KEGG   ENZYME: 2.1.2.13
Entry
EC 2.1.2.13                 Enzyme                                 
Name
UDP-4-amino-4-deoxy-L-arabinose formyltransferase;
UDP-L-Ara4N formyltransferase;
ArnAFT
Class
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
Sysname
10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase
Reaction(IUBMB)
10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose [RN:R07660]
Reaction(KEGG)
R07660
Substrate
10-formyltetrahydrofolate [CPD:C00234];
UDP-4-amino-4-deoxy-beta-L-arabinopyranose [CPD:C16153]
Product
5,6,7,8-tetrahydrofolate [CPD:C00101];
UDP-4-deoxy-4-formamido-beta-L-arabinopyranose [CPD:C16154]
Comment
The activity is part of a bifunctional enzyme also performing the reaction of EC 1.1.1.305 [UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)].
History
EC 2.1.2.13 created 2010
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K10011  UDP-4-amino-4-deoxy-L-arabinose formyltransferase / UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)
Genes
ECO: b2255(arnA)
ECJ: JW2249(yfbG)
ECD: ECDH10B_2415(arnA)
EBW: BWG_2028(arnA)
ECOK: ECMDS42_1825(yfbG)
ECE: Z3513
ECS: ECs_3143(arnA)
ECF: ECH74115_3396(arnA)
ETW: ECSP_3132(arnA)
ELX: CDCO157_2906
EOJ: ECO26_3245(arnA)
EOH: ECO103_2721(arnA)
ECOO: ECRM13514_3011
ECOH: ECRM13516_2956
ESL: O3K_08215
ESO: O3O_17420
ESM: O3M_08165
ECK: EC55989_2501(yfbG)
ECG: E2348C_2399(arnA)
EOK: G2583_2795(arnA)
ELR: ECO55CA74_13835
ELH: ETEC_2389
ECW: EcE24377A_2550(arnA)
EUN: UMNK88_2807
ECP: ECP_2298
ENA: ECNA114_2348(yfbG)
ECOS: EC958_2593(yfbG)
ECV: APECO1_4306(yfbG)
ECOA: APECO78_15095
ECX: EcHS_A2400(arnA)
ECM: EcSMS35_2409(arnA)
ECY: ECSE_2514
ECR: ECIAI1_2331(yfbG)
ECQ: ECED1_2721(yfbG)
EUM: ECUMN_2596(yfbG)
ECT: ECIAI39_2402(yfbG)
EOC: CE10_2638(arnA)
EBR: ECB_02181(yfbG)
EBL: ECD_02181(arnA)
EBE: B21_02140(arnA)
EBD: ECBD_1404
ECI: UTI89_C2537(yfbG)
EIH: ECOK1_2491(arnA)
ECZ: ECS88_2404(yfbG)
ECC: c2797(yfbG)
ELO: EC042_2498(arnA)
ELN: NRG857_11435
ESE: ECSF_2135
ECL: EcolC_1394
EKO: EKO11_1509
EKF: KO11_11410(arnA)
EAB: ECABU_c25890(arnA)
EDH: EcDH1_1403
EDJ: ECDH1ME8569_2191(arnA)
ELU: UM146_05525
ELW: ECW_m2446(arnA)
ELL: WFL_11970(arnA)
ELC: i14_2596(yfbG)
ELD: i02_2596(yfbG)
ELP: P12B_c2349(arnA)
ELF: LF82_0136(arnA)
ECOL: LY180_11710
ECOI: ECOPMV1_02416(arnA)
ECOJ: P423_12625
