KEGG   ENZYME: 2.1.1.8
Entry
EC 2.1.1.8                  Enzyme                                 
Name
histamine N-methyltransferase;
histamine 1-methyltransferase;
histamine methyltransferase;
histamine-methylating enzyme;
imidazolemethyltransferase;
S-adenosylmethionine-histamine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:histamine N-tele-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Ntau-methylhistamine [RN:R02155]
Reaction(KEGG)
R02155
Substrate
S-adenosyl-L-methionine [CPD:C00019];
histamine [CPD:C00388]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
Ntau-methylhistamine [CPD:C05127]
History
EC 2.1.1.8 created 1965
Pathway
ec00340  Histidine metabolism
ec01100  Metabolic pathways
Orthology
K00546  histamine N-methyltransferase
Genes
HSA3176(HNMT)
PTR742204(HNMT)
PPS100970136(HNMT)
GGO101141216(HNMT)
PON100174618(HNMT)
PPYG129031328(HNMT)
HMH116462939(HNMT)
SSYN129472388(HNMT)
MCC703857 706713(HNMT)
MCF101867462(HNMT) 135964432
MTHB126932244
MNI105492589(HNMT) 105498647
CSAB103217003(HNMT)
CATY105575026 105590363
TGE112636099 112636474
MLEU105550223(HNMT) 105553680
RRO104672066(HNMT)
TFN117095061(HNMT)
PTEH111528181(HNMT)
CANG105507253(HNMT)
CJC100405862(HNMT)
SBQ101041589(HNMT)
CIMI108300473(HNMT)
ANAN105723646(HNMT)
CSYR103276269(HNMT)
MMUR105857643(HNMT)
LCAT123643525(HNMT)
PCOQ105806874 105815351
OGA100946532(HNMT)
MMU140483(Hnmt)
MCAL110287683(Hnmt)
MPAH110319128(Hnmt)
RNO81676(Hnmt)
MCOC116089779(Hnmt)
ANU117710970(Hnmt)
ASYL127685024(Hnmt)
MUN110563412(Hnmt)
CGE100759779 100761300
MAUA101839605(Hnmt)
PROB127222552(Hnmt)
PLEU114692749(Hnmt)
MORG121462799(Hnmt)
MFOT126500206
AAMP119819086(Hnmt)
NGI103726551(Hnmt)
HGL101702942(Hnmt)
CPOC100135537(Hnmt)
CCAN109681803 109681804
DORD105996105(Hnmt)
DSP122110849(Hnmt)
PLOP125350724(Hnmt)
NCAR124980212
MMMA107136821(Hnmt)
ITI101955230(Hnmt)
OCU100347399
OPI101521079(HNMT)
TUP102469391
GVR103608726(HNMT)
CFA476133(HNMT)
CLUD112648833(HNMT)
VVP112909578(HNMT)
VLG121481974(HNMT)
NPO129495561 129514605
AML100481941(HNMT)
UMR103667681(HNMT)
UAH113263407(HNMT)
UAR123782459(HNMT)
ELK111143222
LLV125095920
MPUF101687140(HNMT)
MNP132013051(HNMT)
MLK131826968(HNMT)
NVS122902695(HNMT)
ORO101368085(HNMT)
EJU114207302(HNMT)
ZCA113920985(HNMT)
MLX118012493(HNMT)
NSU110585668(HNMT)
LWW102733782(HNMT)
FCA101093704(HNMT)
PYU121030502(HNMT)
PCOO112871215(HNMT)
PBG122481293(HNMT)
PVIV125173775(HNMT)
LRUF124516223
LGF123598867(HNMT)
AJU106969447
PTG102954667(HNMT)
PPAD109270411(HNMT)
PUC125911651
PLEZ122225948(HNMT)
HHV120220316(HNMT)
BTA613413(HNMT)
BOM102279160(HNMT)
BIU109568122(HNMT)
BBUB102395473(HNMT)
BBIS104998511(HNMT)
CHX102169059(HNMT)
OAS101102876(HNMT)
BTAX128043691(HNMT)
CSUM138076800(HNMT)
ODA120854497(HNMT)
CCAD122453760(HNMT)
MREE136165283(HNMT)
OVR110149691(HNMT)
MBEZ129537738(HNMT)
SSC100624677(HNMT)
CFR102506628(HNMT)
CBAI105083386(HNMT)
CDK105092265(HNMT)
VPC102543745(HNMT)
BACU102997526(HNMT)
BMUS118898548(HNMT)
LVE103075160(HNMT)
OOR101278018 101281948(HNMT)
LALB132521854(HNMT) 132529213
DLE111172721(HNMT)
PCAD102996034(HNMT)
PSIU116756298(HNMT) 116760948
PPHC136125756(HNMT)
NASI112412417(HNMT)
ECB100051119(HNMT)
EPZ103553344(HNMT)
EAI106845596(HNMT)
MYB102249926(HNMT)
MYD102774069(HNMT)
MMYO118662268(HNMT)
MLF102421337(HNMT)
MDT132238671(HNMT)
MYUM139015712(HNMT)
PKL118709789(HNMT)
EFUS103287771(HNMT)
MNA107531142(HNMT)
DRO112313104(HNMT)
SHON118975029(HNMT)
AJM119040294(HNMT)
PDIC114494348(HNMT)
PHAS123832492(HNMT)
MMF118625533(HNMT)
PPAM129061962(HNMT)
HAI109372885(HNMT) 109374605
RFQ117026346(HNMT)
PALE102888765(HNMT)
PGIG120611952(HNMT)
