KEGG   ENZYME: 2.1.1.336
Entry
EC 2.1.1.336                Enzyme                                 
Name
norbelladine O-methyltransferase;
N4OMT1 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:norbelladine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + norbelladine = S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine [RN:R08437]
Reaction(KEGG)
R08437
Substrate
S-adenosyl-L-methionine [CPD:C00019];
norbelladine [CPD:C16701]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
4'-O-methylnorbelladine [CPD:C16702]
Comment
The enzyme, characterized from the plants Nerine bowdenii and Narcissus pseudonarcissus (daffodil), participates in the biosynthesis of alkaloids produced by plants that belong to the Amaryllidaceae family.
History
EC 2.1.1.336 created 2016
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K21311  norbelladine O-methyltransferase
Genes
PDA: 103722554
EGU: 105032438
AOF: 109830129
MSIN: 131239507 131239508 131239510 131239511
NCOL: 116248520
Reference
1  [PMID:14109227]
  Authors
MANN JD, FALES HM, MUDD SH.
  Title
ALKALOIDS AND PLANT METABOLISM. VI. O-METHYLATION IN VITRO OF NORBELLADINE, A PRECURSOR OF AMARYLLIDACEAE ALKALOIDS.
  Journal
J Biol Chem 238:3820-3 (1963)
Reference
2  [PMID:25061748]
  Authors
Kilgore MB, Augustin MM, Starks CM, O'Neil-Johnson M, May GD, Crow JA, Kutchan TM
  Title
Cloning and characterization of a norbelladine 4'-O-methyltransferase involved in the biosynthesis of the Alzheimer's drug galanthamine in Narcissus sp. aff. pseudonarcissus.
  Journal
PLoS One 9:e103223 (2014)
DOI:10.1371/journal.pone.0103223
  Sequence
[ag:AIL54541]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.336
IUBMB Enzyme Nomenclature: 2.1.1.336
ExPASy - ENZYME nomenclature database: 2.1.1.336
BRENDA, the Enzyme Database: 2.1.1.336
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