KEGG   ENZYME: 2.1.1.356
Entry
EC 2.1.1.356                Enzyme                                 
Name
[histone H3]-lysine27 N-trimethyltransferase;
KMT6A (gene name);
KMT6B (gene name);
EZH1 (gene name);
EZH2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-trimethyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine27;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
Reaction(KEGG)
(other) R03875 R04866 R04867
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine27;
[histone H3]-N6-methyl-L-lysine27;
[histone H3]-N6,N6-dimethyl-L-lysine27
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine27;
[histone H3]-N6-methyl-L-lysine27;
[histone H3]-N6,N6-dimethyl-L-lysine27
Comment
This entry describes enzymes that successively methylate the L-lysine27 residue of histone H3 (H3K27), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. The methylation of lysine27 leads to transcriptional repression of the affected target genes. The enzyme associates with other proteins to form a complex that is essential for activity. The enzyme can also methylate some non-histone proteins. cf. EC 2.1.1.369, [histone H3]-lysine27 N-methyltransferase and EC 2.1.1.371, [histone H3]-lysine27 N-dimethyltransferase.
History
EC 2.1.1.356 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.356, modified 2020
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11430  [histone H3]-lysine27 N-trimethyltransferase EZH2
K17451  [histone H3]-lysine27 N-trimethyltransferase EZH1
Genes
HSA2145(EZH1) 2146(EZH2)
PTR454697(EZH1) 745437(EZH2)
PPS100967877(EZH1) 100971244(EZH2)
GGO101126515(EZH1) 101147968(EZH2)
PON100171872(EZH1) 100447447(EZH2)
NLE100580962(EZH2) 100604860(EZH1)
HMH116474881(EZH1) 116814486(EZH2)
MCC709075(EZH2) 711173(EZH1)
MCF102130547(EZH1) 102146280(EZH2)
MTHB126938434 126951580
MNI105472105(EZH1) 105474849(EZH2)
CSAB103227182(EZH2) 103243395(EZH1)
CATY105579681(EZH1) 105584692(EZH2)
PANU101001043(EZH2) 101009052(EZH1)
TGE112609092(EZH1) 112620861(EZH2)
MLEU105546371(EZH2) 105552946(EZH1)
RRO104667012(EZH2) 104680126(EZH1)
RBB108522307(EZH2) 108526767(EZH1)
TFN117066944(EZH1) 117072340(EZH2)
PTEH111537351(EZH1) 111551469(EZH2)
CANG105502991(EZH1) 105511283(EZH2)
CJC100394758(EZH2) 100411881(EZH1)
SBQ101038203(EZH1) 101051611(EZH2)
CIMI108285619(EZH2) 108289813(EZH1)
CSYR103259718(EZH2) 103270693(EZH1)
MMUR105859397(EZH1) 105873325(EZH2)
LCAT123620971(EZH1) 123647560(EZH2)
PCOQ105820263(EZH1) 105824626(EZH2)
OGA100953538(EZH1) 100961114(EZH2)
MMU14055(Ezh1) 14056(Ezh2)
MCAL110295592(Ezh2) 110304611(Ezh1)
MPAH110315211(Ezh2) 110331872(Ezh1)
RNO303547(Ezh1) 312299(Ezh2)
MCOC116078739(Ezh1) 116098837(Ezh2)
ANU117710591(Ezh1) 117720944(Ezh2)
MUN110547503(Ezh2) 110550881(Ezh1)
CGE100758055(Ezh2) 100760595(Ezh1)
MAUA101824592(Ezh2) 101829787(Ezh1)
PROB127214236(Ezh2) 127216130 127216586(Ezh1)
PLEU114682787(Ezh1) 114698004(Ezh2)