PVP105288335(HNMT)
RAY107511202(HNMT)
MJV108398856(HNMT)
TOD119255798(HNMT)
SARA101546126(HNMT)
SFUM130026892(HNMT)
SETR126009344(HNMT)
LAV100674300(HNMT)
TMU101349793
ETF101657707(HNMT)
DNM101430514(HNMT)
MDO100012612(HNMT)
GAS123242278(HNMT)
SHR100914453(HNMT)
AFZ127554366
PCW110223777(HNMT)
TVP118837489(HNMT)
PBRV138146126(HNMT)
OAA100080018
TACU119932550
GGA424298(HNMT)
PCOC116227438
MGP100542432
CJO107316986
TPAI128077114
LMUT125697023
NMEL110400130
APLA101795218
ACYG106039378
CATA118252588
AFUL116490827
TGU100228106
LSR110480615
SCAN103814270
PMOA120498640
OTC121337545
PRUF121356775
ATRC139593917
GFR102040696
FAB101817812
OMA130255399
PHI102114649
PMAJ107207179(HNMT)
CCAE111932325
CCW104694077
CBRC103619651
ACOE138113211
ETL114057695
ZAB102074954
ZLE135450466
ACHL103808894
SVG106849897
MMEA130573795
HRT120755398
SATI136363719
CCIC134047340
FPG101917359
FCH102055002(HNMT)
CCRI104162747(HNMT)
NNT104409170(HNMT)
SHAB115608906(HNMT)
ACUN113482038(HNMT)
TALA104365700
ACHC115343201
HALD104318026(HNMT)
HLE104836532
AGEN126039923
HHAR128144365
GCL127018488
CSTI104556365
LDI104342639
MNB103776435(HNMT)
DPUB104306702
PPUS135181306
AVIT104273077
BRHI104495937
EGZ104129540
NNI104009763
PCRI104028028(HNMT)
PCAO104043569(HNMT)
PADL103912632
AFOR103899260(HNMT)
FGA104069094(HNMT)
GSTE104257472(HNMT)
CBOY140657319
CLV102087354
CNIC135990387
MUI104542051
PGUU104457463
PLET104613687(HNMT)
EHS104509242(HNMT)
CMAC104482961
CUCA104065207
TEO104376947(HNMT)
BREG104641906(HNMT)
OHA104333258
ACAR104523791(HNMT)
CPEA104391140(HNMT)
CVF104292343
RTD128912424
CRID134518591
AAM106498438
AROW112977108
NPD112948591
TGT104580280(HNMT)
DNE112997450
SCAM104145709
ASN102388667
AMJ102572645
CPOO109322991
GGN109301351
PSS102449429(HNMT)
CMY102948037(HNMT)
CCAY125645170(HNMT)
DCC119863406(HNMT)
CPIC101935284(HNMT)
TST117884846(HNMT)
CABI116834811(HNMT)
MRV120374640(HNMT)
ACS100567693
ASAO132775363
PVT110086141
SUND121917764
PBI103058167(HNMT)
PMUR107285856(HNMT)
CTIG120299297(HNMT)
TSR106557223(HNMT)
PGUT117669707(HNMT)
APRI131203482(HNMT)
PTEX113449716(HNMT)
NSS113415916(HNMT)
VKO123027561
PMUA114604687
PRAF128422148
ZVI118092546(HNMT)
HCG128326989
GJA107120669(HNMT)
STOW125427339
EMC129323361
XLA380306(hnmt.S) 495426(hnmt.L)
XTR779808(hnmt)
NPR108796922(HNMT)
RTEM120944138 120944139 120944140
ACAT141147121(HNMT) 141147122 141147124
BBUF121008099 121008100 121008103 121008826 121008827 121008828
BGAR122944677 122945170 122945627 122945635 122945676
DTC141049287(HNMT)
PWL138285315(HNMT)
MUO115474055(HNMT)
GSH117361327(HNMT)
DRE445242(hnmt)
SRX107720324 107751616
SANH107658225 107663827
SGH107558040 107577691
CCAR109051662(hnmt)
CAUA113076734
CGIB128019674
PTET122351174(hnmt)
LROH127170632(hnmt)
GRF141340658(hnmt)
OMC131547230(hnmt)
PPRM120466712(hnmt)
RKG130076591(hnmt) 130083761
MAMB125270035(hnmt)
CIDE127518446
CERY137035807(hnmt)
TROS130555782(hnmt) 130555823
TDW130427073(hnmt)
MANU129438594 129452501 129452502
PDAB135731058 135731060 135731061 135731065 135731066 135771830 135782474 135782475
IPU100528906(hnmt) 108276868
IFU128608440(hnmt) 128620641
PHYP113526256(hnmt) 113544802
SMEO124383082 124383170(hnmt) 124383298 124393633 124393634
TFD113650194 113650195 113650196 113653115 113653116 125139718
TVC132850446 132850447(hnmt) 132863300 132863594 132863595 132863596 132863767 132863768
CGAR128505396 128505397 128505545 128505562 128505597 128505624 128524280 128524429 128524675(hnmt)
NGRA132873143 132881412 132883583 132883587 132892100
TRN134324056 134324131
AMEX103033680 103033996(hnmt)
CMAO118812068
EEE113577948 113584942 113585227 113585243
