KEGG   ENZYME: 2.1.1.361
Entry
EC 2.1.1.361                Enzyme                                 
Name
[histone H4]-lysine20 N-methyltransferase;
KMT5A (gene name);
SET8 (gene name);
PR-SET7 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 = S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20
Reaction(KEGG)
(other) R03875
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H4]-L-lysine20
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H4]-N6-methyl-L-lysine20
Comment
The enzyme catalyses the monomethylation of the L-lysine20 residue of histone H4 (H4K20). This event is usually followed by further methylation by EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase. This enzyme plays a pivotal role in DNA replication. Activity is high during the G2 and M phases, but declines significantly during G1 and S phases. Mutations in the enzyme have severe consequences, including DNA double-strand breaks, activation of DNA damage checkpoints, defective cell cycle progression, and reduced cell proliferation.
History
EC 2.1.1.361 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.361
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11428  [histone H4]-lysine20 N-methyltransferase SETD8
K20795  [histone H4]-lysine20 N-methyltransferase PRDM6
Genes
HSA387893(KMT5A) 93166(PRDM6)
PTR452343(KMT5A) 742318(PRDM6)
PPS100978154 100982491(PRDM6) 100986737(KMT5A) 117978852
GGO101143097(PRDM6) 101145513(KMT5A)
PON100451760(KMT5A) 100460132(PRDM6)
PPYG129010500(KMT5A) 129036743(PRDM6)
NLE100579681(PRDM6) 100580339(KMT5A)
HMH116470339(PRDM6) 116477743(KMT5A)
MCC703499(PRDM6) 709345(KMT5A)
MCF102128021(KMT5A) 102142246(PRDM6)
MTHB126930652 126957524
MNI105463145(PRDM6) 105494001(KMT5A)
CSAB103239328(KMT5A) 103244427(PRDM6)
CATY105591004(SETD8) 105599677(PRDM6)
PANU101010043(KMT5A) 101014277(PRDM6)
TGE112625690(PRDM6) 112635259(KMT5A)
MLEU105528012(SETD8) 105545038(PRDM6)
RRO104660930(PRDM6) 104666320(KMT5A)
RBB108520391(PRDM6) 108540752(KMT5A)
TFN117065954(PRDM6) 117080344 117089217(KMT5A)
PTEH111527675(PRDM6) 111538508 111539563
CANG105516385(SETD8) 105526098 105527423(PRDM6)
CJC100411011(PRDM6) 100414548(KMT5A)
SBQ101040690(SETD8) 101047827(PRDM6)
CIMI108294847 108306767(PRDM6) 108315116(KMT5A)
ANAN105704644 105713398(KMT5A) 105714374(PRDM6)
CSYR103271959(KMT5A) 103275779(PRDM6)
MMUR105880868(KMT5A) 105884549(PRDM6)
LCAT123626118(KMT5A) 123648463(PRDM6)
PCOQ105825686(SETD8) 105826327(PRDM6)
OGA100940536(KMT5A) 100963252(PRDM6)
MMU225518(Prdm6) 67956(Kmt5a)
MCAL110284774(Prdm6) 110295130(Kmt5a)
MPAH110312821(Kmt5a) 110333293(Prdm6)
RNO100361623(Kmt5al2) 100909949(Kmt5al1) 288346(Kmt5al3) 307305(Prdm6) 689820(Kmt5a)
MCOC116068429(Kmt5a) 116087169(Prdm6)
ANU117698248(Kmt5a) 117719895(Prdm6)
MUN110552670(Kmt5a) 110559610(Prdm6)
CGE100773424(Prdm6) 100774411(Kmt5a)
MAUA101824166 101824988(Kmt5a) 101825910(Prdm6)
PROB127234198(Prdm6) 127237018(Kmt5a)
PLEU114686055 114694780(Prdm6) 114704516(Kmt5a)
MORG121437304 121441958 121446283(Kmt5a) 121453606
MFOT126504306 126506031
AAMP119815859(Prdm6) 119825159(Kmt5a)