MORG121433641(Ezh2) 121442390(Ezh1)
MFOT126510201 126515091
AAMP119807752(Ezh2) 119811825(Ezh1)
NGI103731383(Ezh2) 103735912(Ezh1)
HGL101702710(Ezh2) 101723063(Ezh1)
CPOC100713765(Ezh2) 100720693(Ezh1)
CCAN109687337(Ezh1) 109695508(Ezh2)
DORD105989599(Ezh2) 106003218(Ezh1)
DSP122103240(Ezh1) 122105935(Ezh2)
PLOP125347276(Ezh2) 125365186(Ezh1)
NCAR124979151 124991619
MMMA107148970(Ezh2) 107150556(Ezh1)
OCU100345157 100351852
OPI101528017(EZH2) 101532815(EZH1)
TUP102485788(EZH1) 102495627(EZH2)
GVR103589846(EZH1) 103592394(EZH2)
CFA475511(EZH2) 480516(EZH1)
CLUD112650879(EZH2) 112655496(EZH1)
VVP112910738(EZH1) 112934818(EZH2)
VLG121473241(EZH1) 121489952(EZH2)
NPO129508144(EZH1) 129515846(EZH2)
AML100466177(EZH2) 100472619(EZH1)
UMR103668955(EZH2) 103672584(EZH1)
UAH113241452(EZH2) 113265406(EZH1)
UAR123781811(EZH1) 123788819(EZH2)
ELK111151338 111154333
LLV125080977 125087359
MPUF101683241(EZH1) 101684407(EZH2)
MNP132004387(EZH1) 132015600(EZH2)
MLK131816628(EZH1) 131829906(EZH2)
NVS122905177(EZH2) 122906181(EZH1)
ORO101369941(EZH2) 101379551(EZH1)
EJU114201361(EZH1) 114211667(EZH2)
ZCA113911424(EZH2) 113939411(EZH1)
MLX118021219(EZH2) 118024929(EZH1)
NSU110573309(EZH1) 110582991(EZH2)
LWW102745380 102750824
FCA101087309(EZH2) 101099602(EZH1)
PYU121028154(EZH2) 121045039(EZH1)
PCOO112854058(EZH1) 112866486(EZH2)
PBG122485620(EZH1) 122488472(EZH2)
PVIV125157254(EZH2) 125158457(EZH1)
LRUF124522075 124524657
PTG102956220(EZH2) 102961028(EZH1)
PPAD109258535(EZH1) 109269218(EZH2)
PUC125927686 125930933
AJU106972615 106981407
HHV120246406(EZH2) 120248460(EZH1)
BTA509106(EZH2) 533087(EZH1)
BOM102276653(EZH1) 102287858(EZH2)
BIU109557756(EZH2) 109573994(EZH1)
BBUB102405899(EZH2) 102407322(EZH1)
BBIS104990428(EZH1) 104991414(EZH2)
CHX102189343(EZH1) 102190101(EZH2)
OAS101104765(EZH1) 101120745(EZH2)
BTAX128046386(EZH2) 128064455(EZH1)
ODA120867077(EZH1) 120877871(EZH2)
CCAD122438829(EZH2) 122441439(EZH1)
MBEZ129544439(EZH1) 129552745(EZH2)
SSC100518394(EZH1) 100625497(EZH2)
CFR102515793(EZH2) 102516907(EZH1)
CBAI105068876(EZH2) 105080100(EZH1)
CDK105085196(EZH2) 105090473(EZH1)
VPC102524655(EZH2) 102537185(EZH1)
BACU103011369(EZH2) 103015379 103020966
BMUS118886863(EZH1) 118900748(EZH2)
LVE103069623(EZH2) 103073364(EZH1)
OOR101280796(EZH2) 101285746(EZH1)
DLE111166246(EZH1) 111177205(EZH2)
PCAD102994010(EZH2) 102994197(EZH1)
PSIU116745673(EZH1) 116759057(EZH2)
NASI112398349(EZH1) 112398358(EZH2)
ECB100051290(EZH2) 100052411(EZH1)
EPZ103550351(EZH1) 103553703(EZH2)
EAI106826432(EZH1) 106842131(EZH2)
MYB102246299(EZH2) 102259730(EZH1)
MYD102755313(EZH1) 102768989(EZH2)
MMYO118666288(EZH2) 118671482(EZH1)
MLF102417096(EZH1) 102418971(EZH2)
PKL118714189(EZH2) 118726309(EZH1)
EFUS103293078(EZH1) 103297250(EZH2)
MNA107523768(EZH2) 107528927(EZH1)
DRO112298572(EZH1) 112308348(EZH2)
SHON118978195(EZH1) 118979486(EZH2)
AJM119051022(EZH2) 119051949(EZH1)
