KEGG   ENZYME: 2.1.4.1
Entry
EC 2.1.4.1                  Enzyme                                 
Name
glycine amidinotransferase;
arginine-glycine amidinotransferase;
arginine-glycine transamidinase;
glycine transamidinase
Class
Transferases;
Transferring one-carbon groups;
Amidinotransferases
Sysname
L-arginine:glycine amidinotransferase
Reaction(IUBMB)
L-arginine + glycine = L-ornithine + guanidinoacetate [RN:R00565]
Reaction(KEGG)
R00565;
(other) R01686 R01989
Substrate
L-arginine [CPD:C00062];
glycine [CPD:C00037]
Product
L-ornithine [CPD:C00077];
guanidinoacetate [CPD:C00581]
Comment
Canavanine can act instead of arginine.
History
EC 2.1.4.1 created 1961 as EC 2.6.2.1, transferred 1965 to EC 2.1.4.1
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K00613  glycine amidinotransferase
Genes
HSA2628(GATM)
PTR453401(GATM)
PPS100982293(GATM)
GGO101144802(GATM)
PON100171513(GATM)
NLE100597895(GATM)
MCC713306(GATM)
MCF102138299(GATM)
CSAB103245698(GATM)
CATY105588183(GATM)
PANU101004683(GATM)
TGE112627528(GATM)
RRO104653899(GATM)
RBB108530126(GATM)
TFN117070721(GATM)
PTEH111552758(GATM)
CJC100408432(GATM)
SBQ101041854(GATM)
CSYR103264960(GATM)
MMUR105872561(GATM)
LCAT123622168(GATM)
OGA100952301(GATM)
MMU67092(Gatm)
MCAL110284514(Gatm)
MPAH110318211(Gatm)
RNO81660(Gatm)
MCOC116090827(Gatm)
MUN110553249(Gatm)
CGE100771783(Gatm)
MAUA101822558(Gatm)
PLEU114699609(Gatm)
MORG121465869(Gatm)
AAMP119815660(Gatm)
NGI103746955(Gatm)
HGL101696418(Gatm)
CPOC100714491(Gatm)
CCAN109692720(Gatm)
DORD105980982(Gatm)
DSP122114389(Gatm)
NCAR124976880
OCU100338260(GATM)
OPI101526126(GATM)
TUP102470318(GATM)
CLUD112675997(GATM)
VVP112920029(GATM)
VLG121485564(GATM)
AML100468782(GATM)
UMR103656589(GATM)
UAH113269569(GATM)
UAR123801942(GATM)
ELK111160090
LLV125105362
MPUF101678647(GATM)
ORO101386117(GATM)
EJU114226572(GATM)
ZCA113910141(GATM)
MLX118002936(GATM)
FCA414734(GATM)
PYU121041643(GATM)
PBG122468693(GATM)
PTG102969260(GATM)
PPAD109263041(GATM)
AJU106986286 113597959
HHV120243802(GATM)
BTA414732(GATM)
BOM102274253(GATM)
BIU109565164(GATM)
BBUB102405715(GATM)
CHX102184628(GATM)
OAS100174904(GATM)
ODA120852940(GATM)
CCAD122443646(GATM)
SSC100126844(GATM)
CFR102507646(GATM)
CBAI105076989(GATM)
CDK105101687(GATM)
VPC102544379(GATM)
BACU103002160(GATM)
LVE103073454(GATM)
OOR101281194(GATM)
DLE111181639(GATM)
PCAD102980202(GATM)
PSIU116749534(GATM)
ECB100070511(GATM)
EPZ103554027(GATM)
EAI106834989(GATM)
MYB102241381(GATM)
MYD102770940(GATM)
MMYO118651290(GATM)
MLF102437970(GATM)
MNA107535779(GATM)
PKL118722026(GATM)
HAI109396664(GATM)
DRO112311763(GATM)
SHON118992582(GATM)
AJM119054327(GATM)
PDIC114492374(GATM)