NGI103738642(Prdm6) 103739033(Kmt5a)
HGL101720211(Prdm6) 101726359(Kmt5a)
CPOC100734404(Kmt5a)
CCAN109683525(Kmt5a) 109694403(Prdm6)
DORD105985212(Prdm6) 105990613(Setd8)
DSP122098573(Kmt5a) 122103832(Prdm6)
PLOP125349195(Kmt5a) 125351358(Prdm6)
NCAR124987672 124990908
MMMA107155481(Prdm6) 107156385(Kmt5a)
OCU100347868 100354345 100354805
OPI101516912(PRDM6) 101521103(KMT5A)
TUP102471250(KMT5A) 102489496(PRDM6)
GVR103585529(PRDM6) 103606858(SETD8)
CFA100687856(PRDM6) 610615(KMT5A)
CLUD112649926(PRDM6) 112676464
VVP112910203(PRDM6)
VLG121494210(PRDM6)
NPO129494975(PRDM6) 129507931(KMT5A)
AML100481447(PRDM6) 100482312(KMT5A)
UMR103661256(KMT5A) 103670579(PRDM6)
UAH113261649(PRDM6) 113266900(KMT5A)
UAR123779868(KMT5A) 123790588(PRDM6)
ELK111148449 111156510
LLV125082151 125101087
MPUF101672174(PRDM6) 101688179(SETD8)
MNP132023093(KMT5A) 132028028(PRDM6)
MLK131811166(KMT5A) 131832558(PRDM6)
NVS122903070(KMT5A) 122916431(PRDM6)
ORO101370999(PRDM6) 101380066(SETD8)
EJU114200359(KMT5A) 114209391(PRDM6)
ZCA113912844(KMT5A) 113929417(PRDM6)
MLX118016573(PRDM6) 118018398(KMT5A)
NSU110588347(KMT5A) 110591103(PRDM6)
LWW102739906(KMT5A)
FCA101084511(PRDM6) 101086008(KMT5A)
PYU121010394(KMT5A) 121010609(PRDM6)
PCOO112860693(PRDM6) 112870284(KMT5A)
PBG122470153(KMT5A) 122486759(PRDM6)
PVIV125149201(KMT5A) 125174873(PRDM6)
LRUF124518212 124522439
PTG102956571(PRDM6) 102962714(KMT5A)
PPAD109277736(KMT5A) 109278870(PRDM6)
PUC125914249 125935443
AJU106967577 106975271
HHV120236767(KMT5A) 120246097(PRDM6)
BTA519857(PRDM6) 532622(KMT5A)
BOM102264795(KMT5A) 102279737(PRDM6)
BIU109560980 109561855 109571313(KMT5A)
BBUB102392447(KMT5A) 102401941(PRDM6)
BBIS104989668(SETD8) 104993167(PRDM6)
CHX102176319(PRDM6) 102183718(KMT5A)
OAS101103235(PRDM6) 101122308(KMT5A)
BTAX128051594(PRDM6) 128062161(KMT5A)
ODA120864690(PRDM6) 120871058(KMT5A)
CCAD122424360(KMT5A) 122440092(PRDM6)
MBEZ129542239(KMT5A) 129559287(PRDM6)
SSC100524509(PRDM6) 100626555(KMT5A)
CFR102513845(PRDM6) 102521782(KMT5A)
CBAI105080660(SETD8) 105082233(PRDM6)
CDK105102547(KMT5A) 105105065(PRDM6)
VPC102527939(KMT5A) 116278202(PRDM6)
BACU103012927(KMT5A) 103016372(PRDM6)
BMUS118879863(KMT5A) 118892895(PRDM6)
LVE103079356(SETD8) 103088820(PRDM6)
OOR101270549(KMT5A) 101289146(PRDM6)
DLE111182365(PRDM6) 111186967(KMT5A)
PCAD102973557(PRDM6) 102996167(KMT5A)
PSIU116739152(KMT5A) 116751578(PRDM6)
NASI112407769(PRDM6) 112408791(KMT5A)
ECB100060853(KMT5A) 100073092(PRDM6)
EPZ103549882(KMT5A) 103557946(PRDM6)
EAI106842331(KMT5A) 106842785(PRDM6)
MYB102240957 102242179 102255214(PRDM6)
MYD102763890(PRDM6) 102770785(KMT5A)
MMYO118656525 118657022 118678140(KMT5A)
MLF102429936(KMT5A)
PKL118703399(PRDM6) 118725421(KMT5A)
EFUS103286199(PRDM6) 103287217(KMT5A)
MNA107529655(KMT5A) 107540856(PRDM6)
DRO112310724(KMT5A) 112314700(PRDM6)
SHON118974854 118975099(PRDM6) 118991026(KMT5A)
AJM119060733(KMT5A) 119063966(PRDM6)
PDIC114503519(PRDM6) 114509389(KMT5A)
PHAS123818107(PRDM6) 123821187(KMT5A)
MMF118639841(KMT5A) 118642786(PRDM6)
PPAM129083481(PRDM6) 129087254(KMT5A)
HAI109379016(PRDM6) 109386114(KMT5A)