PDIC114502985(EZH1) 114507788(EZH2)
PHAS123815339(EZH2) 123817024(EZH1)
MMF118619754(EZH2) 118633783(EZH1)
PPAM129063401(EZH2) 129086995(EZH1)
HAI109395452(EZH2) 109395755(EZH1)
RFQ117012939(EZH1) 117018256(EZH2)
PALE102879627(EZH1) 102886689(EZH2)
PGIG120601486(EZH2) 120611077(EZH1)
PVP105295713(EZH2) 105306277(EZH1)
RAY107500533(EZH2) 107513838(EZH1)
MJV108386069(EZH1) 108386657(EZH2)
TOD119230360(EZH1) 119248372(EZH2)
SARA101550762(EZH2) 101556796(EZH1)
SETR126003266(EZH2) 126003373 126017177(EZH1)
LAV100664312(EZH2) 100673691(EZH1)
TMU101359039 101360468
ETF101647365(EZH2) 101658357(EZH1)
DNM101416064(EZH2) 101440065(EZH1)
MDO100010738(EZH1) 100013390(EZH2)
GAS123247838(EZH1) 123249372(EZH2)
SHR100926678(EZH2) 100932535(EZH1)
AFZ127560106 127564894
PCW110198374(EZH1) 110201666(EZH2)
OAA100073485(EZH2) 100082851(EZH1)
GGA420023(EZH1) 420784(EZH2)
PCOC116228276(EZH2) 116233592(EZH1)
MGP100540374(EZH2) 100547448(EZH1)
CJO107309835(EZH2) 107325326(EZH1)
TPAI128087776(EZH2) 128089108(EZH1)
LMUT125684708(EZH1) 125690558(EZH2)
NMEL110388515(EZH1) 110390789(EZH2)
APLA101791765(EZH1) 101793453(EZH2)
ACYG106048025(EZH1) 106048735(EZH2)
CATA118250933(EZH2) 118259168(EZH1)
AFUL116486423(EZH2) 116498539(EZH1)
TGU100226728(EZH2) 100227472(EZH1)
LSR110471820(EZH1) 110479186(EZH2)
SCAN103819367(EZH2) 103821570(EZH1)
PMOA120496610(EZH1) 120504998(EZH2)
OTC121346974(EZH2) 121347663(EZH1)
PRUF121351146(EZH1) 121352851(EZH2)
GFR102035477(EZH1) 102038673(EZH2)
FAB101809240(EZH2) 101811414(EZH1)
OMA130248948(EZH2) 130263963(EZH1)
PHI102099930(EZH2) 102103576(EZH1)
PMAJ107200653(EZH2) 107215126(EZH1)
CCAE111923642(EZH2) 111940096(EZH1)
CCW104688925(EZH2) 104697765(EZH1)
CBRC103615761(EZH2) 103621230(EZH1)
ETL114063607(EZH1) 114063865(EZH2)
ZAB102064406(EZH2) 102071551(EZH1)
ZLE135443151(EZH2) 135458672(EZH1)
ACHL103801322(EZH1) 103805215(EZH2)
SVG106858696(EZH1) 106860688(EZH2)
MMEA130581428(EZH1) 130584536(EZH2)
HRT120752327(EZH2) 120763768(EZH1)
FPG101911332(EZH2) 101915579(EZH1)
FCH102052374(EZH1) 102055584(EZH2)
CLV102093761(EZH2) 102097006(EZH1)
EGZ104125781(EZH2) 104134781(EZH1)
NNI104009878(EZH1) 104015388(EZH2)
PCRI104034436(EZH1) 104035749(EZH2)
PLET104614357(EZH1) 104625737(EZH2)
EHS104508378(EZH2)
PCAO104052172(EZH2)
ACUN113477549(EZH2) 113489070
TALA104356937(EZH2) 104365743 122152827
PADL103916088(EZH2) 103919098(EZH1)
AFOR103895384(EZH2) 103901881(EZH1)
ACHC115339606(EZH2) 115344618(EZH1)
HALD104315060 104322961(EZH1)
HLE104828376(EZH2) 104842949(EZH1)
AGEN126038535 126045481
GCL127013221 127026423
CCRI104160341 104166555(EZH2)
CSTI104557499(EZH1)
CMAC104483036(EZH2) 104487486(EZH1)
MUI104537004(EZH2) 104545865(EZH1)
BREG104633949(EZH2) 104641591
FGA104077897(EZH1) 104083691(EZH2)
GSTE104254098(EZH2) 104261338(EZH1)
LDI104342534(EZH1) 104343715(EZH2)
MNB103776905(EZH2)
OHA104334077(EZH2) 104338691(EZH1)
NNT104402768(EZH2)
SHAB115617636(EZH1) 115617674(EZH2)