PHAS123808949(GATM)
MMF118635816(GATM)
RFQ117023921(GATM)
PALE102894268(GATM)
PGIG120622690(GATM)
PVP105288804(GATM)
RAY107514958(GATM)
MJV108400260(GATM)
TOD119238581(GATM)
SARA101545750(GATM)
LAV100660916(GATM)
TMU101346149
DNM101440193(GATM)
MDO100012229(GATM)
GAS123237878(GATM)
SHR100933609(GATM)
PCW110223693(GATM)
OAA100073477(GATM)
GGA395504(GATM)
PCOC116225338(GATM)
MGP100542487(GATM)
CJO107318710(GATM)
NMEL110404020(GATM)
APLA101796257(GATM)
ACYG106043350(GATM)
AFUL116493650(GATM)
TGU100224553(GATM)
LSR110474262(GATM)
SCAN103816037(GATM)
PMOA120508814(GATM)
OTC121343582(GATM)
PRUF121354289(GATM)
GFR102039697(GATM)
FAB101808276(GATM)
PHI102107354(GATM)
PMAJ107209582(GATM)
CCAE111934089(GATM)
CCW104684102(GATM)
CBRC103621332(GATM)
ETL114059938(GATM)
ZAB102071051(GATM)
FPG101924010(GATM)
FCH102054671(GATM)
CLV102083453(GATM)
EGZ104130797(GATM)
NNI104017255(GATM)
PLET104614564(GATM)
PCRI104036389(GATM)
ACUN113484026(GATM)
TALA104369412(GATM)
PADL103922781(GATM)
ACHC115342176(GATM)
HALD104316221(GATM)
CCRI104155600(GATM)
CSTI104549346(GATM)
EHS104503784(GATM)
CMAC104487389(GATM)
FGA104070636(GATM)
GSTE104258334(GATM)
LDI104348433(GATM)
MNB103773642(GATM)
OHA104334644(GATM)
AAM106496407(GATM)
AROW112963479(GATM)
NPD112952878(GATM)
DNE112996031(GATM)
ASN102388460(GATM)
AMJ102568516(GATM)
CPOO109308765(GATM)
GGN109288565(GATM)
PSS102462002(GATM)
CMY102929788(GATM)
CPIC101937786(GATM)
TST117883580(GATM)
CABI116830926(GATM)
MRV120373132(GATM)
ACS100560810(gatm)
PVT110077278(GATM)
SUND121935179(GATM)
PBI103064593(GATM)
PMUR107302512(GATM)
TSR106543998(GATM)
PGUT117675722(GATM)
VKO123027702(GATM)
PMUA114584508(GATM)
ZVI118093110(GATM)
GJA107123452(GATM)
STOW125446205(GATM)
XLA108712892(gatm.S) 379386(gatm.L)
XTR394568(gatm)
NPR108804813(GATM)
RTEM120931291(GATM)
BBUF120985854 120985861
BGAR122927604(GATM)
DRE266799(gatm)
SRX107726335 107727396(gatm)
SANH107665388 107703934(gatm)
SGH107569972 107595361(gatm)
CCAR109070558 109083988(gatm)
CAUA113061329 113118059 113118060 113118439
PPRM120484866(gatm)
MAMB125253751(gatm)
IPU124627116 124627117
PHYP113526986(gatm)
SMEO124395443(gatm)
TFD125146166(gatm)
AMEX103044592(gatm)
EEE113577297(gatm)
TRU101070450(gatm)
TNGGSTEN00018017G001
LCO104919779(gatm)
NCC104953028(gatm)
CGOB115023491(gatm)
ELY117253809(gatm) 117258442
EFO125880219(gatm) 125903378
PLEP121943876 121944821 121965349
SLUC116054650(gatm) 116055480
ECRA117947582(gatm)
PFLV114553990(gatm)
GAT120810358(gatm)
PPUG119225866(gatm)
MSAM119890800(gatm)
CUD121525039(gatm)
ALAT119018688(gatm)
MZE101463884(gatm)
ONL100689888(gatm)
OAU116311662(gatm)
OLA101156236(gatm)
OML112161201(gatm)
XMA102228536(gatm)
XCO114142460(gatm)