RFQ117017602(KMT5A) 117024498(PRDM6)
PALE102889990(PRDM6) 102897510(KMT5A)
PGIG120590885(PRDM6) 120616022(KMT5A)
PVP105289367(KMT5A) 105290874(PRDM6)
RAY107511140(PRDM6) 107515249(KMT5A)
MJV108400443(PRDM6) 108408425(KMT5A)
TOD119243542(PRDM6) 119245049(KMT5A)
SARA101540129(SETD8) 101557162(PRDM6)
SETR126002027(KMT5A) 126006064(PRDM6)
LAV100657495(PRDM6) 100673523(KMT5A)
TMU101353514 101358425
ETF101641327(KMT5A) 101644936(PRDM6)
DNM101414380(KMT5A) 101439546(PRDM6)
MDO100014170(PRDM6) 100023739(KMT5A)
GAS123231332(PRDM6) 123244631(KMT5A)
SHR100919577(PRDM6) 100933547(KMT5A)
AFZ127542111 127542390 127545404 127562337
PCW110196792(KMT5A) 110223799(PRDM6)
TVP118828010(PRDM6) 118833026 118851423(KMT5A)
OAA100075898(KMT5A) 114808134(PRDM6)
GGA416825(KMT5A) 426800(PRDM6)
PCOC116228636(KMT5A)
MGP100540244(KMT5A)
CJO107306730(PRDM6) 107321176(KMT5A)
TPAI128084807(KMT5A) 128089575(PRDM6)
LMUT125687132(PRDM6) 125701678(KMT5A)
NMEL110390181(PRDM6) 110406291(KMT5A)
APLA101791393(PRDM6) 101791981(KMT5A)
ACYG106031170(KMT5A) 106046221(PRDM6)
CATA118257207(KMT5A) 118258319(PRDM6)
AFUL116495994(KMT5A) 116501112(PRDM6)
TGU100225643(KMT5A) 100229699(PRDM6)
LSR110471779(KMT5A) 110479151(PRDM6)
SCAN103818327(KMT5A) 103821458 115485138
PMOA120509636(KMT5A) 120513557(PRDM6)
OTC121331505(PRDM6) 121338931(KMT5A)
PRUF121362572(PRDM6) 121365047(KMT5A)
GFR102037830(KMT5A) 102042417(PRDM6)
FAB101815311(PRDM6) 101821143(KMT5A)
OMA130259825(KMT5A) 130265532(PRDM6)
PHI102107973(PRDM6) 102109183(SETD8)
PMAJ107211636(KMT5A) 107216286(PRDM6)
CCAE111936365(KMT5A) 111941215(PRDM6)
CCW104688723(KMT5A) 104690502(PRDM6)
CBRC103611636(PRDM6) 103616016(KMT5A)
ETL114054956(KMT5A) 114055348(PRDM6)
ZAB102060759(KMT5A) 102075464(PRDM6)
ZLE135454649(KMT5A) 135459778(PRDM6)
ACHL103797331(PRDM6) 103806489(SETD8)
SVG106852006(PRDM6) 106852390(KMT5A)
MMEA130574514(PRDM6) 130581001(KMT5A)
HRT120760454(KMT5A) 120765604(PRDM6)
FPG101914736(KMT5A) 101915352(PRDM6)
FCH102050773(PRDM6) 102053153(KMT5A)
CLV102089973(KMT5A) 102097159(PRDM6)
EGZ104124245(PRDM6) 104130151(SETD8)
NNI104012509(PRDM6) 104020902(SETD8)
PCRI104023788(SETD8) 104038182
PLET104620595(SETD8) 104624542
EHS104502556(SETD8) 104513170
PCAO104039362(SETD8) 104048902(PRDM6)
ACUN113485973(KMT5A) 113489673(PRDM6)
TALA104355475(KMT5A) 104362362(PRDM6)
PADL103914479(PRDM6) 103914547(SETD8)
AFOR103902872(KMT5A) 103903028(PRDM6)
ACHC115337406(PRDM6) 115345824(KMT5A)
HALD104310615(SETD8) 104318949
HLE104828186(PRDM6) 104840920(SETD8)
AGEN126035838 126040879
GCL127023006 127027726
CCRI104160072(PRDM6) 104165021(SETD8)
CSTI104549246(SETD8) 104552905(PRDM6)
CMAC104473009(SETD8) 104485198
MUI104545868(SETD8) 104548511
BREG104635738(SETD8) 104638597
FGA104069168(SETD8) 104078388(PRDM6)
GSTE104250299(SETD8) 104256291(PRDM6)
LDI104339768(SETD8) 104348450(PRDM6)
MNB103776190 103776967(SETD8)
OHA104327609(SETD8) 104327991(PRDM6)
NNT104399055(SETD8) 104408128(PRDM6)
SHAB115614939(KMT5A) 115619843(PRDM6)
DPUB104300379(PRDM6) 104308378(SETD8)
PGUU104457692(SETD8) 104465797
ACAR104517510(KMT5A) 104525072(PRDM6)