DPUB104298305(EZH2) 104309571(EZH1)
PGUU104467158(EZH2)
ACAR104525061
CPEA104385652(EZH1) 104392172(EZH2)
AVIT104278791(EZH2)
CVF104295308(EZH2) 104295343(EZH1)
RTD128906343(EZH2) 128919318(EZH1)
CUCA104054392(EZH1) 104065929(EZH2)
TEO104375779(EZH1) 104380061(EZH2)
BRHI104495767(EZH2)
AAM106491114(EZH1) 106495267(EZH2)
AROW112968758(EZH1) 112970378(EZH2)
NPD112942708(EZH2) 112951845(EZH1)
TGT104567375(EZH2) 104578212(EZH1)
DNE112995826(EZH1) 112997513(EZH2)
SCAM104150320(EZH2) 104153616(EZH1)
ASN102372569(EZH2) 102383438(EZH1)
AMJ102562122(EZH2) 102566481(EZH1)
CPOO109313034(EZH2) 109320378(EZH1)
GGN109289608(EZH1) 109291897(EZH2)
PSS102453330(EZH2) 102463087(EZH1)
CMY102932650(EZH2) 102934538(EZH1)
CCAY125626681(EZH1)
DCC119848921(EZH1) 119851691(EZH2)
CPIC101934118(EZH1) 101937752(EZH2)
TST117869136(EZH1) 117872630(EZH2)
CABI116820359(EZH1) 116825808(EZH2)
MRV120392159(EZH1) 120397786(EZH2)
ACS100559669(ezh1) 100564989(ezh2)
ASAO132778389(EZH1) 132778518(EZH2)
PVT110080273(EZH1) 110088673(EZH2)
SUND121932530(EZH2) 121934119(EZH1)
PBI103051581(EZH2) 103052924(EZH1)
PMUR107288847(EZH2) 107290401 107302416(EZH1)
CTIG120301016(EZH1) 120316554(EZH2)
TSR106547020(EZH2) 106554239(EZH1)
PGUT117664836(EZH1) 117664971(EZH2)
APRI131197311(EZH1) 131197792(EZH2)
PTEX113437363(EZH2) 113447275(EZH1)
NSS113420059(EZH1) 113421522(EZH2)
VKO123031879(EZH1) 123035557(EZH2)
PMUA114581626(EZH1) 114607413(EZH2)
PRAF128398552(EZH2) 128400001(EZH1)
ZVI118077677(EZH2) 118094881(EZH1)
HCG128330017(EZH1) 128331826(EZH2)
GJA107119624(EZH2) 107123351(EZH1)
STOW125441240(EZH2)
EMC129337484(EZH2) 129338808(EZH1)
XLA100381148(ezh2.S) 108701022(ezh1.L) 108702719(ezh1.S) 399174(ezh2.L)
XTR100493532(ezh1) 550047(ezh2)
NPR108794364(EZH2) 108796324(EZH1)
RTEM120918306(EZH1) 120940356(EZH2)
BBUF121001574(EZH2) 121004042(EZH1)
BGAR122938454(EZH2) 122941062(EZH1)
MUO115470435(EZH2) 115481816(EZH1)
GSH117347407(EZH1) 117353865(EZH2)
DRE664754(ezh1) 768133(ezh2)
SRX107720007 107721487 107727220 107741938
SANH107654511 107686697(ezh2) 107688127 107695380
SGH107549206 107590376 107595131 107601290
CCAR109057529 109074719(ezh2) 109102790
CAUA113042268 113046841 113066022 113097179
CGIB127946210 127951387 127952888 128013173
PTET122329728(ezh2) 122342087(ezh1)
LROH127155628(ezh2) 127163486(ezh1)
OMC131532968(ezh2) 131536328(ezh1)
PPRM120475953(ezh2) 120489865(ezh1)
RKG130076064(ezh1) 130087642(ezh2)
MAMB125258300(ezh2) 125271852(ezh1)
CIDE127505796 127509033
MASI127431759 127434185 127449771 127451124
TROS130547163(ezh2) 130561746(ezh1)
TDW130413153(ezh2) 130426412(ezh1)
MANU129425704(ezh2) 129433583(ezh1) 129433788
IPU108256455 108279279
IFU128599471(ezh2) 128603001(ezh1)
PHYP113528051(ezh1) 113541351(ezh2)
SMEO124375475(ezh2) 124396605(ezh1)
TFD113652122(ezh1) 113660270(ezh2)
TVC132840289(ezh2) 132861544(ezh1)
TRN134300051(ezh1) 134301131(ezh2)
AMEX103027230(ezh2) 103044086(ezh1)
