890 K6T36_17895(cobJ)
HACB : Hbl1158_00230 Hbl1158_00235(cobJ)
HDF : AArcSl_3201(cbiH) AArcSl_3202(cbiH2)
HSAL : JMJ58_03965 JMJ58_03970(cobJ)
HAKZ : J0X25_12025(cobJ) J0X25_12030
HXA : Halxa_2935 Halxa_2936
NPE : Natpe_2698 Natpe_2699
NVR : FEJ81_12465(cobJ) FEJ81_12470
NPL : FGF80_12110(cobJ) FGF80_12115
NAY : HYG81_15655(cobJ) HYG81_15660
HALY : HYG82_01055 HYG82_01060(cobJ)
HJT : DVR14_03465(cobJ) DVR14_03470
HLO : J0X27_16680 J0X27_16685(cobJ)
HLC : CHINAEXTREME18605 CHINAEXTREME18610
NOU : Natoc_4258 Natoc_4259
HLR : HALLA_10080 HALLA_10085
NAJ : B1756_11715 B1756_11720
NAG : AArcMg_1622 AArcMg_1623
NAN : AArc1_2018 AArc1_2019
NARA : QQ977_12330(cobJ) QQ977_12335
NBG : DV706_02620 DV706_02625(cobJ)
NAS : GCU68_10920(cobJ) GCU68_10925
HDA : BB347_03445 BB347_03450
TVO : TVG0973788(TVG0973788)
» show all
Taxonomy
Reference
Authors
Scott AI, Roessner CA, Stolowich NJ, Spencer JB, Min C, Ozaki SI.
Title
Biosynthesis of vitamin B12. Discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group.
Journal
Reference
Authors
Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F
Title
Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.131
LinkDB
All DBs