KEGG   ENZYME: 2.1.1.293
Entry
EC 2.1.1.293                Enzyme                                 
Name
6-hydroxytryprostatin B O-methyltransferase;
ftmD (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 6-hydroxytryprostatin B = S-adenosyl-L-homocysteine + tryprostatin A [RN:R10588]
Reaction(KEGG)
R10588
Substrate
S-adenosyl-L-methionine [CPD:C00019];
6-hydroxytryprostatin B [CPD:C20513]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
tryprostatin A [CPD:C20607]
Comment
Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
History
EC 2.1.1.293 created 2013
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18280  6-hydroxytryprostatin B O-methyltransferase
Genes
PPEIPpBr36_10525 PpBr36_10847
NHENECHADRAFT_63896
CHIGCH63R_06247
AFMAFUA_8G00200
NFINFIA_093710
AORAO090010000047
ANGANI_1_2036014(An01g15010)
AFVAFLA_013583
ALUCAKAW2_20014A AKAW2_50914A
APUUAPUU_60065A
TMFPMAA_001900 PMAA_100900
TRGTRUGW13939_04213 TRUGW13939_04351
ABEARB_02574 ARB_07989
TVETRV_04616 TRV_05502
PTEPTT_20107
 » show all
Reference
1  [PMID:23649274]
  Authors
Kato N, Suzuki H, Okumura H, Takahashi S, Osada H
  Title
A point mutation in ftmD blocks the fumitremorgin biosynthetic pathway in Aspergillus fumigatus strain Af293.
  Journal
Biosci Biotechnol Biochem 77:1061-7 (2013)
DOI:10.1271/bbb.130026
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.293
IUBMB Enzyme Nomenclature: 2.1.1.293
ExPASy - ENZYME nomenclature database: 2.1.1.293
BRENDA, the Enzyme Database: 2.1.1.293
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