CMAO118798962(ezh2) 118820890(ezh1)
EEE113589064(ezh2) 113590056
CHAR105898624(ezh1) 105905243(ezh2)
TRU101068728(ezh2) 101070195(ezh1)
TFS130513649(ezh2) 130514975(ezh1)
TNGGSTEN00022022G001
LCO104923910(ezh1) 104933871(ezh2)
NCC104940789(ezh2) 104944052
TBEN117493372(ezh1) 117495748(ezh2)
CGOB115012089(ezh1)
PGEO117451145(ezh1) 117465631(ezh2)
GACU117539161(ezh2) 117548328(ezh1)
EMAC134878111(ezh1) 134884098(ezh2)
ELY117264665(ezh2) 117268570(ezh1)
EFO125880116(ezh1) 125881496(ezh2)
PLEP121956843(ezh1) 121960957(ezh2)
SLUC116053723(ezh2) 116059672(ezh1)
ECRA117957411(ezh1)
ESP116702481(ezh1)
PFLV114548931(ezh2) 114569339(ezh1)
GAT120811509 120811957 120828335(ezh1)
PPUG119198295(ezh2) 119220821(ezh1)
AFB129097979(ezh1) 129110715(ezh2)
CLUM117734833(ezh1) 117749840(ezh2)
PSWI130188705(ezh1) 130205958(ezh2)
MSAM119892146(ezh1) 119896631(ezh2)
SCHU122866432(ezh2) 122868348(ezh1)
CUD121527226(ezh2) 121529431(ezh1)
ALAT119009068(ezh2) 119014259(ezh1)
MZE101464777 101474304(ezh1) 112429845(ezh2)
ONL100695015(ezh1) 100702594(ezh2)
OAU116312482(ezh1) 116329347(ezh2)
OLA100125823(ezh2) 101166385(ezh1)
OML112146093(ezh1) 112152487(ezh2)
CSAI133421960(ezh1) 133423128(ezh2)
XMA102218572(ezh2) 102228014(ezh1)
XCO114136427(ezh2) 114160264(ezh1)
XHE116712102(ezh2) 116735642(ezh1)
PRET103457011(ezh2) 103468644(ezh1) 103469387
PFOR103131053(ezh2) 103142220
PLAI106952635 106961042(ezh2)
PMEI106917493(ezh1) 106927381(ezh2)
GAF122821237(ezh1) 122824393(ezh2)
PPRL129352499(ezh1) 129354400 129378965
CVG107091776(ezh1) 107097879(ezh2)
CTUL119778867(ezh1) 119791669(ezh2)
GMU124858145(ezh2) 124863422 124864203
NFU107378461(ezh1) 107383138(ezh2)
KMR108243802(ezh1) 108249555(ezh2)
ALIM106528219(ezh1) 106531656(ezh2)
NWH119421914(ezh1) 119426627(ezh2)
AOCE111564547(ezh1) 111570645(ezh2)
MCEP124998234(ezh1) 125024464(ezh2)
CSEM103377188(ezh2) 103393149(ezh1)
POV109634330(ezh1)
SSEN122776786(ezh2) 122785080(ezh1)
HHIP117753555(ezh2) 117765699(ezh1)
HSP118098326(ezh2) 118123196(ezh1)
PPLT128425901(ezh2) 128458042(ezh1)
SMAU118288457(ezh1) 118291307(ezh2)
LCF108884998 108900993
SDU111217595(ezh1) 111238320(ezh2)
SLAL111647273(ezh2) 111660565(ezh1)
XGL120785995(ezh1) 120789563(ezh2)
HCQ109508596 109521815(ezh2)
SSCV125983811 125986045
SBIA133492409(ezh2) 133514174(ezh1)
PEE133396535(ezh2) 133414903(ezh1)
PTAO133465488(ezh1) 133470168(ezh2)
BPEC110158320(ezh2) 110166859(ezh1)
MALB109951056(ezh2) 109964204(ezh1)
BSPL114852915(ezh2) 114859794(ezh1)
SJO128378277(ezh1) 128382102(ezh2)
SASA106578387(ezh2) 106590561 106601045 106607313
STRU115152097(ezh2) 115171134 115195415 115198163
OTW112215484(ezh2) 112226003 112258676(ezh1)
OMY110486277 110535410(ezh2) 110538212
OGO123991259(ezh2) 123999293 124015525
ONE115104148 115105003(ezh2) 115110290 115116302
OKI109891924 109898438 109909923(ezh2)
OKE118361674(ezh2) 118365283 118369743 118370832
SALP111972867(ezh2) 111980227
