KEGG   ENZYME: 2.1.1.8
Entry
EC 2.1.1.8                  Enzyme                                 
Name
histamine N-methyltransferase;
histamine 1-methyltransferase;
histamine methyltransferase;
histamine-methylating enzyme;
imidazolemethyltransferase;
S-adenosylmethionine-histamine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:histamine N-tele-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Ntau-methylhistamine [RN:R02155]
Reaction(KEGG)
R02155
Substrate
S-adenosyl-L-methionine [CPD:C00019];
histamine [CPD:C00388]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
Ntau-methylhistamine [CPD:C05127]
History
EC 2.1.1.8 created 1965
Pathway
ec00340  Histidine metabolism
ec01100  Metabolic pathways
Orthology
K00546  histamine N-methyltransferase
Genes
HSA3176(HNMT)
PTR742204(HNMT)
PPS100970136(HNMT)
GGO101141216(HNMT)
PON100174618(HNMT)
MCC703857 706713(HNMT)
MCF101867462(HNMT)
CSAB103217003(HNMT)
CATY105575026 105590363
TGE112636099 112636474
RRO104672066(HNMT)
TFN117095061(HNMT)
PTEH111528181(HNMT)
CJC100405862(HNMT)
SBQ101041589(HNMT)
CSYR103276269(HNMT)
MMUR105857643(HNMT)
OGA100946532(HNMT)
MMU140483(Hnmt)
MCAL110287683(Hnmt)
MPAH110319128(Hnmt)
RNO81676(Hnmt)
MCOC116089779(Hnmt)
MUN110563412(Hnmt)
CGE100759779 100761300
PLEU114692749(Hnmt)
NGI103726551(Hnmt)
HGL101702942(Hnmt)
CPOC100135537(Hnmt)
CCAN109681803 109681804
DORD105996105(Hnmt)
DSP122110849(Hnmt)
NCAR124980212
OCU100347399(HNMT)
OPI101521079(HNMT)
TUP102469391
CFA476133(HNMT)
VVP112909578(HNMT)
VLG121481974(HNMT)
AML100481941(HNMT)
UMR103667681(HNMT)
UAH113263407(HNMT)
UAR123782459(HNMT)
ELK111143222
LLV125095920
MPUF101687140(HNMT)
ORO101368085(HNMT)
EJU114207302(HNMT)
ZCA113920985(HNMT)
MLX118012493(HNMT)
FCA101093704(HNMT)
PYU121030502(HNMT)
PBG122481293(HNMT)
PTG102954667(HNMT)
PPAD109270411(HNMT)
AJU106969447(HNMT)
HHV120220316(HNMT)
BTA613413(HNMT)
BOM102279160(HNMT)
BIU109568122(HNMT)
BBUB102395473(HNMT)
CHX102169059(HNMT)
OAS101102876(HNMT)
ODA120854497(HNMT)
CCAD122453760(HNMT)
SSC100624677(HNMT)
CFR102506628(HNMT)
CBAI105083386(HNMT)
CDK105092265(HNMT)
VPC102543745(HNMT)
BACU102997526(HNMT)
LVE103075160(HNMT)
OOR101281948(HNMT)
DLE111172721(HNMT)
PCAD102996034(HNMT)
PSIU116756298(HNMT) 116760948
ECB100051119(HNMT)
EPZ103553344(HNMT)
EAI106845596(HNMT)
MYB102249926(HNMT)
MYD102774069(HNMT)
MMYO118662268(HNMT)
MLF102421337(HNMT)
MNA107531142(HNMT)
PKL118709789(HNMT)
HAI109372885(HNMT) 109374605
DRO112313104(HNMT)
SHON118975029(HNMT)
AJM119040294(HNMT)
PDIC114494348(HNMT)
PHAS123832492(HNMT)
MMF118625533(HNMT)
RFQ117026346(HNMT)
PALE102888765(HNMT)
PGIG120611952(HNMT)
PVP105288335(HNMT)
RAY107511202(HNMT)
MJV108398856(HNMT)
TOD119255798(HNMT)
SARA101546126(HNMT)
LAV100674300(HNMT)
TMU101349793
DNM101430514(HNMT)
MDO100012612(HNMT)
GAS123242278(HNMT)
SHR100914453(HNMT)
PCW110223777(HNMT)
OAA100080018
GGA424298(HNMT)
PCOC116227438
MGP100542432
CJO107316986
NMEL110400130
APLA101795218
ACYG106039378(HNMT)
AFUL116490827
TGU100228106
LSR110480615
SCAN103814270
PMOA120498640
OTC121337545
PRUF121356775
GFR102040696
FAB101817812
PHI102114649
PMAJ107207179
CCAE111932325
CCW104694077
ETL114057695
ZAB102074954
FPG101917359
FCH102055002(HNMT)
CLV102087354
EGZ104129540
NNI104009763
ACUN113482038(HNMT)
TALA104365700
PADL103912632
ACHC115343201
AAM106498438
AROW112977108
NPD112948591
DNE112997450
ASN102388667
AMJ102572645
CPOO109322991
GGN109301351
PSS102449429(HNMT)
CMY102948037(HNMT)
CPIC101935284(HNMT)
TST117884846(HNMT)
CABI116834811(HNMT)
MRV120374640(HNMT)
ACS100567693
PVT110086141
SUND121917764
PBI103058167(HNMT)
PMUR107285856(HNMT)
TSR106557223(HNMT)
PGUT117669707(HNMT)
VKO123027561
PMUA114604687
ZVI118092546(HNMT)
GJA107120669(HNMT)
STOW125427339
XLA380306(hnmt.S) 495426(hnmt.L)
XTR779808(hnmt)
NPR108796922(HNMT)
RTEM120944138 120944139 120944140
BBUF121008099 121008100 121008103 121008826 121008827 121008828
