Entry
Name
23S rRNA (guanine2069-N7)-methyltransferase;
rlmK (gene name);
23S rRNA m7G2069 methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:23S rRNA (guanine2069-N7)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + guanine2069 in 23S rRNA = S-adenosyl-L-homocysteine + N7-methylguanine2069 in 23S rRNA
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
guanine2069 in 23S rRNA
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
N7-methylguanine2069 in 23S rRNA
Comment
The enzyme specifically methylates guanine2069 at position N7 in 23S rRNA. In gamma-proteobacteria the enzyme also catalyses EC
2.1.1.173 , 23S rRNA (guanine2445-N2)-methyltransferase, while in beta-proteobacteria the activities are carried out by separate proteins [1]. The enzyme from the gamma-proteobacterium Escherichia coli has RNA unwinding activity as well [1].
History
EC 2.1.1.264 created 2012
Orthology
K12297 23S rRNA (guanine2069-N7)-methyltransferase / 23S rRNA (guanine2445-N2)-methyltransferase
K25136 23S rRNA (guanine2069-N7)-methyltransferase
Genes
ECOO : ECRM13514_1055(rlmL)
ECOH : ECRM13516_0990(rlmL)
ELR : ECO55CA74_05775(rlmL)
ECOA : APECO78_08730(rlmL)
EDJ : ECDH1ME8569_0899(rlmL)
ECOI : ECOPMV1_00978(rlmL)
SEM : STMDT12_C10830(rlmL)
SETC : CFSAN001921_11860(rlmL)
SEEN : SE451236_11165(rlmL)
SENH : CFSAN002069_03700(rlmL)
SEEH : SEEH1578_14545(rlmL)
SENJ : CFSAN001992_06625(rlmL)
SEEC : CFSAN002050_11700(rlmL)
SEEB : SEEB0189_014255(rlmL)
SENC : SEET0819_11960(rlmL)
EHU : D5067_0015035(rlmKL)
REE : electrica_03343(rlmL)
RTG : NCTC13098_05002(rlmL)
CLAP : NCTC11466_02997(rlmL)
KIE : NCTC12125_02018(rlmL)
BAGE : BADSM9389_27040(rlmL)
AHN : NCTC12129_01875(rlmL)
SGOE : A8O29_014780(rlmKL)
METY : MRY16398_37380(rlmL)
PSHI : SAMEA2665130_1223(rlmL)
MPHG : MPHASIOC01_000619(rlmKL)
FPUL : ACBV55_07395(rlmKL)
SMW : SMWW4_v1c17260(rlmL)
SERS : SERRSCBI_08310(rlmL)
SFJ : SAMEA4384070_1782(rlmL)
SOF : NCTC11214_05079(rlmL_1)
SSAR : SSARUM_001695(rlmKL)
PAQU : DMB82_0009225(rlmKL)
PARL : PEC302110_17920(rlmKL)
DIC : Dpoa569_0001575(rlmKL)
EHD : ERCIPSTX3056_367(rlmL)
BAPF : BUMPF009_CDS00233(rlml)
BAPG : BUMPG002_CDS00234(rlml)
BAPU : BUMPUSDA_CDS00233(rlml)
BAPW : BUMPW106_CDS00233(rlml)
TPTY : NCTC11468_01381(rlmL)
PHEI : NCTC12003_02728(rlmL)
PRJ : NCTC6933_01351(rlmL_1)
LRI : NCTC12151_01446(rlmL)
HIC : NTHIC486_00915(rlmL)
HPIT : NCTC13334_01379(rlmL)
HHZ : NCTC10839_01794(rlmL)
HAEG : NCTC8502_01123(rlmL)
PDAG : 4362423_00287(rlmL)
PCAI : K7G93_001038(rlmKL)
ADP : NCTC12871_00394(rlmL)
ALIG : NCTC10568_00064(rlmL)
ASEG : NCTC10977_00997(rlmL)
AVT : NCTC3438_01852(rlmL)
PAET : NCTC13378_01202(rlmL)
XFU : XFF4834R_chr29190(rlmL)
XPH : XppCFBP6546_18250(rlmKL)