EFE: EFER_0914(yfbG)
EAL: EAKF1_ch3724c(arnA)
EMA: C1192_00610
ESZ: FEM44_01470(arnA)
STY: STY2529
STT: t0564
SEX: STBHUCCB_6050
SENT: TY21A_02870
STM: STM2299(yfbG)
SEO: STM14_2837(yfbG)
SEV: STMMW_23231
SEY: SL1344_2268(yfbG)
SEM: STMDT12_C23200
SEJ: STMUK_2329(yfbG)
SEB: STM474_2395(yfbG)
SEF: UMN798_2481
SETU: STU288_07870
SETC: CFSAN001921_05300
SENR: STMDT2_22681
SEND: DT104_23571
SENI: CY43_12320
SEEN: SE451236_17690
SPT: SPA0564(yfbG)
SEK: SSPA0528
SPQ: SPAB_00682
SEI: SPC_1412(yfbG)
SEH: SeHA_C2539
SHB: SU5_02894
SENH: CFSAN002069_20350
SEEH: SEEH1578_20770
SEE: SNSL254_A2484
SENN: SN31241_34040
SEW: SeSA_A2527
SEA: SeAg_B2435
SENS: Q786_11335
SED: SeD_A2643
SEG: SG2328(yfbG)
SEL: SPUL_0591(yfbG)
SEGA: SPUCDC_0591(yfbG)
SET: SEN2281(yfbG)
SENA: AU38_11530
SENO: AU37_11540
SENV: AU39_11540
SENQ: AU40_12920
SENL: IY59_11855
SENJ: CFSAN001992_22080
SEEC: CFSAN002050_18420
SEEB: SEEB0189_008075
SEEP: I137_02725
SENB: BN855_23800
SENE: IA1_11450
SENC: SEET0819_18585
SBG: SBG_2088
SBZ: A464_2413
SBV: N643_10210
SALZ: EOS98_07550
SFX: S2467(ybfG)
SFV: SFV_2325
SFE: SFxv_2577(arnA)
SFN: SFy_3321
SFS: SFyv_3396
SFT: NCTC1_02567(arnA)
SSN: SSON_2316
SBO: SBO_2292
SBC: SbBS512_E2631(arnA)
SDZ: Asd1617_03305
SHQ: A0259_15095
ENC: ECL_04861
ENL: A3UG_21620
ECLG: EC036_42110
ECLE: ECNIH2_22145
ECLN: ECNIH4_01690
ECLY: LI62_23410
ECLO: ENC_26920
EHM: AB284_03400
EAU: DI57_19845
EKB: BFV64_22140
ENO: ECENHK_20885
EEC: EcWSU1_04282(arnA)
ELG: BH714_14215
ECAN: CWI88_21375
ERN: BFV67_20790
ECLS: LI67_022825
ECHG: FY206_22985(arnA)
ESH: C1N69_21595
ENT: Ent638_2077
EAS: Entas_4174
ENR: H650_13745
ENX: NI40_020910
ENF: AKI40_0312
LNI: CWR52_13980(arnA)
EBG: FAI37_08130(arnA)
END: A4308_05625
ENZ: G0034_21540(arnA)
EHU: D5067_0001335(arnA)
EMOR: L6Y89_21005(arnA)
ENB: ELK40_21280(arnA)
KPN: KPN_03845(yfbG)
KPU: KP1_5182
KPM: KPHS_50000
KPP: A79E_0271
KPH: KPNIH24_24920
KPZ: KPNIH27_23840
KPV: KPNIH29_24760
KPW: KPNIH30_25210
KPY: KPNIH31_24265
KPG: KPNIH32_26080
KPC: KPNIH10_24885
KPQ: KPR0928_24405
KPT: VK055_3625(arnA)
KPO: KPN2242_22235
KPR: KPR_5072(arnA)
KPJ: N559_0309
KPI: D364_19670
KPA: KPNJ1_00281
KPS: KPNJ2_00283
KPX: PMK1_01347(arnA)
KPB: FH42_15560
KPNE: KU54_001385
KPNU: LI86_01380
KPNK: BN49_0272(arnA)
KVA: Kvar_0256
KPE: KPK_0268(arnA)
KPK: A593_09430
