KEGG   ENZYME: 2.1.1.366
Entry
EC 2.1.1.366                Enzyme                                 
Name
[histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase;
KMT1E (gene name);
SETDB1 (gene name);
KIAA0067 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[histone H3]-N6,N6-dimethyl-L-lysine9 N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
Reaction(KEGG)
(other) R04867
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-N6,N6-dimethyl-L-lysine9
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine9
Comment
The enzyme methylates only dimethylated lysine9 of histone H3 (H3K9), forming the trimethylated form. This modification influences the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. The enzyme is highly upregulated in Huntington disease patients. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, and EC 2.1.1.368, [histone H3]-lysine9 N-dimethyltransferase, and EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase.
History
EC 2.1.1.366 created 2020
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K11421  [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
Genes
HSA9869(SETDB1)
PTR469481(SETDB1)
PPS100972839(SETDB1)
GGO101146215(SETDB1)
PON100431310(SETDB1)
PPYG129029750(SETDB1)
NLE100581330(SETDB1)
HMH116469470(SETDB1)
SSYN134734244(SETDB1)
MCC716141(SETDB1)
MCF102117410(SETDB1)
MTHB126931370
MNI105497821(SETDB1)
CSAB103247223(SETDB1)
CATY105590302(SETDB1)
PANU101002056(SETDB1)
TGE112620272(SETDB1)
MLEU105534755(SETDB1)
RRO104681064(SETDB1)
RBB108533259(SETDB1)
TFN117075079(SETDB1)
PTEH111543630(SETDB1)
CANG105508932(SETDB1)
CJC100411734(SETDB1)
SBQ101042658(SETDB1)
CIMI108316459(SETDB1)
ANAN105724222(SETDB1)
MMUR105872992(SETDB1)
LCAT123633944(SETDB1)
PCOQ105821953(SETDB1)
OGA100940994(SETDB1)
MMU84505(Setdb1)
MCAL110291522(Setdb1)
MPAH110320737(Setdb1)
RNO689883(Setdb1)
MCOC116093409(Setdb1)
ANU117706616(Setdb1)
MUN110560774(Setdb1)
CGE100765697(Setdb1)
MAUA101843804(Setdb1)
PROB127232822(Setdb1)
PLEU114682368(Setdb1)
MORG121437839 121450501
MFOT126489995
AAMP119800749(Setdb1)
NGI103730089(Setdb1)
HGL101715248(Setdb1)
CPOC100721293(Setdb1)
CCAN109681205(Setdb1)
DORD105984728(Setdb1)
DSP122109123(Setdb1)
PLOP125360015(Setdb1)
NCAR124959679
MMMA107156826(Setdb1)
OCU100355877
OPI101525521(SETDB1)
TUP102502264(SETDB1)
GVR103600244(SETDB1)
CFA483186(SETDB1)
CLUD112663993(SETDB1)
VVP112907769(SETDB1)
VLG121490848(SETDB1)
NPO129501338(SETDB1)
AML100482250(SETDB1)
UMR103667532(SETDB1)
UAH113246155(SETDB1)
UAR123787733(SETDB1)
ELK111162065
LLV125097118
MPUF101677094(SETDB1)
MNP132001451(SETDB1)
MLK131808783(SETDB1)
NVS122900483(SETDB1)
ORO101372094(SETDB1)
EJU114197337(SETDB1)
ZCA113925244(SETDB1)
MLX118000316(SETDB1)
NSU110578595(SETDB1)
LWW102732334(SETDB1)
FCA101094118(SETDB1)
PCOO112871086(SETDB1)
PBG122481136(SETDB1)
