| Entry |
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| Name |
methanethiol S-methyltransferase;
mddA (gene name)
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:methanethiol S-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + methanethiol = S-adenosyl-L-homocysteine + dimethyl sulfide [RN: R11546]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
methanethiol [CPD: C00409]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
dimethyl sulfide [CPD: C00580]
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| Comment |
The enzyme, found in many bacterial taxa, is involved in a pathway that converts L-methionine to dimethyl sulfide.
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| History |
EC 2.1.1.334 created 2016
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K21310 | methanethiol S-methyltransferase |
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| Genes |
| KAK: | Kalk_00940 Kalk_16030 |
| TTC: | FOKN1_0851 FOKN1_1887 |
| THIC: | TspCOW1_07630 TspCOW1_18210 |
| URU: | DSM104443_01185(mddA2) |
| BJA: | blr1218(blr1218) blr5741(blr5741) |
| BJU: | BJ6T_39950 BJ6T_86370 |
| BJP: | RN69_19390 RN69_41710 |
| BRAD: | BF49_4049 BF49_5906 |
| BOT: | CIT37_16210 CIT37_25595 CIT37_39470 |
| BRQ: | CIT40_02495 CIT40_20695 |
| BGQ: | X265_14955 X265_33805 |
| BSYM: | CIT39_00950 CIT39_07755 CIT39_20025 |
| BBET: | F8237_17865 F8237_19115 F8237_27600 |
| BARH: | WN72_32005 WN72_45170 |
| BBAN: | J4G43_033245 J4G43_034335 J4G43_048295 |
| BCAN: | BcanWSM471_05235 BcanWSM471_25480 |
| BCOU: | IC761_04600 IC761_33850 |
| BXN: | I3J27_03965 I3J27_24750 |
| BROS: | QUH67_11270 QUH67_12530 QUH67_23685 |
| BRAZ: | LRP30_07715 LRP30_39970 |
| BRAY: | ML401_03145 ML401_09475 ML401_21890 ML401_25655 |
| BLUP: | AB3L03_14605(mddA) AB3L03_27745(mddA) AB3L03_31180(mddA) |
| BRAN: | RX330_04120 RX330_30545 |
| BRAB: | RX331_12180 RX331_20320 |
| TARV: | FIU28_07425 FIU28_25840 |
| OAT: | OAN307_c35280 OAN307_c44610 OAN307_c45110 |
| SMED: | JNX03_02535 JNX03_19835 |
| SPHJ: | BSL82_06745 BSL82_19500 |
| RDI: | CMV14_24260 CMV14_25270 |
| ALTC: | P7228_09875 P7228_10860 |
| FER: | FNB15_06080 FNB15_08750 |
| LPAV: | PLANPX_1065 PLANPX_3038 PLANPX_3920 |
| AMUC: | Pan181_19040 Pan181_48760 |
| BMEI: | Spa11_04660 Spa11_43010 |
| TPLA: | ElP_34770 ElP_54920 |
| ABAC: | LuPra_00228 LuPra_03028 |
| LUB: | TBR22_A11690 TBR22_A21120 |
| RHOZ: | GXP67_16175 GXP67_16205 |
| MKN: | MKAN_17270 MKAN_21360 MKAN_26235 |
| MYE: | AB431_14970 AB431_23815 |
| MHAD: | B586_16210 B586_17385 |
| MPAG: | C0J29_07305 C0J29_19855 |
| MBAI: | MB901379_01199 MB901379_01267 |
| MCB: | Mycch_1328 Mycch_3521 Mycch_4537 |
| MAIC: | MAIC_09920 MAIC_26250 |
| MPHU: | MPHO_18500 MPHO_20060 |
| MPAE: | K0O64_14365 K0O64_23430 |
| MCRO: | MI149_15160 MI149_23840 |
| HALQ: | Hrr1229_016730 Hrr1229_017875 |
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| Reference |
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| Authors |
Carrion O, Curson AR, Kumaresan D, Fu Y, Lang AS, Mercade E, Todd JD |
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| Title |
A novel pathway producing dimethylsulphide in bacteria is widespread in soil environments. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.334 |
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| LinkDB |
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