BGAR122944677 122945170 122945627 122945635 122945676
DRE445242(hnmt)
SRX107720324 107751616
SANH107658225 107663827
SGH107558040 107577691
CCAR109051662
CAUA113076734
PPRM120466712(hnmt)
MAMB125270035(hnmt)
IPU100528906(hnmt) 108276868
PHYP113526256(hnmt) 113544802
SMEO124383082 124383170(hnmt) 124383298 124393633 124393634
TFD113650194 113650195 113650196 113653115 113653116 125139718
AMEX103033680 103033996
EEE113577948 113584942 113585227 113585243
TRU101066023
TNGGSTEN00020755G001
LCO104926342 104926343
NCC104963990 104965736(hnmt)
CGOB115026531
ELY117249266
PLEP121949368(hnmt) 121949542
SLUC116037798
ECRA117952955(hnmt)
PFLV114564332
GAT120834198
PPUG119228666
MSAM119903791 119903905 119903906
CUD121522302
MZE101475481 101475778
ONL100703530(hnmt) 100704419
OAU116316553 116316556
OLA101158841 101174335
OML112154869
XMA102234300 102235596
XCO114148898 114148899
XHE116723633
PRET103460754 103460763
PFOR103150649
PLAI106934825
PMEI106923411(hnmt)
GAF122840104(hnmt)
CVG107099305 107099306
CTUL119776831
GMU124871875
NFU107389879 107390214 107390215
KMR108238570
ALIM106525772(hnmt)
NWH119419052(hnmt)
AOCE111571844 111571846
CSEM103392316(hnmt)
POV109631194 109631203
SSEN122765462
HHIP117754829
LCF108886889 108886891
SDU111218535 111218536
SLAL111668738 111668746
XGL120802039 120802041
HCQ109523407 109523408
BPEC110156105 110156182 110156194 110160769 110165649 110173352 110173658
MALB109957092 109959613
SASA100196123(hnmt)
OTW112239669 112239670
OMY110501994 110501995
OGO124037206 124037289
ONE115114247 115124003
SALP112074908 112074909
SNH120064048 120064049
ELS105009037 105009038
SFM108927911 108937993
PKI111834433 111834438 111834439 111842325
AANG118213670(hnmt) 118223933
LOC102684020(hnmt) 102684614
PSPA121323636(hnmt)
ARUT117409074 117409089
LCM102356420(HNMT) 102356694 102361094 102365060 102365327 106703836
CMK103180417(hnmt)
BFO118405123 118413352 118414123 118414189 118416229 118423053 118427802 118427861 118428039 118429296 118429364
BBEL109463342 109466566 109472447 109473261 109473546 109474887 109475022 109476229 109477812 109479703 109479704 109480067 109480121 109483095 109483890 109484391 109484758 109487789
SPU100888125 100888796 100889342 100891191 100892228 115926043 115927194 115928132 115929228 576540 581824 582038 584390 587894 764668
APLC110973248 110973250 110973581 110973582 110973635 110973718 110973719 110973747 110973752 110977804 110977805 110983465 110985102 110986424 110986425 110986434
SKO100313634 100369335 100369757 100370527 100372250 100372330 100373828 100373875 100376946 100377097 100377821 102801665 102801851 102803272 102803795 102804990 102805965 102807442 102807875 102809059 102809174 102809929 102810340
NVE116614128 116614129 116619812 5500978 5510493 5513259
EPA110231613 110231614 110232231 110237463 110238561 110242372 110242373 110245025 110246401 110247714 110248237 110248426 110250668
ATEN116286436 116287043 116290127 116296836 116300426 116301610 116301611 116306456
ADF107338158 107343921 107343922 107347573 107347579
AMIL114953965 114964256 114964257 114964262 114964267 114971044
PDAM113672896 113677551 113678227 113678235
SPIS111320298 111326664 111333303 111333487 111334769 111334779 111338539 111345286
DGT114520662 114527607 114528324 114534460 114534461 114534462 114534463 114534464 114534465 114534467 114534468 114534469 114534470 114534471 114534472 114536842
XEN124446317 124454151 124454153 124454154 124454155 124454733
HMG100214195
 » show all
Reference
1  [PMID:13804910]
  Authors
BROWN DD, TOMCHICK R, AXELROD J.
  Title
The distribution and properties of a histamine-methylating enzyme.
  Journal
J Biol Chem 234:2948-50 (1959)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.8
IUBMB Enzyme Nomenclature: 2.1.1.8
ExPASy - ENZYME nomenclature database: 2.1.1.8
BRENDA, the Enzyme Database: 2.1.1.8
CAS: 9029-80-5
LinkDB

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