KEGG ENZYME: 2.1.1.391

ENZYME: 2.1.1.391

Entry

EC 2.1.1.391                Enzyme

Name

demethylgadusol O-methyltransferase;
gadusol synthase;
desmethyl gadusol O-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:demethylgadusol 2-O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + demethylgadusol = S-adenosyl-L-homocysteine + gadusol [RN:R13236]

Reaction(KEGG)

R13236

Substrate

S-adenosyl-L-methionine [CPD:C00019];
demethylgadusol [CPD:C22843]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
gadusol [CPD:C22846]

Comment

The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 1.3.1.126, 2-epi-5-epi-valiolone dehydrogenase.

History

EC 2.1.1.391 created 2023

Orthology

K27180

2-epi-5-epi-valiolone dehydrogenase / demethylgadusol O-methyltransferase

Genes

GGA:	427595(HSD17B14)

PCOC:

116239517

MGP:

100539521

LMUT:

125698928

NMEL:

110404901

APLA:

101799721

ACYG:

106035461

CATA:

118248298

AFUL:

116493133

TGU:

100220728

SCAN:

103817204

PMOA:

120514102

OTC:

121347313

PRUF:

121350570

GFR:

102035220

FAB:

101811274

OMA:

130258466

PHI:

102106494

PMAJ:

107210123

CCAE:

111935282

CCW:

104683367

CBRC:

103624387

ETL:

114070866

ZAB:

102064640

ACHL:

103801836

SVG:

106850326

MMEA:

130573735

HRT:

120758375

FPG:

101919857

FCH:

102050380

CLV:

102090989

EGZ:

104132680

NNI:

104017002

PCRI:

104035598

PLET:

104623815

EHS:

104510750

PCAO:

104053892

ACUN:

113484874

TALA:

104367530

PADL:

103921829

AFOR:

103903316

ACHC:

115333431

HALD:

104316123

HLE:

104835325

AGEN:

126049929

GCL:

127021668

CCRI:

104164037

CSTI:

104552977

CMAC:

104477206

MUI:

104544299

BREG:

104642376

LDI:

104347206

MNB:

103776755

OHA:

104331382

NNT:

104409958

SHAB:

115614836

DPUB:

104308149

PGUU:

104465706

CPEA:

104388117

AVIT:

104267135

CVF:

104285190

RTD:

128915711

CUCA:

104061235

TEO:

104376371

BRHI:

104498892

AAM:

106483813

AROW:

112970541

NPD:

112958683

TGT:

104568936

SCAM:

104140966

PSS:

102457357

CMY:

102930500

CCAY:

125640551

DCC:

119858417

CPIC:

101935589

TST:

117879970

CABI:

116820413

MRV:

120369035

ACS:

100554218

ASAO:

132766704

PVT:

110077700

SUND:

121920321

PMUA:

114590905

PRAF:

128408717

ZVI:

118080056

HCG:

128345691

XLA:	100158280(MGC147226.S)

XTR:	780086(MGC147226)

NPR:

108786178

RTEM:

120945167

BBUF:

120978448

BGAR:

122943624

DRE:	541322(zgc:113054)

SRX:	107713510 107750276

SANH:

107666963 107680730

SGH:	107584471 107599438

CAUA:

113050481 113096077

CGIB:

127960178 128015849

PTET:

122347014(zgc:113054)

LROH:

127167199

OMC:

131542645

PPRM:

120491652

RKG:

130087420

MAMB:

125273456

CIDE:

127514920

MASI:

127445878 127449111

TROS:

130557343

TDW:

130425142

MANU:

129451276

AMEX:

103021811

CMAO:

118808675

CHAR:

105909985

LCO:

104922195

NCC:

104967325

TBEN:

117475566

CGOB:

115008435

GACU:

117543689

EMAC:

134883513

ELY:

117256495

EFO:

125895529

PLEP:

121957745

SLUC:

116036489

ECRA:

117943945

ESP:

116687340

PFLV:

114554302

GAT:

120835675

PPUG:

119229406

AFB:

129105645

CLUM:

117731046

PSWI:

130208772(zgc:113054)

MSAM:

119885941

SCHU:

122865549

CUD:

121507503

ALAT:

119021886

MZE:

101474366

ONL:

100697673

OAU:

116312425

OLA:

101163242

OML:

112145089

CSAI:

133448921

XMA:

102222561

XCO:

114147841

XHE:

116710902

PRET:

103465591

PFOR:

103129385

GAF:

122834118

PPRL:

129353592

CVG:

107082361

CTUL:

119783617

GMU:

124857128

NFU:

107385807

KMR:

108247579

ALIM:

106518257

AOCE:

111566138

MCEP:

125007378

CSEM:

103386309

POV:

109629028

SSEN:

122768789

HHIP:

117762039

HSP:

118105524

SMAU:

118309765

LCF:

108898864

SDU:

111221906

SLAL:

111668680

XGL:

120783458

BPEC:

110170265

BSPL:

114856131

SJO:

128355230

SASA:

106565741

STRU:

115207553

OTW:

112220213

OMY:

110494595

OGO:

124003812

ONE:

115143400

OKI:

109898094

OKE:

118388340

SALP:

111969388

SNH:

120060128

CCLU:

121575039

ELS:

105017436

SFM:

108923381

LOC:

102695979

ARUT:

117963408

CSL:	COCSUDRAFT_55647

AAF:	AURANDRAFT_30097

» show all

Reference

1 [PMID:25965179]

Authors

Osborn AR, Almabruk KH, Holzwarth G, Asamizu S, LaDu J, Kean KM, Karplus PA, Tanguay RL, Bakalinsky AT, Mahmud T.

Title

De novo synthesis of a sunscreen compound in vertebrates.

Journal

Elife 4:05919 (2015)
DOI:10.7554/eLife.05919

Sequence

[dre:541322]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.391

IUBMB Enzyme Nomenclature:

2.1.1.391

ExPASy - ENZYME nomenclature database:

2.1.1.391

BRENDA, the Enzyme Database:

2.1.1.391

LinkDB

DBGET integrated database retrieval system