KEGG   ENZYME: 2.1.4.4
Entry
EC 2.1.4.4                  Enzyme                                 
Name
valine amidinotransferase;
ktmE (gene name);
st-amdT (gene name)
Class
Transferases;
Transferring one-carbon groups;
Amidinotransferases
Sysname
L-arginine:L-valine amidinotransferase
Reaction(IUBMB)
L-arginine + L-valine = N-amidino-L-valine + L-ornithine [RN:R13429]
Reaction(KEGG)
R13429
Substrate
L-arginine [CPD:C00062];
L-valine [CPD:C00183]
Product
N-amidino-L-valine [CPD:C22989];
L-ornithine [CPD:C00077]
Comment
The enzyme, characterized from the bacterium Salinispora tropica, participates in the biosynthesis of ketomemicins. In vitro the enzyme could use multiple other amino acids, including L-cysteine, L-isoleucine, L-leucine, L-methionine, L-tyrosine, L-phenylalanine and L-tryptophan instead of L-valine.
History
EC 2.1.4.4 created 2024
Orthology
K27988  valine amidinotransferase
Genes
STRVEZV63_00425
STPStrop_1716
SAQSare_2924
Reference
1  [PMID:27289319]
  Authors
Ogasawara Y, Fujimori M, Kawata J, Dairi T.
  Title
Characterization of three amidinotransferases involved in the biosynthesis of ketomemicins.
  Journal
Bioorg Med Chem Lett 26:3662-4 (2016)
DOI:10.1016/j.bmcl.2016.05.090
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.4.4
IUBMB Enzyme Nomenclature: 2.1.4.4
ExPASy - ENZYME nomenclature database: 2.1.4.4
BRENDA, the Enzyme Database: 2.1.4.4
LinkDB

DBGET integrated database retrieval system