CHAR105902674(hnmt)
SPIL134078269(hnmt)
TRU101066023
TFS130531548
TNGGSTEN00020755G001
LCO104926342 104926343
NCC104965736(hnmt)
TBEN117485990(hnmt)
CGOB115026531
PGEO117467056
GACU117560070 117560107
EMAC134866910
ELY117249266
EFO125899943
PLEP121949368(hnmt) 121949542
SLUC116037798
ECRA117952955(hnmt)
ESP116698060(hnmt)
PFLV114564332
GAT120834198
PPUG119228666
AFB129104744
CLUM117750964
PSWI130206687
CANA137783004
CVE137892649(hnmt) 137892691
MSAM119903791 119903905 119903906
SCHU122886117(hnmt)
CUD121522302
SPUL138592802
LMIX132986997
ALAT119026437(hnmt)
ASTR137589730 137605020 137605775 137605831 137606112 137606113 137606189 137606190 137606274 137606330 137606352 137606353 137606393 137606394 137606396 137606398 137606399 137606400 137606403 137606404 137606473 137606484 137606486 137606512 137606573 137606578 137606590 137606593 137606605 137606648
MZE101475481 101475778
ONL100703530(hnmt) 100704419
OAU116316553 116316556
OLA101158841 101174335
OML112154869
CSAI133446307(hnmt)
XMA102234300 102235596
XCO114148898 114148899
XHE116723633
PRET103460754 103460763
PFOR103150649
PLAI106934825
PMEI106923411(hnmt)
GAF122840104(hnmt)
PPRL129360992
CVG107099305 107099306
CTUL119776831
GMU124871875
NFU107389879 107390214 107390215
KMR108238570
ALIM106525772(hnmt)
NWH119419052(hnmt)
AOCE111571844
EJA138201319
BFRE138620968
MCEP125017164
CSEM103392316(hnmt)
POV109631194 109631203
SSEN122765462
SSOE131455535(hnmt)
HHIP117754829
HSP118120086
PPLT128455873
SMAU118282524
LCF108886889 108886891
SDU111218535 111218536
SLAL111668738 111668746
XGL120802039 120802041
HCQ109523407
SSCV125973188(hnmt)
SBIA133512671
PEE133410536(hnmt)
PTAO133486717(hnmt)
BPEC110156105 110156194 110160769 110165649 110173352 110173658
ENY140359088 140359224 140359917(hnmt)
MALB109957092 109959613
BSPL114847444 114847446 114847447
SJO128367826
GMH115533372
SASA100196123(hnmt)
STRU115155375 115155377 115164641
OTW112239669 112239670
OMY110501994 110501995
OGO124037206 124037289
ONE115114247 115124003
OKI109875241 109877269
OKE118370362
OMM135518284 135547741
OCLA139381017 139387542
SALP112074908 112074909
SNH120064048 120064049
CCLU121534555 121560621
ELS105009037 105009038
OEP134017574
SFM108927911 108937993
PKI111834433 111834438 111834439 111842325
AANG118213670(hnmt) 118223933
AROT135241282(hnmt) 135250831
CCOG133116653 133116654 133125209
LOC102684020(hnmt) 102684614
PSPA121323636(hnmt)
ARUT117409074 117409089
PSEX120531712(hnmt)
LCM102356420(HNMT) 102356694 102361094 102365060 102365327 106703836
CMK103180417(hnmt)
CPLA122551716 122551717
HOC132817333 132817405
BFO118405123 118413352 118414123 118414189 118416229 118423053 118427802 118427861 118428039 118429296 118429364
BBEL109463342 109466566 109472447 109473261 109473546 109474887 109475022 109476229 109477812 109479703 109479704 109480067 109480121 109483095 109483890 109484391 109484758 109487789
SPU100888125 100888796 100889342 100891191 100892228 115926043 115927194 115928132 115929228 576540 581824 582038 584390 587894 764668
LPIC129254475 129255058 129257507 129257825 129258566 129258568 129258594 129259581 129260159 129261046 129263264 129266024 129266784 129272879 129272994 129273436 129273437 129275093 129276149 129277206 129277254 129278326 129279801 129280968
AJJ139954619 139954944 139961200 139966307 139969810 139977584 139978507 139978818 139978872 139978874 139979145 139981647 139984320 139984394 139984395 139984396
APLC110973248 110973250 110973581 110973582 110973635 110973718 110973719 110973747 110973752 110977804 110977805 110983465 110985102 110986424 110986425 110986434
