Entry Name theobromine synthase;
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:7-methylxanthine N3-methyltransferase
Reaction(IUBMB) S-adenosyl-L-methionine + 7-methylxanthine = S-adenosyl-L-homocysteine + 3,7-dimethylxanthine [RN:
R07919 ]
Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
7-methylxanthine [CPD:
C16353 ]
Product S-adenosyl-L-homocysteine [CPD:
C00021 ];
3,7-dimethylxanthine [CPD:
C07480 ]
Comment This is the third enzyme in the caffeine-biosynthesis pathway. This enzyme can also catalyse the conversion of paraxanthine into caffeine, although the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis [2,3].
History EC 2.1.1.159 created 2007
Pathway ec01110 Biosynthesis of secondary metabolites
ec01120 Microbial metabolism in diverse environments
Orthology Genes CARB : 113707907 113708187 113710465
Taxonomy Reference Authors Ogawa M, Herai Y, Koizumi N, Kusano T, Sano H
Title 7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties.
Journal Sequence Reference Authors Uefuji H, Ogita S, Yamaguchi Y, Koizumi N, Sano H
Title Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants.
Journal Sequence Reference Authors Yoneyama N, Morimoto H, Ye CX, Ashihara H, Mizuno K, Kato M.
Title Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme.
Journal Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.159
LinkDB All DBs