CPEA104388755(SETD8) 104391240(PRDM6)
AVIT104273219(SETD8) 104275291(PRDM6)
CVF104282255(SETD8) 104294239(PRDM6)
RTD128902631(PRDM6) 128916957(KMT5A)
CUCA104061037(PRDM6) 104068460(SETD8)
TEO104369654(SETD8) 104379022(PRDM6)
BRHI104492388 104492471(SETD8)
AAM106484130 106497676(KMT5A)
AROW112962511(KMT5A) 112965157(PRDM6)
NPD112945813(KMT5A) 112953531(PRDM6)
TGT104574851(SETD8) 104580314(PRDM6)
DNE112991842(KMT5A) 112992354(PRDM6)
SCAM104138814(SETD8) 104150296(PRDM6)
ASN102380913(PRDM6) 102382842(KMT5A)
AMJ102569777(PRDM6) 102571182(KMT5A)
CPOO109312708(KMT5A) 109323639(PRDM6)
GGN109290516(KMT5A) 109297186(PRDM6)
PSS102458837(PRDM6) 102463287(KMT5A)
CMY102929316(KMT5A) 102942167(PRDM6)
CCAY125623204(KMT5A) 125636408(PRDM6)
DCC119843904(KMT5A) 119856237(PRDM6)
CPIC101932163(KMT5A) 101947533(PRDM6)
TST117879252(PRDM6) 117888053(KMT5A)
CABI116831030(PRDM6) 116836714(KMT5A)
MRV120386460(KMT5A) 120407456(PRDM6)
ACS100552008(prdm6) 100559474(kmt5a)
ASAO132767240(PRDM6) 132781355(KMT5A)
PVT110077521(PRDM6) 110083872(KMT5A)
SUND121916628(KMT5A) 121923239(PRDM6)
PBI103053204(KMT5A) 103057070(PRDM6)
PMUR107285441(KMT5A) 107292729(PRDM6)
CTIG120301984(PRDM6) 120316702(KMT5A)
TSR106540545(SETD8) 106540743(PRDM6)
PGUT117661309(PRDM6) 117672147(KMT5A)
APRI131185573(KMT5A) 131193382(PRDM6)
PTEX113445479(PRDM6) 113448664(KMT5A)
NSS113414534(PRDM6) 113425036(KMT5A)
VKO123028707(KMT5A) 123031474(PRDM6)
PMUA114586282(KMT5A) 114606447(PRDM6)
PRAF128403602(KMT5A) 128423233(PRDM6)
ZVI118075547(KMT5A) 118076680(PRDM6)
HCG128337839(KMT5A) 128346614(PRDM6)
GJA107114655(PRDM6) 107117211(KMT5A)
STOW125437159(PRDM6) 125442912(KMT5A)
EMC129335019(PRDM6) 129341573(KMT5A)
XLA100158384(kmt5a.S) 108707198(prdm6.S) 108717331(prdm6.L) 398318(kmt5a.L)
XTR100494529(prdm6) 780276(kmt5a)
NPR108787307(KMT5A) 108799254(PRDM6)
RTEM120932151(PRDM6) 120934096(KMT5A)
BBUF120988467(PRDM6) 120988620(KMT5A)
BGAR122934655(KMT5A) 122935336(PRDM6)
MUO115463228(PRDM6) 115480711(KMT5A)
GSH117352297 117352539(PRDM6) 117365706(KMT5A)
DRE100004770(kmt5ab) 101886516(prdm6) 751629(kmt5aa)
SRX107706747 107713557 107722327 107726219 107728092 107740028
SANH107655184 107657332 107693405(kmt5a) 107702926 107703628 107704173 107704572(prdm6)
SGH107548535(kmt5a) 107554512 107556037 107573249(prdm6) 107578348 107588935
CCAR109059003 109067610 109074173 109074406 109080144 109084763 109088593 109095529(prdm6)
CAUA113052697 113052839 113054712 113085032 113094229(kmt5a) 113106897 113110209
CGIB127958296 127963374 127966870 127990317 128018085 128020806
PTET122333772(kmt5aa) 122346190(kmt5ab) 122350132(prdm6)
LROH127164824(kmt5ab) 127169980(prdm6) 127172239(kmt5aa)
OMC131540749(kmt5ab) 131545628(prdm6) 131547944(kmt5aa)
PPRM120461932(prdm6) 120472105(kmt5ab) 120483070(kmt5aa)
RKG130069118(kmt5ab) 130076729(prdm6) 130094948(kmt5aa)
MAMB125262448(kmt5aa) 125267634(kmt5ab) 125280692(prdm6)
CIDE127513635 127517329 127521439
MASI127414562 127423857 127432609 127433711 127436002
TROS130546290(kmt5aa) 130566440(kmt5ab) 130567577(prdm6)
TDW130411644(kmt5aa) 130420150(kmt5ab) 130440366(prdm6)