XHE116718958(gatm)
PRET103462051(gatm)
PFOR103143582(gatm)
PLAI106952031(gatm)
PMEI106919692(gatm)
GAF122841175(gatm)
CVG107085365(gatm)
CTUL119771724(gatm)
GMU124866538(gatm)
NFU107381709(gatm)
KMR108251614(gatm)
ALIM106533979(gatm)
NWH119422919(gatm)
AOCE111563874(gatm)
MCEP125005677(gatm)
CSEM103379055(gatm)
POV109625190(gatm)
SSEN122771958(gatm)
HHIP117754274(gatm)
HSP118116551(gatm)
LCF108887928(gatm)
SDU111224823(gatm)
SLAL111656863(gatm)
XGL120794648(gatm)
HCQ109525754(gatm)
BPEC110173080(gatm)
MALB109963291 109963352
BSPL114852694(gatm)
SASA106562859(gatm) 106587738 106595761
OTW112238738(gatm)
OMY110509504 110509505
OGO124035474(gatm)
ONE115116925
SALP112072607(gatm)
SNH120049950(gatm)
CCLU121546381(gatm)
ELS105025337(gatm)
SFM108941032(gatm)
PKI111844938(gatm)
AANG118227169(gatm)
LOC102689047(gatm)
PSPA121294328 121299285
ARUT117429023 117962314
LCM102352460(GATM)
CMK103186480(gatm)
RTP109914139(gatm)
BFO118411990
BBEL109468728
CIN100186832
SCLV120325895 120326872 120336603 120344467 120347444
SPU581473
APLC110984199 110985062
SKO100366449 100366596 100375259 100376812
BCOO119075010 119075259
LAK106169635
SMMSmp_144220
SHXMS3_0014956
OVIT265_04080
NVE5507403
EPA110235729 110243807 110244478 110251786
ATEN116298461 116304210
ADF107328199 107335258 107358664 107358668
AMIL114975958 114975964 114977165
PDAM113679841
SPIS111335280
DGT114525297 114525311 114525312
XEN124450369
AQU100639745
CCPCHC_T00001047001
NCRNCU07176(amt)
NTENEUTE1DRAFT35080(NEUTE1DRAFT_35080)
SMPSMAC_06919
FPUFPSE_05438
MAWMAC_04410
MAJMAA_09776
CMTCCM_04987
ACHEACHE_30467A
CIMCIMG_06186
CPWCPC735_027330
UREUREG_04197
FFUCLAFUR5_01803 CLAFUR5_04895
PIFPITG_05117
PSOJPHYSODRAFT_289076
SPARSPRG_05189
GTTGUITHDRAFT_100748
YMOHRD69_02430
SFGAV650_20525
ROXBV494_25605
DZCW909_07295
BRBEH207_12120
EAMEAMY_0520(hsvA)
EAYEAM_2910(hsvA)
EPYEpC_01150(hsvA) EpC_31010(hsvA)
EPREPYR_00119(hsvA) EPYR_03348(hsvA)
ERJEJP617_12770(hsvA) EJP617_16790(hsvA)
ETPLU633_02420
PSTWDSJ_25115
PLUplu0158
PLUMA4R40_00770
PAYPAU_00111
PTTVY86_08765
PAKHB0X70_00665
PLUICE143_00660
XBVXBW1_3292(gatm)
XNEXNC1_2236
XNMXNC2_2162
XDOXDD1_2127
XHOA9255_04935
LGULG3211_3686(gatm)
VSHBSZ05_24405
PPRPBPRA0993(AT)
PGBH744_1c1693
PDSCAY62_17855
PSTPSPTO_0873
PSPPSPPH_4303
PSAVPSA3335_07310
PCABJGS08_08235
PCOFPOR16_07780
PTREI9H09_08415
PCHEY04_08050
PCZPCL1606_44000
PCPJM49_21820
PSEMTO66_08450
PANRA7J50_2183
SHLShal_0690
PSYPCNPT3_10695
ASIPAQUSIP_22650(strB1)
MMAIsS8_0925
TLOJ9253_15730
THIPN838_23705
HAKKO116_01581
ZPLZBT109_1556
GSNYC6258_01313
NANINCTC12227_01827(strB1)
PTESJQU52_13660
WBOMIS45_09670
LHKLHK_03077
BOKDM82_841(gatm)
BOCBG90_89
BGDbgla_1g14680
