Entry
Name
(R,S)-reticuline 7-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:(R,S)-reticuline 7-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-laudanine [RN:
R10605 ];
(2) S-adenosyl-L-methionine + (R)-reticuline = S-adenosyl-L-homocysteine + (R)-laudanine [RN:
R10606 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
(S)-reticuline [CPD:
C02105 ];
(R)-reticuline [CPD:
C05178 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
(S)-laudanine [CPD:
C20712 ];
(R)-laudanine [CPD:
C09555 ]
Comment
The enzyme from the plant Papaver somniferum (opium poppy) methylates (S)- and (R)-reticuline with equal efficiency and is involved in the biosynthesis of tetrahydrobenzylisoquinoline alkaloids.
History
EC 2.1.1.291 created 2013
Pathway
ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K13390 (R,S)-reticuline 7-O-methyltransferase
Genes
MEAN : 126683461 126683462 126683463
MING : 122067164 122088069
CJF : 131032902 131032932 131035982 131036012 131047846 131047849 131050978 131050981 131051042 131051044 131051045 131051047 131051098 131051350 131067902 131067904 131067905 131067939 131067941 131067943 131069774 131073486 131078154 131078155 131078159 131078176 131874135
Taxonomy
Reference
Authors
Ounaroon A, Decker G, Schmidt J, Lottspeich F, Kutchan TM
Title
(R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy.
Journal
Sequence
Reference
Authors
Weid M, Ziegler J, Kutchan TM
Title
The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.291
LinkDB
All DBs