KEGG   ENZYME: 2.1.1.291
Entry
EC 2.1.1.291                Enzyme                                 
Name
(R,S)-reticuline 7-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(R,S)-reticuline 7-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-laudanine [RN:R10605];
(2) S-adenosyl-L-methionine + (R)-reticuline = S-adenosyl-L-homocysteine + (R)-laudanine [RN:R10606]
Reaction(KEGG)
R10605 R10606;
(other) R08787 R08788
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-reticuline [CPD:C02105];
(R)-reticuline [CPD:C05178]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-laudanine [CPD:C20712];
(R)-laudanine [CPD:C09555]
Comment
The enzyme from the plant Papaver somniferum (opium poppy) methylates (S)- and (R)-reticuline with equal efficiency and is involved in the biosynthesis of tetrahydrobenzylisoquinoline alkaloids.
History
EC 2.1.1.291 created 2013
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13390  (R,S)-reticuline 7-O-methyltransferase
Genes
MEAN126683461 126683462 126683463
MING122067164 122088069
PSOM113338827
CJF131032902 131032932 131035982 131036012 131047846 131047849 131050978 131050981 131051042 131051044 131051045 131051047 131051098 131051350 131067902 131067904 131067905 131067939 131067941 131067943 131069774 131073486 131078154 131078155 131078159 131078176 131874135
Reference
1  [PMID:14675446]
  Authors
Ounaroon A, Decker G, Schmidt J, Lottspeich F, Kutchan TM
  Title
(R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy.
  Journal
Plant J 36:808-19 (2003)
DOI:10.1046/j.1365-313X.2003.01928.x
  Sequence
Reference
2  [PMID:15353584]
  Authors
Weid M, Ziegler J, Kutchan TM
  Title
The roles of latex and the vascular bundle in morphine biosynthesis in the opium  poppy, Papaver somniferum.
  Journal
Proc Natl Acad Sci U S A 101:13957-62 (2004)
DOI:10.1073/pnas.0405704101
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.291
IUBMB Enzyme Nomenclature: 2.1.1.291
ExPASy - ENZYME nomenclature database: 2.1.1.291
BRENDA, the Enzyme Database: 2.1.1.291
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