Entry
Name
glycine amidinotransferase;
arginine-glycine amidinotransferase;
arginine-glycine transamidinase;
glycine transamidinase
Class
Transferases;
Transferring one-carbon groups;
Amidinotransferases
BRITE hierarchy
Sysname
L-arginine:glycine amidinotransferase
Reaction(IUBMB)
L-arginine + glycine = L-ornithine + guanidinoacetate [RN:
R00565 ]
Reaction(KEGG)
Substrate
Product
Comment
Canavanine can act instead of arginine.
History
EC 2.1.4.1 created 1961 as EC 2.6.2.1, transferred 1965 to EC 2.1.4.1
Pathway
ec00260 Glycine, serine and threonine metabolism
ec00330 Arginine and proline metabolism
Orthology
K00613 glycine amidinotransferase
Genes
XLA : 108712892(gatm.S) 379386(gatm.L)
BBUF : 120985854 120985861
SRX : 107726335 107727396(gatm)
SANH : 107665388 107703934(gatm)
SGH : 107569972 107595361(gatm)
CCAR : 109070558 109083988
CAUA : 113061329 113118059 113118060 113118439
CGIB : 127934673 127977792
OMC : 131524423(gatm) 131547274
RKG : 130073417 130088808(gatm)
MASI : 127417436 127456417
PDAB : 135739885 135773944
IFU : 128606309 128606310 128607141
ELY : 117253809(gatm) 117258442
EFO : 125880219(gatm) 125903378
PLEP : 121943876 121944821 121965349
SLUC : 116054650(gatm) 116055480
ASTR : 137594181 137594183 137594184 137594271 137594277 137597682(gatm)
MALB : 109963291 109963352
SASA : 106562859(gatm) 106587738 106595761
STRU : 115166756 115182351
OCLA : 139384540 139411759
CCOG : 133131736(gatm) 133131737
PSPA : 121294328 121299285
ARUT : 117429023 117962314
SCLV : 120325895 120326872 120336603 120344467 120347444
APLC : 110984199 110985062
ARUN : 117287856 117300881
AFIL : 140145058 140145059 140145061 140154263 140154274 140154294 140163385 140167156 140168937
AJC : 117101367 117114725 117119544 117121871 117124427
SKO : 100366449 100366596 100375259 100376812
PFLL : 139127918 139127958
BCOO : 119075010 119075259
MCAF : 127720506 127730451
LLON : 135487187 135498922 135500263 135502931
EPA : 110235729 110243807 110244478 110251786
ATEN : 116298461 116304210
ADF : 107328199 107335258 107358664 107358668
MCAZ : 138041914 138041927
MFOO : 138008247 138008250
DGT : 114525297 114525311 114525312
HSY : 130613429 130613430 130613431 130614120 130614172 130621503 130644672 130647690 130654754
NTE : NEUTE1DRAFT35080(NEUTE1DRAFT_35080)
SMP : 10801911(SMAC4_06919)
MAW : 19248721(J3458_020996)
AMUS : LMH87_001736 LMH87_005212 LMH87_007426 LMH87_009183
CPW : 9695037(D8B26_006545)
FFU : CLAFUR5_01803 CLAFUR5_04895
EPY : EpC_01150(hsvA) EpC_31010(hsvA)
EPR : EPYR_00119(hsvA) EPYR_03348(hsvA)
ERJ : EJP617_12770(hsvA) EJP617_16790(hsvA)
XGR : QL128_10505 QL128_18180
ASIP : AQUSIP_22650(strB1)
NANI : NCTC12227_01827(strB1)
SCU : SCE1572_05025 SCE1572_12210
SCHJ : DDV21_005700 DDV21_005710
EGD : GS424_000785 GS424_005950
AHAT : ADCFC_20140 ADCFC_20190
RTS : CE91St31_30280 CE91St31_30420
EBZ : J7S26_06915 J7S26_07955
SGU : SGLAU_01210(strB2) SGLAU_27745
SLE : sle_17590(sle_17590)
SCLF : BB341_02055 BB341_02500
SALJ : SMD11_0304 SMD11_1003
SRK : FGW37_09925 FGW37_30380
SHK : J2N69_18920 J2N69_33140
SPAZ : ABXI76_02555 ABXI76_32240
KAB : B7C62_08835 B7C62_33385
GYU : FE374_00550 FE374_03125
AHW : NCTC11636_00331(strB1)
AIR : AIF0345_1636(strB1_1) AIF0345_1638(strB1_2)
ASLA : NCTC11923_01951(strB1)
AVC : NCTC10951_00764(strB1)
MPRO : BJP34_00300 BJP34_24870
» show all
Taxonomy
Reference
1
Authors
Borsook H, Dubnoff JW.
Title
The formation of glycocyamine in animal tissues.
Journal
J Biol Chem 138:389-403 (1941)
Reference
Authors
CONCONI F, GRAZI E.
Title
TRANSAMIDINASE OF HOG KIDNEY. I. PURIFICATION AND PROPERTIES.
Journal
J Biol Chem 240:2461-4 (1965)
Reference
Authors
McGuire DM, Tormanen CD, Segal IS, Van Pilsum JF.
Title
The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats. Purification and some properties of rat kidney transamidinase.
Journal
J Biol Chem 255:1152-9 (1980)
Sequence
Reference
4
Authors
Ratner S.
Title
Transamidination.
Journal
In: Boyer PD, Lardy H, Myrback K (eds). The Enzymes. 2nd ed. Vol. 6. New York: Academic Press; 1962. p. 267-275.
Reference
Authors
RATNER S, ROCHOVANSKY O.
Title
Biosynthesis of guanidinoacetic acid. I. Purification and properties of transamidinase.
Journal
Reference
Authors
RATNER S, ROCHOVANSKY O.
Title
Biosynthesis of guanidinoacetic acid. II. Mechanism of amidine group transfer.
Journal
Reference
Authors
WALKER JB.
Title
Biosynthesis of arginine from canavanine and ornithine in kidney.
Journal
J Biol Chem 218:549-56 (1956)
Reference
Authors
WALKER JB.
Title
Studies on the mechanism of action of kidney transamidinase.
Journal
J Biol Chem 224:57-66 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.4.1
ExPASy - ENZYME nomenclature database: 2.1.4.1
BRENDA, the Enzyme Database: 2.1.4.1
LinkDB
All DBs