DWDDSCW_62380
AGEAA314_04994
SCUSCE1572_05025 SCE1572_12210
CCROCMC5_027020
BJAblr2071(blr2071)
BOTCIT37_13285
BARHWN72_28550
NWINwi_2321
MEAMex_1p3682(gatm)
MDIMETDI4255(gatm)
MEXMext_3451
MCHMchl_3760
MPOMpop_3649
MZAB2G69_24815
MRDMrad2831_0977
METM446_6335
MNOMnod_7150
MORMOC_1194
METAY590_16950
MAQUMaq22A_c16010
MPHYMCBMB27_00572
MEEDA075_31545
METDC0214_18900
METXA3862_25690
METSDK389_19230
METIDK427_24685
MMESMMSR116_26120
MTEADK419_17605
MINDmvi_46360
MOGMMB17_13625
MTADM6G65_03890
BIDBind_1964
MSCBN69_0965
MBRYB1812_00380
MROSEHO51_11005
MHEYH2LOC_007360
MPARF7D14_01045
MTWCQW49_05080
PSINCAK95_06395
RBMTEF_16145
CMBCSW64_04265
JANJann_0016
RDERD1_1472(gatM)
RPONG3256_14250
ROMEI983_09005
PTPRCA23_c30240
GCEKYE46_01120
ACROK3J57_08005
AMAQGO499_16990
PUBSAR11_0688(gatM)
PEGE5R92_02630
APMHIMB5_00002720
HAXBALOs_2792
SCHJDDV21_005700 DDV21_005710
LMELEUM_0821
LMMMI1_03790
LMKLMES_0744
LSUA6B45_03985
ESSATZ33_14275
CKUUL82_00540
NSLBOX37_26485
NTPCRH09_11975
NODFOH10_04445
NAHF5544_17975
SPINKV203_18615
SRCM271_50175
SMALSMALA_7755 SMALA_7768
SSOII1A49_42615 I1A49_42680
SBHSBI_09248
SDVBN159_6038(gatm)
SALUDC74_7768
SALLSAZ_40100
SGUSGLAU_01210(strB2) SGLAU_27745
STREGZL_00895
SCWTU94_25155 TU94_32250
SLDT261_7858
SLCSL103_12430
STRCAA958_19360
SCZABE83_25970
SCXAS200_45505
SLEsle_17590(sle_17590)
SCLFBB341_02055 BB341_02500
STSIA4E84_37140
SALWCP975_31450
SCADDN051_05330
SLSSLINC_3009
SNRSNOUR_04235
SSIAA7J05_04910
SALFSMD44_07808
SALJSMD11_0304 SMD11_1003
SNZDC008_26680
SDXC4B68_21985
SQZFQU76_06035
SGZC0216_14490 C0216_32535
SHAWCEB94_01860
SRKFGW37_09925 FGW37_30380 FGW37_33175
SGALCP966_11390
SAQUEJC51_29480
SCAVCVT27_08725
SSEOD0Z67_21815 D0Z67_21830
SBYH7H31_13990
SRIMCP984_39795
SCINCP977_31325
SPACB1H29_17175
STSUB7R87_06020
SCOECP976_38615
SSPBCP982_06080
SFEUIM697_09145
SVDCP969_02995 CP969_04800
SMOBJ7W19_02000 J7W19_32390
SPRACP972_22815
SPEUCGZ69_01885
SROIIAG44_38835
SXNIAG42_37485
SHKJ2N69_18920 J2N69_33140
SANUK7396_05200
STRYEQG64_08860
SINEKI385_15405
KABB7C62_08835 B7C62_33385
KITCFP65_5909
GYUFE374_00550 FE374_03125
PACPPA0632
PAKHMPREF0675_3699
PAVTIA2EST22_03190
PAXTIA2EST36_03165
PAZTIA2EST2_03110
PAWPAZ_c06700(gatm)
PADTIIST44_11340
PCNTIB1ST10_03265
PACCPAC1_03290
PACHPAGK_1497
PACNTIA1EST1_03180
CACNRN83_03680
NEXNE857_02065
ACTWF7P10_20380
NOABKM31_13755
SENSACE_4336
SACGFDZ84_23315
AMDAMED_6240
AMNRAM_32010
AMMAMES_6150
AMZB737_6150
AMIAmir_2021
SSYIEKG83_28805
KALKALB_5520 KALB_6138
KPHYAOZ06_16915
LEDBBK82_35685
ACTIUA75_05160
ACADUA74_05155
SAQSare_2924
MICHFJK98_21005
CATICS0771_62090
DVCDvina_20435
MCUHMPREF0573_10280
TPYCQ11_05510
TPYOX956_02185
AOSAXE84_10915
