Entry
Name
malonyl-S-ACP:biotin-protein carboxyltransferase;
malonyl-S-acyl-carrier protein:biotin-protein carboxyltransferase;
MadC/MadD;
MadC,D;
malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxyltransferase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
BRITE hierarchy
Sysname
malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxytransferase
Reaction(IUBMB)
a malonyl-[acyl-carrier protein] + a biotinyl-[protein] = an acetyl-[acyl-carrier protein] + a carboxybiotinyl-[protein] [RN:
R08936 ]
Reaction(KEGG)
Substrate
malonyl-[acyl-carrier protein] [CPD:
C01209 ];
biotinyl-[protein] [CPD:
C18046 ]
Product
acetyl-[acyl-carrier protein] [CPD:
C03939 ];
carboxybiotinyl-[protein] [CPD:
C18047 ]
Comment
Derived from the components MadC and MadD of the anaerobic bacterium Malonomonas rubra, this enzyme is a component of EC
7.2.4.4 , biotin-dependent malonate decarboxylase. The carboxy group is transferred from malonate to the cofactor of the biotin protein (MadF) with retention of configuration [2]. Similar to EC
4.1.1.87 , malonyl-S-ACP decarboxylase, which forms part of the biotin-independent malonate decarboxylase (EC
4.1.1.88 ), this enzyme also follows on from EC
2.3.1.187 , acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetyl-[acyl-carrier protein] [3].
History
EC 2.1.3.10 created 2008, modified 2018
Orthology
K20510 malonyl-S-ACP:biotin-protein carboxyltransferase subunit MadC
K20511 malonyl-S-ACP:biotin-protein carboxyltransferase subunit MadD
Genes
KPZ : KPNIH27_22440 KPNIH27_22445
KPB : FH42_14170 FH42_14175
KLW : DA718_03335(mdcE) DA718_03340
KGR : JJJ10_02970(mdcE) JJJ10_02975
KPAS : LUW96_03545 LUW96_03550(mdcE)
KLC : K7H21_02980(mdcE) K7H21_02985
KLM : BWI76_25005 BWI76_25010
KLP : GUC22_02880(mdcE) GUC22_02885
CAMA : F384_01155 F384_01160
CTEL : GBC03_24695 GBC03_24700(mdcE)
SFO : Z042_24845 Z042_26175
RHOL : RBJ75_08045(mdcE) RBJ75_08050
RCP : RCAP_rcp00127(mdcE) RCAP_rcp00128(mdcB)
RAP : RHOA_4940(madC) RHOA_4941(madD)
ATI : AL072_31130 AL072_31135
AHU : A6A40_23020(mdcE) A6A40_23025
AZZ : DEW08_20130(mdcE) DEW08_20135
DES : DSOUD_0385 DSOUD_0386
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Taxonomy
Reference
Authors
Berg M, Hilbi H, Dimroth P
Title
Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function.
Journal
Sequence
Reference
2
Authors
Micklefield J, Harris KJ, Groger S, Mocek U, Hilbi H, Dimroth P, Floss HG.
Title
Stereochemical course of malonate decarboxylase in Malonomonas rubra has biotin decarboxylation with retention.
Journal
J Am Chem Soc 117:1153-1154 (1995)
Reference
Authors
Dimroth P, Hilbi H
Title
Enzymic and genetic basis for bacterial growth on malonate.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.1.3.10
ExPASy - ENZYME nomenclature database: 2.1.3.10
LinkDB
All DBs