KVD: KR75_06785
KVQ: SP68_13375
KOX: KOX_05070
KOE: A225_5481
KOY: J415_04690
KOM: HR38_03545
KMI: VW41_09735
KOK: KONIH1_27595
KOC: AB185_08785
KQU: AVR78_03065
EAE: EAE_05690
EAR: CCG32860
KQV: B8P98_01400
KLL: BJF97_27260
KLW: DA718_01740(arnA)
KAR: LGL98_01375(arnA)
KGR: JJJ10_01555(arnA)
KPAS: LUW96_05000(arnA)
KLC: K7H21_01525(arnA)
ROR: RORB6_20125
RON: TE10_00870
RPLN: B1209_01360
RAO: DSD31_01460
RTG: NCTC13098_00333(arnA)
REE: electrica_00259(arnA)
CFD: CFNIH1_22840
CBRA: A6J81_24925
CWE: CO701_06615
CYO: CD187_07865
CPOT: FOB25_18990(arnA)
CFQ: C2U38_16795
CAMA: F384_12075
CAF: AL524_10820
CIF: AL515_15745
CFAR: CI104_17410
CIR: C2U53_27260
CIE: AN232_12520
CPAR: CUC49_11795
CTEL: GBC03_13055(arnA)
CITZ: E4Z61_01455(arnA)
CARS: E1B03_18230(arnA)
HDE: HDEF_0857(arnA)
SECT: A359_07480
SEHC: A35E_00191
EBT: EBL_c14160(arnA)
CNT: JT31_02770
CEM: LH23_15425
CEN: LH86_14575
CLAP: NCTC11466_02466(arnA)
PGE: LG71_17165
ESC: Entcl_0249
KLE: AO703_20170
KSA: C813_16860
KOR: AWR26_01315(arnA)
KRD: A3780_23415
KCO: BWI95_09185
KOT: EH164_01280(arnA)
KPSE: IP581_21855(arnA)
KOB: HF650_22355(arnA)
KOO: O9K67_01545(arnA)
KGO: CEW81_01535
KIE: NCTC12125_04155(arnA)
KAS: KATP_02600(arnA)
KLU: K7B04_06715(arnA)
LEF: LJPFL01_4009
LEW: DAI21_05805
BUF: D8682_04200(arnA)
BAGE: BADSM9389_18930
BFT: MNO13_11290(arnA)
SYM: K6K13_03645(arnA)
METY: MRY16398_42510(arnA)
AHN: NCTC12129_01387(arnA_1)
YRE: HEC60_16740(arnA)
SGOE: A8O29_001750(arnA)
KIN: AB182_18760
PDZ: HHA33_21215(arnA)
PSGC: G163CM_02790(arnA)
EBF: D782_1295
EBC: C2U52_29970
YPE: YPO2420
YPK: y1919
YPH: YPC_2055
YPA: YPA_1764
YPN: YPN_1874
YPM: YP_2207(wcaG9)
YPP: YPDSF_0730
YPG: YpAngola_A2610(arnA)
YPZ: YPZ3_1467
YPT: A1122_14040
YPD: YPD4_1432
YPX: YPD8_1513
YPW: CH59_4254
YPJ: CH55_496
YPV: BZ15_1105
YPL: CH46_2685
YPS: YPTB2328(pmrI)
YPO: BZ17_126
YPI: YpsIP31758_1727(arnA)
YPY: YPK_1833
YPB: YPTS_2403
YPQ: DJ40_4257
YPU: BZ21_1616
YPR: BZ20_3915
YPC: BZ23_1902
YPF: BZ19_1693
YEN: YE2190
YEP: YE105_C2003
YEY: Y11_08001
YEL: LC20_02959
YEW: CH47_1625
YET: CH48_3631
YEF: FORC2_2213
YEE: YE5303_20321
YSI: BF17_20740
YAL: AT01_262
YFR: AW19_1396
YIN: CH53_4133
YKR: CH54_266
YRO: CH64_735
YRU: BD65_479
YRB: UGYR_02450
YMA: DA391_12025
YHI: D5F51_07870(arnA)
YCA: F0T03_10080(arnA)
YMO: HRD69_16410(arnA)