MANU129414431(prdm6) 129441120(kmt5ab) 129446503(kmt5aa)
IPU108256031(kmt5ab) 108265069 108276718(kmt5aa)
IFU128599066(kmt5ab) 128607806(prdm6) 128620161(kmt5aa)
PHYP113542401 113544710(kmt5a) 113547211(prdm6)
SMEO124393992(kmt5aa) 124399512(prdm6)
TFD113638387(kmt5aa) 113655973(prdm6)
TVC132854032(prdm6) 132863456(kmt5aa)
TRN134317598(prdm6) 134332356(kmt5aa) 134335451(kmt5ab)
AMEX103024833 103046457(kmt5aa) 103046528(prdm6) 111197404(kmt5ab) 125781346 125782436 125785953 125787564 125806109
CMAO118812882(prdm6) 118824954(kmt5aa) 118827214(kmt5ab)
EEE113571045(prdm6) 113581614 113584033(kmt5a)
CHAR105889376(kmt5aa) 105905089(kmt5ab) 105907553(prdm6)
TRU101062904(kmt5a) 101063309(prdm6) 101068946
TFS130517062(kmt5aa) 130525629(kmt5ab) 130526149(prdm6)
TNGGSTEN00007631G001 GSTEN00025268G001 GSTEN00029438G001 GSTEN00031036G001
LCO104920299(kmt5a) 104935163(prdm6) 104940038
NCC104947636 104962306(setd8)
TBEN117473218(prdm6) 117476384(kmt5aa) 117496893(kmt5ab)
CGOB115013499 115014170(prdm6) 115016800(kmt5a)
PGEO117453157(prdm6) 117453176(kmt5ab) 117456051(kmt5aa)
GACU117555403(prdm6) 117561043(kmt5ab) 117561434(kmt5aa)
EMAC134868523(kmt5aa) 134873978(prdm6) 134874034(kmt5ab)
ELY117252541(prdm6) 117253040(kmt5ab) 117269340(kmt5aa)
EFO125890454(kmt5ab) 125890825(prdm6) 125906085(kmt5aa)
PLEP121944730(prdm6) 121944809(kmt5ab) 121959919
SLUC116051045(kmt5aa) 116054117(prdm6) 116056808(kmt5ab)
ECRA117944403(prdm6) 117944747(kmt5ab) 117959177(kmt5aa)
ESP116689426(prdm6) 116690287 116704008
PFLV114556014 114556289(prdm6) 114571152(kmt5a)
GAT120831092(kmt5ab) 120831743(kmt5aa)
PPUG119224952(kmt5ab) 119225651(prdm6) 119226398(kmt5aa)
AFB129101029(kmt5ab) 129101216(prdm6) 129102900(kmt5aa)
CLUM117735828(prdm6) 117736716(kmt5ab) 117740929(kmt5aa)
PSWI130196067(prdm6) 130196295(kmt5ab) 130205142(kmt5aa)
MSAM119891381(kmt5ab) 119891864(prdm6) 119914618(kmt5aa) 119917840
SCHU122865281(kmt5aa) 122875973(kmt5ab) 122876825(prdm6)
CUD121510055(kmt5ab) 121510064(prdm6) 121524944(kmt5aa)
ALAT119019228(prdm6) 119019846(kmt5ab) 119029806(kmt5aa)
MZE101468308(prdm6) 101470368(kmt5a) 101485410 112433498 112434147 112436186 112436306
ONL100702115 100709871(prdm6) 109194214(kmt5a) 109195113 109202029
OAU116313178(kmt5aa) 116313574(prdm6) 116332401(kmt5ab) 120440039 120442224
OLA101169793(kmt5a) 101172663 105354834(prdm6)
OML112137690(prdm6) 112148771(kmt5ab) 112163317(kmt5aa) 118599191
CSAI133450524(kmt5ab) 133450828 133450839(prdm6) 133455038(kmt5aa)
XMA102219947(kmt5a) 102220630(prdm6) 102233201
XCO114149247(kmt5a) 114154537 114154779(prdm6)
XHE116725040(kmt5a) 116729855 116729983(prdm6)
PRET103461350 103470267 103470825(prdm6) 103473254(kmt5a)
PFOR103151021(kmt5a) 103151865 103151868 103151873 103152623(prdm6)
PLAI106942166 106942497 106943016 106945940(prdm6) 106954785(kmt5a)
PMEI106909822 106918989(prdm6) 106925250(kmt5a) 106928543 106929479
GAF122819727(kmt5aa) 122828541(prdm6) 122828794(kmt5ab)
PPRL129365904(prdm6) 129372146(kmt5ab) 129374296(kmt5aa)
CVG107084661(prdm6) 107086058 107087301
CTUL119784767(kmt5aa) 119784854(prdm6) 119790158(kmt5ab)