SNH120027757(ezh2) 120034253 120036107 120050935
CCLU121549776(ezh2) 121550571 121569320 121569566
ELS105013194(ezh1) 105022040(ezh2)
SFM108919665 108928200 108935505 108941744
PKI111834007 111842507 111854999 111855907
AANG118221790(ezh1) 118225181 118233043
LOC102691488(ezh2) 102693111(ezh1)
PSPA121301885(ezh1) 121312792(ezh2) 121314254 121324064
ARUT117400656 117433259(ezh1) 117434945 117435499(ezh2)
PSEX120518228(ezh1) 120529475(ezh2)
LCM102364190(EZH1)
CMK103187005(ezh2)
RTP109916301(ezh2)
CPLA122550253(ezh2)
HOC132815737(ezh2) 132830997(ezh1)
LERI129710221(ezh2)
PMRN116941022(EZH2)
LRJ133344794(EZH2)
BFO118425900
BBEL109467729
CIN100177449
SCLV120335278
SPU585842
LPIC129259114
APLC110990448
AJC117112530
DMEDmel_CG6502(E(z))
DER6546346
DSE6605167
DSIDsimw501_GD12857(Dsim_GD12857)
DYADyak_GE20265
DAN6506463
DSR110185151
DPO4813247
DPE6601386
DMN108151423
DWI6646360
DGR6558285
DMODmoj_GI13833
DAZ108614083
DNV108652219
DHE111599772 115483471
DVI6624012
CCAT101455440
BOD106619558
BDR105232803
RZE108370183
AOQ129240184
TDA119666991 119687883 119688054 119688144 119688147
MDE101887292 131800424
SCAC106087388
LCQ111677283
LSQ119614536
GFS119645251
ECOE129941674
CLON129610358
HIS119648857
AGA1268848
ACOZ120948731
AARA120893279
AMER121591956 121602658
ASTE118510092
AFUN125770027
AMOU128301631
AALI118467385
AAG5577466
AALB109401157
ASUA134225247
CQUCpipJ_CPIJ006484
CPII120416716 128092797
CNS116340857 116344071
BCOO119068923 119078807 119080015
AME552235
ALAB122713477
ADR102678011
AFLR100867952
BIM100747000
BBIF117207732
BVK117238218
BVAN117159968
BTER100647736
BAFF126919935
BPYO122570473
BPAS132905833
FVI122533983
CCAL108631087
OBB114880742
OLG117606141
MGEN117228010
NMEA116428165
CGIG122404142
SOC105197183
MPHA105835069
AEC105143480
ACEP105617407
PBAR105425935
VEM105559070
HST105184373
DQU106746421
CFO105250747
FEX115233373
LHU105670949
PGC109855910
OBO105285382
PCF106792137
PFUC122525409
VPS122635282
VCRB124431562
VVE124954996
NVI100113526
CSOL105367879
TPRE106651387
LHT122499779 122511656
LBD127277752 127279198
MDL103577404
CGLO123262913
FAS105265326
DAM107046807
AGIF122853050
CINS118068514
VCAN122415890
CCIN107267176
DSM124404333
NPT124211689
NFB124175319
NLO107219792
NVG124297568
AROA105693746
TCA659759
DPA109536169
SOY115874701
AGRG126747677
ATD109608998
CSET123319971
AGB108913249 108915184
LDC111504696
DVV114329981
NVL108560889
APLN108742245
PPYR116173810
OTU111413774
BMOR101745450
BMAN114243273
MSEX115452002
DPLKGM_212341
BANY112043421
MJU123868174
NIQ126774368
VCD124536144
MCIX123659464
PMAC106718913
PPOT106100291
PXU106121339
PRAP110995414
PBX123709915
PNAP125048650
ZCE119840822
CCRC123694626
LSIN126976658
AAGE121739447
HAW110375985
HZE124634857
TNL113498098
SLIU111358949
OFU114359841
ATRA106133305
PGW126372734
LGLY125232110
CFEL113384451 113384584
API100168406
DNX107161946
AGS114123060
RMD113551950
ACOO126846688
DVT126895354