XHD : LMG31886_27330(rlmL)
SCYC : AB1723_02770(rlmKL)
STEJ : FQS62_007530(rlmKL)
STEZ : ACEPA4_06910(rlmKL)
SLAB : AB9L18_13595(rlmKL)
LAUX : LA521A_25340(rlmKL)
LARE : HIV01_001535(rlmKL)
LLZ : LYB30171_01850(rlmL)
THEX : ICG51_000608(rlmKL)
VAU : VANGNB10_cI1263(rlmL)
VPL : SA104470976_01224(rlmL)
VIB : VspSTUT11_15950(rlmL)
VIS : VspSTUT16_16280(rlmL)
PHOT : L4174_008240(rlmKL)
PALD : LU682_020515(rlmKL)
PVD : CFBP1590__2157(rlmL)
PPRC : PFLCHA0_c19190(rlmL1)
PMUD : NCTC8068_01600(rlmL)
PFW : PF1751_v1c41100(rlmL)
PFF : PFLUOLIPICF715630(rlmL)
PPUU : PputUW4_03608(rlmL)
PMOE : HV782_010130(rlmKL)
PTRT : HU722_0021685(rlmKL)
PSAM : HU731_008065(rlmKL)
PSHH : HU773_019960(rlmKL)
PPRG : HU725_007430(rlmKL)
PANH : HU763_008470(rlmKL)
PTW : TUM18999_17610(rlmL)
PTAE : NCTC10697_01203(rlmL)
MSHE : MAALD49_22980(rlmL)
MAMM : ABNF92_02485(rlmKL)
MFLI : ACGK9W_04445(rlmKL)
PSYC : DABAL43B_0928(rlmL)
ACUM : C9E88_009775(rlmKL)
MCAT : MC25239_01080(rlmL)
MCUN : NCTC10297_01164(rlmL)
MORK : MOXK02_11540(rlmKL)
MORX : MOXK23_08650(rlmKL)
SCAA : TUM17387_21850(rlmL)
SEUR : FM038_013690(rlmKL)
SHEH : ABIS04_06235(rlmKL)
PLZ : S4054249_11600(rlmL)
APEL : CA267_018585(rlmKL)
SALH : HMF8227_01425(rlmL)
HARO : R50071_21710(rlmKL)
SLIO : R50072_16070(rlmKL)
LLG : 44548918_00017(rlmL)
LJR : NCTC11533_00021(rlmL)
LCJ : NCTC11976_00702(ycbY)
LWA : SAMEA4504053_0024(rlmL)
LSS : NCTC12082_02045(rlmL)
LADL : NCTC12735_00101(rlmL)
LANT : TUM19329_03230(rlmL)
MISZ : MishRS11D_16370(rlmL)
MECH : Q9L42_006955(rlmKL)
MLAU : ACEPPP_02620(rlmKL)
FTR : NE061598_05290(rlmL)
MPIN : LGT42_008940(rlmKL)
TIB : THMIRHAM_17880(rlmL)
TSE : THMIRHAS_20710(rlmL)
TZO : THMIRHAT_05800(rlmL)
TFRI : Thiofri_01545(rlmL)
GAI : IMCC3135_27030(rlmL)
HAAH : HALA3H3_30043(ycbY)
HAAZ : HaloA020_22490(rlmL)
ALCA : ASALC70_04049(rlmL_2)
AEL : NCTC12917_02141(rlmL)
PAGI : ABHF91_08490(rlmKL)
CHJ : NCTC10426_00320(rlmL)
CDIZ : CEDIAZO_02049(rlmL)
NWE : SAMEA3174300_0769(rlmL_2)
NZO : SAMEA4504057_1766(rlmL_2)
NCI : NCTC10296_02027(rlmL_2)
NCZ : NCTC10294_00586(rlmL_1)
NANI : NCTC12227_00950(rlmL_2)
ECOR : SAMEA4412678_1347(rlmL_1)
PLG : NCTC10937_02054(rlmL)
DBK : DGMP_34010 DGMP_37640
MFF : MFFC18_28560(rlmK_2)
ECUL : PVA46_02985 PVA46_06945(rlmKL)
ENEM : PVA44_01830(rlmKL) PVA44_06015
EET : PVA45_01905(rlmKL) PVA45_06460
BBAE : FRD01_07945 FRD01_13315
PCAT : Pcatena_03190(rlmL)
SHI : Shel_00510 Shel_26220
RTS : CE91St31_14500(rlmL)
» show all
Taxonomy
Reference
Authors
Kimura S, Ikeuchi Y, Kitahara K, Sakaguchi Y, Suzuki T, Suzuki T
Title
Base methylations in the double-stranded RNA by a fused methyltransferase bearing unwinding activity.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.264
LinkDB
All DBs