GMU124872904(kmt5aa) 124877283(prdm6) 124878265(kmt5ab)
NFU107375146 107386117(prdm6) 107394219(kmt5a)
KMR108234482(kmt5ab) 108245860(prdm6) 108248169(kmt5aa)
ALIM106511939 106523808(setd8) 106527566 106533133
NWH119413069(kmt5ab) 119425123(kmt5aa)
AOCE111565810 111566914(prdm6) 111576642
MCEP124996558(kmt5aa) 125012176(kmt5ab) 125012780(prdm6)
CSEM103389958 103397505 103397995(prdm6)
POV109626470(kmt5a) 109638204
SSEN122758422(kmt5aa) 122769022(kmt5ab) 122769149(prdm6)
HHIP117767484(kmt5ab) 117768446(prdm6) 117771531(kmt5aa)
HSP118098042(kmt5aa) 118114691(prdm6) 118115071(kmt5ab)
PPLT128424596(kmt5aa) 128437660(kmt5ab) 128437745(prdm6)
SMAU118310057(kmt5aa) 118313817(prdm6) 118314035
LCF108874937 108878140(kmt5ab) 108897302(kmt5aa)
SDU111217857(kmt5a) 111230938 111239241(prdm6)
SLAL111649965 111658242 111667134(prdm6)
XGL120805543(kmt5ab) 120805697(prdm6) 120806784(kmt5aa)
HCQ109513448(prdm6) 109525154 109529122
SSCV125979925 125994035 125994152
SBIA133490551(kmt5aa) 133498922(prdm6) 133499651(kmt5ab)
PEE133400124(kmt5ab) 133400162(prdm6) 133413732(kmt5aa)
PTAO133474871(kmt5ab) 133475748(prdm6) 133489815(kmt5aa)
BPEC110168947 110171341 110172486(kmt5a)
MALB109953053 109957446(prdm6) 109961594(kmt5a)
BSPL114861706(prdm6) 114862890(kmt5ab) 114866997(kmt5aa)
SJO128365016(kmt5ab) 128380747(kmt5aa)
SASA106562505 106568287 106568308 106585273(kmt5a) 106587041(prdm6)
STRU115149301(kmt5a) 115159250 115164478 115167640(prdm6)
OTW112219631(kmt5aa) 112233539(kmt5ab) 112248945(prdm6) 112257473
OMY110523849 110525699(kmt5ab) 110526138(prdm6) 110537078
OGO123999640(kmt5aa) 124033969(prdm6) 124034294 124048656
ONE115105910(kmt5a) 115111631 115112017(prdm6) 115127850
OKI109868488 109874149(prdm6) 109880068 109892437
OKE118387821 118391486 118393236 118393619(prdm6)
SALP111958152 111961353 111973725(prdm6) 111974204 111981803(kmt5a)
SNH120023165(kmt5ab) 120026139 120044218 120051923(prdm6)
CCLU121530937 121574138 121582766 121584618(prdm6)
ELS105014800(kmt5a) 105025387(prdm6) 105026110
SFM108934749(kmt5a) 108938054(prdm6)
PKI111856522(prdm6) 111860044(kmt5a)
AANG118206487(kmt5ab) 118206970(prdm6) 118213194(kmt5aa)
LOC102686646(kmt5a) 102697014(prdm6)
PSPA121296780 121299694 121302484 121315476
ARUT117408833 117426360 117962465 117962511
PSEX120532709(prdm6) 120540871(kmt5aa)
LCM102355801(KMT5A) 102357740(PRDM6)
CMK103182382(prdm6) 103188010
RTP109918332(kmt5ab)
CPLA122551012 122565544
HOC132827003 132827953(prdm6)
LERI129695800(prdm6) 129709245
PMRN116942008(PRDM6) 116944662(KMT5A)
LRJ133340495(KMT5A) 133343740(PRDM6)
BFO118409536 118426346
BBEL109463004 109476176 109484669
CIN100176062
SCLV120342049
SPU100892850 105440265 105442287 115917928 115918102 115921211 115921240 115923119 115926391 592467
LPIC129258272
APLC110987820
AJC117108879
SKO100313707 100367079
DMEDmel_CG3307(Set8)
DER6552524
DSE6606408
DSIDsimw501_GD18956(Dsim_GD18956)
DYADyak_GE24231
DSR110176489
DPO4801942
DPE6587245
DMN108155042
DWI6647761
DGR6568421
DMODmoj_GI22805
DAZ108621090
DNV108659415
DHE111601499
DVI6631209
CCAT101458467
BOD106617779
BDR105229910
