Entry
Name
amine N-methyltransferase;
nicotine N-methyltransferase;
tryptamine N-methyltransferase;
arylamine N-methyltransferase;
tryptamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:amine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine [RN:
R02808 ]
Reaction(KEGG)
Substrate
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
methylated amine [CPD:
C02436 ]
Comment
An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.
History
EC 2.1.1.49 created 1976, modified 1990 (EC 2.1.1.81 created 1989, incorporated 1990)
Pathway
Orthology
Genes
HGL : 101710622(Inmt) 106008943
OCU : 100008695(INMT) 100338404
CBAI : 105081898(INMT) 105082129
CDK : 105095849 105106408 116154033
EAI : 106830978 106831065(INMT)
SARA : 101538793(INMT) 101539242
SETR : 126025505 126025529
ASAO : 132782581 132782593 132782794
XLA : 108696501 108696502 108697004 108697006 108699501 379432(nnmt.L) 399013(inmt.L)
XTR : 100491548 496676(nnmt) 548447 594924(inmt)
NPR : 108799420 108799728 108799731
RTEM : 120915490 120915491 120915505 120915524 120926873 120926876
BBUF : 120996795 120996849 120999241
BGAR : 122926837 122928942
MUO : 115481614 115481769 115481991
GSH : 117347473 117347493 117347584 117347883
BBEL : 109468493 109478432 109485111
CSCU : 111615693 111641734
GAE : 121366614 121378382 121378383 121378452 121379017 121379235
HRJ : 124258498 124265701 124265717
HASI : 137264908 137264909 137265153 137265915 137294335
LAK : 106157416 106157421 106157433 106157912 106157913 106157914 106162346 106165307 106170527 106180314 106181959
» show all
Taxonomy
Reference
Authors
Ansher SS, Jakoby WB.
Title
Amine N-methyltransferases from rabbit liver.
Journal
J Biol Chem 261:3996-4001 (1986)
Reference
Authors
Crooks PA, Godin CS, Damani LA, Ansher SS, Jakoby WB.
Title
Formation of quaternary amines by N-methylation of azaheterocycles with homogeneous amine N-methyltransferases.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.49
ExPASy - ENZYME nomenclature database: 2.1.1.49
CAS: 51377-47-0 111694-10-1
LinkDB
All DBs