BTAB109035984
DCI103523265 103523266
CLEC106666006
HHAL106683851
NLU111049820
HVI124354234
MQU128993213 128993334
PHUPhum_PHUM294210
FOC113217481
TPAL117641471
ZNE110841374
CSEC111869805
SGRE126355235
BROR134546159
IEL124155376
FCD110843965 110857006
DPXDAPPUDRAFT_300071
DMK116918493
DPZ124343142
PJA122252149
PCHN125041678
PMOO119581855
HAME121853532
PCLA123775372
CQD128684118
PTRU123519778
ESN126982068
MNZ135217736
HAZT108673784
EAF111715319
LSM121115248
TCF131893215
PPOI119106231
ISC8034361
DSV119441781
RSAN119378928
RMP119181087
VDE111251585
VJA111260309
TUT107365534
DPTE113792645
DFR124492770
PTEP107455687
ABRU129984254
UDV129225237
SDM118181810
LPOL106461894 106462330
CELCELE_R06A4.7(mes-2)
CBRCBG_00165 CBG_02150 CBG_05455 CBG_11099(Cbr-mes-2)
CRQGCK72_004674 GCK72_025986
BMYBM_BM5240(Bma-mes-2)
LOALOAG_00180
LGILOTGIDRAFT_200654
PVUL126832116
PCAN112556350
BGT106059787
GAE121385465
HRF124150131
HRJ124262532
CRG105330640
CVN111123912
CANU128193017
OED125678862
MYI110442389
PMAX117318179
MCAF127717617
MMER123529371
RPHI132732154 132732499
DPOL127877252
OBI106874217
OSN115219651
LJP135464656
LAK106181368
LLON135499688
NVE5501069
EPA110249650
ATEN116290023
ADF107350429
AMIL114967312
PDAM113673889
SPIS111323365
DGT114531596
XEN124452547
HMG100201207
HSY130641372
TADTRIADDRAFT_54464
ATHAT4G02020(SWN)
ALY9311013
CRB17882618
CSAT104707901 104713584 104737584
EUSEUTSA_v10028423mg
BRP103836786
BNA106426666 106435598
BOE106319095
RSZ108825666
THJ104825939
CPAP110819540
CIT102606927
CICCICLE_v10018849mg
PVY116118256
MINC123223850
TCC18613700
GRA105764061
GHI107940563 107945999
GAB108479536
HSYR120173651 120182107
DZI111283842 111304998 111314069
EGR104456681
GMX100795451 100808730
GSJ114370487 114378397
PVUPHAVU_007G213900g
VRA106772407
VAR108326306
VUN114191522
VUM124843994
CCAJ109808053
APRC113871144
MTR11427647
TPRA123903060
CAM101502118
PSAT127097815
VVO131643959
LJALj5g3v1598420.1(Lj5g3v1598420.1) Lj5g3v1598420.2(Lj5g3v1598420.2) Lj5g3v1598420.3(Lj5g3v1598420.3) Lj5g3v1598420.4(Lj5g3v1598420.4)
ADU107464955
AIP107617664
AHF112710560 112777406
LANG109346276
PCIN129306511
QSAO6P43_010861
FVE101297254
RCN112175251
PPER18768715
PMUM103334006
PAVI110749358
PDUL117637147
MDM103432626 103449206
MSYL126590143 126617321
PXB103938338 103967180
ZJU107426143
MNT21393062
CSAV115707433
CSV101219756
CMO103494730
BHJ120090993
MCHA111022418
CMAX111492820
CMOS111452363
CPEP111788624
RCU8267339
JCU105642627
HBR110639819 110657868
MESC110613259
POP7455428 7481403
PEU105137192 105137984
PALZ118041065 118046868
JRE109007312 109007313
CILL122315722 122318333
CAVE132170356
QSU112038731
QLO115972544
TWL120000074
VVI100255466
VRI117918012
SLY100134891(EZ1)
SPEN107001506
SOT102598283
SSTN125851298
SDUL129887109
CANN107840794
LBB132644930
NTA107769800 107801572
NSY104232085
NTO104099615
NAU109225973
INI109191258
ITR116004606
SIND105165191
OEU111377026 111411753