ACTPB6G06_08790
ACTCCHIBA101_0264
ANEATCC27039_09790
AHWNCTC11636_00331(strB1)
AIRNCTC12972_02110(strB1_1) NCTC12972_02114(strB1_2)
ASLANCTC11923_01951(strB1)
AVCNCTC10951_00764(strB1)
AWEJG540_09270
AMAMHPC72_00875
AREPID810_11415
ACTMHCQ94_05555
FSLEJO69_10275
FLHEJ997_09995
WIKH8R18_07530
RUBGBA63_19875
CWOCwoe_2444
CCUCcur_01930
ELEElen_0143 Elen_1163
EYYEGYY_01720
EGDGS424_000785 GS424_005950
GPAGPA_26090
AEQAEQU_0379 AEQU_0384
AHATADCFC_20140 ADCFC_20190
CBACJI75_05715
RTSCE91St31_30280 CE91St31_30420
EBZJ7S26_06915 J7S26_07955
PMGP9301_14361
AMRAM1_0523
THECFFX45_00675
MARMAE_21180
CYNCyan7425_3009
TERTery_3130
PAGHNIES204_43670
MPROBJP34_00300 BJP34_24870
RIVRiv7116_2072
KBSEPA93_12910
GOGC1280_30850
TMEDDWB79_06760
BRMBmur_0416
BPOBP951000_0055
BPJB2904_orf1338
BPIPBPP43_02825
BPWWESB_1480
SBRSY1_02940
APRDHLG78_04130
METVK4897_00440
AGWQT03_C0001G0659
 » show all
Reference
1
  Authors
Borsook, H. and Dubnoff, J.W.
  Title
The formation of glycocyamine in animal tissues.
  Journal
J Biol Chem 138:389-403 (1941)
Reference
2  [PMID:14304853]
  Authors
CONCONI F, GRAZI E.
  Title
TRANSAMIDINASE OF HOG KIDNEY. I. PURIFICATION AND PROPERTIES.
  Journal
J Biol Chem 240:2461-4 (1965)
Reference
3  [PMID:6766137]
  Authors
McGuire DM, Tormanen CD, Segal IS, Van Pilsum JF.
  Title
The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats. Purification and some properties of rat kidney transamidinase.
  Journal
J Biol Chem 255:1152-9 (1980)
  Sequence
[rno:81660]
Reference
4
  Authors
Ratner, S.
  Title
Transamidination.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 267-275.
Reference
5  [PMID:13355454]
  Authors
RATNER S, ROCHOVANSKY O.
  Title
Biosynthesis of guanidinoacetic acid.  I.  Purification and properties of transamidinase.
  Journal
Arch Biochem Biophys 63:277-95 (1956)
DOI:10.1016/0003-9861(56)90044-3
Reference
6  [PMID:13355455]
  Authors
RATNER S, ROCHOVANSKY O.
  Title
Biosynthesis of guanidinoacetic acid.  II.  Mechanism of amidine group transfer.
  Journal
Arch Biochem Biophys 63:296-315 (1956)
DOI:10.1016/0003-9861(56)90045-5
Reference
7  [PMID:13278360]
  Authors
WALKER JB.
  Title
Biosynthesis of arginine from canavanine and ornithine in kidney.
  Journal
J Biol Chem 218:549-56 (1956)
Reference
8  [PMID:13398387]
  Authors
WALKER JB.
  Title
Studies on the mechanism of action of kidney transamidinase.
  Journal
J Biol Chem 224:57-66 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.4.1
IUBMB Enzyme Nomenclature: 2.1.4.1
ExPASy - ENZYME nomenclature database: 2.1.4.1
BRENDA, the Enzyme Database: 2.1.4.1
CAS: 9027-35-4
LinkDB

DBGET integrated database retrieval system