YAS: N0H69_13325(arnA)
YKI: HRD70_14680(arnA)
SMAR: SM39_1617(arnA)
SMAC: SMDB11_1430(arnA)
SMW: SMWW4_v1c21850(arnA)
SPE: Spro_2156
SRR: SerAS9_2098
SRL: SOD_c19700(arnA)
SRY: M621_10855
SPLY: Q5A_010900(arnA)
SRS: SerAS12_2098
SRA: SerAS13_2099
SMAF: D781_1987
SLQ: M495_10685
SERF: L085_17840
SERS: SERRSCBI_10245
SFW: WN53_19960
SFG: AV650_15780
SRZ: AXX16_3142
SERA: Ser39006_002825
SERQ: CWC46_02825
SERM: CLM71_09860
SQU: E4343_05430(arnA)
SFJ: SAMEA4384070_2214(arnA)
SOF: NCTC11214_04679(arnA)
SSUR: ATE40_007630
SURI: J0X03_13095(arnA)
SRHZ: FO014_23580(arnA)
SENP: KHA73_10950(arnA)
SNEM: NLX84_10995(arnA)
SFO: Z042_26220
RAH: Rahaq_2821
RACE: JHW33_08070(arnA)
RAQ: Rahaq2_2851
RAA: Q7S_14230
ROX: BV494_08900
RVC: J9880_20975(arnA)
GQU: AWC35_22975
FSM: CCS41_07075
EAME: GXP68_08320(arnA)
RBAD: H2866_15890(arnA)
RCB: O1V66_09895(arnA)
ECA: ECA3144
PATR: EV46_15565
PATO: GZ59_31540
PCT: PC1_2926
PCC: PCC21_029640
PCV: BCS7_14885
PWA: Pecwa_1352
PPAR: A8F97_12115
PEC: W5S_1258
PWS: A7983_01545
PPOA: BJK05_09745
PBRA: B5S52_07015
PPUJ: E2566_15105(arnA)
PARI: I2D83_06975(arnA)
PVZ: OA04_31390(arnA)
PPAV: LOZ86_14660(arnA)
PPOO: LW347_14885(arnA)
PACB: M9782_17065(arnA)
DDD: Dda3937_01078(yfbG)
DZE: Dd1591_4226
DDC: Dd586_4198
DZC: W909_20290
DSO: A4U42_09035
CED: LH89_12335
DFN: CVE23_22445
DDQ: DDI_4291
DAQ: DAQ1742_04456(arnA)
DIC: Dpoa569_003891(arnA)
DDA: Dd703_4017
BGJ: AWC36_13855
BIZ: HC231_18665(arnA)
SGL: SG1843
SOD: Sant_1032(arnA)
PES: SOPEG_3209(arnA)
SLIG: GTU79_03960(arnA)
EAM: EAMY_1085(yfbG)
EAY: EAM_1092(arnA)
ETA: ETA_23810(arnA)
EPY: EpC_25160(arnA)
EPR: EPYR_02726(yfbG)
EBI: EbC_12130(arnA)
ERJ: EJP617_22110(arnA)
EPE: CI789_12800
ERWI: GN242_15080(arnA)
ETP: LU633_08580(arnA)
ERP: LJN55_05940(arnA)
EGE: EM595_p0068(arnA)
WBR: b2255
WGL: WIGMOR_0622(arnA)
PAM: PANA_4004(arnA)
PLF: PANA5342_p10122(arnA)
PAJ: PAJ_p0005(arnA)
PAQ: PAGR_p093
PVA: Pvag_pPag10070(yfbG)
PAGG: AL522_03075
PAO: Pat9b_5646
PAGC: BEE12_23615
PSTW: DSJ_25425
PANS: FCN45_22930(arnA)
PEY: EE896_21540(arnA)
PDIS: D8B20_18360(arnA) D8B20_20975(arnA)
PJI: KTJ90_19030(arnA)
PANO: OJ965_20760(arnA)
TCI: A7K98_14380
TPTY: NCTC11468_02692(arnA)
KPIE: N5580_08200(arnA)
PLU: plu2658(pbgP3)
PLUM: A4R40_13235
PAY: PAU_01877(arnA)
PTT: VY86_18210
PAKH: B0X70_13545
PLUI: CE143_13540