RZE108367961
AOQ129252920
TDA119677458
MDE101900242 131803727
LCQ111690642
LSQ119600570
GFS119634779
ECOE129954104
AGA1274161
ACOZ120961174
AARA120908677
AMER121589543
ASTE118517717
AFUN125767766
AMOU128297853
AALI118465873
AAG5570016
ASUA134219321 134219322
CQUCpipJ_CPIJ000732
CPII120419555
CNS116344844 116344849
BCOO119084217
AME412027
ACER107997274
ALAB122711479
ADR102675279
AFLR100872063
BIM100745456
BBIF117216719
BVK117232767
BVAN117164919
BTER100649334
BAFF126924694
BPYO122570154
BPAS132914266
FVI122529823
CCAL108631655
OBB114877636
OLG117604946
MGEN117221976
NMEA116426766
CGIG122396133
SOC105195427
MPHA105838593
AEC105146968
ACEP105619051
PBAR105426851
VEM105560777
HST105188422
DQU106743812
CFO105251700
FEX115234102
LHU105673005
PGC109855440
OBO105281625
PCF106791652
PFUC122518984
VPS122634476
VCRB124429987
VVE124954677
NVI100123008 100123020 100677939
CSOL105359046 105368743
TPRE106658250 106658254 111693283
LHT122511522
LBD127277317
MDL103578031
FAS105263204
DAM107039969
AGIF122851993
VCAN122419548
CCIN107273195
DSM124407198
NPT124214562
NFB124177945
NLO107217471
NVG124300327
AROA105685147
TCA657891
DPA109543766 109543771
SOY115881507
AGRG126733460 126749230
ATD109602979
CSET123319926
AGB108909439 108909442
LDC111509070
DVV114332836
NVL108557301
APLN108737955
PPYR116162082
OTU111423470
BMOR101738260
MSEX115441344
DPLKGM_206896
BANY112049996
MJU123871380
NIQ126775229
VCD124532782
MCIX123663426
PMAC106709118
PPOT106108377
PXU106117926
PRAP111004357
PBX123709244
PNAP125054222
ZCE119833070
CCRC123700481
LSIN126974211
AAGE121728115
HAW110370812
HZE124639441
TNL113502956 113509008
SLIU111360462 111360948
OFU114364202
ATRA106134192
GMW113515025
PXY105384001
PGW126376040
LGLY125236303
CCRN123299042
API100161505
DNX107170040
AGS114119070
RMD113548056
ACOO126846096
DVT126909599
BTAB109032364
DCI103508290
CLEC106663755
HHAL106681150
NLU111047050 120352923
HVI124369030
MQU128997949
PHUPhum_PHUM315980
FOC113207206
TPAL117642704 117651861
ZNE110830787
CSEC111862820
SGRE126285361
BROR134532903
IEL124155832
FCD110853144
DPXDAPPUDRAFT_311914
DMK116931250
DPZ124349030
PVM113807185
PJA122266915
PCHN125035469
PMOO119583751
HAME121868774
PCLA123757935
CQD128703843
PTRU123512449
ESN127008651
MNZ135198645
HAZT108667100
EAF111697097 111709992
LSM121127499
TCF131884070 131886047
PPOI119099287 119099433
DSV119445842
RSAN119390239
RMP119172941
VDE111255286
VJA111260884
TUT107366892 107367013
DPTE113793328
DFR124495473
CSCU111636826
PTEP107444515
ABRU129971399
UDV129218562 129226092
SDM118195453
LPOL106472304
PMEO129589222
CELCELE_T26A5.7(set-1)
CBRCBG_16281 CBG_16282 CBG_19678(Cbr-set-1)
CRQGCK72_010704 GCK72_023057
NAINECAME_10199
BMYBM_BM12185(Bma-set-1)
LOALOAG_02341
TSPTsp_09846 Tsp_09848
LGILOTGIDRAFT_117025
PVUL126823902
PCAN112562936
BGT106067552 106070335
GAE121368110
HRF124133359
HRJ124272407 124276593
CRG105318653 117684757
CVN111134306
CANU128186593
OED125650397
MYI110442348 110445834
PMAX117333146
MCAF127712630
MMER123533535 123547644
RPHI132754519
DPOL127870116
MAEA128205549 128232909 128235719 128245101
OBI106878187
