KEGG   ENZYME: 2.1.1.28
Entry
EC 2.1.1.28                 Enzyme                                 
Name
phenylethanolamine N-methyltransferase;
noradrenaline N-methyltransferase;
noradrenalin N-methyltransferase;
norepinephrine methyltransferase;
norepinephrine N-methyltransferase;
phenethanolamine methyltransferase;
phenethanolamine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine [RN:R04033]
Reaction(KEGG)
R04033;
(other) R02533
Substrate
S-adenosyl-L-methionine [CPD:C00019];
phenylethanolamine [CPD:C02735]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N-methylphenylethanolamine [CPD:C03711]
Comment
Acts on various phenylethanolamines; converts noradrenaline into adrenaline.
History
EC 2.1.1.28 created 1972
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K00553  phenylethanolamine N-methyltransferase
Genes
HSA5409(PNMT)
PTR454634(PNMT)
PPS100978896(PNMT)
GGO101140487(PNMT)
PON100450669(PNMT)
NLE100603046(PNMT)
MCC697444(PNMT)
MCF102144850(PNMT)
CSAB103243536(PNMT)
CATY105579551(PNMT)
PANU101008479(PNMT)
TGE112609871(PNMT)
RRO104674852(PNMT)
RBB108527783(PNMT)
TFN117067090(PNMT)
PTEH111537273(PNMT)
CJC100405480(PNMT)
SBQ101032723(PNMT)
CSYR103275270(PNMT)
MMUR105872103(PNMT)
LCAT123620835(PNMT)
OGA100954802(PNMT)
MMU18948(Pnmt)
MCAL110306272(Pnmt)
MPAH110332744(Pnmt)
RNO24661(Pnmt)
MCOC116078086(Pnmt)
MUN110562946(Pnmt)
CGE100768410(Pnmt)
MAUA101842703(Pnmt)
PLEU114706966(Pnmt)
MORG121442328 121456155
AAMP119811412(Pnmt)
NGI103743823(Pnmt)
HGL101706187(Pnmt)
CPOC100727379(Pnmt)
CCAN109694115(Pnmt)
DORD106002191(Pnmt)
DSP122100311(Pnmt)
NCAR124980951
OCU100355890(PNMT)
OPI101529625(PNMT)
TUP102501155(PNMT)
CFA491023(PNMT)
CLUD112655419(PNMT)
VVP112918118(PNMT)
VLG121473337(PNMT)
AML100480535(PNMT)
UMR103662175(PNMT)
UAH113265179(PNMT)
UAR123779538(PNMT)
ELK111151828
LLV125086857
MPUF101694546(PNMT)
ORO101365469(PNMT)
EJU114198479(PNMT)
ZCA113907960(PNMT)
MLX118025065(PNMT)
FCA101101350(PNMT)
PYU121044912(PNMT)
PBG122485477(PNMT)
PTG102961408(PNMT)
PPAD109247421(PNMT)
AJU106980500(PNMT)
HHV120229107(PNMT)
BTA281413(PNMT)
BOM102267416(PNMT)
BIU109574122(PNMT)
BBUB102410415(PNMT)
CHX102175988(PNMT)
OAS101103826(PNMT)
ODA120867218(PNMT)
SSC100144479(PNMT)
CFR102520076(PNMT)
CBAI105073263(PNMT)
CDK105099042(PNMT)
VPC102539133(PNMT)
BACU103001658(PNMT)
LVE103074918(PNMT)
OOR101283122(PNMT)
DLE111166487(PNMT)
PCAD102991209(PNMT)
PSIU116745885(PNMT)
ECB100033859(PNMT)
EPZ103550153(PNMT)
EAI106826394(PNMT)
MYB102249392(PNMT)
MYD102758984(PNMT)
MMYO118672411(PNMT)
MLF102427470(PNMT)
MNA107528967(PNMT)
PKL118702176(PNMT)
HAI109380659(PNMT)
DRO112316421(PNMT)
SHON118978084(PNMT)
AJM119045744(PNMT)
PDIC114503842(PNMT)
PHAS123817477(PNMT)
MMF118634656(PNMT)
RFQ117012975(PNMT)
PALE102883108 102885798
PGIG120611193(PNMT)
PVP105307496(PNMT)
RAY107520713(PNMT)
MJV108390001(PNMT)
TOD119231999(PNMT)
SARA101540554(PNMT)
LAV100655935(PNMT)
TMU101355696
DNM101414088(PNMT)
MDO100017260(PNMT)
GAS123245478(PNMT)
SHR100928301(PNMT)
PCW110215827(PNMT)
OAA100079586(PNMT)
GGA100858738(PNMT)
PCOC116233706(PNMT)
MGP104914599(PNMT) 104916482
CJO107325268(PNMT)
NMEL110388710(PNMT)
APLA113840035(PNMT)
AFUL116498579(PNMT)
