Entry Name selenocysteine Se-methyltransferase;
Class Transferases;BRITE hierarchy
Sysname S-methyl-L-methionine:L-selenocysteine Se-methyltransferase
Reaction(IUBMB) S-methyl-L-methionine + L-selenocysteine = L-methionine + Se-methyl-L-selenocysteine [RN:
R10430 ]
Reaction(KEGG) Substrate S-methyl-L-methionine [CPD:
C03172 ];
L-selenocysteine [CPD:
C05688 ]
Product L-methionine [CPD:
C00073 ];
Se-methyl-L-selenocysteine [CPD:
C05689 ]
Comment The enzyme uses S-adenosyl-L-methionine as methyl donor less actively than S-methyl-L-methionine. The enzyme from broccoli (Brassica oleracea var. italica) also has the activity of EC
2.1.1.10 , homocysteine S-methyltransferase [4].
History EC 2.1.1.280 created 2013
Reference Authors Neuhierl B, Bock A
Title On the mechanism of selenium tolerance in selenium-accumulating plants. Purification and characterization of a specific selenocysteine methyltransferase from cultured cells of Astragalus bisculatus.
Journal Sequence Reference Authors Neuhierl B, Thanbichler M, Lottspeich F, Bock A
Title A family of S-methylmethionine-dependent thiol/selenol methyltransferases. Role in selenium tolerance and evolutionary relation.
Journal Sequence Reference Authors Lyi SM, Heller LI, Rutzke M, Welch RM, Kochian LV, Li L
Title Molecular and biochemical characterization of the selenocysteine Se-methyltransferase gene and Se-methylselenocysteine synthesis in broccoli.
Journal Sequence Reference Authors Lyi SM, Zhou X, Kochian LV, Li L
Title Biochemical and molecular characterization of the homocysteine S-methyltransferase from broccoli (Brassica oleracea var. italica).
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.280
LinkDB All DBs
