KEGG ENZYME: 2.1.1.240

ENZYME: 2.1.1.240

Entry

EC 2.1.1.240                Enzyme

Name

trans-resveratrol di-O-methyltransferase;
ROMT;
resveratrol O-methyltransferase;
pterostilbene synthase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase

Reaction(IUBMB)

2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction) [RN:R09872];
(1a) S-adenosyl-L-methionine + trans-resveratrol = S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene [RN:R09870];
(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene = S-adenosyl-L-homocysteine + pterostilbene [RN:R09871]

Reaction(KEGG)

R09870 R09871 R09872

Substrate

S-adenosyl-L-methionine [CPD:C00019];
trans-resveratrol [CPD:C03582];
3-methoxy-4',5-dihydroxy-trans-stilbene [CPD:C20154]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
pterostilbene [CPD:C10287];
3-methoxy-4',5-dihydroxy-trans-stilbene [CPD:C20154]

Comment

The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.

History

EC 2.1.1.240 created 2012

Pathway

ec00945

Stilbenoid, diarylheptanoid and gingerol biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K16040

trans-resveratrol di-O-methyltransferase

Genes

RARG:

115729264 115732674 115750649 115750657 115750668

AANS:

126791663

AGLU:

133861103

VVI:	100233030(OMT2.1) 100243765 100247173 100247273 100248917 100250627 100254011 100255808 100257423 100259140 100260877 100263651 100854823 132254760

VRI:	117925800 117925802 117926250 117926260 117926349 117926834 117926835 117926836

DLT:	127791382 127791503 127791629 127791630 127792241 127792251 127792379 127792667 127792669 127792670 127792671 127792672 127811796 127811802 127811805 127811894 127811895 127811896 127811897 127811898 127812064 127812220 127812221

Reference

1 [PMID:18799660]

Authors

Schmidlin L, Poutaraud A, Claudel P, Mestre P, Prado E, Santos-Rosa M, Wiedemann-Merdinoglu S, Karst F, Merdinoglu D, Hugueney P

Title

A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine.

Journal

Plant Physiol 148:1630-9 (2008)
DOI:10.1104/pp.108.126003

Sequence

[vvi:100233030]

Other DBs

ExplorEnz - The Enzyme Database: