KEGG ENZYME: 2.1.1.9

ENZYME: 2.1.1.9

Entry

EC 2.1.1.9                  Enzyme

Name

thiol S-methyltransferase;
S-methyltransferase;
thiol methyltransferase;
TMT

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:thiol S-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a methyl thioether [RN:R01235]

Reaction(KEGG)

R01235;
(other) R04931

Substrate

S-adenosyl-L-methionine [CPD:C00019];
thiol [CPD:C00145]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
methyl thioether [CPD:C20791]

Comment

H2S and a variety of alkyl, aryl and heterocyclic thiols and hydroxy thiols can act as acceptors.

History

EC 2.1.1.9 created 1965

Orthology

K28672

thiol S-methyltransferase

Genes

HSA:	196410(TMT1B) 25840(TMT1A)

PTR:	740603(TMT1A) 747675(TMT1B)

PPS:	100984383(TMT1A) 100989062(TMT1B)

GGO:	101126590(TMT1B) 101135962(TMT1A)

PON:	100173708(TMT1A) 100439398(TMT1B)

PPYG:

129009293(TMT1B) 129009604(TMT1A)

NLE:	100588968(METTL7A) 100599043(METTL7B)

HMH:	116461754(TMT1A) 116480955(TMT1B)

SSYN:

129466715(TMT1B) 129491078(TMT1A)

MCC:	693894(METTL7A) 709549(METTL7B)

MCF:	102127872(TMT1A) 102131630(TMT1B)

MTHB:

126931060 126931167

MNI:	105474182(METTL7B) 105474361

CSAB:

103238310(METTL7A) 103238478(METTL7B)

CATY:

105580349(METTL7A) 105587333(METTL7B)

PANU:

101009902(METTL7A) 101021058(METTL7B)

TGE:	112634326(METTL7A) 112634362(METTL7B)

MLEU:

105527866(METTL7A) 105532011(METTL7B)

RRO:	104673714(METTL7B) 104679682(METTL7A)

RBB:	108516028(METTL7B) 108541996(METTL7A)

TFN:	117089976(METTL7B) 117090127(METTL7A)

PTEH:

111541888(METTL7B) 111542006(METTL7A)

CANG:

105500579(METTL7B)

CJC:	100401279(TMT1B) 100404559 103795233

SBQ:	101040417(METTL7A) 101050923(METTL7B)

CIMI:

108296821(METTL7B) 108316003(METTL7A)

ANAN:

105715911(TMT1B)

CSYR:

103255293(METTL7B) 103276687(METTL7A)

MMUR:

105870010(METTL7A)

LCAT:

123640375(METTL7A)

ERUF:

138397094(TMT1A)

PCOQ:

105815280(METTL7B) 105817731(METTL7A)

OGA:	100947775 100948096 100961634(METTL7B)

MMU:	393082(Tmt1a2) 554292(Methig1) 668178(Tmt1a3) 70152(Tmt1a) 71664(Tmt1b)

MCAL:

110302899(Mettl7b) 110310526

MPAH:

110326221(Mettl7b) 110334941(Mettl7a)

RNO:	315306(Mettl7a) 366792(Mettl7b)

MCOC:

116075888(Mettl7b) 116079805(Higd1c)

ANU:	117696877(Mettl7b) 117701628 117701630 117701681 117719369(Mettl7a)

ASYL:

127667781 127667782 127671229(Tmt1b)

MUN:	110561552(Tmt1a) 110563161(Tmt1b)

CGE:	100764211(Mettl7a) 100773333(Mettl7b)

MAUA:

101825898(Mettl7a) 101842329(Mettl7b)

PROB:

127215603(Tmt1b) 127226079(Tmt1a)

PLEU:

114681740(Mettl7b) 114696673(Mettl7a)

PMAV:

102906524(Tmt1a) 102927854(Tmt1b)

MORG:

121441516(Mettl7a) 121458718(Mettl7b)

MFOT:

126488746 126492005

AAMP:

119803480(Mettl7b) 119823432(Mettl7a)

CNL:	130866614(Tmt1b) 130888991(Tmt1a)

NGI:	103730625(Mettl7a) 103738831(Mettl7b)

HGL:	101703440(Mettl7b) 101723080(Mettl7a)

CPOC:

100717217(Mettl7b) 100719068(Mettl7a)

CCAN:

109696214(Mettl7b) 109696738(Mettl7a)

DORD:

105987472(Mettl7a) 105988336(Mettl7b)

DSP:	122098344(Mettl7a) 122124205(Mettl7b)

DMER:

138840796(Tmt1a) 138841597(Tmt1b)

PLOP:

125363399(Mettl7b) 125364851(Mettl7a)

NCAR:

124982536 124982624 124983380

MMMA:

107140211(Mettl7b) 107148627 107148629 107148630

ITI:	101958858(Mettl7a)

OCU:	100345746 100346006 103344945 127487419

OPI:	101530504(METTL7A) 101534638(METTL7B)

OCZ:	121155610(METTL7A) 121163187(METTL7B)

TUP:	102473825(METTL7A) 102491988(METTL7B)

GVR:	103587505(METTL7A) 103599054(METTL7B)

CFA:	100685262(METTL7A) 474390(METTL7B)

CLUD:

112678054(METTL7B) 112678327(METTL7A)

VVP:	112921249(METTL7A) 112922417(METTL7B)

VLG:	121480275(METTL7A) 121490881(METTL7B)

NPO:	129511685(TMT1B) 129517424(TMT1A)

AML:	100475681(METTL7B) 100479923(METTL7A)

UMR:	103675483(METTL7A)

UAH:	113256463(TMT1B) 113257619(TMT1A)

UAR:	123787286(METTL7B) 123794748(METTL7A)

ELK:	111157885 111160221

LLV:	125106763 125107262

MPUF:

101690866(METTL7A) 101693732(METTL7B)

MNP:	132019674(TMT1A) 132019767(TMT1B)

MLK:	131838636(TMT1B) 131838766(TMT1A)

NVS:	122891475(METTL7A) 122891647(METTL7B)

ORO:	101366964(METTL7B) 101382033(METTL7A)

EJU:	114214978(METTL7B) 114225795(METTL7A)

ZCA:	113921977(METTL7A) 113922713(METTL7B)

MLX:	118008750(METTL7B) 118008849(METTL7A)

MANO:

123839495 123843666(TMT1B) 123843750(TMT1A)

NSU:	110577744(METTL7B) 110593640(METTL7A)

LWW:	102727465(METTL7B)

FCA:	101089531(METTL7B) 111556213(METTL7A)

PYU:	121038580(METTL7A) 121040973(METTL7B)

PCOO:

112863899(METTL7B) 112867172(METTL7A)

PBG:	122473393(METTL7A) 122473718(METTL7B)

PVIV:

125170069(TMT1A) 125170189(TMT1B)

LRUF:

124501255 124501294

LGF:	123590054(METTL7B) 123591210(METTL7A)

AJU:	106969222 106986903

PTG:	102954451(METTL7B)

PPAD:

109249109(METTL7A) 109270293(METTL7B)

PUC:	125919049 125919195

PLEZ:

122224549 122224655(METTL7B)

HHV:	120219961(METTL7B) 120237893(METTL7A)

CCRU:

144222757(TMT1A) 144222784 144226147(TMT1B)

BTA:	506952(TMT1B) 613844(TMT1A)

BOM:	102270564(TMT1A) 102282496(TMT1B)

BIU:	109559103 109559106(METTL7A) 109559399(METTL7B)

BBUB:

102400376 102405928(METTL7B)

BKE:	129649616(TMT1B) 129653763

BBIS:

104988038(METTL7B) 105001510

CHX:	102168424 102179920(METTL7B)

OAS:	101115696(TMT1B) 101117657(TMT1A)

BTAX:

128047989(TMT1A) 128048684(TMT1B)

CSUM:

138078317 138079278(TMT1B)

ODA:	120857406(METTL7B) 120858201(METTL7A)

CCAD:

122427605(METTL7A) 122427805(METTL7B)

MREE:

136167135 136167370(TMT1B)

OVR:	110146981(TMT1A) 110147178(TMT1B)

MBEZ:

129535736(TMT1B) 129536916(TMT1A)

SSC:	110258456(METTL7A) 110260568 110260683(METTL7B)

CFR:	102523835(METTL7B) 106730639(METTL7A) 116667621

CBAI:

105076230(METTL7A) 105081437(METTL7B)

CDK:	105084216(METTL7A) 105106267

VPC:	102539981(METTL7B) 102545023(METTL7A)

BACU:

103008258(METTL7B) 103011443(METTL7A)

BMUS:

118902156(METTL7B) 118902719(METTL7A)

LVE:	103080638(METTL7B) 103091635(METTL7A)

OOR:	101273462(TMT1B) 101280235(TMT1A)

LALB:

132529461(TMT1B) 132529568(TMT1A) 132529962

GMF:	115841317(TMT1A) 115858635(TMT1B)