OSN115216802 115228427
LJP135476862
LAK106173811
SMMSmp_055310
SHXMS3_00005891(KMT5A)
OVIT265_05161
EGLEGR_02931
LLON135483868
NVE116601963 116619195 116619196 116619198 5509219 5510380 5510391 5514175 5518226 5518227 5520359
EPA110232839 110242476 110252276 110252283 110253323 110253439 110253440 110253496 110253497 110253500
ATEN116288855 116290567 116290576 116290935 116303623 116303624 116303633 116305629
ADF107333633 107333634 107333696 107333697 107333699 107333700 107333701 107343202 107347668
AMIL114953657 114956003 114961844 114961845 114961846 114961847 114961848 114961850 114961851 114972890
PDAM113670441 113672624 113672625 113672651 113672652 113672653 113672654 113672655 113679436 113684845
SPIS111322434 111322526 111322790 111322987 111333025 111335406 111335791 111336163 111336247 111339595
DGT114522454 114522456 114522520 114522531 114522584 114522647 114522697 114537567 114538303
XEN124434221 124450553 124454775 124454793 124454879
HMG100201879 100204152 100208645
HSY130655788
RES135683223 135687296
TADTRIADDRAFT_59058
AQU100636664 100639445
SREPTSG_09393
DFADFA_00963
PFAPF3D7_0403900
PFDPFDG_02606
PFHPFHG_00728
PREIPRSY57_0401500
PGABPGSY75_0403900
PYOPY17X_1003000
PCBPCHAS_1002500
PBEPBANKA_1001600
PVVPVVCY_0800190
PKNPKNH_0301900
PVXPVX_001050
PCYPCYB_031160
PRELPRELSG_0301100(SET8)
TANTA21435
TPVTP01_0281
TOTTOT_010000260
BEQBEWA_031890
BBOBBOV_IV004680
BMICBMR1_02g00765
CPVcgd4_370
CHOChro.40051
 » show all
Reference
1  [PMID:12121615]
  Authors
Fang J, Feng Q, Ketel CS, Wang H, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Simon JA, Zhang Y
  Title
Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase.
  Journal
Curr Biol 12:1086-99 (2002)
DOI:10.1016/s0960-9822(02)00924-7
  Sequence
[hsa:387893]
Reference
2  [PMID:12086618]
  Authors
Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D
  Title
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.
  Journal
Mol Cell 9:1201-13 (2002)
DOI:10.1016/s1097-2765(02)00548-8
  Sequence
[hsa:387893]
Reference
3  [PMID:18166648]
  Authors
Jorgensen S, Elvers I, Trelle MB, Menzel T, Eskildsen M, Jensen ON, Helleday T, Helin K, Sorensen CS
  Title
The histone methyltransferase SET8 is required for S-phase progression.
  Journal
J Cell Biol 179:1337-45 (2007)
DOI:10.1083/jcb.200706150
  Sequence
[hsa:387893]
Reference
4  [PMID:19223465]
  Authors
Oda H, Okamoto I, Murphy N, Chu J, Price SM, Shen MM, Torres-Padilla ME, Heard E, Reinberg D
  Title
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development.
  Journal
Mol Cell Biol 29:2278-95 (2009)
DOI:10.1128/MCB.01768-08
  Sequence
[mmu:67956]
Reference
5  [PMID:23345616]
  Authors
Jorgensen S, Schotta G, Sorensen CS
  Title
Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic  integrity.
  Journal
Nucleic Acids Res 41:2797-806 (2013)
DOI:10.1093/nar/gkt012
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.361
IUBMB Enzyme Nomenclature: 2.1.1.361
ExPASy - ENZYME nomenclature database: 2.1.1.361
BRENDA, the Enzyme Database: 2.1.1.361
LinkDB

DBGET integrated database retrieval system