TGU100228437(PNMT)
LSR110471932(PNMT)
PMOA120496644(PNMT)
OTC121347647(PNMT)
PRUF121354027
GFR102031976(PNMT)
PHI102110801(PNMT)
CCAE111944131
CCW120411314(PNMT)
ETL114071804(PNMT)
NNI104017695(PNMT)
TALA116962923(PNMT)
ACHC115344854(PNMT)
AROW112969536(PNMT)
NPD112960207(PNMT)
DNE112978741(PNMT)
ASN102370069(PNMT)
AMJ102558831(PNMT)
CPOO109320279(PNMT)
CMY102946470(PNMT)
CPIC101947293(PNMT)
TST117869275(PNMT)
CABI116831383(PNMT)
MRV120392099(PNMT)
ACS100565710(pnmt)
PVT110082064(PNMT)
SUND121934184(PNMT)
PBI103057808(PNMT)
PMUR107303015(PNMT)
TSR106538850(PNMT)
PGUT117664671(PNMT)
VKO123031789(PNMT)
PMUA114582804(PNMT)
ZVI118095231(PNMT)
GJA107114737(PNMT)
STOW125445179(PNMT)
XLA108700775(pnmt.L) 108702360(pnmt.S)
XTR100492236(pnmt)
NPR108792760(PNMT)
RTEM120918714(PNMT)
BBUF121005290(PNMT)
BGAR122942578(PNMT)
DRE100332609
SRX107716495(pnmt)
SANH107676565
SGH107571312
CCAR109092887
CAUA113097040(pnmt)
PPRM120488708
MAMB125251887
IPU108273631
PHYP113535195(pnmt)
SMEO124400866
TFD113662506
AMEX103022410
EEE113576882(pnmt)
TRU101068284(pnmt)
LCO104922126 104933416
NCC104943468(pnmt) 104960380
CGOB115024816(pnmt)
ELY117247628
EFO125880726
PLEP121959377
SLUC116048219 116050010 116050892 116055161 116055163 116061328 116061329
ECRA117936956 117958272
PFLV114547626(pnmt) 114568862 114569203 114569205 114569206 114570235 114570242
GAT120819704
PPUG119213098
MSAM119916634
CUD121528851
ALAT119010219
MZE101478707(pnmt)
ONL100704948(pnmt)
OAU116327519
OLA101172030(pnmt)
OML112154569
XMA102217979(pnmt)
XCO114151774(pnmt)
XHE116726809(pnmt)
PRET103481424(pnmt)
PFOR103142266(pnmt)
PLAI106949709(pnmt)
PMEI106920906(pnmt)
GAF122822990
CVG107089993(pnmt)
CTUL119774906
GMU124874672
NFU107387578(pnmt)
KMR108247644
ALIM106516992(pnmt)
NWH119423675
AOCE111566735(pnmt)
MCEP125022515
CSEM103381482(pnmt)
POV109626801(pnmt)
SSEN122759235
HHIP117753434
HSP118100870
LCF108901731(pnmt)
SDU111220132(pnmt)
SLAL111657100(pnmt)
XGL120794598
HCQ109513412(pnmt)
BPEC110154403(pnmt)
MALB109962872(pnmt)
BSPL114845670
SASA106579371(pnmt)
OTW112223306
OMY110491677
OGO124047743
ONE115106201(pnmt)
SALP111977642(pnmt)
SNH120045776
CCLU121582224
ELS105006836(pnmt)
SFM108919132(pnmt)
PKI111856096(pnmt)
AANG118221305
LOC102687297(pnmt)
PSPA121324706
ARUT117435192
LCM102365914(PNMT)
CMK103183857
RTP109930472(pnmt)
BFO118404812 118408157 118411785 118425090 118427144 118428020
BBEL109485686 109485819
DMK116915613 116920610 116924061
PTRU123513674
HAZT108680444
LSM121121405
PPOI119090506
ISCIscW_ISCW020997
MYI110456502 110459317 110459319
BLEPAL038_03540
 » show all
Reference
1  [PMID:13863458]
  Authors
AXELROD J.
  Title
Purification and properties of phenylethanolamine-N-methyl transferase.
  Journal
J Biol Chem 237:1657-60 (1962)
Reference
2  [PMID:5412063]
  Authors
Connett RJ, Kirshner N.
  Title
Purification and properties of bovine phenylethanolamine N-methyltransferase.
  Journal
J Biol Chem 245:329-34 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.28
IUBMB Enzyme Nomenclature: 2.1.1.28
ExPASy - ENZYME nomenclature database: 2.1.1.28
BRENDA, the Enzyme Database: 2.1.1.28
CAS: 9037-68-7
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