ARUN117288791 117288792 117289394 117289395 117289571 117289658 117290112 117290755 117290946 117293411 117293781 117294499 117294798 117298072 117298073 117299801 117304426
AAMU139934675 139934676 139934757 139934809 139934847 139934968 139935016 139935074 139935305 139935361 139935728 139936597 139938113 139938458 139938605 139939744 139940522 139940861 139946114 139946544 139948734 139954400
AFIL140135793 140136116 140136196 140137575 140137701 140139959 140140057 140140293 140140294 140140318 140140439 140140441 140140582 140140704 140141044 140142295 140144693 140144694 140144695 140144697 140144698 140144700 140144701 140144702 140144704 140146633 140146635 140146636 140146641 140147033 140147251 140147608 140151674 140151778 140152021 140154429 140157621 140161634 140161915 140162103 140162150 140162468 140162469 140162470 140162623 140163717 140163718 140164007 140164023 140164845 140164893 140164894 140166074 140166081 140166090 140166102 140166188 140166325 140166731 140167278 140167279 140167295 140167296 140167299 140167640 140167689 140167690 140167691 140167692 140167693 140167694 140167696 140167697 140167698 140167699 140169008 140172519 140172520
SKO100313634 100369335 100369757 100370527 100372250 100372330 100373828 100373875 100376946 100377097 102801665 102801851 102803272 102803795 102804990 102805965 102807442 102807875 102809059 102809174 102809929 102810340
PFLL139114004 139114724 139115967 139115968 139117810 139119599 139119651 139122499 139122528 139124535 139124872 139127163 139127561 139128142 139128808 139128813 139128845 139129477 139129491 139130193 139130194 139130680 139131504 139131505 139131506 139131651 139131652 139131654 139131655 139131656 139132511 139132542 139132544 139132606 139132735 139133160 139133316 139133317 139133318 139133322 139133323 139133324 139133325 139133326 139133442 139133443 139133709 139133819 139134259 139134281 139134619 139135031 139135144 139135847 139135884 139136503 139136883 139137539 139137540 139139417 139139921 139144063 139146180 139147031 139147307 139147310 139147346 139147347 139147386 139147503 139147611 139147616 139147618 139147619 139147674 139147987 139148582 139152386
NVE116614128 116614129 116619812 5500978 5510493 5513259
EPA110231613 110231614 110232231 110237463 110238561 110242372 110242373 110245025 110246401 110247714 110248237 110248426 110250668
ATEN116286436 116287043 116290127 116296836 116300426 116301610 116301611 116306456
ADF107338158 107343921 107343922 107347573 107347579
AMIL114953965 114964257 114964262 114964267 114971044
MCAZ138015730 138015742 138027033 138027073 138046859
MFOO137967238 137967350 137967701 137978851 138006159
PDAM113672896 113677551 113678227 113678235
SPIS111320298 111326664 111333303 111333487 111334769 111334779 111338539 111345286
DGT114520662 114527607 114528324 114534460 114534461 114534462 114534463 114534464 114534465 114534467 114534468 114534469 114534470 114534471 114534472 114536842
XEN124446317 124454151 124454153 124454154 124454155 124454733
HMG100214195
HSY130622864
RES135684686 135686352 135694018 135695983 135696033
 » show all
Reference
1  [PMID:13804910]
  Authors
BROWN DD, TOMCHICK R, AXELROD J.
  Title
The distribution and properties of a histamine-methylating enzyme.
  Journal
J Biol Chem 234:2948-50 (1959)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.8
IUBMB Enzyme Nomenclature: 2.1.1.8
ExPASy - ENZYME nomenclature database: 2.1.1.8
BRENDA, the Enzyme Database: 2.1.1.8
CAS: 9029-80-5
LinkDB

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