| Entry |
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| Name |
thiol S-methyltransferase;
S-methyltransferase;
thiol methyltransferase;
TMT
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:thiol S-methyltransferase
|
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a methyl thioether [RN: R01235]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
methyl thioether [CPD: C20791]
|
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| Comment |
H2S and a variety of alkyl, aryl and heterocyclic thiols and hydroxy thiols can act as acceptors.
|
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| History |
EC 2.1.1.9 created 1965
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| Reference |
|
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| Authors |
Borchardt RT, Cheng CF. |
|---|
| Title |
Purification and characterization of rat liver microsomal thiol methyltransferase. |
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| Journal |
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| Reference |
2 |
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| Authors |
Bremer J, Greenberg DM. |
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| Title |
Enzymic methylation of foreign sulfhydryl compounds. |
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| Journal |
Biochim Biophys Acta 46:217-224 (1961) |
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| Reference |
|
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| Authors |
Weisiger RA, Jakoby WB. |
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| Title |
Thiol S-methyltransferase from rat liver. |
|---|
| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.1.9 |
| ExPASy - ENZYME nomenclature database: | 2.1.1.9 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 2.1.1.9 |
| BRENDA, the Enzyme Database: | 2.1.1.9 |
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| LinkDB |
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