PVIV125159475(SETDB1)
LRUF124514448
PTG102970727(SETDB1)
PPAD109257028(SETDB1)
PUC125912118
AJU106979835
HHV120241290(SETDB1)
BTA100138100(SETDB1)
BOM102288279(SETDB1)
BIU109555305(SETDB1)
BBUB102408652(SETDB1)
BBIS104987649(SETDB1)
CHX102180982(SETDB1)
OAS101109230(SETDB1)
BTAX128044362(SETDB1)
ODA120855906(SETDB1)
CCAD122434373(SETDB1)
MBEZ129540648(SETDB1)
SSC100157920(SETDB1)
CFR102512057(SETDB1)
CBAI105071738(SETDB1)
CDK105103196(SETDB1)
VPC102545931(SETDB1)
BACU103009894(SETDB1)
BMUS118897508(SETDB1)
LVE103076461(SETDB1)
OOR101270688(SETDB1)
DLE111169744(SETDB1)
PSIU116751422(SETDB1)
NASI112411620(SETDB1)
ECB100059254(SETDB1)
EPZ103547642(SETDB1)
EAI106846522(SETDB1)
MYB102257713(SETDB1)
MYD102773684(SETDB1)
MMYO118672742(SETDB1)
MLF102441225(SETDB1)
PKL118727467(SETDB1)
EFUS103298980(SETDB1)
MNA107539129(SETDB1)
DRO112313537(SETDB1)
AJM119034734(SETDB1)
PDIC114488934(SETDB1)
PHAS123804304(SETDB1)
MMF118637044(SETDB1)
PPAM129062305(SETDB1)
HAI109372277(SETDB1)
RFQ117014537(SETDB1)
PGIG120585218(SETDB1)
PVP105303858(SETDB1)
RAY107499036(SETDB1)
MJV108409453(SETDB1)
TOD119237184(SETDB1)
SARA101554078(SETDB1)
SETR125997533(SETDB1)
LAV100673374(SETDB1)
TMU101349341
ETF101658224(SETDB1)
DNM101437951(SETDB1)
MDO100618580(SETDB1)
GAS123244280(SETDB1)
SHR100928904(SETDB1)
AFZ127559091
PCW110220597(SETDB1)
TVP118856139(SETDB1)
OAA100091318(SETDB1)
GGA100859816(SETDB1)
PCOC116238423(SETDB1)
MGP100542346(SETDB1)
CJO107324577(SETDB1)
TPAI128071922(SETDB1)
LMUT125685794(SETDB1)
NMEL110387900(SETDB1)
APLA101794756(SETDB1)
ACYG106049268(SETDB1)
CATA118260462(SETDB1)
AFUL116499648(SETDB1)
TGU100231651(SETDB1)
LSR110476821(SETDB1)
SCAN103824025
PMOA120502592(SETDB1)
OTC121335607(SETDB1)
PRUF121353495(SETDB1)
GFR102034546(SETDB1)
OMA130263386(SETDB1)
PHI102101563(SETDB1)
PMAJ107214655(SETDB1)
CCAE111939473(SETDB1)
CBRC103619600(SETDB1)
ETL114071955(SETDB1)
ZAB102061470(SETDB1)
ZLE135457730(SETDB1)
SVG106862356(SETDB1)
MMEA130587054(SETDB1)
HRT120764209(SETDB1)
FPG101912073(SETDB1)
FCH102055212(SETDB1)
CLV102094505(SETDB1)
EGZ104129700(SETDB1)
NNI104014430(SETDB1)
PCRI104037271(SETDB1)
PLET104619247(SETDB1)
EHS104509218(SETDB1)
PCAO104051886(SETDB1)
ACUN113488725(SETDB1)
TALA116964156 122152589
PADL103919479(SETDB1)
AFOR103900501(SETDB1)
ACHC115345534(SETDB1)
HALD104312868(SETDB1)
HLE104830529(SETDB1)
AGEN126040314
GCL127027051
CCRI104157123(SETDB1)
CMAC104487401
MUI104548107
BREG104638314(SETDB1)
FGA104082850(SETDB1)
GSTE104254890(SETDB1)
OHA104330237(SETDB1)
NNT104409719
SHAB115602619(SETDB1)
PGUU104471117(SETDB1)
ACAR104527661(SETDB1)
CPEA104390376(SETDB1)
CVF104285442(SETDB1)
RTD128900884(SETDB1)
CUCA104066027(SETDB1)
TEO104372742(SETDB1)
AAM106495416(SETDB1)
AROW112972521(SETDB1)
NPD112952968(SETDB1)
TGT104573259(SETDB1)
DNE112990032(SETDB1)
SCAM104139540(SETDB1)
