KEGG   ENZYME: 2.1.1.248
Entry
EC 2.1.1.248                Enzyme                                 
Name
methylamine---corrinoid protein Co-methyltransferase;
mtmB (gene name);
monomethylamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
monomethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Reaction(IUBMB)
methylamine + a [Co(I) methylamine-specific corrinoid protein] = a [methyl-Co(III) methylamine-specific corrinoid protein] + NH3 [RN:R10014]
Reaction(KEGG)
R10014;
(other) R09998
Substrate
methylamine [CPD:C00218];
[Co(I) methylamine-specific corrinoid protein]
Product
[methyl-Co(III) methylamine-specific corrinoid protein];
NH3 [CPD:C00014]
Comment
The enzyme, which catalyses the transfer of a methyl group from methylamine to a methylamine-specific corrinoid protein (MtmC), is involved in methanogenesis from methylamine. The enzyme contains the unusual amino acid pyrrolysine [3]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.
History
EC 2.1.1.248 created 2012
Pathway
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K16176  methylamine---corrinoid protein Co-methyltransferase
Genes
SDFACG33_12615
DOEDENOEST_1155 DENOEST_1170
DEOCAY53_02475
DMLDmul_02380(mtmB)
DEKDSLASN_08540
CTHDCDO33_18585
DAEDtox_0025
FWADCMF_02210 DCMF_07385 DCMF_08180 DCMF_08800 DCMF_08825 DCMF_12475 DCMF_12480 DCMF_14680 DCMF_24475
ELIMB2M23_05155 B2M23_05160
VGUHYG85_16645
VPYHZI73_14240
AARAcear_1719
SRISELR_27700(mtmB)
MANAMAMMFC1_01966 MAMMFC1_01967
ETTAZF37_07305
PSUBPelsub_P2997
OCKEXM22_00710
CPORBED41_14915
MBAMbar_A0843 Mbar_A0846
MBYMSBRM_0150 MSBRM_1850
MBWMSBRW_0156 MSBRW_0158 MSBRW_1099
MBARMSBR2_0560 MSBR2_2231
MBAKMSBR3_0508 MSBR3_2282 MSBR3_2284
MACMA_0144(mtmB1) MA_2972(mtmB2)
MMAMM_1436(mtmB) MM_1437(mtmB) MM_3335(mtmB) MM_3336(mtmB)
MMAZMmTuc01_3441
MMJMSMAS_1346 MSMAS_3227
MMACMSMAC_2710 MSMAC_3249
MVCMSVAZ_1890 MSVAZ_3365
MEKMSKOL_1876 MSKOL_3326
MLSMSLAZ_3202 MSLAZ_3204
METMMSMTP_1524 MSMTP_3128
MEFMSWH1_1133 MSWH1_3075 MSWH1_3077
MEQMSWHS_1207 MSWHS_3286
MSJMSSAC_0121 MSSAC_0126 MSSAC_1323
MSZMSSIH_0112 MSSIH_1617
MSWMSSIT_0113 MSSIT_0116 MSSIT_1628
MTHRMSTHT_1926
MTHEMSTHC_1357
MHORMSHOH_1819 MSHOH_3974
MMETMCMEM_0625 MCMEM_0969 MCMEM_0978
MELOJ7W08_01185 J7W08_01690
MMHMmah_1399
MHAZBHR79_06675 BHR79_07765 BHR79_07770 BHR79_07860 BHR79_07865
MEVMetev_1068 Metev_1350 Metev_1467
MZHMzhil_0326 Mzhil_0630 Mzhil_1522 Mzhil_1525
MPYMpsy_1674 Mpsy_1675(mtmB1) Mpsy_1677(mtmB2) Mpsy_1711(mtmB3)
MZIHWN40_00850
MHZMetho_0013 Metho_0035 Metho_0036
TARTALC_01093 TALC_01094
MAXMMALV_11290 MMALV_11300
MERMMINT_08870 MMINT_08950
MEARMpt1_c05730(mtmB11) Mpt1_c05760(mtmB13)
MARCAR505_1327 AR505_1328
TPETpen_1211
THBN186_07205
THFMA03_03050
THELIG193_00145
 » show all
Reference
1  [PMID:9195968]
  Authors
Burke SA, Krzycki JA
  Title
Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.
  Journal
J Biol Chem 272:16570-7 (1997)
DOI:10.1074/jbc.272.26.16570
  Sequence
Reference
2  [PMID:9642198]
  Authors
Burke SA, Lo SL, Krzycki JA
  Title
Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine.
  Journal
J Bacteriol 180:3432-40 (1998)
DOI:10.1128/JB.180.13.3432-3440.1998
  Sequence
Reference
3  [PMID:15450490]
  Authors
Krzycki JA
  Title
Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases.
  Journal
Curr Opin Chem Biol 8:484-91 (2004)
DOI:10.1016/j.cbpa.2004.08.012
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.248
IUBMB Enzyme Nomenclature: 2.1.1.248
ExPASy - ENZYME nomenclature database: 2.1.1.248
BRENDA, the Enzyme Database: 2.1.1.248
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