KEGG   ENZYME: 2.1.1.49
Entry
EC 2.1.1.49                 Enzyme                                 
Name
amine N-methyltransferase;
nicotine N-methyltransferase;
tryptamine N-methyltransferase;
arylamine N-methyltransferase;
tryptamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:amine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine [RN:R02808]
Reaction(KEGG)
R02808 > R02174 R02910;
(other) R08537
Substrate
S-adenosyl-L-methionine [CPD:C00019];
amine [CPD:C00706]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methylated amine [CPD:C02436]
Comment
An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.
History
EC 2.1.1.49 created 1976, modified 1990 (EC 2.1.1.81 created 1989, incorporated 1990)
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00562  methyltransferase
Genes
HSA11185(INMT)
PTR463912(INMT)
PPS100986665(INMT)
GGO101143120(INMT)
PON100171421(INMT)
NLE100603670(INMT)
MCC694969(INMT)
MCF102139220(INMT)
CSAB103226272(INMT)
CATY105596176(INMT)
PANU100998123(INMT)
TGE112620035(INMT)
RRO104663737(INMT)
RBB108532381(INMT)
PTEH111522205(INMT)
CJC100387750(INMT)
SBQ101035075(INMT)
CSYR103254460(INMT)
MMUR105855099(INMT)
OGA100957733(INMT)
MMU21743(Inmt)
MCAL110296762(Inmt)
MPAH110317265(Inmt)
RNO368066(Inmt)
MCOC116098126(Inmt)
MUN110555148(Inmt)
CGE100773805(Inmt)
MAUA101835859(Inmt)
PLEU114689706(Inmt)
MORG121439573(Inmt)
NGI103729450(Inmt)
HGL101710622(Inmt) 106008943
CPOC100724009
NCAR124991696
OCU100008695(INMT) 100338404
OPI101526879 101531959
TUP102502473(INMT)
ORO105758206(INMT)
BTA527922(INMT)
BOM102270640(INMT)
BIU109557473(INMT)
BBUB102411712(INMT)
CHX102186084
OAS101123289
ODA120877395(INMT)
CCAD122438422(INMT)
SSC100512997(INMT)
CFR102503927 102504745
CBAI105081898(INMT) 105082129
CDK105095849 105106408 116154033
VPC102537199(INMT)
BACU103019292
LVE103070876
OOR101284322(INMT)
DLE111180005(INMT)
PCAD102980842(INMT)
PSIU116759859(INMT)
ECB100055070
EPZ103541247(INMT)
EAI106830978 106831065(INMT)
MNA107544372(INMT)
MJV108403655(INMT)
TOD119244139 119249740
SARA101538793(INMT) 101539242
LAV100671921(INMT)
TMU101350596
DNM101412422(INMT)
OAA100081148(INMT)
ACS100553677
XLA108696501 108696502 108697004 108697006 108699501 379432(nnmt.L) 399013(inmt.L)
XTR100491548 496676(nnmt) 548447 594924(inmt)
NPR108799420 108799728 108799731
RTEM120915490 120915491 120915492 120915493 120915505 120915524 120926873 120926876
BBUF120996795 120996849 120999241
BGAR122926837 122928942
BBEL109468493 109478432 109485111
SKO100367711
PCHN125036405
ISCIscW_ISCW001554 IscW_ISCW007034
DSV119434542
CSCU111615693 111641734
SDM118188870 118205359
NAINECAME_02876
GAE121366614 121377222 121378382 121378383 121378452 121379017 121379235
HRF124132441 124145666
HRJ124258498 124265701 124265717
MYI110462853
PMAX117341599
LAK106157416 106157421 106157433 106157912 106157913 106157914 106162346 106165307 106170527 106180314 106181959
ADF107342266
AMIL114946916
PDAM113682356
PBWD172_003270
 » show all
Reference
1  [PMID:3949799]
  Authors
Ansher SS, Jakoby WB.
  Title
Amine N-methyltransferases from rabbit liver.
  Journal
J Biol Chem 261:3996-4001 (1986)
Reference
2  [PMID:3377829]
  Authors
Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB.
  Title
Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases.
  Journal
Biochem Pharmacol 37:1673-7 (1988)
DOI:10.1016/0006-2952(88)90426-1
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.49
IUBMB Enzyme Nomenclature: 2.1.1.49
ExPASy - ENZYME nomenclature database: 2.1.1.49
BRENDA, the Enzyme Database: 2.1.1.49
CAS: 51377-47-0 111694-10-1
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