ASN102382539(SETDB1)
AMJ102575637(SETDB1)
CPOO109324826(SETDB1)
CMY102937828(SETDB1)
CCAY125625560(SETDB1)
DCC119848135(SETDB1)
CPIC101931963(SETDB1)
TST117869706(SETDB1)
CABI116817630(SETDB1)
MRV120390026(SETDB1)
ACS100565799(setdb1)
ASAO132764180(SETDB1)
PVT110081479(SETDB1)
SUND121916245(SETDB1)
PBI103053131(SETDB1)
PMUR107292899(SETDB1)
CTIG120317077(SETDB1)
TSR106546292(SETDB1)
PGUT117670132(SETDB1)
APRI131186537(SETDB1)
PTEX113452534 113452537
VKO123032928(SETDB1)
PMUA114586177(SETDB1)
PRAF128403733(SETDB1)
ZVI118075630(SETDB1)
HCG128337288(SETDB1)
GJA107121584(SETDB1)
STOW125436664(SETDB1)
EMC129342370(SETDB1)
XLA108700333(setdb1.S) 432147(setdb1.L)
XTR100490309(setdb1)
NPR108789810(SETDB1)
RTEM120920703(SETDB1)
BBUF120981785(SETDB1)
BGAR122923222(SETDB1)
MUO115458064(SETDB1)
GSH117349981(SETDB1)
DRE553292(setdb1a) 768131(setdb1b)
SRX107717459 107723461 107724106 107739578
SANH107656477 107671207 107693347 107700161
SGH107573682 107582057 107589406 107599511
CCAR109105279 109111939 109111941
CAUA113060012 113062169 113077897 113116442 113120007
CGIB127935667 127974706 127979020 128030992
PTET122360609(setdb1b)
LROH127178914(setdb1b) 127182106(setdb1a)
OMC131522361(setdb1b) 131525288(setdb1a)
PPRM120483677(setdb1a) 120484392(setdb1b)
RKG130070813(setdb1a) 130101819(setdb1b)
MAMB125243644(setdb1b) 125275542(setdb1a)
CIDE127497987 127500631
MASI127420967 127425596 127452895 127453831
TROS130557672(setdb1b) 130567279(setdb1a)
TDW130415319(setdb1a) 130433287(setdb1b)
MANU129447933(setdb1b) 129454460(setdb1a)
IPU108266106(setdb1b) 108272679(setdb1a)
IFU128607541(setdb1b) 128615241(setdb1a)
PHYP113535137 113542451(setdb1)
SMEO124382145(setdb1a) 124384982(setdb1b)
TFD113641276(setdb1a) 113643512(setdb1b)
TVC132842876(setdb1a) 132846150(setdb1b)
TRN134310974(setdb1b) 134329935(setdb1a)
AMEX103028156(setdb1a)
CMAO118805978(setdb1a) 118824354(setdb1b)
EEE113570608(setdb1) 113572599
CHAR105912991(setdb1b)
TRU101075200(setdb1)
TFS130532902
TNGGSTEN00015370G001
LCO104920543(setdb1)
NCC104944919(setdb1)
TBEN117471276 117480563(setdb1b)
CGOB115021722
PGEO117461095(setdb1b)
GACU117541016(setdb1b)
EMAC134861592(setdb1b)
ELY117266438(setdb1b)
EFO125893368
PLEP121946021
SLUC116049589(setdb1b)
ECRA117946699(setdb1b)
ESP116691442(setdb1)
PFLV114557339
GAT120810231(setdb1b)
PPUG119198096(setdb1b)
AFB129109882
CLUM117745225(setdb1b)
PSWI130213014(setdb1b)
MSAM119897547(setdb1b)
SCHU122881587(setdb1b)
CUD121514026(setdb1b)
ALAT119006504(setdb1b)
MZE101465322(setdb1)
ONL100710331(setdb1)
OAU116321097(setdb1b)
OLA101158302(setdb1)
OML112143498
CSAI133432938(setdb1b)
XMA102235762(setdb1)
XCO114141956(setdb1)
XHE116717442(setdb1)
PRET103478723(setdb1)
PFOR103136616 103136620
PLAI106938375 106943293
PMEI106922006(setdb1)
GAF122830571(setdb1b)
PPRL129371135(setdb1b)
CVG107088829(setdb1)
