KEGG ENZYME: 2.1.2.14

ENZYME: 2.1.2.14

Entry

EC 2.1.2.14                 Enzyme

Name

GDP-perosamine N-formyltransferase;
wbkC (gene name)

Class

Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases

Sysname

10-formyltetrahydrofolate:GDP-alpha-D-perosamine N-formyltransferase

Reaction(IUBMB)

10-formyltetrahydrofolate + GDP-alpha-D-perosamine = tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine [RN:R12790]

Reaction(KEGG)

R12790

Substrate

10-formyltetrahydrofolate [CPD:C00234];
GDP-alpha-D-perosamine [CPD:C20638]

Product

tetrahydrofolate [CPD:C00101];
GDP-N-formyl-alpha-D-perosamine [CPD:C22397]

Comment

The enzyme, characterized from the bacterium Brucella melitensis, synthesizes a building block of the O antigen produced by Brucella species.

History

EC 2.1.2.14 created 2021

Pathway

ec00541

Biosynthesis of various nucleotide sugars

ec01100

Metabolic pathways

Orthology

K00607

GDP-perosamine N-formyltransferase

Genes

YEP:	YE105_C1510

YET:

CH48_3104

BME:

BMEI1418

BMEL:

DK63_2070

BMI:	BMEA_A0555

BMZ:	BM28_A0534

BMG:	BM590_A0536

BMW:	BMNI_I0525

BMEE:

DK62_884

BMF:

BAB1_0540

BMB:	BruAb1_0540

BMC:	BAbS19_I05060

BAA:	BAA13334_I03106

BABO:

DK55_547

BABR:

DO74_1339

BABT:

DK49_311

BABB:

DK48_1578

BABU:

DK53_537

BABS:

DK51_923

BABC:

DO78_454

BMS:

BR0517

BSI:	BS1330_I0516

BSF:	BSS2_I0504

BSUI:

BSSP1_I1186

BSUP:

BSPT1_I1197

BSUV:

BSPT2_I1182

BSUC:

BSSP2_I0533

BMT:	BSUIS_A0548(arnA)

BSZ:

DK67_1446

BSV:	BSVBI22_A0516

BSW:	IY71_02635

BSG:	IY72_02360

BOV:

BOV_0521

BCS:	BCAN_A0529(arnA)

BSK:	BCA52141_I0862

BOL:	BCOUA_I0517

BCAR:

DK60_600

BCAS:

DA85_02475

BMR:

BMI_I519

BPP:

BPI_I548

BPV:

DK65_842

BVL:	BF3285c1_0240

BRU:	BFS01_02560

TMUR:

JBF11_02245

» show all

Reference

1 [PMID:11081580]

Authors

Godfroid F, Cloeckaert A, Taminiau B, Danese I, Tibor A, de Bolle X, Mertens P, Letesson JJ.

Title

Genetic organisation of the lipopolysaccharide O-antigen biosynthesis region of brucella melitensis 16M (wbk).

Journal

Res Microbiol 151:655-68 (2000)
DOI:10.1016/s0923-2508(00)90130-x

Sequence

[bme:BMEI1418]

Reference

2 [PMID:28636341]

Authors

Riegert AS, Chantigian DP, Thoden JB, Tipton PA, Holden HM.

Title

Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis.

Journal

Biochemistry 56:3657-3668 (2017)
DOI:10.1021/acs.biochem.7b00494

Sequence

[bme:BMEI1418]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.2.14

IUBMB Enzyme Nomenclature:

2.1.2.14

ExPASy - ENZYME nomenclature database:

2.1.2.14

BRENDA, the Enzyme Database:

2.1.2.14

LinkDB

DBGET integrated database retrieval system