PMR: PMI1045(arnA)
PMIB: BB2000_1082(arnA)
PVL: AOB99_07275
PVG: CRN77_13920
PHAU: PH4a_14255
PROT: BTA34_06475
PCOL: F1325_08400(arnA)
PCIB: F9282_08350(arnA)
PPEE: I6G31_01860(arnA)
XBO: XBJ1_2534(arnA)
XBV: XBW1_3010(pbgP)
XNE: XNC1_1837(pbgP3)
XNM: XNC2_1782(pbgP)
XDO: XDD1_1781(pbgP)
XPO: XPG1_1548(pbgP)
XHO: A9255_06875
XBU: HGO23_09000(arnA)
PSI: S70_19365
PSX: DR96_2785
PSTA: BGK56_01430
PRG: RB151_019250(arnA)
PALA: CO695_16000
PHEI: NCTC12003_02332(arnA)
PRQ: CYG50_07550(arnA)
PRJ: NCTC6933_01643(arnA)
PVC: G3341_11935(arnA)
PMAG: JI723_11840(arnA)
MMK: MU9_2436
ANS: ArsFIN_16500(arnA)
AED: E3U36_11970(arnA)
AET: LDL57_09095(arnA)
MWI: MNY66_06895(arnA)
EIC: NT01EI_1415
ETR: ETAE_1293
ETD: ETAF_1205
ETE: ETEE_3268(arnA)
ETC: ETAC_06130
EDW: QY76_13725
EDL: AAZ33_06730(arnA)
EHO: A9798_10285
HAV: AT03_10625
HPAR: AL518_15205
OPO: DSM2777_16850
LPV: HYN51_11420
PFQ: QQ39_15925
VSH: BSZ05_00680
PAE: PA3554(arnA)
PAEV: N297_3677
PAEI: N296_3677
PAU: PA14_18350(fmt)
PAP: PSPA7_1591
PAG: PLES_14791
PAF: PAM18_1432
PNC: NCGM2_4680(fmt)
PAEB: NCGM1900_2729(fmt)
PDK: PADK2_06595
PSG: G655_07030
PRP: M062_18825
PAEP: PA1S_07650
PAER: PA1R_gp1373
PAEM: U769_07125
PAEL: T223_07365
PAES: SCV20265_1508
PAEU: BN889_03925
PAEG: AI22_26255
PAEC: M802_3674
PAEO: M801_3542
PCQ: PcP3B5_10970(arnA)
PMUI: G4G71_27470(arnA)
PNT: G5B91_05475(arnA)
POR: APT59_21350
PSB: Psyr_2691
PSYR: N018_13795
PSP: PSPPH_2804(arnA)
PAVL: BKM03_14600
PVD: CFBP1590_0593(arnA)
PCAB: JGS08_12945(arnA)
PCOF: POR16_12505(arnA)
PTRE: I9H09_12560(arnA)
PSYI: MME58_14000(arnA)
PAST: N015_24155(arnA)
PFL: PFL_3045(arnA)
PPRC: PFLCHA0_c30730(arnA)
PPRO: PPC_3073
PFN: HZ99_09570
PFO: Pfl01_2843
PFS: PFLU_3041
PFC: PflA506_2684(arnA)
PPZ: H045_08710
PFB: VO64_0275
PMAN: OU5_0511(arnA)
PTV: AA957_29330
PCG: AXG94_01710
PVR: PverR02_15960
PAZO: AYR47_22455
POI: BOP93_12505
PRX: HRH33_14000(arnA)
PFW: PF1751_v1c26890(arnA)
PFF: PFLUOLIPICF722870
PFX: A7318_13375
PDR: H681_05040
PSK: U771_15900
PKC: PKB_4721(arnA)
PCH: EY04_14440
PCZ: PCL1606_30720
PCP: JM49_15600
PFZ: AV641_11485
PPV: NJ69_08675
PSEM: TO66_15070
PPSY: AOC04_08565
PSOS: POS17_3049
PANR: A7J50_2964
PPSL: BJP27_15085
PYM: AK972_2830
PKE: DLD99_14965
PGG: FX982_03612
PPSH: G5J76_14665(arnA)
PGY: AWU82_13400
PEZ: HWQ56_11375(arnA)
