KEGG   ENZYME: 2.1.1.248
Entry
EC 2.1.1.248                Enzyme                                 

Name
methylamine---corrinoid protein Co-methyltransferase;
mtmB (gene name);
monomethylamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
monomethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Reaction(IUBMB)
methylamine + a [Co(I) methylamine-specific corrinoid protein] = a [methyl-Co(III) methylamine-specific corrinoid protein] + NH3 [RN:R10014]
Reaction(KEGG)
R10014;
(other) R09998
Substrate
methylamine [CPD:C00218];
[Co(I) methylamine-specific corrinoid protein]
Product
[methyl-Co(III) methylamine-specific corrinoid protein];
NH3 [CPD:C00014]
Comment
The enzyme, which catalyses the transfer of a methyl group from methylamine to a methylamine-specific corrinoid protein (MtmC), is involved in methanogenesis from methylamine. The enzyme contains the unusual amino acid pyrrolysine [3]. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. The methylated corrinoid protein is substrate for EC 2.1.1.247, methylated methylamine-specific corrinoid protein:coenzyme M methyltransferase.
History
EC 2.1.1.248 created 2012
Pathway
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K16176  methylamine---corrinoid protein Co-methyltransferase
Genes
SDF: ACG33_12615
DOE: DENOEST_1155 DENOEST_1170
DEO: CAY53_02475
DML: Dmul_02380(mtmB)
CTHD: CDO33_18585
DAE: Dtox_0025
FWA: DCMF_02210 DCMF_07385 DCMF_08180 DCMF_08800 DCMF_08825 DCMF_12475 DCMF_12480 DCMF_14680 DCMF_24475
ELIM: B2M23_05155 B2M23_05160
VGU: HYG85_16645
VPY: HZI73_14240
SRI: SELR_27700(mtmB)
MAC: MA_0144(mtmB1) MA_2972(mtmB2)
MMA: MM_1436(mtmB) MM_1437(mtmB) MM_3335(mtmB) MM_3336(mtmB)
MTHR: MSTHT_1926
MTHE: MSTHC_1357
MMH: Mmah_1399
MPY: Mpsy_1674 Mpsy_1675(mtmB1) Mpsy_1677(mtmB2) Mpsy_1711(mtmB3)
MEAR: Mpt1_c05730(mtmB11) Mpt1_c05760(mtmB13)
TPE: Tpen_1211
 » show all
Reference
1  [PMID:9195968]
  Authors
Burke SA, Krzycki JA
  Title
Reconstitution of Monomethylamine:Coenzyme M methyl transfer with a corrinoid protein and two methyltransferases purified from Methanosarcina barkeri.
  Journal
J Biol Chem 272:16570-7 (1997)
DOI:10.1074/jbc.272.26.16570
  Sequence
Reference
2  [PMID:9642198]
  Authors
Burke SA, Lo SL, Krzycki JA
  Title
Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine.
  Journal
J Bacteriol 180:3432-40 (1998)
DOI:10.1128/JB.180.13.3432-3440.1998
  Sequence
Reference
3  [PMID:15450490]
  Authors
Krzycki JA
  Title
Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases.
  Journal
Curr Opin Chem Biol 8:484-91 (2004)
DOI:10.1016/j.cbpa.2004.08.012
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.248
IUBMB Enzyme Nomenclature: 2.1.1.248
ExPASy - ENZYME nomenclature database: 2.1.1.248
BRENDA, the Enzyme Database: 2.1.1.248
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