CTUL119783009(setdb1b)
GMU124866219(setdb1b)
NFU107379696(setdb1)
KMR108241152(setdb1b)
ALIM106515090
NWH119410006(setdb1b)
AOCE111586482(setdb1)
MCEP125016823(setdb1b)
CSEM103388279(setdb1)
POV109633224
SSEN122774888
HHIP117777184(setdb1b)
HSP118113532(setdb1b)
PPLT128449795(setdb1b)
SMAU118299766(setdb1b)
LCF108885905
SDU111230127(setdb1)
SLAL111652197(setdb1)
XGL120784269(setdb1b)
HCQ109522778(setdb1)
SSCV125975637
SBIA133501043(setdb1b)
PEE133401340(setdb1b)
PTAO133479743(setdb1b)
BPEC110163046(setdb1)
MALB109970226
BSPL114842555(setdb1b)
SJO128366464(setdb1b)
SASA106574954 106588190
STRU115173296 115176358 115189463
OTW112236082 112247848 112266649
OMY110496022 110520820 110536431
OGO123998183 124005934 124012669
ONE115113782 115123820 115128219
OKI109883759 109886460 109907679
OKE118374768 118383196 118399124
SALP111955709 111964582(setdb1)
SNH120022441 120031206 120037512
CCLU121543877 121586324 123484099
ELS105018987(setdb1) 105030119
SFM108923796(setdb1)
PKI111853328(setdb1)
AANG118225516(setdb1b)
PSPA121306955
ARUT117395637 117962652
PSEX120538027(setdb1a)
LCM102356699(SETDB1)
HOC132805644(setdb1b)
LERI129715984
PMRN116939538
LRJ133346612
BFO118414026
BBEL109475626
CIN101242243
SCLV120329266
SPU764341
LPIC129268305
APLC110986848
SKO100372058
DMEDmel_CG12196(egg)
DER6548401
DSE6618876
DSIDsimw501_GD24920(Dsim_GD24920)
DYADyak_GE11418
DAN6494410
DSR110189614
DPO6898620
DPE6592281
DMN108159156 117192580
DWI6640308
DGR6560486
DMODmoj_GI19513
DAZ108615991
DNV108654234
DHE111593833
DVI6626333
CCAT101450333
BOD106626903
BDR105225468
RZE108370615
AOQ129244009
TDA119680913 119682533
MDE101893339
SCAC106082649
LCQ111689074
LSQ119601703
GFS119641642
ECOE129949527
CLON129614622
HIS119647111
ACOZ120955372
AARA120903557
AMER121597845
ASTE118513879
AFUN125766226
AMOU128303339
AALI118467738
AALB109429413
CQUCpipJ_CPIJ016652
CPII120413132
CNS116338143 116352420
BCOO119079737 119083129
AME409098
ACER107998869
ALAB122720229
ADR102672185
AFLR100863269
BIM100745488
BBIF117210113
BVK117241892
BVAN117157119
BTER100647514
BAFF126921232
BPYO122573667
BPAS132912755
FVI122531369
CCAL108631329
OBB114874120
OLG117607392
MGEN117223965
NMEA116430891
CGIG122395723
SOC105201335
MPHA105833491
AEC105144993
ACEP105620791
PBAR105429250
VEM105561499
HST105186113
DQU106745347
CFO105256000
FEX115233743
LHU105670399
PGC109857860
OBO105284457
PCF106790393
PFUC122518795
VPS122627174
VCRB124432543
VVE124947055
NVI100120014
CSOL105360527
TPRE106652487
LHT122499168
LBD127281984
MDL103577834
CGLO123274316
FAS105268216
DAM107040220
AGIF122848592 122849411
VCAN122416190
CCIN107264745
DSM124409918
NPT124217567
NFB124181100
NLO107217676
NVG124303853
AROA105690658
TCA658295
DPA109543261
SOY115881509
ATD109602736
CSET123319875
AGB108909991
LDC111513341
DVV114328293
NVL108566549
APLN108744087
PPYR116161259