DDP:	132433680(TMT1A) 132433749(TMT1B)

DLE:	111173910(METTL7B) 111174004(METTL7A)

PCAD:

102983233(TMT1B) 102989013(TMT1A)

PSIU:

116760576(METTL7A) 116760595(METTL7B)

PPHC:

136130469(TMT1A) 136130963(TMT1B)

NASI:

112394095(METTL7A) 112394130(METTL7B)

ECB:	100051234(METTL7B) 100060363(METTL7A)

EPZ:	103545910(TMT1A) 103560208(TMT1B)

EAI:	106835219(METTL7A) 106841314(METTL7B)

MYB:	102253388(METTL7A)

MYD:	102772165(METTL7A)

MMYO:

118651422(METTL7A)

MLF:	102426183(METTL7A)

MDT:	132227581(TMT1A)

MYUM:

139007136(TMT1A)

PKL:	118730154(METTL7A)

EFUS:

103285295(TMT1A)

MNA:	107528270(METTL7A)

DRO:

112318333

SHON:

118976420(METTL7A)

AJM:

119042957

PDIC:

114514157

PHAS:

123812994(METTL7A)

MMF:	118624087(METTL7A)

PPAM:

129084848(TMT1A)

HAI:	109393269(METTL7A) 109396849(METTL7B)

RFQ:	117028243 117028730(METTL7B)

PALE:

102890058(METTL7B) 102892800

PGIG:

120602141 120602150 120604818 120604819

PVP:

105311423

RAY:	107509800 107509803 107514274 107521277(METTL7B)

MJV:	108388326 108389179(METTL7A) 108395929(METTL7B)

TOD:	119247917(TMT1A)

SARA:

101558557(METTL7A) 101559273

SFUM:

130029346(TMT1A)

SETR:

126022619(TMT1A)

LAV:	100661406(METTL7A) 100665184(METTL7B)

TMU:	101340342 101360155

ETF:	101639612(METTL7B) 101664683(METTL7A)

DNM:	101441790(METTL7B) 101443906 101444357

MDO:	100013174(METTL7B)

GAS:	123249110(METTL7A) 123250334(METTL7B)

SHR:	100926589(METTL7A)

AFZ:

127564335

PCW:	110194122(METTL7A) 110210895(METTL7B)

TVP:	118849860(METTL7B) 118849868(METTL7A)

PBRV:

138154186(TMT1B) 138164634(TMT1A)

MLAO:

141514813(TMT1A) 141515131(TMT1B)

TACU:

119933345(METTL7A)

GGA:	426871(METTL7A)

PCOC:

116239676(METTL7A)

MGP:	100542973(METTL7A)

CJO:	107325711(METTL7A)

TPAI:

128091860(TMT1A)

LMUT:

125685534(METTL7A)

NMEL:

110389163(METTL7A)

APLA:

101797486(METTL7A) 110353396

AACU:

137846036(TMT1A)

OJA:	118155572(METTL7A)

ACYG:

106047730 106047731

CATA:

118260230

AFUL:

116500008(METTL7A) 116500009

TGU:	100218813(METTL7A)

LSR:	110478531(TMT1A)

SCAN:

103823853(METTL7A)

PMOA:

120500665(METTL7A)

OTC:	121333732(METTL7A)

PRUF:

121353985(METTL7A)

ATRC:

139585876(TMT1A)

GFR:	102036112(METTL7A)

FAB:	101810581(METTL7A)

OMA:

130265728

PHI:	102105031(METTL7A)

PMAJ:

107215645(METTL7A)

CCAE:

111940494(METTL7A)

CBRC:

103613207(METTL7A)

ACOE:

138099977(TMT1A)

ETL:	114069953(METTL7A)

ZAB:	106630011(METTL7A)

ZLE:

135459225

SVG:	106863137(METTL7A)

MMEA:

130586363

HRT:	120764519(TMT1A)

SATI:

136372737(TMT1A)

CFAI:

136303873(TMT1A)

CCIC:

134054955

FPG:

101910655

FCH:

102046698

CCRI:

104161525

SHAB:

115618763

ACUN:

113491046 113491053

ANOC:

141971901

SURA:

141936748 141936749

TALA:

104355625(METTL7A) 104355629

ACHC:

115351001

HALD:

104320637

HLE:

104831144

AGEN:

126046309

HHAR:

128151968 128151971

BBUT:

142041252(TMT1A)

GCL:	127028435 127028441

CSTI:

104549829(METTL7A)

MNB:	103768412 103770222

DPUB:

104305497

PPUS:

135174324

AVIT:

104267415 104274233

BRHI:

104492963(METTL7A)

EGZ:

104132772

NNI:	104011974 104011975

PCRI:

104024148

PCAO:

104044193

PARX:

142048580(TMT1A)

PADL:

103914666(METTL7A)

AFOR:

103894914(METTL7A)

FGA:	104069468 104069473

CBOR:

142073657 142073658

GSTE:

104250453 104250576

CBOY:

140644516 140644517

MAME:

142421132 142421133

CLV:	102090298(METTL7A)

CNIC:

136000561(TMT1A)

MUI:

104541114

PGUU:

104472427(METTL7A)

PLET:

104623427

EHS:

104508618

CMAC:

104473288

CUCA:

104055640(TMT1A)

TEO:

104372838

BREG:

104629339

GAME:

129197987 129197988

OHA:	104326603(METTL7A)

ACAR:

104517823

CPEA:

104385600(METTL7A)

CVF:	104284800(METTL7A)

RTD:	128901313(TMT1A)

CRID:

134526945

LMIC:

141734023(TMT1A)

NARQ:

141476292(TMT1A)

AAM:	106499429(METTL7A)

AROW:

112975213

NPD:	112950293(METTL7A) 112950294

TGT:

104575192

DNE:

112991674

SCAM:

104144026 104144027(METTL7A)

ASN:

102385785

AMJ:	102571011(METTL7A)

CPOO:

109324438

GGN:

109293271

PSS:

102453766

CIZ:	142003122 142003350

CMY:

102935470

CCAY:

125627513

LKP:

140900975

NDS:

141974928

DCC:

119845643

CPIC:

101931820

TST:	117889172(METTL7A)

CABI:

116828344

MRV:

120390985

ACS:

100557412

ASAO:

132768274

PVT:

110074161

SUND:

121922168(METTL7A)

PBI:	103048342(METTL7A)

PMUR:

107291897

CTIG:

120320250

PCAE:

139312750

APRI:

131192150(TMT1A)

PTEX:

113443138(METTL7A)

NSS:	113421106(METTL7A)

VKO:

123019338

PMUA:

114587070 114587140

PRAF:

128407128 128407130

ZVI:

118081455

HCG:

128341898

GJA:	107116931 107117864

STOW:

125428367

EMC:	129327226 129329255(TMT1A)

XLA:	496010 496284(mettl7a.3.L)

XTR:	779612(mettl7a.2)

NPR:	108793559 108793561

RTEM:

120929406

ACAT:

141127349

PADS:

140327435 140327457

BBUF:

120993839

BGAR:

122932750(METTL7A)

DTC:

141091259

HSQ:

130358842

PWL:	138292316 138292317 138294083

MUO:

115466793

GSH:

117357708

DRE:	569046(tmt1a.3) 569089(tmt1a.2) 569131(tmt1a.1)

SRX:	107711020 107740572

SANH:

107667380

SGH:

107585130

CCAR:

109052583 109052623

CAUA:

113050363 113094273

CGIB:

127960211 128015737 128015738

PTET:

122346460 122346461

LROH:

127167000(tmt1a.1) 127167002

GRF:

141347104

OMC:	131542027(tmt1a.1) 131542028

PPRM:

120491398 120491400

RKG:

130087549

MAMB:

125273718 125273719(mettl7a.3)

CIDE:

127513972 127513973

CERY:

137011108

MASI:

127448762

TROS:

130556734(tmt1a.1)

TDW:

130425330

MANU:

129451054

PDAB:

135746264

IPU:

108271752

IFU:

128614585

SMEO:

124383608

TFD:

113649515

TVC:

132844110

CGAR:

128526249

NGRA:

132885544

TRN:

134316621

AMEX:

107197751(mettl7a.1)

CMAO:

118808261 118808265

EEE:

113590224

CHAR:

105897872(mettl7a.1)

SPIL:

134092443

ASAD:

121707745(mettl7a.1)

TRU:	101064349 101076983

TFS:	130524384 130524385

TNG:	GSTEN00027229G001

LCO:

104931274

NCC:	104966811(mettl7a)

TBEN:

117489497 117489498

CGOB:

115007756 115008724

PGEO:

117446980

GACU:

117551033 117551087

EMAC:

134883488

ELY:	117256219 117256533

EFO:	125893219 125895617

PLEP:

121951028 121952894

SLUC:

116065720 116065726

ECRA:

117944128 117944129

ESP:	116688482 116688483

PFLV:

114554271 114554272

GAT:	120834681 120834682

PPUG:

119229850 119229851

AFB:	129105568 129105792

CLUM:

117731435 117731436

PSWI:

130208518

CANA:

137796244 137796495

CVE:	137879485 137879630

MSAM:

119886439 119886582

SCHU:

122867299

EARM:

139282731 139283038

CUD:	121507055 121507438

SPUL:

138606017 138606305

LMIX:

132977789 132977790

HTC:	141793671 141793681

ALAT:

119021019 119021020

ASTR:

137595753

PKLU:

139214054 139217901

MZE:	101484749 101485242

ONL:	100703146 100703416

OAU:	116328481 116328543

OLA:	101162432 101174569

OML:	112144703 112144708

CSAI:

133448737 133448739

XMA:	102216653 102232534

XCO:	114135129 114135130

XHE:	116709737 116709738

PRET:

103465360 103465363

PFOR:

103147637(mettl7a) 103147640

PLAI:

106962539 106962540

PMEI:

106931705 106931706(mettl7a)

GAF:	122834770 122834772

PPRL:

129357979 129357992

CVG:	107082094 107082095

CTUL:

119785403 119785404

GMU:	124857081 124857082

NFU:	107384045 107384046

KMR:	108235575 108235639

ALIM:

106518051 106518052

NWH:	119412574 119412843

AOCE:

111588752 111588757

EJA:	138201569 138201580

BFRE:

138626673 138626678

MCEP:

125007277 125007279(mettl7a.1)

CSEM:

103385975 103385978

POV:	109629147 109629400

SSEN:

122768321 122768324

SSOE:

131461303(tmt1a.1)

HHIP:

117761894 117761895

HSP:	118102211 118102219

PPLT:

128456567 128456667

SMAU:

118309144 118309145

LCF:	108881436 108881441

SDU:	111221620 111221849

SLAL:

111667646 111667842

XGL:	120807028 120807103

HCQ:	109522408 109522409

SSCV:

125977654

SBIA:

133507658

PEE:

133408752

PTAO:

133483085

BPEC:

110158710

ENY:

140365222

MALB:

109956216

BSPL:

114855894 114856001 114856003

SJO:	128355459 128355460

SSCO:

134004478 134004487

TTY:	137181676 137181677

GMH:	115557256 115557257

SASA:

106565596 106583149

STRU:

115149865 115207905

OTW:	112216948 112255497

OMY:

110527134

OGO:	124003524 124019543

ONE:

115146010

OKI:	109891581 109895289

OKE:	118372681 118388633

OMM:	135539916 135541068

OCLA:

139371032 139414362

SALP:

111966255 112068060

SNH:	120061577 120064779

SFON:

129816030 129847034

CCLU:

121575915 121578514

ELS:	105017012 105017013

OEP:	134023707 134023716(tmt1a.1)

SFM:	108918361(mettl7a)

PKI:

111832898

AANG:

118210605

AROT:

135237652

CCOG:

133109950

PSPA:

121308895

ARUT:

117967001

LCM:	102361907(METTL7A)

RTP:

125487440

CPLA:

122543288

CPUN:

140471362

HOC:

132805756

SCAU:

119958209

STOZ:

140405439

LERI:

129714661

HAKA:

140741176

PMRN:

116949608

LRJ:

133348033

BFO:

118419153

BBEL:

109487855

SKO:

102804712

SPRM:

135091688 135091862 135091943 135106525

CCLM:

134189747 134190033

» show all

Reference

1 [PMID:623768]

Authors

Borchardt RT, Cheng CF.

Title

Purification and characterization of rat liver microsomal thiol methyltransferase.

Journal

Biochim Biophys Acta 522:340-53 (1978)
DOI:10.1016/0005-2744(78)90068-2

Reference

Authors

Bremer J, Greenberg DM.

Title

Enzymic methylation of foreign sulfhydryl compounds.

Journal

Biochim Biophys Acta 46:217-224 (1961)

Reference

3 [PMID:485170]

Authors

Weisiger RA, Jakoby WB.

Title

Thiol S-methyltransferase from rat liver.

Journal

Arch Biochem Biophys 196:631-7 (1979)
DOI:10.1016/0003-9861(79)90317-5

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.9

IUBMB Enzyme Nomenclature:

2.1.1.9

ExPASy - ENZYME nomenclature database:

2.1.1.9

UM-BBD (Biocatalysis/Biodegradation Database):

2.1.1.9

BRENDA, the Enzyme Database:

2.1.1.9

CAS:

9029-81-6

LinkDB

DBGET integrated database retrieval system