EGT105955031
SSPL121740851 121786771
SMIL131000363
SHIS125222555
APAN127258826
HAN110936360
ECAD122593656
LSV111896585
CCAV112507709
DCR108205006
CSIN114315404
RVL131314430
AEW130751223
BVG104894773
SOE110776989
CQI110733034
ATRI130797594
MOF131156775
NNU104598779
MING122090550
TSS122659648
PSOM113346922
OSA4332612 4340748
DOSAOs03t0307800-01(Os03g0307800) Os06t0275500-01(Os06g0275500)
OBR102702548 102706390
OGL127767491 127776745
BDI100832275 100846057
ATS109742834 109781665
TDC119285509 119296293 119332633 119335528
TAES123085669 123092326 123097675 123149880 123161470 123164379
TUA125521330 125551908 125551964
LPER127293421 127295609
LRD124700106 124700491 124702220
SBI8070885 8083989
ZMA541954 541955 542659
SITA101782952 101784446
SVS117837308 117852666
PVIR120652612 120670018 120690547 120702724
PHAI112875021 112890741
PDA103724029
EGU105057349
MUS103996916
ZOF122012549 122015196
DCT110098601
PEQ110031838
AOF109848223
MSIN131231909
NCOL116262371
ATR18430224
MBRMONBRDRAFT_30718
TPSTHAPSDRAFT_268872
PIFPITG_10068
PSOJPHYSODRAFT_491036
 » show all
Reference
1  [PMID:12351676]
  Authors
Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y
  Title
Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
  Journal
Science 298:1039-43 (2002)
DOI:10.1126/science.1076997
  Sequence
[hsa:2146]
Reference
2  [PMID:12435631]
  Authors
Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D
  Title
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.
  Journal
Genes Dev 16:2893-905 (2002)
DOI:10.1101/gad.1035902
  Sequence
[hsa:2146]
Reference
3  [PMID:15231737]
  Authors
Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R, Farnham PJ
  Title
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.
  Journal
Genes Dev 18:1592-605 (2004)
DOI:10.1101/gad.1200204
  Sequence
[hsa:2146]
Reference
4  [PMID:17200670]
  Authors
Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, Eden E, Yakhini Z, Ben-Shushan E, Reubinoff BE, Bergman Y, Simon I, Cedar H
  Title
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo  methylation in cancer.
  Journal
Nat Genet 39:232-6 (2007)
DOI:10.1038/ng1950
  Sequence
[hsa:2146]
Reference
5  [PMID:19026780]
  Authors
Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH
  Title
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
  Journal
Mol Cell 32:491-502 (2008)
DOI:10.1016/j.molcel.2008.10.016
  Sequence
[mmu:14055 14056]
Reference
6  [PMID:21317239]
  Authors
Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E
  Title
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.
  Journal
Genes Dev 25:485-98 (2011)
DOI:10.1101/gad.2019811
  Sequence
[mmu:14055 14056]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.356
IUBMB Enzyme Nomenclature: 2.1.1.356
ExPASy - ENZYME nomenclature database: 2.1.1.356
BRENDA, the Enzyme Database: 2.1.1.356
LinkDB

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