PZE: HU754_015370(arnA)
PMOE: HV782_015475(arnA)
PSEP: C4K39_5051
PVW: HU752_017360(arnA)
PTRT: HU722_0015210(arnA)
PSAM: HU731_001845(arnA)
PTZ: HU718_015610(arnA)
PSHH: HU773_014130(arnA)
PASG: KSS96_15130(arnA)
PTAE: NCTC10697_02216(arnA)
PGF: J0G10_15710(arnA)
PIZ: LAB08_R27610(arnA)
PPEG: KUA23_15325(arnA)
PFIT: KJY40_15500(arnA)
SSE: Ssed_0924
SMAI: EXU30_10565(arnA)
AGZ: M0C34_01280(arnA)
AGQ: LQZ07_01155(arnA)
ZPL: ZBT109_1561
AHA: AHA_0990
AHY: AHML_05290
AHD: AI20_14310
AHR: V428_05510
AHP: V429_05515
AHJ: V469_17840
AHH: RY45_05455
AHI: VU14_17560
AAJ: BOQ57_04915
ASA: ASA_3309(arnA)
AEO: O23A_p2676
ASR: WL1483_257(arnA)
ADH: CK627_21275
AJD: I6H43_09520(arnA)
AEJ: E5E97_09525(arnA)
ABES: IU367_16730(arnA)
SALN: SALB1_1040
SADE: GFK82_00483(arnA)
BHG: I6G56_25840
SECH: B18_00735
DBK: DGMP_23970(arnA)
DAX: FDQ92_14880(arnA)
AMUC: Pan181_15280(arnA)
BPIT: BPIT_06360
VBC: C5Q97_16955
 » show all
Reference
1  [PMID:15695810]
  Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
  Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
  Journal
J Biol Chem 280:14154-67 (2005)
DOI:10.1074/jbc.M414265200
  Sequence
[eco:b2255]
Reference
2  [PMID:15807526]
  Authors
Gatzeva-Topalova PZ, May AP, Sousa MC
  Title
Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance.
  Journal
Biochemistry 44:5328-38 (2005)
DOI:10.1021/bi047384g
  Sequence
[eco:b2255]
Reference
3  [PMID:15809294]
  Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
  Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
  Journal
J Biol Chem 280:23000-8 (2005)
DOI:10.1074/jbc.M501534200
  Sequence
[eco:b2255]
Reference
4  [PMID:15939024]
  Authors
Gatzeva-Topalova PZ, May AP, Sousa MC
  Title
Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance.
  Journal
Structure 13:929-42 (2005)
DOI:10.1016/j.str.2005.03.018
  Sequence
[eco:b2255]
Reference
5  [PMID:17928292]
  Authors
Yan A, Guan Z, Raetz CR
  Title
An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli.
  Journal
J Biol Chem 282:36077-89 (2007)
DOI:10.1074/jbc.M706172200
  Sequence
[eco:b2255]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.2.13
IUBMB Enzyme Nomenclature: 2.1.2.13
ExPASy - ENZYME nomenclature database: 2.1.2.13
BRENDA, the Enzyme Database: 2.1.2.13
LinkDB

DBGET integrated database retrieval system