OTU111417041
BMOR101742950
BMAN114244119
MSEX115449535
BANY112051969
VCD124541909
MCIX123668144
PMAC106721248
PPOT106107193
PXU106124549
PRAP110997400 123690471
ZCE119838086
LSIN126974695
AAGE121726757
HAW110383113(egg)
HZE124643704
TNL113502290
SLIU111354717 111354836
OFU114359561
ATRA106130051
GMW113514571
PXY105392435
CCRN123299289
API100165352 100574903
DNX107166873 107167319
AGS114120564 114123773
RMD113553560 113553623
ACOO126843160
DVT126893853 126893854 126902782
BTAB109030364
DCI103505795
CLEC106668530 106670703
HHAL106679343
NLU111059365
HVI124365706
MQU128991472
PHUPhum_PHUM415050
FOC113208911
TPAL117650092
ZNE110837361
CSEC111863266
BROR134538554
IEL124153937
FCD110847722 110850679
DPXDAPPUDRAFT_303556 DAPPUDRAFT_304216
DMK116929683 116932783
DPZ124312290 124351093
PJA122257422
PCHN125026400
PMOO119580115
HAME121855413
PCLA123771664
CQD128698001
PTRU123508802
ESN126983536
MNZ135200471 135200933 135204636
HAZT108673081
EAF111695332 111709742
LSM121123621
TCF131879963
PPOI119104173 119107951 119107955
DSV119440663 119450321
RSAN119383419
RMP119170383
VDE111249984
VJA111269829
TUT107372205
CSCU111615256 111617813
PTEP107451716
ABRU129981000
UDV129222062
SDM118186516
LPOL106458997
CELCELE_R05D3.11(met-2)
CBRCBG_18157(Cbr-met-2)
CRQGCK72_010167
BMYBM_BM5216(Bma-met-2)
LOALOAG_17898
PVUL126821962
PCAN112559730
GAE121381868
HRF124120055
HRJ124288313
CRG105332598
CVN111131506
OED125646988
MYI110459908
PMAX117335866
MMER123536313
RPHI132726729
MAEA128232410
OBI106873585
OSN115213825
LJP135469398
LAK106167373
SMMSmp_150850.1
SHXMS3_00010918(SETDB1B)
OVIT265_08195
EGLEGR_06122
LLON135492813
NVE5506681
EPA110238173
ATEN116288332
AMIL114974694
PDAM113666302
DGT114527359
XEN124455467
HMG100203637
 » show all
Reference
1  [PMID:11791185]
  Authors
Yang L, Xia L, Wu DY, Wang H, Chansky HA, Schubach WH, Hickstein DD, Zhang Y
  Title
Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor.
  Journal
Oncogene 21:148-52 (2002)
DOI:10.1038/sj.onc.1204998
  Sequence
[mmu:84505]
Reference
2  [PMID:14536086]
  Authors
Wang H, An W, Cao R, Xia L, Erdjument-Bromage H, Chatton B, Tempst P, Roeder RG, Zhang Y
  Title
mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.
  Journal
Mol Cell 12:475-87 (2003)
DOI:10.1016/j.molcel.2003.08.007
Reference
3  [PMID:22939622]
  Authors
Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter FM, Mittler G, Genoud C, Goyama S, Kurokawa M, Son J, Reinberg D, Lachner M, Jenuwein T
  Title
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.
  Journal
Cell 150:948-60 (2012)
DOI:10.1016/j.cell.2012.06.048
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.366
IUBMB Enzyme Nomenclature: 2.1.1.366
ExPASy - ENZYME nomenclature database: 2.1.1.366
BRENDA, the Enzyme Database: 2.1.1.366
LinkDB

DBGET integrated database retrieval system